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1. 发明授权

US08998808B2 System for identifying patient response to anesthesia infusion 有权
标题翻译：用于识别患者对麻醉输液的反应的系统
公开(公告)号：US08998808B2
公开(公告)日：2015-04-07
申请号：US10561074
申请日：2004-06-21
申请人： Le Yi Wang , Hong Wang , Gang George Yin
发明人： Le Yi Wang , Hong Wang , Gang George Yin
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06F19/3468 , A61B5/0476 , A61B5/0484 , A61B5/4821 , A61M5/142 , A61M5/1723 , A61M2202/0241 , A61M2205/52 , A61M2230/10 , G06F19/00 , G06F19/3481
摘要： A generic model structure captures basic characteristics in BIS-based patients' responses to anesthesia and surgical stimulation, the model being used in combination with the insight of an anesthesiologist. The model structure represents the patient response with a time delay, a time constant for response speed, and a nonlinear function for drug sensitivity. Clinical data confirms the model structure and is used to establish parameters and function forms for individual patients. A feedback and predictive control strategy for anesthesia drug infusion is then introduced on the basis of the patient model. Feedback control alone cannot avoid large fluctuations in BIS values when significant surgical stimulation is imposed, as a result of time delays in a patient's response to drug infusion. Predictive control attenuates fluctuations of BIS levels from surgical stimulation.
摘要翻译：通用模型结构捕获了基于BIS的患者对麻醉和手术刺激的反应的基本特征，该模型与麻醉师的洞察结合使用。模型结构表示患者反应时间延迟，反应速度的时间常数和药物敏感性的非线性函数。临床资料证实了模型结构，用于为个体患者建立参数和功能形式。然后在患者模型的基础上引入麻醉药物输注的反馈和预测控制策略。由于患者对药物输注的反应时间延迟，单独的反馈控制不能避免在施加显着的手术刺激时BIS值的大的波动。预测控制减少BIS水平从手术刺激的波动。

2. 发明申请

US20070219059A1 Method and system for continuous monitoring and training of exercise 审中-公开
标题翻译：持续监测和训练运动的方法和系统
公开(公告)号：US20070219059A1
公开(公告)日：2007-09-20
申请号：US11725514
申请日：2007-03-19
申请人： Mark H. Schwartz , Le Yi Wang , Hong Wang
发明人： Mark H. Schwartz , Le Yi Wang , Hong Wang
IPC分类号： A63B15/02 , A63B71/00
CPC分类号： A61B7/003 , A61B5/0205 , A61B5/02405 , A61B5/0402 , A61B5/7203 , A61B5/721 , A61B7/04 , A63B21/0628 , A63B22/02 , A63B22/0605 , A63B22/0664 , A63B24/0062 , A63B24/0075 , A63B24/0084 , A63B69/16 , A63B71/0622 , A63B2022/0652 , A63B2022/0658 , A63B2024/0068 , A63B2071/0627 , A63B2220/13 , A63B2220/17 , A63B2220/20 , A63B2220/40 , A63B2225/10 , A63B2225/15 , A63B2225/20 , A63B2225/50 , A63B2225/54 , A63B2230/04 , A63B2230/06 , A63B2230/42 , A63B2230/43 , G06F1/1626 , G06F19/3481
摘要： A method and system is invented for continuous monitoring, real-time analysis, and automated and personalized training of exercise. The system embodies a multi-sensor data acquisition system to measure body sounds, body signs, vital signs, motions, and machine settings continuously and automatically. The system is able to capture the body sounds and other vital signs, analyze them, and report and display summarized results. The signal processing functions utilize a unique signal separation and noise removal methodology by which authentic signals can be extracted from interfered signals and in noisy environments, even when signals and noises have similar frequency components or are statistically dependent.The method and system will facilitate continuous monitoring, real-time analysis, and computerized evaluation of level of effort, physical stress, and resulting fatigue during physical activity or exercise. In addition, based on body sound data, or in combination with other monitored physiological signals, and knowledge of the individual and exercise being performed, the system will evaluate the person's physical performance and then act as an automated coach to guide exercise intensity and duration thereby optimizing and individualizing the training process. The invention is especially targeted, but not limited to, cardiopulmonary monitoring for athletes for improving the efficiency and safety of exercise, rehabilitation programs for out-of-shape individuals, and routine exercise of the general population.
摘要翻译：发明了一种方法和系统，用于连续监测，实时分析和自动化和个性化的运动训练。该系统体现了一种多传感器数据采集系统，可以持续，自动地测量身体声音，身体体征，生命体征，运动和机器设置。该系统能够捕获身体声音和其他生命体征，分析它们，并报告和显示总结结果。信号处理功能利用独特的信号分离和噪声去除方法，通过该方法可以从干扰信号和噪声环境中提取真实信号，即使信号和噪声具有相似的频率分量或统计依赖。该方法和系统将有助于持续监测，实时分析，以及在身体活动或运动期间的努力水平，身体压力和疲劳导致的计算机化评估。另外，根据身体声音数据，或与其他被监测的生理信号结合，以及执行个人和运动的知识，系统将评估人的身体表现，然后作为自动化教练来引导运动强度和持续时间，从而优化和个性化培训过程。本发明特别针对但不限于运动员的心肺监测，以提高运动的效率和安全性，体外个体的康复计划和一般人群的常规运动。

