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1. 发明授权

US4482547A Substituted-1,3,4-benzotriazepines 失效
标题翻译：取代的1,3,4-苯并三氮杂
公开(公告)号：US4482547A
公开(公告)日：1984-11-13
申请号：US412047
申请日：1982-08-26
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： A61K31/55 , A61P31/04 , C07D255/04
CPC分类号： C07C243/00 , C07D255/04
摘要： This invention relates to substituted-1,3,4-benzotriazepines of the formula ##STR1## wherein X and Y are each independently hydrogen, lower alkyl, halogen, lower alkoxy, nitro and hydroxyl; R.sub.1 and R.sub.3 are each independently hydrogen or alkyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, Ar lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tautomeric form when the substituent for R.sub.1 and/or R.sub.3 in the above formula is hydrogen. The compound of this invention may be used as antihypertensive agents.
摘要翻译：本发明涉及下式的取代-1,3,4-苯并三氮杂其中X和Y各自独立地为氢，低级烷基，卤素，低级烷氧基，硝基和羟基; R1和R3各自独立地为氢或烷基; R2是氢，低级烷基，环烷基低级烷基，苯基，Ar低级烷基，羟基和巯基; m和n各自独立地为0或1的整数，当m为0时，n为1，反之亦然; 并且p和q独立地为1或2的整数。当上式中的R 1和/或R 3的取代基是氢时，本发明中还包括互变异构形式的取代的1,3,4-苯并三氮杂衍生物。本发明化合物可用作抗高血压药。

2. 发明授权

US4526891A Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins 失效
标题翻译： 6,11-二氢-11-氧代二苯并[b，e]氧杂七环素的取代烷基胺衍生物
公开(公告)号：US4526891A
公开(公告)日：1985-07-02
申请号：US474106
申请日：1983-03-10
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： A61K31/335 , A61K31/435 , A61K31/443 , A61K31/445 , A61K31/495 , A61P25/04 , C07C65/24 , C07D313/12 , C07D405/06 , C07D405/14 , C07D471/10
CPC分类号： C07D405/06 , C07C65/24 , C07D313/12 , C07D405/14 , C07D471/10
摘要： This invention relates to compounds of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF.sub.3 ; R is H, and lower alkyl, R.sub.1 is CH.sub.3 SO.sub.3 and ##STR2## where R.sub.2 and R.sub.3 are the same or different and are hydrogen, lower alkyl, mesyl (CH.sub.3 SO.sub.2 --), and cycloalkyl loweralkyl; ##STR3##
摘要翻译：本发明涉及下式的化合物：其中X是氢，卤素，低级烷氧基，低级烷基，硝基，羟基和CF 3; R为H，低级烷基，R 1为CH 3 SO 3，且R 2和R 3相同或不同，为氢，低级烷基，甲磺酰基（CH 3 SO 2 - ）和环烷基低级烷基; + TR

3. 发明授权

US4477465A Substituted 4,10-dihydro-10-oxothieno benzoxepins 失效
标题翻译：取代的4,10-二氢-10-氧代噻吩并苯并氧杂苯环酮
公开(公告)号：US4477465A
公开(公告)日：1984-10-16
申请号：US474218
申请日：1983-03-10
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07D495/04 , A61K31/38
CPC分类号： C07D495/04
摘要： This invention relates to substituted 4,10-dihydro-10-oxothieno benzoxepins of the formula, ##STR1## where R is hydrogen and lower alkyl; R.sub.1 is ##STR2## where R.sub.2 is hydrogen, lower alkyl and benzyl of the formula ##STR3## where X is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, nitro, and amino; ##STR4## where R.sub.3 and R.sub.4 are the same or different and are hydrogen and lower alkyl; ##STR5## where R.sub.5 and R.sub.6 are the same or different and are lower alkyl; and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明涉及下式的取代的4,10-二氢-10-氧代噻吩并苯并恶庚质，其中R是氢和低级烷基; R 1是其中R 2是氢，低级烷基和下式的苄基，其中X是氢，低级烷基，低级烷氧基，卤素，三氟甲基，硝基和氨基; 其中R3和R4相同或不同，为氢和低级烷基; 其中R 5和R 6相同或不同，为低级烷基; 及其药学上可接受的酸加成盐。

