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1. 发明申请

US20050191324A1 Flavoring systems for pharmaceutical compositions and methods of making such compositions 审中-公开
标题翻译：用于药物组合物的调味剂系统和制备这种组合物的方法
公开(公告)号：US20050191324A1
公开(公告)日：2005-09-01
申请号：US11118733
申请日：2005-04-29
申请人： Laman Alani , Donald Gauwitz , Dilip Kaul , John Lipari , Soumojeet Ghosh , Kennan Marsh , Richard Whelan , Vanik Petrossian
发明人： Laman Alani , Donald Gauwitz , Dilip Kaul , John Lipari , Soumojeet Ghosh , Kennan Marsh , Richard Whelan , Vanik Petrossian
IPC分类号： A61K9/00 , A61K31/7056
CPC分类号： A61K47/46 , A61K9/0095 , A61K47/02 , A61K47/12
摘要： A flavoring system for a liquid pharmaceutical composition and pharmaceutical compositions containing such flavoring systems are disclosed. Flavoring systems of the invention include at least one sweetening agent, at least two flavored ingredients, and at least one flavor modifier selected from the group consisting of citric acid, sodium citrate, sodium chloride, and mixtures thereof. At least two of the flavored ingredients are selected from the group consisting of a vanilla flavored ingredient, a peppermint flavored ingredient, a menthol flavored ingredient, a cotton candy flavored ingredient, and mixtures thereof. The one or more sweetening agents comprise glycerin, monoammonium glycyrrhizinate, saccharin sodium, acesulfame potassium, high fructose corn syrup, and/or mixtures thereof. Pharmaceutical compositions of the invention include a flavoring system of the invention, a solvent system, and at least one pharmaceutically active agent, such as lopinavir or derivatives thereof, ritonavir or derivatives thereof, or mixtures thereof. Methods for making such liquid pharmaceutical compositions are also disclosed.
摘要翻译：公开了一种用于液体药物组合物的调味体系和含有这种调味体系的药物组合物。本发明的调味系统包括至少一种甜味剂，至少两种调味成分和至少一种选自柠檬酸，柠檬酸钠，氯化钠及其混合物的调味剂。至少两种调味成分选自香草调味成分，薄荷调味成分，薄荷醇风味成分，棉花糖调味成分及其混合物。一种或多种甜味剂包括甘油，甘草酸单铵盐，糖精钠，乙酰磺胺酸钾，高果糖玉米糖浆和/或其混合物。本发明的药物组合物包括本发明的调味剂体系，溶剂体系和至少一种药物活性剂，例如洛匹那韦或其衍生物，利托那韦或其衍生物，或其混合物。还公开了制备这种液体药物组合物的方法。

2. 发明授权

US07566151B2 Temporary lighting support assembly for scaffolding systems 有权
标题翻译：脚手架系统临时照明支援装配
公开(公告)号：US07566151B2
公开(公告)日：2009-07-28
申请号：US11683942
申请日：2007-03-08
申请人： Brendan Whelan , Richard Whelan
发明人： Brendan Whelan , Richard Whelan
IPC分类号： F21S13/10
CPC分类号： F21V21/088 , E04G5/00 , F21W2131/10 , F21W2131/1005
摘要： The present invention is concerned with providing a support for temporary lighting for use with scaffolding systems. The support assembly comprises of two main components and the required fastening systems to affix lighting fixtures and mast light fixtures embodied in two configurations. The support consists of a thin walled pipe with a tube half clamp welded to one end and a thin walled tee welded to the opposite end. The clamp and tee are orientated to provide the support with a precise mounting position. A second thin walled pipe is positioned concentrically through the tee to create framework that has an angled appearance. The second pipe is maintained annular and concentric to the first pipe by means of two washer type collars welded above and below the tee that constrains both pipes to each other. A small space between the collar and tee provides the second pipe with unconstrained rotational movement. Lanyards incorporated in the support are fixed directly to the scaffold for job site safety concerns. Another aspect of the invention is the tube half clamp, which can provide quick assembly and infinite positional placement on a horizontal or vertical pipe member of a scaffolding system.
摘要翻译：本发明涉及提供用于脚手架系统的临时照明的支撑。支撑组件包括两个主要部件和所需的紧固系统，以固定以两种构造体现的照明灯具和灯具灯具。支撑件由一个薄壁管道组成，管子半夹具焊接在一端，而薄壁三通管焊接到另一端。定位夹具和三通以提供具有精确安装位置的支撑。第二个薄壁管道同心地定位穿过三通，以创建具有成角度外观的框架。第二管道通过两个垫圈型环保持环形并与第一管道同心，两个垫圈型套管焊接在三通管上方和下方，将两个管道彼此约束。领口和三通之间的一个小空间为第二根管提供了无约束的旋转运动。挂在支架上的挂绳直接固定在脚手架上，用于工作现场的安全考虑。本发明的另一方面是管半夹具，其可以在脚手架系统的水平或垂直管构件上提供快速组装和无限位置放置。

