专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08258168B2 2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof 有权
标题翻译： 2H-或3H-苯并[E]吲唑-1-基]氨基甲酸酯衍生物，其制备和治疗用途
公开(公告)号：US08258168B2
公开(公告)日：2012-09-04
申请号：US13348241
申请日：2012-01-11
申请人： Laurent Dubois , Yannick Evanno , Christian Maloizel , Mireille Sevrin
发明人： Laurent Dubois , Yannick Evanno , Christian Maloizel , Mireille Sevrin
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/56 , C07D231/54 , C07D401/12
摘要： Compounds corresponding to the formula (I) as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
摘要翻译：对应于本公开内容中定义的式（I）的化合物以及制备此类化合物的方法，用于此类方法的中间体，含有本发明化合物的药物组合物和使用它们的治疗方法。

2. 发明授权

US08114899B2 2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof 有权
标题翻译： 2H-或3H-苯并[e]吲唑-1-基氨基甲酸酯衍生物，其制备和治疗用途
公开(公告)号：US08114899B2
公开(公告)日：2012-02-14
申请号：US12360535
申请日：2009-01-27
申请人： Laurent DuBois , Yannick Evanno , Christian Maloizel , Mireille Sevrin
发明人： Laurent DuBois , Yannick Evanno , Christian Maloizel , Mireille Sevrin
IPC分类号： A61K31/416 , C07D231/54 , C07D413/02
CPC分类号： C07D231/56 , C07D231/54 , C07D401/12
摘要： Compounds corresponding to the formula (I) as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
摘要翻译：对应于本公开内容中定义的式（I）的化合物以及制备此类化合物的方法，用于此类方法的中间体，含有本发明化合物的药物组合物和使用它们的治疗方法。

3. 发明申请

US20090143380A1 2H- OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF 有权
标题翻译： 2H-或3H-苯并[E]吲哚-1-基碳酸酯衍生物，其制备和治疗用途
公开(公告)号：US20090143380A1
公开(公告)日：2009-06-04
申请号：US12360535
申请日：2009-01-27
申请人： Laurent DUBOIS , Yannick Evanno , Christian Maloizel , Mireille Sevrin
发明人： Laurent DUBOIS , Yannick Evanno , Christian Maloizel , Mireille Sevrin
IPC分类号： A61K31/416 , C07D231/54 , C07D401/04 , A61K31/5377 , A61P25/16 , A61P25/28 , A61P25/02 , A61K31/4439 , C07D413/04
CPC分类号： C07D231/56 , C07D231/54 , C07D401/12
摘要： Compounds corresponding to the formula (I) as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
摘要翻译：对应于本公开内容中定义的式（I）的化合物以及制备此类化合物的方法，用于此类方法的中间体，含有本发明化合物的药物组合物和使用它们的治疗方法。

4. 发明申请

US20120108584A1 2H OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF 有权
标题翻译： 2H-或3H-苯并[E]吲哚-1-基碳酸酯衍生物，其制备和治疗用途
公开(公告)号：US20120108584A1
公开(公告)日：2012-05-03
申请号：US13348241
申请日：2012-01-11
申请人： Laurent DUBOIS , Yannick Evanno , Christian Maloizel , Mireille Sevrin
发明人： Laurent DUBOIS , Yannick Evanno , Christian Maloizel , Mireille Sevrin
IPC分类号： A61K31/416 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/454 , C07D403/12 , A61K31/496 , A61P25/02 , A61P25/28 , A61P25/22 , A61P25/08 , A61P25/00 , A61P13/12 , A61P9/10 , A61P9/00 , A61P37/06 , A61P35/00 , A61P29/00 , C07D231/54
CPC分类号： C07D231/56 , C07D231/54 , C07D401/12
摘要： Compounds corresponding to the formula (I) as defined in the disclosure, as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
摘要翻译：对应于本公开内容中定义的式（I）的化合物以及制备此类化合物的方法，用于此类方法的中间体，含有本发明化合物的药物组合物和使用它们的治疗方法。

5. 发明授权

US07501449B2 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof 有权
标题翻译： 2H-或3H-苯并[e]吲唑-1-基氨基甲酸酯衍生物，其制备和治疗用途
公开(公告)号：US07501449B2
公开(公告)日：2009-03-10
申请号：US11549293
申请日：2006-10-13
申请人： Laurent DuBois , Yannick Evanno , Christian Maloizel , Mireille Sevrin
发明人： Laurent DuBois , Yannick Evanno , Christian Maloizel , Mireille Sevrin
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/56 , C07D231/54 , C07D401/12
摘要： Compounds corresponding to the formula (I) as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions containing the compounds of the invention, and methods of treatment using them.
摘要翻译：对应于本公开内容定义的式（I）化合物的化合物以及制备此类化合物的方法，用于此类方法的中间体，含有本发明化合物的药物组合物和使用它们的治疗方法。