4. 发明授权

US4742171A Method of synthesizing 1,4-dihydro-benzo[c]-1,5-naphthyridin-2(3H)-ones 失效
标题翻译：合成1,4-二氢 - 苯并[c] -1,5-萘啶-2（3H） - 酮的方法
公开(公告)号：US4742171A
公开(公告)日：1988-05-03
申请号：US926752
申请日：1986-11-04
申请人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
发明人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
IPC分类号： C07D207/28 , C07D471/04 , C07D471/06
CPC分类号： C07D471/04 , C07D207/28
摘要： There is described a method of synthesizing 1,4-dihydro-benzo[c]-1,5-naphthyridin-2(3H)-ones having the formula ##STR1## where X is hydrogen, halogen, loweralkyl, loweralkoxy, trifluoromethyl or hydroxy, which method consists essentially of the aromatization and rearrangement of 1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10(2H,5H)-dione oximes of the formula below: ##STR2##
摘要翻译：描述了一种合成具有式“IMAGE”的1,4-二氢 - 苯并[c] -1,5-二氮杂萘-2（3H） - 酮的方法，其中X是氢，卤素，低级烷基，低级烷氧基，三氟甲基或羟基，该方法基本上由以下公式的1,10a-二氢吡咯并[1,2-b]异喹啉-3,10（2H，5H） - 二酮肟的芳构化和重排组成：

5. 发明授权

US4670562A Dihydropyrrolo[1,2-b]isoquinolinedione oximes 失效
标题翻译：二氢吡咯并[1,2-b]异喹啉二酮肟
公开(公告)号：US4670562A
公开(公告)日：1987-06-02
申请号：US926691
申请日：1986-11-04
申请人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
发明人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
IPC分类号： C07D207/28 , C07D471/04
CPC分类号： C07D471/04 , C07D207/28
摘要： There is disclosed novel compounds of the formula ##STR1## where X is H, halogen, loweralkyl, loweralkoxy, -CF.sub.3, or -OH; R is H, loweralkyl, arylloweralkyl, diarylloweralkyl, loweralkanoyl, arylloweralkanoyl or diarylloweralkanoyl; and R.sub.1 is H.sub.2, O or --NR.sub.2 R.sub.3, R.sub.2 and R.sub.3 being independently H or loweralkyl, or taken together with the nitrogen atom to which they are attached constitute ##STR2## R.sub.4 in turn being H, loweralkyl, hydroxyloweralkyl, aryl, arylloweralkyl or diarylloweralkyl or pharmaceutically acceptable acid addition salts thereof, which are useful for enchancing memory.
摘要翻译：公开了新的式（Ⅰ）化合物，其中X是H，卤素，低级烷基，低级烷氧基，-CF 3或-OH; R为H，低级烷基，芳基低级烷基，二芳基低级烷基，低级烷酰基，芳基低级烷酰基或二芳基低级烷酰基; 并且R 1是H 2，O或-NR 2 R 3，R 2和R 3独立地是H或低级烷基，或者与它们所连接的氮原子一起构成H 4，R 4又是H，低级烷基，羟基低级烷基，芳基，芳基低级烷基或二芳基低级烷基或其药学上可接受的酸加成盐，其可用于增强记忆。

6. 发明授权

US5008285A (6,11-dihydro-11-oxodibenz[b,e]oxepin-yl)pentanoic acids and derivatives thereof 失效
标题翻译：（6,11-二氢-11-氧代二苯并[b，e]氧杂环庚烯基）戊酸及其衍生物
公开(公告)号：US5008285A
公开(公告)日：1991-04-16
申请号：US430045
申请日：1989-11-01
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07C65/24 , C07D313/12
CPC分类号： C07D313/12 , C07C65/24
摘要： Novel (6,11-dihydro-11-oxodibenz[b,e]oxepinyl)pentanoic acids and derivatives thereof, intermediates and processes for the preparation thereof, and methods for suppressing arthritis-like inflammation utilizing compounds or compositions thereof are disclosed.
摘要翻译：公开了新型（6,11-二氢-11-氧代二苯并[b，e]氧自由基）戊酸及其衍生物，其中间体及其制备方法，以及利用化合物或其组合物抑制关节炎样炎症的方法。

