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1. 发明授权

US08958891B2 Reinforced suture sleeve 有权
标题翻译：加强缝合套管
公开(公告)号：US08958891B2
公开(公告)日：2015-02-17
申请号：US12833061
申请日：2010-07-09
申请人： Larry Kane , Qingshan Ye
发明人： Larry Kane , Qingshan Ye
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/057 , A61N1/059 , A61N2001/0582
摘要： A reinforced suture sleeve designed to cover and protect a medical lead from physical damage resulting from an over tightened suture is described. The reinforced suture sleeve comprises a metallic tubular insert with at least one slot that cut through the surface of the insert in a spiraled pattern. A biocompatible and pliable polymeric body is molded over the insert. The spiraled cut slot in the metallic tubular insert provides flexibility without degrading structural integrity. An alternate embodiment comprises a polymeric body provided with an embedded fiber mesh made of polymeric fibers, metallic fibers or combinations thereof. The fiber mesh prevents an over tightened suture from cutting through the suture sleeve and damaging the medical lead.
摘要翻译：描述了一种设计用于覆盖和保护医疗用铅的增强缝合套筒免受由过紧的缝合引起的物理伤害。加强缝合套筒包括具有至少一个槽的金属管状插入件，其以螺旋形图案穿过插入件的表面。在插入物上模制生物相容且柔韧的聚合物体。金属管状插入件中的螺旋切割槽提供了灵活性，而不降低结构完整性。另一个实施方案包括聚合物主体，其设置有由聚合物纤维，金属纤维或其组合制成的嵌入的纤维网。纤维网防止过紧的缝合线穿过缝合套筒并损坏医用引线。

2. 发明申请

US20110009935A1 Reinforced Suture Sleeve 有权
标题翻译：加强缝合套管
公开(公告)号：US20110009935A1
公开(公告)日：2011-01-13
申请号：US12833061
申请日：2010-07-09
申请人： Larry Kane , Qingshan Ye
发明人： Larry Kane , Qingshan Ye
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/057 , A61N1/059 , A61N2001/0582
摘要： A reinforced suture sleeve designed to cover and protect a medical lead from physical damage resulting from an over tightened suture is described. The reinforced suture sleeve comprises a metallic tubular insert with at least one slot that cut through the surface of the insert in a spiraled pattern. A biocompatible and pliable polymeric body is molded over the insert. The spiraled cut slot in the metallic tubular insert provides flexibility without degrading structural integrity. An alternate embodiment comprises a polymeric body provided with an embedded fiber mesh made of polymeric fibers, metallic fibers or combinations thereof. The fiber mesh which an over tightened suture from cutting through the suture sleeve and damaging the medical lead.
摘要翻译：描述了一种设计用于覆盖和保护医疗用铅的增强缝合套筒免受由过紧的缝合引起的物理伤害。加强缝合套筒包括具有至少一个槽的金属管状插入件，其以螺旋形图案穿过插入件的表面。在插入物上模制生物相容且柔韧的聚合物体。金属管状插入件中的螺旋切割槽提供了灵活性，而不降低结构完整性。另一个实施方案包括聚合物主体，其设置有由聚合物纤维，金属纤维或其组合制成的嵌入的纤维网。纤维网，其过度紧固的缝合线从切割穿过缝合套筒并损坏医用引线。

3. 发明授权

US07993305B2 Splittable valved introducer apparatus 有权
标题翻译：可分离阀门导引装置
公开(公告)号：US07993305B2
公开(公告)日：2011-08-09
申请号：US12603596
申请日：2009-10-22
申请人： Qingshan Ye , Aaron Opbroek
发明人： Qingshan Ye , Aaron Opbroek
IPC分类号： A61M5/178
CPC分类号： A61M25/0668
摘要： An improved splittable medical device introducer designed to introduce a medical device such as a lead or catheter, into a patient's vasculature without loss of blood or the introduction of air is described. The introducer assembly is designed to easily separate in a smooth tactile manner without disrupting placement of the medical device during removal of the introducer. The introducer is composed of a fluoropolymeric material which combined with an internal stress confining structure propagates a stress initiated by the operator that tears the entire introducer assembly in two without creating a jagged separated edge.
摘要翻译：描述了一种改进的可分开的医疗装置引导器，其被设计成将诸如引线或导管的医疗装置引入患者的脉管系统中而不会损失血液或引入空气。导引器组件设计成容易地以平滑的触觉方式分离，而不会在移除导引器期间中断医疗装置的放置。引导器由含氟聚合物材料组成，其与内部应力限制结构组合，传播由操作者发起的应力，其将两个整个导引器组件撕裂而不产生锯齿状的分离边缘。

