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1. 发明申请

US20120077773A1 USE OF A COMPOSITION FOR THE TREATMENT OF MUCOSITIS 有权
标题翻译：使用组合物治疗肌瘤
公开(公告)号：US20120077773A1
公开(公告)日：2012-03-29
申请号：US13376947
申请日：2010-06-10
申请人： Lars Adolfsson , Olle Larm , Anders Westermark
发明人： Lars Adolfsson , Olle Larm , Anders Westermark
IPC分类号： A61K31/727 , A61P29/00 , A61P1/00 , A61K31/737
CPC分类号： A61K31/722 , A61K9/006 , A61K9/10 , A61K31/721 , A61K31/727 , A61K31/737 , A61K47/36 , A61K2300/00
摘要： A composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate, for use in the treatment of mucositis in a mammalian subject, to a method of preventing or treating mucositis in a mammalian subject, by applying topically a composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate. The composition further relates to a pharmaceutical composition for topical administration of an ionic complex of chitosan and heparin.
摘要翻译：一种具有脱乙酰壳多糖离子配合物和负载多糖的组合物，其用于治疗哺乳动物受试者的粘膜炎的肝素，硫酸乙酰肝素和硫酸葡聚糖，用于预防或治疗粘膜炎的方法哺乳动物受试者，通过局部施用具有壳聚糖离子络合物和带负电荷的多糖的组合物，所述多糖选自肝素，硫酸乙酰肝素和硫酸葡聚糖。组合物还涉及用于局部施用壳聚糖和肝素的离子络合物的药物组合物。

2. 发明授权

US08906883B2 Treatment of oral mucositis by administering an ionic complex of chitosan and a negatively charged polysaccharide selected from heparin, heparan sulfate and dextran sulfate 有权
标题翻译：通过给予壳聚糖离子络合物和选自肝素，硫酸乙酰肝素和硫酸葡聚糖的带负电荷的多糖来治疗口腔粘膜炎
公开(公告)号：US08906883B2
公开(公告)日：2014-12-09
申请号：US13376947
申请日：2010-06-10
申请人： Lars Adolfsson , Olle Larm , Anders Westermark
发明人： Lars Adolfsson , Olle Larm , Anders Westermark
IPC分类号： A61K31/722 , A61K31/721 , A61K31/727 , A61K31/737 , A61K9/10 , A61K9/00 , A61K47/36
CPC分类号： A61K31/722 , A61K9/006 , A61K9/10 , A61K31/721 , A61K31/727 , A61K31/737 , A61K47/36 , A61K2300/00
摘要： A composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate, for use in the treatment of mucositis in a mammalian subject, to a method of preventing or treating mucositis in a mammalian subject, by applying topically a composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate. The composition further relates to a pharmaceutical composition for topical administration of an ionic complex of chitosan and heparin.
摘要翻译：一种具有脱乙酰壳多糖离子配合物和负载多糖的组合物，其用于治疗哺乳动物受试者的粘膜炎的肝素，硫酸乙酰肝素和硫酸葡聚糖，用于预防或治疗粘膜炎的方法哺乳动物受试者，通过局部施用具有壳聚糖离子络合物和带负电荷的多糖的组合物，所述多糖选自肝素，硫酸乙酰肝素和硫酸葡聚糖。组合物还涉及用于局部施用壳聚糖和肝素的离子络合物的药物组合物。

3. 发明授权

US08758286B2 Method for removing cytokines from blood with surface immobilized polysaccharides 有权
标题翻译：用表面固定多糖从血液中去除细胞因子的方法
公开(公告)号：US08758286B2
公开(公告)日：2014-06-24
申请号：US12958355
申请日：2010-12-01
申请人： Robert S Ward , Keith R. McCrea , Olle Larm , Lars Adolfsson
发明人： Robert S Ward , Keith R. McCrea , Olle Larm , Lars Adolfsson
IPC分类号： A61M5/00 , B01D61/00 , A61M1/36 , A61M1/38 , A61M1/34 , A61K31/722 , A61K31/728 , A61K31/727
CPC分类号： A61M1/362 , A61K31/60 , A61K31/722 , A61K31/727 , A61K31/728 , A61M1/3472 , A61M1/3496 , A61M1/36 , A61M1/3621 , A61M1/3673 , A61M1/3679 , A61M1/3687 , A61M1/38 , A61M2202/0057
摘要： The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
摘要翻译：本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或表面处理的固体，基本上非微孔的底物接触，从血液或血清（血液）中除去细胞因子和/或病原体的方法对待除去的细胞因子或病原体（吸附物）具有结合亲和力的其它分子或化学基团（吸附介质或介质），并且其中所述介质中的间质通道的大小与介质的量平衡表面积和培养基上结合位点的表面浓度，以提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