7. 发明授权

US4751238A Substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins 失效
标题翻译： 6,11-二氢-11-氧代二苯并[b，e]氧杂七环素的取代烷基胺衍生物
公开(公告)号：US4751238A
公开(公告)日：1988-06-14
申请号：US875844
申请日：1986-06-18
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07C65/24 , C07D313/12 , C07D405/06 , C07D405/14 , C07D471/10 , A61K31/335
CPC分类号： C07D405/06 , C07C65/24 , C07D313/12 , C07D405/14 , C07D471/10
摘要： This invention relates to substituted alkyl amine derivatives of 6,11-dihydro-11-oxodibenz[b,e]oxepins of the formula: ##STR1## where X is hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF.sub.3 ; R is H, and lower alkyl, R.sub.1 is CH.sub.3 SO.sub.3 and ##STR2## where R.sub.2 and R.sub.3 are the same of different and are hydrogen, lower alkyl, mesyl (CH.sub.3 SO.sub.2 --), and cycloalkyl loweralkyl; ##STR3## and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明涉及下式的6,11-二氢-11-氧代二苯并[b，e]氧杂环丁烷的取代的烷基胺衍生物，其中X是氢，卤素，低级烷氧基，低级烷基，硝基，羟基和CF 3; R是H，低级烷基，R 1是CH 3 SO 3和其中R 2和R 3是不同的并且是氢，低级烷基，甲磺酰基（CH 3 SO 2 - ）和环烷基低级烷基; + TR 及其药学上可接受的酸加成盐。

8. 发明授权

US4742061A Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents 失效
标题翻译： Benzoc [c] -1,5-萘啶和相关化合物作为记忆增强剂
公开(公告)号：US4742061A
公开(公告)日：1988-05-03
申请号：US870585
申请日：1986-06-04
申请人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
发明人： Lawrence L. Martin , Linda L. Setescak , Susan J. Scott
IPC分类号： C07D207/28 , C07D471/04 , A61K31/495 , A61K31/435 , C07D401/14 , C07D487/04
CPC分类号： C07D471/04 , C07D207/28
摘要： There are disclosed novel compounds of the formula ##STR1## where m is 1 or 2; each X is independently H, halogen, loweralkyl, loweralkoxy, --CF.sub.3, or --OH; R is H, loweralkyl, chloroloweralkyl, bromoloweralkyl, iodoloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, thienylloweralkyl, furylloweralkyl, loweralkanoyl, chloroloweralkanoyl, bromoloweralkanoyl, iodoloweralkanoyl, aminoloweralkanoyl, loweralkylaminoloweralkanoyl, diloweralkylaminoloweralkanoyl, aroyl, arylloweralkanoyl or diarylloweralkanoyl, thienylloweralkanoyl, furylloweralkanoyl; and R.sub.1 is .dbd.O, ##STR2## or --NR.sub.2 R.sub.3, R.sub.2 and R.sub.3 being independently H or loweralkyl, or taken together with the nitrogen atom to which they are attached constituting ##STR3## R.sub.4 in turn being H, loweralkyl, hydroxyloweralkyl, aryl, arylloweralkyl or diarylloweralkyl, with the proviso that when R.sub.1 is --NR.sub.2 R.sub.3, R is nonexistent, that when R.sub.1 is .dbd.O, R is not an acyl group and that when R.sub.1 is ##STR4## R is not chloroloweralkyl, bromoloweralkyl or iodoloweralkyl; or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.
摘要翻译：公开了新颖的式（Ⅰ）化合物，其中m为1或2; 每个X独立地为H，卤素，低级烷基，低级烷氧基，-CF 3或-OH; R为H，低级烷基，chloroloweralkyl，bromoloweralkyl，iodoloweralkyl，aminoloweralkyl，loweralkylaminoloweralkyl，diloweralkylaminoloweralkyl，芳基低级烷基，diarylloweralkyl，thienylloweralkyl，furylloweralkyl，loweralkanoyl，chloroloweralkanoyl，bromoloweralkanoyl，iodoloweralkanoyl，aminoloweralkanoyl，loweralkylaminoloweralkanoyl，diloweralkylaminoloweralkanoyl，芳酰基，arylloweralkanoyl或diarylloweralkanoyl，thienylloweralkanoyl，furylloweralkanoyl; R 1和R 2独立地是H或低级烷基，或者与它们所连接的氮原子一起构成R 4，其又是H，低级烷基，羟基低级烷基，芳基，芳基低级烷基或二芳基低级烷基，条件是当R 1是-NR 2 R 3时，R不存在，当R 1是= O时，R不是酰基，而当R 1是R 1时，R不是氯代低级烷基，溴代低级烷基或碘代低级烷基; 或其药学上可接受的酸加成盐，其可用于增强记忆。

