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    • 1. 发明申请
    • METHOD AND DEVICE FOR CHROMATOGRAPHIC PURIFICATION
    • 用于色谱纯化的方法和装置
    • US20110042310A1
    • 2011-02-24
    • US12916367
    • 2010-10-29
    • Lars AUMANNMassimo MORBIDELLI
    • Lars AUMANNMassimo MORBIDELLI
    • B01D15/08
    • G01N30/468B01D15/1828B01D15/1864
    • A process for continuous or quasi-continuous purification of a multi-component mixture (F) by means of individual chromatographic columns through which the mixture is fed by means of at least one solvent(s). The multi-component mixture (F) at least comprises light impurities (A), an intermediate product (B) to be purified and heavy impurities (C), and the columns are grouped into at least four sections (α,β,γ,δ). After or within a switch time (t*) the last column from the first section (α) is moved to the first position of the second section (β), the last column of the second section (β) is moved to the first position of the third section (γ), the last column of the third section (γ) is moved to the first position of the fourth section (δ) and the last column of the fourth section (δ) is moved to become the first column of the first section (α).
    • 通过单独的色谱柱连续或准连续纯化多组分混合物(F)的方法,混合物通过其通过至少一种溶剂进料。 多组分混合物(F)至少包含轻质杂质(A),待纯化的中间产物(B)和重杂质(C),并将该列分成至少四个部分(α,bgr,γ ,δ)。 在切换时间(t *)之后或之内,从第一部分(α)的最后一列移动到第二部分(&bgr;)的第一个位置,第二部分(&bgr;)的最后一列被移动到 第三部分(γ)的第一位置,第三部分(γ)的最后一列移动到第四部分(δ)的第一位置,第四部分(δ)的最后一列被移动成第一部分 第一段(α)的列。