4. 发明申请

US20080147158A1 Implantable Medical Lead Having Coil Electrode 审中-公开
标题翻译：具有线圈电极的可植入医用铅
公开(公告)号：US20080147158A1
公开(公告)日：2008-06-19
申请号：US11956724
申请日：2007-12-14
申请人： Jeffrey Zweber , Jesse Geroy , Qingshan Ye
发明人： Jeffrey Zweber , Jesse Geroy , Qingshan Ye
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/0534 , A61N1/0551 , A61N1/0563
摘要： Medical electrical leads including coil electrodes having polymeric material between but not over the coil turns. Some leads can be used for neurological sensing and/or stimulation applications. The coil electrodes are more flexible, bendable, and stretchable relative to corresponding cylindrical band electrodes. The polymer fill between the coil turns provides more column strength than coil electrodes having empty space between the coil turns. Some leads have a lumen for receiving stiffening members while others do not have such lumens. An introducer needle can be used to introduce a steerable sheath containing the lead. The sheath and lead can be advanced to near the target site and the sheath removed. The present invention can be used to advantage in peripheral nerve and other applications. Some leads are made by masking the coil electrode outer surface with heat shrink material and filling the coil inter-strand regions with polymer.
摘要翻译：医用电引线包括线圈电极，其具有聚合材料，但不超过线圈匝。一些引线可用于神经感觉和/或刺激应用。线圈电极相对于相应的圆柱形带状电极更灵活，可弯曲和可拉伸。线圈之间的聚合物填充提供比在线圈匝之间具有空白空间的线圈电极更多的柱强度。一些引线具有用于接收加强构件的内腔，而其他导线不具有这样的腔。导引针可用于引入含有铅的可导向护套。护套和铅可以前进到目标位置附近，鞘被去除。本发明可以用于周围神经和其他应用中。通过用热收缩材料掩蔽线圈电极外表面并用聚合物填充线圈股间区域来制造一些引线。

5. 发明申请

US20070255166A1 Contactless Interconnect for Transducers 失效
标题翻译：非接触式互感器
公开(公告)号：US20070255166A1
公开(公告)日：2007-11-01
申请号：US11380315
申请日：2006-04-26
申请人： James Carney , Michael Schugt , Qingshan Ye , Can Cinbis
发明人： James Carney , Michael Schugt , Qingshan Ye , Can Cinbis
IPC分类号： A61N1/00 , A61B5/00
CPC分类号： A61B5/0422 , A61B5/0215 , A61B5/02158 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B2562/028 , A61N1/056 , A61N1/36514
摘要： A medical device for implantation within a patient comprising a lead body including a conductor within the lead body and a transducer supported by the lead body. The conductor is electrically coupled to the transducer by a conductive fluid, paste or gel. The conductive fluid, paste or gel may be contained within a well in the lead body. The transducer may be a MEMS chip and/or an integrated circuit and may perform any of a variety of functions such as sensing physiological data.
摘要翻译：一种用于植入患者体内的医疗装置，包括：引线体，其包括引线体内的导体;以及由引线体支撑的换能器。导体通过导电流体，糊剂或凝胶电耦合到换能器。导电流体，糊状物或凝胶可以包含在引线体内的阱中。换能器可以是MEMS芯片和/或集成电路，并且可以执行诸如感测生理数据的各种功能中的任何一种。

6. 发明申请

US20060025748A1 Ion sensor for long term use in complex medium 有权
标题翻译：离子传感器长期在复杂介质中使用
公开(公告)号：US20060025748A1
公开(公告)日：2006-02-02
申请号：US10903377
申请日：2004-07-30
申请人： Qingshan Ye
发明人： Qingshan Ye
IPC分类号： A61M31/00 , A61B5/05
CPC分类号： A61B5/14542 , A61B5/14546 , A61B5/1473
摘要： Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
摘要翻译：用于测量目标离子浓度的装置和方法使用电极对。该对包括工作电极和参考电极。工作电极和参比电极是离子选择电极（ISE）。参考ISE可以包括钠ISE。 ISE对与体液相互作用，其中目标离子浓度随时间而变化超过钠离子浓度。一对一对ISE膜基本上仅在离子载体中变化。 ISE对可以确定目标离子浓度与体内钠离子浓度之比。抽取血液中钠浓度的定期测定可用于校准ISE对，并提供目标离子浓度作为输出。或者，在心脏或肾衰竭患者中，钾/钠ISE对有效地监测钾浓度随时间的变化。然后，可以实施手动或自动滴定利尿剂材料以维持所需的钾浓度。

