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1. 发明授权

US09560974B2 Luminescence based noninvasive remote parameter sensor and sensing method 有权
标题翻译：基于发光的无创远程参数传感器和感测方法
公开(公告)号：US09560974B2
公开(公告)日：2017-02-07
申请号：US13539067
申请日：2012-06-29
申请人： Leah Tolosa , Hung Lam , Yordan Kostov , Steven M Falk , Govind Rao
发明人： Leah Tolosa , Hung Lam , Yordan Kostov , Steven M Falk , Govind Rao
IPC分类号： A61B5/00 , A61B5/01
CPC分类号： A61B5/01 , A61B5/0071 , A61B5/6832 , A61B5/74 , A61B2503/045
摘要： A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.
摘要翻译：提供了一种非侵入式远程参数传感器和感测方法，特别适用于远程监测皮肤温度。传感器和感测方法利用基于发光的传感器，其对皮肤无毒且无刺激性。传感器优选地使用嵌入软水凝胶中的一种或多种类型的荧光团。传感器用激发光照亮，通过检测和分析来自荧光团的发射光来监测温度。因为使用软水凝胶，所以在温度测量结束时，传感器可以轻轻地从皮肤上擦去。

2. 发明申请

US20130079661A1 LUMINESCENCE BASED NONINVASIVE REMOTE PARAMETER SENSOR AND SENSING METHOD 有权
标题翻译：基于光谱的非动态遥测参数传感器和感测方法
公开(公告)号：US20130079661A1
公开(公告)日：2013-03-28
申请号：US13539067
申请日：2012-06-29
申请人： Leah Tolosa , Hung Lam , Yordan Kostov , Steven M. Falk , Govind Rao
发明人： Leah Tolosa , Hung Lam , Yordan Kostov , Steven M. Falk , Govind Rao
IPC分类号： A61B5/01 , A61B5/00
CPC分类号： A61B5/01 , A61B5/0071 , A61B5/6832 , A61B5/74 , A61B2503/045
摘要： A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.
摘要翻译：提供了一种非侵入式远程参数传感器和感测方法，特别适用于远程监测皮肤温度。传感器和感测方法利用基于发光的传感器，其对皮肤无毒且无刺激性。传感器优选地使用嵌入软水凝胶中的一种或多种类型的荧光团。传感器用激发光照亮，通过检测和分析来自荧光团的发射光来监测温度。因为使用软水凝胶，所以在温度测量结束时，传感器可以轻轻地从皮肤上擦去。

3. 发明授权

US08993972B2 Fluorescence based sensors utilizing a mirrored cavity 有权
标题翻译：基于荧光的传感器利用镜像腔
公开(公告)号：US08993972B2
公开(公告)日：2015-03-31
申请号：US12692752
申请日：2010-01-25
申请人： Govind Rao , Hung Lam , Yordan Kostov , Leah Tolosa , Xudong Ge
发明人： Govind Rao , Hung Lam , Yordan Kostov , Leah Tolosa , Xudong Ge
IPC分类号： G01T1/20 , G01N21/64
CPC分类号： G01N21/645
摘要： A fluorescence based sensor system that provides improved signal-to-noise over prior systems is provided. The system includes a fluorescence based sensing medium that is contained a recessed cavity with reflective sides that allow for more uniform excitation of the fluorescence based sensing medium by the excitation light.
摘要翻译：提供了基于荧光的传感器系统，其提供了比现有系统更好的信噪比。该系统包括基于荧光的感测介质，其包含具有反射侧的凹腔，其允许通过激发光更均匀地激发基于荧光的感测介质。

