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    • 10. 发明申请
    • REGULATION OF MAMMALIAN KERATINOUS TISSUE USING HEXAMIDINE COMPOSITIONS
    • 使用HEXAMIDINE组合物调理马马里兰KERATINOUS组织
    • US20100278765A1
    • 2010-11-04
    • US12835244
    • 2010-07-13
    • Donald Lynn Bissett
    • Donald Lynn Bissett
    • A61K8/67A61K31/455A61K31/7008A61K38/02A61K38/05A61K31/56A61K31/522A61Q1/00A61Q17/04A61Q19/04A61Q19/00A61Q19/06A61P29/00A61P17/10A61P17/18A61P31/04A61P31/10A61P17/00
    • A61K8/40A61K8/347A61K8/43A61K8/606A61K8/671A61K8/675A61Q19/00A61Q19/007A61Q19/02A61Q19/06A61Q19/08
    • The present invention relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of a skin care composition comprising: a) a safe and effective amount of a hexamidine compound selected from the group consisting of hexamidine, its salts, and derivatives; b) a safe and effective amount of one or more skin care active selected from the group consisting of sugar amine, vitamin B3, retinoid, peptide, phytosterol, butylated hydroxytoluene and butylated hydroxyanisole, their derivatives, and combinations thereof; and c) a dermatologically acceptable carrier for the hexamidine and the skin care active. In additional embodiments, the above composition is suitable for preventing, retarding, and/or treating dark under-eye circles, puffy eyes, sagging, sallowness as well as spider vessels and/or red blotchiness of skin, promoting skin desquamation, exfoliation, and/or turnover, regulating and/or reducing pore size appearance, preventing/retarding tanning, regulating oily/shiny appearance, preventing, retarding, and/or treating hyperpigmentation in mammalian skin, preventing, retarding, and/or treating itchiness of mammalian skin, preventing, retarding, and/or treating dryness of skin, preventing, retarding, and/or treating fine lines and wrinkles, preventing, retarding, and/or treating skin atrophy of mammalian skin, softening and/or smoothing lips, hair and nails of a mammal, and preventing, retarding, and/or treating the appearance of cellulite in mammalian skin.
    • 本发明涉及用于调节哺乳动物角质组织状况的方法,其中各方法包括局部施用于需要这种治疗的哺乳动物的角质组织的步骤,安全有效量的皮肤护理组合物,其包含:a) 安全有效量的选自己脒,其盐和衍生物的己脒化合物; b)安全有效量的一种或多种选自糖胺,维生素B3,类视色素,肽,植物甾醇,丁基化羟基甲苯和丁基化羟基苯甲醚,其衍生物及其组合的护肤活性物质; 和c)用于己脒和皮肤护理活性的皮肤病学可接受的载体。 在另外的实施方案中,上述组合物适合于预防,延缓和/或治疗黑眼圈,浮肿眼睛,下垂,黄斑以及蜘蛛血管和/或皮肤红斑,促进皮肤脱屑,剥脱和 /或周转,调节和/或减少毛孔外观,防止/阻滞鞣制,调节油性/光泽外观,预防,延缓和/或治疗哺乳动物皮肤色素沉着过度,预防,延缓和/或治疗哺乳动物皮肤的瘙痒, 防止,延缓和/或治疗皮肤干燥,预防,延缓和/或治疗细纹和皱纹,预防,延缓和/或治疗哺乳动物皮肤的萎缩,软化和/或平滑唇,头发和指甲 哺乳动物,并且预防,延缓和/或治疗哺乳动物皮肤中脂肪团的外观。