4. 发明授权

US08663148B2 Device and method for restoration of the condition of blood 有权
标题翻译：恢复血液状况的装置及方法
公开(公告)号：US08663148B2
公开(公告)日：2014-03-04
申请号：US12665156
申请日：2008-06-18
申请人： Olle Larm , Tomas Bergström , Jonas Axelsson , Lars Adolfsson , Robert S. Ward , Keith McCrea
发明人： Olle Larm , Tomas Bergström , Jonas Axelsson , Lars Adolfsson , Robert S. Ward , Keith McCrea
IPC分类号： A61M1/14 , C08B37/10
CPC分类号： A61M1/3679 , A61K31/70 , B01J20/3272 , B01J20/3274 , Y02A50/411
摘要： The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
摘要翻译：本发明涉及一种用于从血液或血液成分体外去除有害物质的装置，其包括通过共价终点附着固定在固体基质上的全长肝素。本发明还涉及从哺乳动物血液或血液成分体外去除有害物质的方法。本发明还涉及将全长肝素与固体底物共价连接的方法。

5. 发明申请

US20110184377A1 METHOD FOR REMOVING CYTOKINES FROM BLOOD WITH SURFACE IMMOBILIZED POLYSACCHARIDES 有权
标题翻译：用表面固定化多糖从血液中去除细胞因子的方法
公开(公告)号：US20110184377A1
公开(公告)日：2011-07-28
申请号：US12958355
申请日：2010-12-01
申请人： Robert S. WARD , Keith R. MCCREA , Olle Larm , Lars Adolfsson
发明人： Robert S. WARD , Keith R. MCCREA , Olle Larm , Lars Adolfsson
IPC分类号： A61M5/00 , B01D61/00
CPC分类号： A61M1/362 , A61K31/60 , A61K31/722 , A61K31/727 , A61K31/728 , A61M1/3472 , A61M1/3496 , A61M1/36 , A61M1/3621 , A61M1/3673 , A61M1/3679 , A61M1/3687 , A61M1/38 , A61M2202/0057
摘要： The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
摘要翻译：本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或表面处理的固体，基本上非微孔的底物接触，从血液或血清（血液）中除去细胞因子和/或病原体的方法对待除去的细胞因子或病原体（吸附物）具有结合亲和力的其它分子或化学基团（吸附介质或介质），并且其中所述介质中的间质通道的大小与介质的量平衡表面积和培养基上结合位点的表面浓度，以提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

6. 发明申请

US20100249689A1 DEVICE AND METHOD FOR RESTORATION OF THE CONDITION OF BLOOD 有权
标题翻译：用于恢复血液条件的装置和方法
公开(公告)号：US20100249689A1
公开(公告)日：2010-09-30
申请号：US12665156
申请日：2008-06-18
申请人： Olle Larm , Tomas Bergström , Jones Axelsson , Lars Adolfsson , Robert S. Ward , Keith Mccrea
发明人： Olle Larm , Tomas Bergström , Jones Axelsson , Lars Adolfsson , Robert S. Ward , Keith Mccrea
IPC分类号： A61M1/14 , B05D5/00 , B01D39/16 , B01D63/02 , B01D61/24
CPC分类号： A61M1/3679 , A61K31/70 , B01J20/3272 , B01J20/3274 , Y02A50/411
摘要： The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
摘要翻译：本发明涉及一种用于从血液或血液成分体外去除有害物质的装置，其包括通过共价终点附着固定在固体基质上的全长肝素。本发明还涉及从哺乳动物血液或血液成分体外去除有害物质的方法。本发明还涉及将全长肝素与固体底物共价连接的方法。