4. 发明授权

US08654319B2 Chlorophyll and turbidity sensor system 有权
标题翻译：叶绿素和浊度传感器系统
公开(公告)号：US08654319B2
公开(公告)日：2014-02-18
申请号：US13142284
申请日：2010-01-25
申请人： Govind Rao , Hung Lam , Yordan Kostov , Leah Tolosa , Xudong Ge
发明人： Govind Rao , Hung Lam , Yordan Kostov , Leah Tolosa , Xudong Ge
IPC分类号： G01N1/00
CPC分类号： G01N33/5308 , G01N21/05 , G01N21/15 , G01N21/532 , G01N21/645 , G01N21/6486 , G01N21/82 , G01N21/8507 , G01N2021/635 , G01N2021/6432 , G01N2201/0218 , G01N2201/0627
摘要： A low cost sensing system that can measure both chlorophyll concentration and turbidity is provided. The system is an optical system that utilizes at least three light sensors for measuring side-scattered and forward scattered light, as well as fluorescence. The system is able to take optical density measurements, steady state fluorescence measurements and maximum fluorescence measurements, and can be configured for wireless control and data transmission. The system may also be housed in one or more fluidtight housings so as to make it submersible.
摘要翻译：提供了可以测量叶绿素浓度和浊度的低成本感测系统。该系统是利用至少三个光传感器来测量侧向散射和向前散射光以及荧光的光学系统。该系统能够进行光密度测量，稳态荧光测量和最大荧光测量，并可配置为无线控制和数据传输。该系统还可以容纳在一个或多个流体密封的壳体中，以使其潜水。

5. 发明申请

US20110273705A1 CHLOROPHYLL AND TURBIDITY SENSOR SYSTEM 有权
标题翻译：氯乙烯和涡轮传感器系统
公开(公告)号：US20110273705A1
公开(公告)日：2011-11-10
申请号：US13142284
申请日：2010-01-25
申请人： Govind Rao , Hung Lam , Yordan Kostov , Leah Tolosa , Xudong Ge
发明人： Govind Rao , Hung Lam , Yordan Kostov , Leah Tolosa , Xudong Ge
IPC分类号： G01J1/42
CPC分类号： G01N33/5308 , G01N21/05 , G01N21/15 , G01N21/532 , G01N21/645 , G01N21/6486 , G01N21/82 , G01N21/8507 , G01N2021/635 , G01N2021/6432 , G01N2201/0218 , G01N2201/0627
摘要： A low cost sensing system that can measure both chlorophyll concentration and turbidity is provided. The system is an optical system that utilizes at least three light sensors for measuring side-scattered and forward scattered light, as well as fluorescence. The system is able to take optical density measurements, steady state fluorescence measurements and maximum fluorescence measurements, and can be configured for wireless control and data transmission. The system may also be housed in one or more fluidtight housings so as to make it submersible.
摘要翻译：提供了可以测量叶绿素浓度和浊度的低成本感测系统。该系统是利用至少三个光传感器来测量侧向散射和向前散射光以及荧光的光学系统。该系统能够进行光密度测量，稳态荧光测量和最大荧光测量，并可配置为无线控制和数据传输。该系统还可以容纳在一个或多个流体密封的壳体中，以使其潜水。

6. 发明申请

US20120283575A1 REMOTE NON-INVASIVE PARAMETER SENSING SYSTEM AND METHOD 审中-公开
标题翻译：远程非入侵参数传感系统及方法
公开(公告)号：US20120283575A1
公开(公告)日：2012-11-08
申请号：US13501081
申请日：2010-10-12
申请人： Govind Rao , Yordan Kostov , Leah Tolosa , Hung Lam
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Hung Lam
IPC分类号： A61B5/01 , A61B6/00
CPC分类号： A61B5/015
摘要： A remote parameter sensing system is provide that includes a gel sensor, a light source, a detector and a controller 140. The gel sensor is in contact with a surface where the parameter is to be measured, and is preferably a gel that is embedded with a chemical that emits light 160 (via, for example, fluorescence) when it is excited by excitation light from the light source at an appropriate excitation frequency. The chemical properties of the gel sensor are such that at least one characteristic of the emission light (such as, for example, emission intensity) varies as a function of variations in the parameter being measured. The system is particularly suited for use as remote body temperature sensing system in incubators and radiant warmers for infant and neonatal care.
摘要翻译：提供了一种远程参数感测系统，其包括凝胶传感器，光源，检测器和控制器140.凝胶传感器与要测量参数的表面接触，并且优选地是嵌入当通过来自光源的激发光以适当的激发频率激发时，发出光160（通过例如荧光）的化学品。凝胶传感器的化学性质使得发射光（例如发光强度）的至少一个特性随着被测参数的变化而变化。该系统特别适用于孵化器中的远程体温感测系统和用于婴儿和新生儿护理的辐射加热器。