6. 发明授权

US6075021A 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics 有权
标题翻译： 1H-吡啶并[3,4-b]吲哚-4-甲酰胺衍生物，其在治疗中的制备和应用
公开(公告)号：US6075021A
公开(公告)日：2000-06-13
申请号：US284070
申请日：1999-04-07
申请人： Yannick Evanno , Mireille Sevrin , Christian Maloizel , Odette Legalloudec , Pascal George
发明人： Yannick Evanno , Mireille Sevrin , Christian Maloizel , Odette Legalloudec , Pascal George
IPC分类号： A61K31/435 , A61K31/437 , A61P25/00 , A61P25/08 , A61P25/20 , A61P25/22 , C07D209/00 , C07D221/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of general formula (I) ##STR1## in which the variables are as defined in the specification, their preparation and their application in therapeutics.
摘要翻译： PCT No.PCT / FR97 / 01750 Sec。 371日期1999年4月7日 102（e）1999年4月7日PCT PCT 1997年10月8日PCT公布。出版物WO98 / 15552 日期1998年4月16日化学通式（I）的化合物，其中变量如说明书中所定义，其制备及其在治疗中的应用。

7. 发明授权

US07868024B2 Derivatives of N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamides, preparation thereof and therapeutic use thereof 有权
标题翻译： N-（杂芳基）-1-杂芳基-1H-吲哚-2-甲酰胺的衍生物，其制备及其治疗用途
公开(公告)号：US07868024B2
公开(公告)日：2011-01-11
申请号：US12504869
申请日：2009-07-17
申请人： Laurent Dubois , Yannick Evanno , André Malanda , Christian Maloizel
发明人： Laurent Dubois , Yannick Evanno , André Malanda , Christian Maloizel
IPC分类号： A61K31/44 , C07D401/06
CPC分类号： C07D401/14
摘要： The invention relates to compounds of formula (I): Wherein X1, X2, X3, X4, Y and W are as described herein. The invention also relates to a preparation method and to a therapeutic application.
摘要翻译：本发明涉及式（I）化合物：其中X1，X2，X3，X4，Y和W如本文所述。本发明还涉及制备方法和治疗应用。

8. 发明授权

US4885302A 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy 失效
标题翻译： 2 - （（4-哌啶基）甲基）-1,2,3,4-四氢异喹啉衍生物，其制备及其在治疗中的应用
公开(公告)号：US4885302A
公开(公告)日：1989-12-05
申请号：US228748
申请日：1988-08-05
申请人： Pascal George , Mireille Sevrin , Christian Maloizel
发明人： Pascal George , Mireille Sevrin , Christian Maloizel
IPC分类号： A61K31/47 , A61K31/475 , A61P9/00 , A61P9/12 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14
摘要： A compound of formula (I) ##STR1## in which R is (a) a hydrogen atom;(b) a linear or branched (C.sub.1 -C.sub.6) alkyl group; an allyl group; a cycloalkylmethyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a phenylmethyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, amino, dimethylamino, cyano, aminocarbonyl, linear or branched (C.sub.1 -C.sub.3) alkyl, linear or branched (C.sub.1 -C.sub.3) alkoxy and linear or branched (C.sub.1 -C.sub.3) alkylthio groups; a 2-phenylethyl group; a 3-phenylpropyl group; a 3-phenyl-2-propenyl group; a phenylcarbonylmethyl group; a naphthylmethyl group; a pyridylmethyl group; a furylmethyl group; or a thienylmethyl group; or(c) a linear or branched (C.sub.2 -C.sub.6) alkanoyl group; a cycloalkylcarbonyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a trifluoroacetyl group; a phenyl-carbonyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, linear or branched (C.sub.1 -C.sub.3) alkyl, linear or branched (C.sub.1 -C.sub.3) alkoxy and linear or branched (C.sub.1 -C.sub.3) alkylthio groups; a 1-oxo-3-phenyl-2-propenyl group; a naphthylcarbonyl group; a pyridylcarbonyl group; a furylcarbonyl group; a thienylcarbonyl group; a (2-indolyl)-carbonyl group; or a (5-indolyl)carbonyl group; or a pharmacologically acceptable acid addition salt thereof.
摘要翻译：式（I）化合物其中R为（a）氢原子; （b）直链或支链（C1-C6）烷基; 烯丙基; 环烷基甲基，其中环烷基部分具有3至6个碳原子; 未取代或被一至三个选自卤素原子和三氟甲基，硝基，氨基，二甲基氨基，氰基，氨基羰基，直链或支链（C 1 -C 3）烷基，直链或支链（C 1 -C 3）烷氧基和直链或支链支链（C1-C3）烷硫基; 2-苯基乙基; 3-苯基丙基; 3-苯基-2-丙烯基; 苯基羰基甲基; 萘基甲基; 吡啶基甲基; 呋喃甲基; 或噻吩甲基; 或（c）直链或支链（C 2 -C 6）烷酰基; 环烷基部分具有3至6个碳原子的环烷基羰基; 三氟乙酰基; 直链或支链（C1-C3）烷基，直链或支链（C1-C3）烷氧基和直链或支链的（C1-C3）烷基，烷硫基; 1-氧代-3-苯基-2-丙烯基; 萘基羰基; 吡啶基羰基; 呋喃基羰基; 噻吩基羰基; （2-吲哚基） - 羰基; 或（5-吲哚基）羰基; 或其药理学上可接受的酸加成盐。