7. 发明授权

US09289540B2 Surface modification for coating 有权
标题翻译：涂层表面改性
公开(公告)号：US09289540B2
公开(公告)日：2016-03-22
申请号：US12776095
申请日：2010-05-07
申请人： Qingshan Ye
发明人： Qingshan Ye
IPC分类号： A61L33/00 , B32B27/28 , B32B27/36 , B32B27/34 , B32B27/40
CPC分类号： A61L33/0017 , B32B27/283 , B32B27/285 , B32B27/34 , B32B27/365 , B32B27/40 , B32B2535/00 , Y10T428/263 , Y10T428/265 , Y10T428/31507 , Y10T428/31551 , Y10T428/31678 , Y10T428/31725
摘要： A modified medical device substrate surface designed to improve adhesion of biomimetic surfactants to the medical device surface, thus reducing the risk of thrombosis is described. The surface modification is accomplished through either an application of a tie layer of a hydrophobic material on the substrate surface intermediate the biomimetic coating or through incorporation of a hydrophobic dopant in the polymeric substrate prior to extrusion or molding. Either method creates a hydrophobically modified surface that enhances the biomimetic surfactant bonding strength.
摘要翻译：描述了改进的医疗器械衬底表面，其设计用于改善仿生表面活性剂与医疗器械表面的粘附，从而降低血栓形成的风险。表面改性是通过在挤压或模塑之前在仿生涂层上方的衬底表面上施加疏水材料的粘结层或通过掺入聚合物基底中的疏水性掺杂剂来实现的。任一种方法都会产生疏水改性的表面，增强仿生表面活性剂的粘结强度。

8. 发明申请

US20100100164A1 CAPACITOR AND INDUCTOR ELEMENTS PHYSICALLY DISPOSED IN SERIES WHOSE LUMPED PARAMETERS ARE ELECTRICALLY CONNECTED IN PARALLEL TO FORM A BANDSTOP FILTER 有权
公开(公告)号：US20100100164A1
公开(公告)日：2010-04-22
申请号：US12607234
申请日：2009-10-28
申请人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noelle Moschiano
发明人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noelle Moschiano
IPC分类号： A61N1/05 , H03H7/01
CPC分类号： H01F27/027 , A61N1/086 , A61N1/3718 , A61N1/3754 , H01F27/40 , H01F2017/065 , H01G4/40 , H03H1/0007 , H03H7/0115 , H03H2001/0042 , H03H2007/013
摘要： One or more inductors and one or more capacitors are physically disposed relative to one another in series and are electrically connected to one another in parallel to form a bandstop filter. Chip inductors and chip capacitors having spaced apart conductive terminals are physically arranged in end-to-end abutting relation to minimize electrical potential between adjacent conductive terminals. The bandstop filter may be hermetically sealed within a biocompatible container for use with an implantable lead or electrode of a medical device. The values of the inductors and the capacitors are selected such that the bandstop filter is resonant at one or more selected frequencies, such as an MRI pulsed frequency.

9. 发明申请

US20100100044A1 Splittable Valved Introducer Apparatus 有权
标题翻译：可分离引导装置
公开(公告)号：US20100100044A1
公开(公告)日：2010-04-22
申请号：US12603596
申请日：2009-10-22
申请人： Qingshan Ye , Aaron Opbroek
发明人： Qingshan Ye , Aaron Opbroek
IPC分类号： A61B17/34
CPC分类号： A61M25/0668
摘要： An improved splittable medical device introducer designed to introduce a medical device such as a lead or catheter, into a patient's vasculature without loss of blood or the introduction of air is described. The introducer assembly is designed to easily separate in a smooth tactile manner without disrupting placement of the medical device during removal of the introducer. The introducer is composed of a fluoropolymeric material which combined with an internal stress confining structure propagates a stress initiated by the operator that tears the entire introducer assembly in two without creating a jagged separated edge.
摘要翻译：描述了一种改进的可分开的医疗装置引导器，其被设计成将诸如引线或导管的医疗装置引入患者的脉管系统中而不会损失血液或引入空气。导引器组件设计成容易地以平滑的触觉方式分离，而不会在移除导引器期间中断医疗装置的放置。引导器由含氟聚合物材料组成，其与内部应力限制结构组合，传播由操作者发起的应力，其将两个整个导引器组件撕裂而不产生锯齿状的分离边缘。

10. 发明授权

US07373195B2 Ion sensor for long term use in complex medium 有权
标题翻译：离子传感器长期在复杂介质中使用
公开(公告)号：US07373195B2
公开(公告)日：2008-05-13
申请号：US10903377
申请日：2004-07-30
申请人： Qingshan Ye
发明人： Qingshan Ye
IPC分类号： A61B5/05
CPC分类号： A61B5/14542 , A61B5/14546 , A61B5/1473
摘要： Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
摘要翻译：用于测量目标离子浓度的装置和方法使用电极对。该对包括工作电极和参考电极。工作电极和参比电极是离子选择电极（ISE）。参考ISE可以包括钠ISE。 ISE对与体液相互作用，其中目标离子浓度随时间而变化超过钠离子浓度。一对一对ISE膜基本上仅在离子载体中变化。 ISE对可以确定目标离子浓度与体内钠离子浓度之比。抽取血液中钠浓度的定期测定可用于校准ISE对，并提供目标离子浓度作为输出。或者，在心脏或肾衰竭患者中，钾/钠ISE对有效地监测钾浓度随时间的变化。然后，可以实施手动或自动滴定利尿剂材料以维持所需的钾浓度。

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