7. 发明授权

US09388373B2 Microscale bioprocessing system and method for protein manufacturing 有权
标题翻译：微型生物处理系统和蛋白质制造方法
公开(公告)号：US09388373B2
公开(公告)日：2016-07-12
申请号：US13823911
申请日：2012-03-08
申请人： Govind Rao , Yordan Kostov , Leah Tolosa , Lam Hung , Xudong Ge , Douglas Frey , Virendra Singh
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Lam Hung , Xudong Ge , Douglas Frey , Virendra Singh
IPC分类号： C12M1/40 , C12M1/00 , C12M1/36
CPC分类号： C12M21/14 , B01D15/327 , B01D15/361 , B01D15/3847 , C07K1/34 , C07K1/36 , C12M21/18 , C12M29/04 , C12M41/34 , C12M41/48 , C12M43/00 , C12M47/12
摘要： A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
摘要翻译：提供了一种用于蛋白质制造的生物处理系统，其紧凑，集成并适合于按需生产和递送治疗性蛋白质给患者。该系统还可用于任何类型蛋白质的按需生产。

8. 发明授权

US09538944B2 Non-invasive analyte sensing system and method 有权
标题翻译：非侵入性分析物传感系统及方法
公开(公告)号：US09538944B2
公开(公告)日：2017-01-10
申请号：US13823903
申请日：2011-09-30
申请人： Govind Rao , Yordan Kostov , Xudong Ge , Leah Tolosa , Hyung Woo , Rose Viscardi
发明人： Govind Rao , Yordan Kostov , Xudong Ge , Leah Tolosa , Hyung Woo , Rose Viscardi
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/14552 , A61B5/6807 , A61B5/6829
摘要： A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.
摘要翻译：提供一种非侵入性气体分析物感测和监测系统和方法，其特别适用于哺乳动物的动脉血气的经皮监测。该系统和方法依赖于待测量分析物扩散到扩散室中，并使用光学化学传感器和相关联的光电子学来远程检测扩散室中的分析物。

9. 发明申请

US20130280797A1 MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING 有权
标题翻译： MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR蛋白质制造
公开(公告)号：US20130280797A1
公开(公告)日：2013-10-24
申请号：US13823911
申请日：2012-03-08
申请人： Govind Rao , Yordan Kostov , Leah Tolosa , Lam Hung , Xudong Ge , Douglas Frey , Virenda Singh
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Lam Hung , Xudong Ge , Douglas Frey , Virenda Singh
IPC分类号： C12M1/40
CPC分类号： C12M21/14 , B01D15/327 , B01D15/361 , B01D15/3847 , C07K1/34 , C07K1/36 , C12M21/18 , C12M29/04 , C12M41/34 , C12M41/48 , C12M43/00 , C12M47/12
摘要： A bioprocessing system for protein manufacturing is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The system can also be used for efficient on-demand production of any type of protein.
摘要翻译：提供了一种用于蛋白质制造的生物处理系统，其紧凑，集成并适合于按需生产和递送治疗性蛋白质给患者。该系统还可用于任何类型蛋白质的按需生产。

10. 发明申请

US20170226467A1 MICROSCALE BIOPROCESSING SYSTEM AND METHOD FOR PROTEIN MANUFACTURING FROM HUMAN BLOOD 审中-公开
公开(公告)号：US20170226467A1
公开(公告)日：2017-08-10
申请号：US15329555
申请日：2015-07-31
申请人： Govind Rao , Yordan Kostov , Leah Tolosa , Kevin Tran , Monohar Pilli , Michael Tolosa , Chandrashekar Gurramkonda
发明人： Govind Rao , Yordan Kostov , Leah Tolosa , Kevin Tran , Monohar Pilli , Michael Tolosa , Chandrashekar Gurramkonda
IPC分类号： C12M1/00 , B01D15/38 , B01D15/36 , B01D15/32 , C12M1/40 , C07K1/36
摘要： A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The patient's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.

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