3. 发明申请

US20060084603A1 IGF-BP3-related methods for inhibiting tumor growth 审中-公开
标题翻译： IGF-BP3相关的抑制肿瘤生长的方法
公开(公告)号：US20060084603A1
公开(公告)日：2006-04-20
申请号：US11197874
申请日：2005-08-05
申请人： Irena Kirman , Richard Whelan
发明人： Irena Kirman , Richard Whelan
IPC分类号： A61K38/18
CPC分类号： A61K38/1709 , A61K38/30
摘要： The subject invention provides a method of inhibiting the proliferation of cells associated with a tumor in a subject which comprises administering to the subject between about 10 μg/kg and about 100 mg/kg of IGF-BP3, thereby inhibiting proliferation of the cells. The subject invention further provides a surgical method which comprises surgically resecting a tumor from a subject and administering to the subject between about 10 μg/kg and about 100 mg/kg of IGF-BP3, so as to inhibit metastasis of any tumor cells released in the subject's blood circulation during resection of the tumor. The subject invention further provides a surgical method which comprises performing a surgical procedure on a subject and administering to the subject between about 10 μg/kg and about 100 mg/kg of IGF-BP3, so as to inhibit proliferation of a tumor cell in the subject. The subject invention also provides an article of manufacture comprising a packaging material having therein IGF-BP3 in an amount suitable for administering a dosage to a subject of between about 10 μg/kg and about 100 mg/kg, and instructions for using the IGF-BP3 prior to, during and/or after a surgical procedure performed on the subject.
摘要翻译：本发明提供了抑制受试者中与肿瘤相关的细胞增殖的方法，其包括向受试者施用约10μg/ kg至约100mg / kg的IGF-BP3，从而抑制细胞的增殖。本发明进一步提供了一种手术方法，其包括从受试者手术切除肿瘤，并向受试者施用约10μg/ kg至约100mg / kg的IGF-BP3，以便抑制任何释放的肿瘤细胞的转移受试者在切除肿瘤期间的血液循环。本发明进一步提供了一种手术方法，其包括对受试者进行外科手术，并且向受试者施用约10μg/ kg至约100mg / kg的IGF-BP3，以便抑制肿瘤细胞的增殖学科。本发明还提供了一种制品，其包括其中具有IGF-BP3的包装材料，其量适于给予受试者约10mug / kg至约100mg / kg的剂量，以及使用IGF- BP3在对受试者进行的外科手术之前，期间和/或之后。

4. 发明申请

US20070211479A1 TEMPORARY LIGHTING SUPPORT ASSEMBLY FOR SCAFFOLDING SYSTEM 有权
标题翻译： SCAFFINGING系统的临时照明支持组件
公开(公告)号：US20070211479A1
公开(公告)日：2007-09-13
申请号：US11683942
申请日：2007-03-08
申请人： Brendan Whelan , Richard Whelan
发明人： Brendan Whelan , Richard Whelan
IPC分类号： F21V19/00
CPC分类号： F21V21/088 , E04G5/00 , F21W2131/10 , F21W2131/1005
摘要： The present invention is concerned with providing a support for temporary lighting for use with scaffolding systems. The support assembly comprises of two main components and the required fastening systems to affix lighting fixtures and mast light fixtures embodied in two configurations. The support consists of a thin walled pipe with a tube half clamp welded to one end and a thin walled tee welded to the opposite end. The clamp and tee are orientated to provide the support with a precise mounting position. A second thin walled pipe is positioned concentrically through the tee to create framework that has an angled appearance. The second pipe is maintained annular and concentric to the first pipe by means of two washer type collars welded above and below the tee that constrains both pipes to each other. A small space between the collar and tee provides the second pipe with unconstrained rotational movement. Lanyards incorporated in the support are fixed directly to the scaffold for job site safety concerns. Another aspect of the invention is the tube half clamp, which can provide quick assembly and infinite positional placement on a horizontal or vertical pipe member of a scaffolding system.
摘要翻译：本发明涉及提供用于脚手架系统的临时照明的支撑。支撑组件包括两个主要部件和所需的紧固系统，以固定以两种构造体现的照明灯具和灯具灯具。支撑件由一个薄壁管道组成，管子半夹具焊接在一端，而薄壁三通管焊接到另一端。定位夹具和三通以提供具有精确安装位置的支撑。第二个薄壁管道同心地定位穿过三通，以创建具有成角度外观的框架。第二管道通过两个垫圈型环保持环形并与第一管道同心，两个垫圈型套管焊接在三通管上方和下方，将两个管道彼此约束。领口和三通之间的一个小空间为第二根管提供了无约束的旋转运动。挂在支架上的挂绳直接固定在脚手架上，用于工作现场的安全考虑。本发明的另一方面是管半夹具，其可以在脚手架系统的水平或垂直管构件上提供快速组装和无限位置放置。

5. 发明申请

US20070142289A1 Use of insulin-like growth factor binding protein 3 (IGF-BP3) for inhibition of tumor growth 审中-公开
标题翻译：使用胰岛素样生长因子结合蛋白3（IGF-BP3）抑制肿瘤生长
公开(公告)号：US20070142289A1
公开(公告)日：2007-06-21
申请号：US11656742
申请日：2007-01-22
申请人： Irena Kirman , Richard Whelan
发明人： Irena Kirman , Richard Whelan
IPC分类号： A61K38/30
CPC分类号： A61K38/30 , A61K38/1709
摘要： A method of inhibiting proliferation of cells associated with a tumor in a subject which comprises administering to the subject a tumor cell proliferation amount of IGF-BP3, thereby inhibiting proliferation of the cells. An improved surgical method which comprises surgically resecting a tumor from a subject and administering to the subject an amount of a protein effective to inhibit metastasis of any tumor cells released in the subject's blood circulation during the surgical resection of the tumor.
摘要翻译：一种抑制受试者与肿瘤相关的细胞增殖的方法，其包括向受试者施用肿瘤细胞增殖量的IGF-BP3，由此抑制细胞的增殖。一种改进的手术方法，其包括从受试者手术切除肿瘤并向受试者施用一定量的有效抑制在手术切除肿瘤期间在受试者的血液循环中释放的任何肿瘤细胞转移的蛋白质。

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