9. 发明授权

US4560701A Oxothienobenzoxepins, medicinal use, and process for the preparation thereof 失效
标题翻译：噻吩并苯并氧辛昔松，药用及其制备方法
公开(公告)号：US4560701A
公开(公告)日：1985-12-24
申请号：US503456
申请日：1983-06-13
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： C07D333/38 , C07D495/04 , A61K31/38 , C07D327/04 , C07D495/02
CPC分类号： C07D495/04 , C07D333/38
摘要： The invention relates to oxothienobenzoxepin compounds of the formula ##STR1## where X together with the carbon atoms to which it is attached is a thiophene ring;R.sub.1 is hydrogen, a straight or branched chain alkyl group having 1 to 5 carbon atoms or a halogen atom;R.sub.2 is hydrogen or a straight chain alkyl group having 1 to 5 carbon atoms; andR.sub.3 is hydroxyl or ##STR2## where R.sub.4 is a straight chain or branched chain alkyl group having 1 to 10 carbon atoms, a phenyl group or a trifluoromethyl group. Methods for preparing the compounds and their use as antiinflammatory and analgesic agents are provided.
摘要翻译：本发明涉及式（I）的噻吩并苯并氧杂环己酮化合物，其中X与连接的碳原子一起为噻吩环; R1是氢，具有1至5个碳原子的直链或支链烷基或卤素原子; R2是氢或碳原子数为1〜5的直链烷基; 并且R 3是羟基或者其中R 4是具有1-10个碳原子的直链或支链烷基，苯基或三氟甲基。提供了制备化合物的方法及其作为抗炎和止痛剂的用途。

10. 发明授权

US4515946A 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives 失效
标题翻译： 6,11-二氢-11-氧代 - 二苯并[b，e]氧杂七环衍生物
公开(公告)号：US4515946A
公开(公告)日：1985-05-07
申请号：US333835
申请日：1981-12-23
申请人： Lawrence L. Martin , Linda L. Setescak
发明人： Lawrence L. Martin , Linda L. Setescak
IPC分类号： A61K31/34 , A61P25/04 , A61P29/00 , C07D313/12 , C07D407/06 , C07D407/12 , C07D413/06 , C07D313/00 , A61K31/335 , A61K31/42
CPC分类号： C07D407/12 , C07D313/12 , C07D413/06
摘要： This invention relates to 6,11-dihydro-11-oxo-dibenz[b,e]oxepin derivatives of the formula ##STR1## where Y is alkyl, alkoxy, halogen or trifluoromethyl, n is 0, 1, 2 or 3; R is ##STR2## where Hal is a halogen; ##STR3## where n is 0, 1, 2 or 3; p is 1 or 2; q is 0, 1, or 2; R.sup.1 to R.sup.7 are the same or different and are hydrogen and alkyl and R.sup.8 is hydrogen, alkyl and phenyl; and R.sup.9 is alkyl and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明涉及式为“IMAGE”的6,11-二氢-11-氧代二苯并[b，e]氧杂七环衍生物，其中Y为烷基，烷氧基，卤素或三氟甲基，n为0,1,2或3; R是其中Hal是卤素; + TR 其中n为0,1,2或3; p为1或2; q是0,1或2; R1至R7相同或不同，为氢和烷基，R8为氢，烷基和苯基; 并且R 9是烷基和其药学上可接受的酸加成盐。

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