3. 发明申请

US20070015972A1 System for identifying patient response to anesthesia infusion 有权
标题翻译：用于识别患者对麻醉输液的反应的系统
公开(公告)号：US20070015972A1
公开(公告)日：2007-01-18
申请号：US10561074
申请日：2004-06-21
申请人： Le Yi Wang , Hong Wang , Gang Yin
发明人： Le Yi Wang , Hong Wang , Gang Yin
IPC分类号： A61B5/00 , G06G7/48 , A61M31/00
CPC分类号： G06F19/3468 , A61B5/0476 , A61B5/0484 , A61B5/4821 , A61M5/142 , A61M5/1723 , A61M2202/0241 , A61M2205/52 , A61M2230/10 , G06F19/00 , G06F19/3481
摘要： A generic model structure captures basic characteristics in BIS-based patients' responses to anesthesia and surgical stimulation, the model being used in combination with the insight of an anesthesiologist. The model structure represents the patient response with a time delay, a time constant for response speed, and a nonlinear function for drug sensitivity. Clinical data confirms the model structure and is used to establish parameters and function forms for individual patients. A feedback and predictive control strategy for anesthesia drug infusion is then introduced on the basis of the patient model. Feedback control alone cannot avoid large fluctuations in BIS values when significant surgical stimulation is imposed, as a result of time delays in a patient's response to drug infusion. Predictive control attenuates fluctuations of BIS levels from surgical stimulation.
摘要翻译：通用模型结构捕获了基于BIS的患者对麻醉和手术刺激的反应的基本特征，该模型与麻醉师的洞察结合使用。模型结构表示患者反应时间延迟，反应速度的时间常数和药物敏感性的非线性函数。临床资料证实了模型结构，用于为个体患者建立参数和功能形式。然后在患者模型的基础上引入麻醉药物输注的反馈和预测控制策略。由于患者对药物输注的反应时间延迟，单独的反馈控制不能避免在施加显着的手术刺激时BIS值的大的波动。预测控制减少BIS水平从手术刺激的波动。

4. 发明授权

US10420166B2 Method for avoiding handover failure 有权
公开(公告)号：US10420166B2
公开(公告)日：2019-09-17
申请号：US13542247
申请日：2012-07-05
申请人： Lixiang Xu , Hong Wang , Huarui Liang
发明人： Lixiang Xu , Hong Wang , Huarui Liang
IPC分类号： H04W76/30 , H04W8/08 , H04W36/00
摘要： Methods for avoiding handover failure are provided. The method includes determining, by a source Base Station (BS), to perform a handover of a User Equipment (UE); determining, by the source BS, whether a target BS connects with a user plane node serving the UE at the source BS; and releasing resources, when the target BS does not connect with the user plane node serving the UE at the source BS.