9. 发明授权

US5380742A 4H-thieno[3,4-c]pyrrole derivatives 失效
标题翻译： 4H-噻吩并[3,4-c]吡咯衍生物
公开(公告)号：US5380742A
公开(公告)日：1995-01-10
申请号：US156780
申请日：1993-11-24
申请人： Mireille Sevrin , Jacques Menin , Christian Maloizel , Juan A. Diaz Martin , Ulpiano Martin Escudero Perez , Manuel Bedoya Zurita , Gregorio Del Sol Moreno , Maria D. Jimenez Bargueno , Magali Romanach Ferrer
发明人： Mireille Sevrin , Jacques Menin , Christian Maloizel , Juan A. Diaz Martin , Ulpiano Martin Escudero Perez , Manuel Bedoya Zurita , Gregorio Del Sol Moreno , Maria D. Jimenez Bargueno , Magali Romanach Ferrer
IPC分类号： A61K31/40 , A61K31/38 , A61P1/12 , A61P3/04 , A61P3/08 , A61P3/10 , A61P9/02 , A61P11/00 , A61P25/02 , C07B61/00 , C07D495/04 , A61K31/415 , C07D403/14
CPC分类号： C07D495/04
摘要： Pyrrole derivatives of formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom, a linear or branched C.sub.1-6 alkyl group, a C.sub.3-6 alkenyl group, a C.sub.1-4 alkoxymethyl group, benzyl, a phenyl group optionally substituted by one or more halogen atoms or alkyl radicals, a CO.sub.2 R group in which R represents a linear or branched C.sub.1-4 alkyl radical, phenyl or benzyl, or a CONR'R" group in which R' and R" each represent, independently of one another, a hydrogen atom or a linear or branched C.sub.1-4 alkyl radical,R.sub.2 represents a hydrogen or halogen atom or a linear or branched C.sub.1-4 alkyl group,and R.sub.3 represents a 4,5-dihydro-1H-imidazol-2-yl or 1H-imidazol-4-yl group, and their addition salts with pharmaceutically acceptable acids are useful in therapeutics as .alpha..sub.2 -antagonists, and .alpha..sub.1 -agonists.
摘要翻译：式（I）的吡咯衍生物，其中R 1表示氢或卤素原子，直链或支链C 1-6烷基，C 3-6烯基，C 1-4烷氧基甲基，苄基，苯基任选被一个或多个卤素原子或烷基取代的CO 2 R基团，其中R表示直链或支链C 1-4烷基，苯基或苄基或CONR'R“基团，其中R'和R”各自独立地表示氢原子或直链或支链C 1-4烷基，R 2表示氢或卤素原子或直链或支链C 1-4烷基，R 3表示4,5-二氢-1H- 咪唑-2-基或1H-咪唑-4-基，它们与药学上可接受的酸的加成盐可用作α2拮抗剂和α1-激动剂的治疗剂。

10. 发明授权

US4925850A Derivatives of 2-((4-piperidinyl)methyl)-1,2,3,4-tetrahydroisoquinoline, their preparation and their application in therapeutics 失效
标题翻译： 2 - （（4-哌啶基）甲基）-1,2,3,4-四氢异喹啉的衍生物，其制备及其在治疗中的应用
公开(公告)号：US4925850A
公开(公告)日：1990-05-15
申请号：US306497
申请日：1989-02-06
申请人： Pascal George , Mireille Sevrin , Christian Maloizel , Arlette Tixidre , Jacques Froissant
发明人： Pascal George , Mireille Sevrin , Christian Maloizel , Arlette Tixidre , Jacques Froissant
IPC分类号： A61K31/47 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/20 , C07D401/06
CPC分类号： C07D401/06
摘要： A compound of formula (I): ##STR1## in which: X is hydrogen or a methyl or methoxy group;Y is a halogen or a methyl or methoxy group; andR is a group of formula --Z--R' in which:Z is a --CH.sub.2 -- group, andR' is a phenyl group unsubstituted or substituted by one, two or three substituents selected from halogen atoms and trifluoromethyl, linear or branched (C.sub.1 -C.sub.3) alkyl and linear or branched (C.sub.1 -C.sub.3) alkoxy groups;or a pharmacologically acceptable acid addition salt thereof.
摘要翻译：式（I）的化合物：其中：X为氢或甲基或甲氧基; Y是卤素或甲基或甲氧基; 并且R是式-ZR'的基团，其中：Z是-CH 2 - 基，R'是未被取代或被1,2或3个选自卤素原子和三氟甲基的取代基取代的苯基，直链或支链（C1 -C 3）烷基和直链或支链（C 1 -C 3）烷氧基; 或其药理学上可接受的酸加成盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式