7. 发明授权

US07492756B2 Arrangement and a method in a switched telecommunication system 有权
标题翻译：交换电信系统中的布置和方法
公开(公告)号：US07492756B2
公开(公告)日：2009-02-17
申请号：US10919585
申请日：2004-08-17
申请人： Mathias Johansson , Lars Adolfsson , Per Backstrom
发明人： Mathias Johansson , Lars Adolfsson , Per Backstrom
IPC分类号： H04L12/66
CPC分类号： H04L49/351 , H04L12/4641 , H04L49/205 , H04L49/354 , H04L49/602 , H04Q3/0016 , H04Q2213/13109 , H04Q2213/13149 , H04Q2213/13166 , H04Q2213/13202 , H04Q2213/13204 , H04Q2213/1325 , H04Q2213/13298 , H04Q2213/13332 , H04Q2213/13349 , H04Q2213/13389
摘要： A telecommunication system and method enables an end user to select communication services from a plurality of communication service networks providing different communication services. A telecommunication switch is connected to the service networks, and one or more local network terminals communicate with the switch through connections configured to carry communications for the different communication services provided by the service networks. A plurality of user devices, each configured to support a corresponding communication service, connect to the network terminal through a plurality of service ports. The network terminal configures the service ports for the respective user devices, and provides communications for a corresponding service to an activating user device in response to an activation of a service port by the activating user device. The telecommunication switch and/or the local network terminal may prioritize communications from particular service networks.
摘要翻译：电信系统和方法使最终用户能够从提供不同通信服务的多个通信服务网络中选择通信服务。电信交换机连接到服务网络，并且一个或多个本地网络终端通过被配置为承载由服务网络提供的不同通信服务进行通信的连接与交换机进行通信。被配置为支持对应的通信服务的多个用户设备通过多个服务端口连接到网络终端。网络终端配置各个用户设备的服务端口，并且响应于激活用户设备对服务端口的激活，向激活用户设备提供用于相应服务的通信。电信交换机和/或本地网络终端可以优先考虑来自特定服务网络的通信。

8. 发明授权

US07573892B2 Centrally situated VoIP 失效
标题翻译：位于中心位置的VoIP
公开(公告)号：US07573892B2
公开(公告)日：2009-08-11
申请号：US11177478
申请日：2005-07-11
申请人： Lars Adolfsson
发明人： Lars Adolfsson
IPC分类号： H04L12/28
CPC分类号： H04L12/2801
摘要： The invention relates to a switch or router (10) connected to and centrally situated adjacent to a voice over Internet protocol box (22) in a premise connected in a broadband network standard. It comprises an interface (14) to a category infrastructure for distribution of data to flats and offices in premises. The category infrastructure (12, 16) comprises four twisted wire pairs to every flat and office, whereby two pairs are utilized by the broadband standard. Voice over Internet is connected through a first cable interface (50) with multiple connections, and a second cable interface (60) connected and wired together in a registered jack (18, 52) with a category infrastructure. Two of the wire pairs (62) provide two voice over Internet protocol subscription possibilities to every flat and office and two of the broadband connections (64).
摘要翻译：本发明涉及一种在宽带网络标准连接的前提下连接到互联网协议盒（22）上的中心位置的交换机或路由器（10）。它包括一个类别基础设施的接口（14），用于将数据分配到房屋中的单位和办公室。类别基础设施（12,16）包括每个平面和办公室的四条双绞线对，由宽带标准使用两对。互联网上的语音通过具有多个连接的第一电缆接口（50）连接，以及第二电缆接口（60），其连接并连接在具有类别基础设施的注册插孔（18,52）中。两个线对（62）为每个平面和办公室以及两个宽带连接（64）提供两个互联网协议订阅可能性的语音。