5. 发明授权

US10089263B2 Synchronization of interrupt processing to reduce power consumption 有权
公开(公告)号：US10089263B2
公开(公告)日：2018-10-02
申请号：US15118501
申请日：2014-03-24
申请人： INTEL CORPORATION , Thiam Wah Loh , Gautham N. Chinya , Per Hammarlund , Reza Fortas , Hong Wang , Huajin Sun
发明人： Thiam Wah Loh , Gautham N. Chinya , Per Hammarlund , Reza Fortas , Hong Wang , Huajin Sun
IPC分类号： G06F13/24
摘要： A processor is disclosed and includes at least one core including a first core, and interrupt delay logic. The interrupt delay logic is to receive a first interrupt at a first time and delay the first interrupt from being processed by a first time delay that begins at the first time, unless the first interrupt is pending at a second time when a second interrupt is processed by the first core. If the first interrupt is pending at the second time, the interrupt delay logic is to indicate to the first core to begin to process the first interrupt prior to completion of the first time delay. Other embodiments are disclosed and claimed.

6. 发明申请

US20180225118A1 METHOD AND SYSTEM TO PROVIDE USER-LEVEL MULTITHREADING 审中-公开
公开(公告)号：US20180225118A1
公开(公告)日：2018-08-09
申请号：US15943614
申请日：2018-04-02
申请人： Ed Grochowski , Hong Wang , John P. Shen , Perry H. Wang , Jamison D. Collins , James Held , Partha Kundu , Raya Leviathan , Tin-Fook Ngai
发明人： Ed Grochowski , Hong Wang , John P. Shen , Perry H. Wang , Jamison D. Collins , James Held , Partha Kundu , Raya Leviathan , Tin-Fook Ngai
IPC分类号： G06F9/30 , G06F9/38
CPC分类号： G06F9/30003 , G06F9/30087 , G06F9/3009 , G06F9/30101 , G06F9/3013 , G06F9/384 , G06F9/3851
摘要： A method and system to provide user-level multithreading are disclosed. The method according to the present techniques comprises receiving programming instructions to execute one or more shared resource threads (shreds) via an instruction set architecture (ISA). One or more instruction pointers are configured via the ISA; and the one or more shreds are executed simultaneously with a microprocessor, wherein the microprocessor includes multiple instruction sequencers.

7. 发明授权

US09867157B2 Method for detachment of MS moving between communication systems 有权
公开(公告)号：US09867157B2
公开(公告)日：2018-01-09
申请号：US12527328
申请日：2008-02-13
申请人： Bing Bu , Xiaoqiang Li , Chunying Sun , Hong Wang , Lixiang Xu , Yanmin Zhu
发明人： Bing Bu , Xiaoqiang Li , Chunying Sun , Hong Wang , Lixiang Xu , Yanmin Zhu
IPC分类号： H04W60/06 , H04W76/06
CPC分类号： H04W60/06 , H04W76/32
摘要： A method for detachment of a mobile set within the equivalent route area moving between the communication systems comprising steps of: during the detachment process is implemented between a mobile set and a service node in one communication system, the service node generates one or more messages and transmits it to the service nodes in one or more communication system within the ERA. If the message is transmitted to the service node within the ERA of only one communication system, this service node transmits this message or the message generated according to this message to the service nodes within the ERA of the other communication system. With the method proposed in present invention, when a mobile is detached from two or more communication systems which share the same ERA, the service nodes in all communication systems within the ERA can still correctly manage the relevant information on this mobile set.

