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1. 发明授权

US5648379A Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents 失效
标题翻译： 2-脱氧-2,3-二脱氢-N-乙酰神经氨酸的衍生物和类似物及其作为抗病毒剂的用途
公开(公告)号：US5648379A
公开(公告)日：1997-07-15
申请号：US325074
申请日：1994-10-19
申请人： Laurence Mark Von Itzstein , Wen-Yang Wu , Tho Van Phan , Basil Danylec , Betty Jin , Peter Malcolm Colman , Joseph Noozhumurry Varghese
发明人： Laurence Mark Von Itzstein , Wen-Yang Wu , Tho Van Phan , Basil Danylec , Betty Jin , Peter Malcolm Colman , Joseph Noozhumurry Varghese
IPC分类号： C07D309/30 , A61K31/00 , A61K31/196 , A61K31/34 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/382 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/505 , A61K31/7012 , A61P31/00 , A61P31/12 , A61P31/14 , C07C47/225 , C07C47/42 , C07C225/20 , C07C233/52 , C07C309/25 , C07C317/12 , C07C321/22 , C07D20060101 , C07D211/70 , C07D211/72 , C07D211/74 , C07D211/78 , C07D211/84 , C07D239/26 , C07D257/02 , C07D257/04 , C07D309/20 , C07D309/22 , C07D309/26 , C07D309/28 , C07D335/02 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D498/04 , C07F9/655 , C07H7/033 , C07C309/20
CPC分类号： C07D309/30 , C07D309/28
摘要： Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.
摘要翻译：描述了2-脱氧-2,3-二脱氢-N-乙酰神经氨酸的衍生物和类似物，其药物制剂，其制备方法及其在治疗病毒感染，特别是流感中的用途。

2. 发明授权

US5639786A Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-D-neuraninic acid 失效
标题翻译： α-D-神经氨酸的抗病毒4-取代-2-脱氧-2,3-二脱氢衍生物
公开(公告)号：US5639786A
公开(公告)日：1997-06-17
申请号：US267309
申请日：1994-06-29
申请人： Laurence Mark Von Itzstein , Wen-Yang Wu , Tho Van Phan , Basil Danylec , Betty Jin
发明人： Laurence Mark Von Itzstein , Wen-Yang Wu , Tho Van Phan , Basil Danylec , Betty Jin
IPC分类号： C07D309/28 , A61K31/35
CPC分类号： C07D309/28
摘要： N-Acetylneuraminic and derivatives of formula (I) ##STR1## pharmaceutical formulations thereof, their use in medicine, in particular as antiviral agents and methods for their preparation are described.
摘要翻译：描述了N-乙酰神经氨酸和式（I）的衍生物，其描述了它们在药物中的用途，特别是抗病毒剂及其制备方法。

3. 发明授权

US5360817A Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid and their use as antiviral agents 失效
标题翻译： 2-脱氧-2,3-二脱氢-N-乙酰神经氨酸的衍生物和类似物及其作为抗病毒剂的用途
公开(公告)号：US5360817A
公开(公告)日：1994-11-01
申请号：US946327
申请日：1992-11-10
申请人： Laurence M. von Izstein , Wen-Yang Wu , Tho V. Phan , Basil Danylec , Betty Jin
发明人： Laurence M. von Izstein , Wen-Yang Wu , Tho V. Phan , Basil Danylec , Betty Jin
IPC分类号： C07D309/30 , A61K31/00 , A61K31/196 , A61K31/34 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/382 , A61K31/41 , A61K31/435 , A61K31/44 , A61K31/505 , A61K31/7012 , A61P31/00 , A61P31/12 , A61P31/14 , C07C47/225 , C07C47/42 , C07C225/20 , C07C233/52 , C07C309/25 , C07C317/12 , C07C321/22 , C07D20060101 , C07D211/70 , C07D211/72 , C07D211/74 , C07D211/78 , C07D211/84 , C07D239/26 , C07D257/02 , C07D257/04 , C07D309/20 , C07D309/22 , C07D309/26 , C07D309/28 , C07D335/02 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D498/04 , C07F9/655 , C07H7/033
CPC分类号： C07D309/30 , C07D309/28
摘要： Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation .and their use in the treatment of viral infections, in particular influenza, are described.
摘要翻译： PCT No.PCT / AU91 / 00161 Sec。 371日期：1992年11月10日 102（e）日期：1992年11月10日PCT 1991年4月24日PCT PCT。 WO91 / 16320 PCT公开号日期：1991年10月31日。2-脱氧-2,3-二脱氢-N-乙酰神经氨酸的衍生物和类似物，其药物制剂，其制备方法及其在治疗病毒感染中的用途，特别是流感，被描述。