9. 发明申请

US20060133351A1 Integrated access device 审中-公开
标题翻译：集成接入设备
公开(公告)号：US20060133351A1
公开(公告)日：2006-06-22
申请号：US11024040
申请日：2004-12-29
申请人： Lars Adolfsson
发明人： Lars Adolfsson
IPC分类号： H04L12/66
CPC分类号： H04M7/0069 , H04M7/006 , H04Q2213/13003 , H04Q2213/13034 , H04Q2213/13039 , H04Q2213/1319 , H04Q2213/13194 , H04Q2213/13298 , H04Q2213/13389
摘要： This invention regards an integrated access device (10) and a method therefore, comprising seamless PSTN to voice over Internet telephony. The access device (10) thus comprises a splitter (12, 32) having a filter filtering out data traffic from a digital subscriber line to the access device (10), allowing PSTN signals to pass through. It further comprises at least two ports (28) for connection of two telephone devices (38, 40), wiring the pair of wires (22) from one of the telephone ports to a pair of PSTN wires of a LAN port (26) receiving incoming PSTN and DSL signals, thus providing exclusion of rewiring in an external splitter (12) and that one of the telephone ports can be utilized booth for Internet voice and PSTN telephony.
摘要翻译：本发明涉及一种集成接入设备（10）及其方法，包括无线PSTN以通过因特网电话进行语音通信。因此，接入设备（10）包括分离器（12,32），其具有过滤器将数据业务从数字用户线路滤除到接入设备（10），从而允许PSTN信号通过。它还包括用于连接两个电话设备（38,40）的至少两个端口（28），将一对电线（22）从一个电话端口接线到接收的LAN端口（26）的一对PSTN电线输入PSTN和DSL信号，从而在外部分离器（12）中排除重新布线，并且可以利用电话端口中的一个用于互联网语音和PSTN电话。

10. 发明授权

US07006486B1 Arrangement and a method in a switched telecommunication system 有权
标题翻译：交换电信系统中的布置和方法
公开(公告)号：US07006486B1
公开(公告)日：2006-02-28
申请号：US09572559
申请日：2000-05-16
申请人： Mathias Johansson , Lars Adolfsson , Per Bäckström
发明人： Mathias Johansson , Lars Adolfsson , Per Bäckström
IPC分类号： H04L12/66
CPC分类号： H04L49/351 , H04L12/4641 , H04L49/205 , H04L49/354 , H04L49/602 , H04Q3/0016 , H04Q2213/13109 , H04Q2213/13149 , H04Q2213/13166 , H04Q2213/13202 , H04Q2213/13204 , H04Q2213/1325 , H04Q2213/13298 , H04Q2213/13332 , H04Q2213/13349 , H04Q2213/13389
摘要： The present invention relates to a telecommunication system giving the option to a user (A1) to select desired services. A switched domain (5) for transmission of data packets has switches (SW1), to which service providers (1–4), and network terminals (NT1–NT7) are connected. The switches have a user port (Pf) through which one single physical connection is connected to an uplink port (Pe) in the network terminal (NT1). The user port (Pf) is configured for the different service providers (1–4) and the network terminals have corresponding service ports (Pc,Pd). The user (A1,8) or an operator (OP1) configures the service ports (Pc,Pd) which corresponds to the desired services (7,8). Using a policy server (PS1), which is connected to the network terminals (NT1) the traffic in these can be given priority. The data packets in the traffic which requires real time transmission, for example television (7), is given priority before data traffic on Intranet (8).
摘要翻译：本发明涉及给用户（A 1）选择所需服务的选择的电信系统。用于传输数据分组的交换域（5）具有连接服务提供商（1-4）和网络终端（NT1-NT7）的交换机（SW 1）。交换机具有用户端口（Pf），通过该用户端口将一个单一物理连接连接到网络终端（NT 1）中的上行链路端口（Pe）。用户端口（Pf）被配置为不同的服务提供商（1-4），并且网络终端具有相应的服务端口（Pc，Pd）。用户（A 1,8）或运营商（OP 1）配置与所需服务对应的服务端口（Pc，Pd）（7,8）。使用连接到网络终端（NT1）的策略服务器（PS 1），可以优先考虑这些流量。需要实时传输的流量中的数据包，例如电视（7）在内网（8）上的数据流量之前被赋予优先权。

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