8. 发明申请

US20170020717A1 Condom with Side Portals 审中-公开
标题翻译：安全套与侧门
公开(公告)号：US20170020717A1
公开(公告)日：2017-01-26
申请号：US15273117
申请日：2016-09-22
申请人： Hong Wang
发明人： Hong Wang
IPC分类号： A61F6/04
CPC分类号： A61F6/04
摘要： A condom of embodiments of the disclosed technology has a tip and base with cords connecting the two, creating portals where the urethra is exposed and fully capable of feeling abrasion with other objects. The base ring is oppositely disposed from the tip and an extreme other end of the condom. The base ring also extends circumferentially and in parallel to a largest circumference of the solid tip, when the cord extends perpendicularly to the largest circumference of the solid tip and the base ring. The largest circumference of the circle referred to herein, in embodiments of the disclosed technology, is a portion of the tip which is closest to the base ring.
摘要翻译：所公开技术的实施例的避孕套具有尖端和底部，其具有连接两者的线，创建出口的位置，其中尿道被暴露并且完全能够感受到与其它物体的磨损。基座环从尖端和避孕套的极端另一端相对设置。当绳索垂直于固体末端和基环的最大圆周延伸时，基环也周向地并且平行于固体末端的最大圆周延伸。在所公开的技术的实施例中，这里提到的圆的最大圆周是尖端的最靠近基环的部分。

9. 发明授权

US09198891B2 Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase 有权
标题翻译：通过抑制蛋白激酶样内质网蛋白激酶治疗癌症的方法
公开(公告)号：US09198891B2
公开(公告)日：2015-12-01
申请号：US13111769
申请日：2011-05-19
申请人： Timothy Cardozo , Hong Wang , David Ron
发明人： Timothy Cardozo , Hong Wang , David Ron
IPC分类号： A61K49/00 , A61K31/225 , A61K31/24 , A61K31/4166 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/496 , A61K31/519 , A61K31/536 , C07D207/416 , C07D239/42 , C07D249/12 , C07D265/22 , C07D277/44 , C07D277/54 , C07D277/66 , C07D307/54 , C07D317/60 , C07D403/04 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/14 , C07D487/04 , C12Q1/48 , G06F19/00 , G06F19/16
CPC分类号： A61K31/225 , A61K31/24 , A61K31/4166 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/496 , A61K31/519 , A61K31/536 , C07D207/416 , C07D239/42 , C07D249/12 , C07D265/22 , C07D277/44 , C07D277/54 , C07D277/66 , C07D307/54 , C07D317/60 , C07D403/04 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/14 , C07D487/04 , C12Q1/485 , G06F19/16 , G06F19/706
摘要： The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases.
摘要翻译：本发明涉及鉴定可用于抑制蛋白激酶样内质网蛋白激酶（PERK）的化合物的方法。该方法包括提供包含PERK活性结构域的第一模型，其中所述活性域选自跨越SEQ ID NO：1的氨基酸残基Asp144至氨基酸残基Ser191的肽和包含氨基酸的肽提供一种或多种候选化合物，评估候选化合物与第一模型之间的接触，以确定一种或多种候选化合物中的哪一种具有结合和/或适合的能力第一模型，以及鉴定基于所述评估具有结合和/或适合第一模型的能力的化合物，作为潜在地可用于抑制PERK的化合物。本发明还涉及可用于抑制PERK的化合物，例如人PERK，以及与治疗PERK介导的疾病有关的方法。

10. 发明申请

US20150153329A1 ASSAY SYSTEM FOR GLP-2 RECEPTOR LIGANDS 审中-公开
标题翻译： GLP-2受体配体的测定系统
公开(公告)号：US20150153329A1
公开(公告)日：2015-06-04
申请号：US14616295
申请日：2015-02-06
申请人： Lidia L. Demchyshyn , Hong Wang
发明人： Lidia L. Demchyshyn , Hong Wang
IPC分类号： G01N33/50 , G01N33/74
CPC分类号： G01N33/5082 , G01N33/5088 , G01N33/74 , G01N2333/605 , G01N2333/726 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.
摘要翻译：本文公开了一种用于在用GLP-2或GLP-2配体处理时测量肠组织的收缩性的方法。还公开了一种直接测量GLP-2或GLP-2配体活性的测定法，并允许在天然组织中筛选推定的GLP-2配体。

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