4. 发明授权

US07157494B2 Dimeric compounds and their use as anti-viral agents 有权
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US07157494B2
公开(公告)日：2007-01-02
申请号：US10494243
申请日：2002-11-08
申请人： Michael D. Dowle , Betty Jin , Simon J. F. Macdonald , Andrew McM Mason , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
发明人： Michael D. Dowle , Betty Jin , Simon J. F. Macdonald , Andrew McM Mason , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： C07D309/28
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，SO 2 NH，NHCO或NHCONH; m为0或1; n为2-6的整数; q是0至3的整数; Y为氢或芳香族取代基，或其药学上可接受的衍生物; 其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途

5. 发明申请

US20050038108A1 Dimeric compounds and their use as anti-viral agents 有权
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US20050038108A1
公开(公告)日：2005-02-17
申请号：US10494243
申请日：2002-11-08
申请人： Michael Dowle , Betty Jin , Simon Macdonald , Andrew McM Mason , Darryl Mcconnell , Van Nguyen , Stepehn Shanahan , Wen-Yang Wu
发明人： Michael Dowle , Betty Jin , Simon Macdonald , Andrew McM Mason , Darryl Mcconnell , Van Nguyen , Stepehn Shanahan , Wen-Yang Wu
IPC分类号： A61K9/12 , A61K9/14 , A61K31/13 , A61K31/351 , A61K31/7052 , A61K45/00 , A61P31/04 , A61P31/12 , A61P31/16 , A61P43/00 , C07D309/28 , A61K31/34 , C07D45/02
CPC分类号： C07D309/28
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，SO2NH，NHCO或NHCONH; m为0或1; n为2-6的整数; q是0至3的整数; Y为氢或芳香族取代基，或其药学上可接受的衍生物; 其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途。

6. 发明授权

US07371755B1 Antiviral agents 失效
标题翻译：抗病毒剂
公开(公告)号：US07371755B1
公开(公告)日：2008-05-13
申请号：US10088282
申请日：2000-09-15
申请人： Guy Krippner , Phillip A. Reece , Keith G. Watson , Wen-Yang Wu , Betty Jin , Simon P. Tucker
发明人： Guy Krippner , Phillip A. Reece , Keith G. Watson , Wen-Yang Wu , Betty Jin , Simon P. Tucker
IPC分类号： C07D413/12 , C07D413/14 , C07D403/12 , C07D409/12 , A61K31/42 , A61K31/496 , A61K31/501 , A61K31/787 , A61P31/16
CPC分类号： C07D401/14 , A61K31/4245 , C07D237/22 , C07D261/08 , C07D413/14 , C07D495/04 , G01N33/56983 , G01N2333/095 , Y02A50/463 , Y02A50/54
摘要： This invention relates to a compound capable of binding to a picornavirus capsid comprising two or more capsid binding moieties.
摘要翻译：本发明涉及能够结合包含两个或多个衣壳结合部分的微小RNA病毒衣壳的化合物。

7. 发明授权

US07223790B2 Dimeric compounds and their use as anti-viral agents 失效
标题翻译：二聚体化合物及其作为抗病毒剂的用途
公开(公告)号：US07223790B2
公开(公告)日：2007-05-29
申请号：US10494260
申请日：2002-11-08
申请人： Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
发明人： Betty Jin , Simon J. F. MacDonald , Darryl McConnell , Van T. T. Nguyen , Stephen E. Shanahan , Wen-Yang Wu
IPC分类号： A61K31/35
CPC分类号： A61K31/351 , A61K31/13 , A61K31/7056 , A61K38/00 , A61K45/06 , A61K47/54 , A61K47/55 , C07D309/28 , C07K5/06104 , A61K2300/00
摘要： The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2–C8 alkyl C3-8 cycloalkyl, C1–C4 alkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection
摘要翻译：本发明涉及通式（I）的化合物; 其中R是氨基或胍基; R 2是乙酰基或三氟乙酰基; X是CONH，NHCO或O; n为2-6的整数; 且Y为C 2 -C 8烷基C 3-8环烷基，C 1 -C 3烷基， 4烷氧基烷基，氨基酸或二肽或其药学上可接受的衍生物，其制备方法，含有它们的药物制剂或其在预防或治疗病毒感染中的用途

8. 发明授权

US07078403B1 Antiviral agents 失效
标题翻译：抗病毒剂
公开(公告)号：US07078403B1
公开(公告)日：2006-07-18
申请号：US10018963
申请日：2000-06-16
申请人： Wen-Yang Wu , Keith Watson , Darryl McConnell , Betty Jin , Guy Krippner
发明人： Wen-Yang Wu , Keith Watson , Darryl McConnell , Betty Jin , Guy Krippner
IPC分类号： A61K31/53
CPC分类号： C07D401/04 , C07D237/20 , C07D237/22 , C07D261/08 , C07D403/04 , C07D417/14
摘要： Disclosed herein are compounds of formula II: wherein Alk, Z, X1, X2, R1, —R10 and R11 are defined herein, and their salts and pharmaceutically acceptable derivatives thereof, as well as other compounds of the general formula Het-A-Alk-W-Ar-C(X2)═NO-X2 where Het, A, W and Ar are also defined herein. These compounds are useful in treating picornavirus infections in mammals. Novel intermediates of these compounds, as well as pharmaceutical compositions and methods of use, are also disclosed herein.
摘要翻译：本文公开了式II的化合物：其中Alk，Z，X 1，X 2，R 1，R 10，本文定义的本文及其盐及其药学上可接受的衍生物，以及通式Het-A-Alk-W-Ar-C（X

9. 发明授权

US09040503B2 Medicinal carbohydrates for treatment of respiratory conditions 有权
标题翻译：用于治疗呼吸道疾病的药用碳水化合物
公开(公告)号：US09040503B2
公开(公告)日：2015-05-26
申请号：US13380219
申请日：2010-07-02
申请人： Betty Jin , Paul Arthur Jones , Ee Ling Seah , Wen Yang Wu , Peter James Jenkins
发明人： Betty Jin , Paul Arthur Jones , Ee Ling Seah , Wen Yang Wu , Peter James Jenkins
IPC分类号： A61K31/70 , A61K31/7008 , A61K31/7012
CPC分类号： A61K31/7028 , A61K9/007 , A61K31/7008 , A61K31/7012 , A61K31/7068 , A61P11/00
摘要： A method of promoting recovery of cell viability of a damaged respiratory cell. The method includes a step of administering to the cell at least one pharmaceutically acceptable compound, which accelerates sialyglycoconjugate biosynthesis to restore sialylglycoconjugates on the surface of the respiratory cell. Also disclosed are a method and a pharmaceutical composition, both for treating a respiratory condition.
摘要翻译：促进受损呼吸细胞的细胞活力恢复的方法。该方法包括向细胞施用至少一种药学上可接受的化合物的步骤，其加速唾液酸糖缀合物的生物合成以恢复呼吸细胞表面上的唾液酸糖缀合物。还公开了用于治疗呼吸状况的方法和药物组合物。

10. 发明授权

US08927565B2 Compositions for veterinary and medical applications 有权
标题翻译：兽医和医疗应用的组成
公开(公告)号：US08927565B2
公开(公告)日：2015-01-06
申请号：US10570509
申请日：2004-08-26
申请人： Betty Jin , Wen-Yang Wu
发明人： Betty Jin , Wen-Yang Wu
IPC分类号： A61K31/4745 , A61K31/717 , A23K1/16 , A23K1/17 , A23K1/18 , A23L1/30 , A61K31/47 , A61K31/718 , A61K31/78
CPC分类号： A61K31/717 , A23K20/132 , A23K20/195 , A23K50/30 , A23K50/75 , A23L33/105 , A61K31/47 , A61K31/718 , A61K31/78 , A61K2300/00
摘要： Compositions including polymeric dialdehydes and compounds of where R1, R2, R7, R8, R9, and R10 may be the same or different and are selected from H, CH3, OH, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl; R3, R4, R5, R6 may be the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl, or R5 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R4 together are ═O, or R4 and R6 are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R3 and R5 together form a double bond or are ═O, or R3 and R4, are the same or different and are selected from H, CH3, OCH3, C2H5, OC2H5OCH2Ph, OCH2PhNO2, F or Cl and R5 and R6 together are ═O; R11 and R12 together form ═CH2, or R11 and R12 may be the same or different and are independently selected from the group consisting of H, CH3, CH2CH3 and CH2CH2CH3; and X is selected from the group consisting of Cl, Br, SO4, I and R13COO, where R13 is CH3 or poly acids, for the treatment of gastrointestinal functional disorders or related conditions as well as for the promotion of general health and weight gain in animals including humans.
摘要翻译：包括聚合二醛和其中R 1，R 2，R 7，R 8，R 9和R 10可以相同或不同并且选自H，CH 3，OH，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl的化合物的组合物; R 3，R 4，R 5，R 6可以相同或不同，选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl，或R 5和R 6相同或不同，选自H， OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 3和R 4一起为=或者R 4和R 6相同或不同，并且选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 3 并且R 5和R 5一起形成双键，或者是=或者R 3和R 4相同或不同，并且选自H，CH 3，OCH 3，C 2 H 5，OC 2 H 5 OCH 2 Ph，OCH 2 PhNO 2，F或Cl和R 5和R 6一起是= R 11和R 12一起形成= CH 2，或者R 11和R 12可以相同或不同，并且独立地选自H，CH 3，CH 2 CH 3和CH 2 CH 2 CH 3; X选自Cl，Br，SO 4，I和R 13 COO，其中R 13为CH 3或多酸，用于治疗胃肠功能障碍或相关病症，以及促进一般健康和体重增加动物包括人类。

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