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1. 发明申请

US20080287553A1 PHARMACEUTICAL COMPOSITIONS COMPRISING PERANHYDROCYCLODEXTRIN 审中-公开
标题翻译：药物组合物包含肾上腺皮质激素
公开(公告)号：US20080287553A1
公开(公告)日：2008-11-20
申请号：US12173439
申请日：2008-07-15
申请人： Lajos Szente , Jozsef Szejtli , Laszlo Jicsinszky , Georg Ludwig Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Laszlo Jicsinszky , Georg Ludwig Kis , Christian Schoch
IPC分类号： A61K47/40
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种包含环戊二烯环糊精，药物和载体的药物组合物，以使用环戊二烯环糊精作为药物转运增强剂（例如渗透促进剂），以及在制备药物组合物中使用环糊精协同辅助系统。

2. 发明申请

US20070282013A1 Pharmaceutical Compositions Comprising Peranhydrocyclodextrin 审中-公开
标题翻译：包含Peranhydroocyclodextrin的药物组合物
公开(公告)号：US20070282013A1
公开(公告)日：2007-12-06
申请号：US11838329
申请日：2007-08-14
申请人： Lajos Szente , Jozsef Szejtli , Laszlo Jicsinszky , Georg Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Laszlo Jicsinszky , Georg Kis , Christian Schoch
IPC分类号： A61K47/40
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种药物组合物，其包含一种药物和载体的环糊精糊精，以使用环己烷环糊精作为药物转运增强剂（例如渗透增强剂），以及在制备药物组合物中使用铀氢环糊精作为协同辅助系统。

3. 发明申请

US20100056476A1 PHARMACEUTICAL COMPOSITIONS COMPRISING PERANHYDROCYCLODEXTRIN 审中-公开
标题翻译：药物组合物包含肾上腺皮质激素
公开(公告)号：US20100056476A1
公开(公告)日：2010-03-04
申请号：US12617074
申请日：2009-11-12
申请人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Ludwig Kis , Christian Scnoch
发明人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Ludwig Kis , Christian Scnoch
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种包含环戊二烯环糊精，药物和载体的药物组合物，以使用环戊二烯环糊精作为药物转运增强剂（例如渗透促进剂），以及在制备药物组合物中使用环糊精协同辅助系统。

4. 发明授权

US07189798B2 Composition containing mixture of dihydroxybutane sulfonates 有权
标题翻译：含有二羟基丁烷磺酸盐混合物的组合物
公开(公告)号：US07189798B2
公开(公告)日：2007-03-13
申请号：US10601877
申请日：2003-06-24
申请人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
发明人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
IPC分类号： C08G63/688 , C07C309/04 , C07C309/08
CPC分类号： G01N30/482 , B01D15/3833 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/29 , B01J2220/54 , C07C309/08 , C08B37/0012 , C08B37/0015 , C08G63/6884
摘要： This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
摘要翻译：本发明涉及新的环糊精衍生物，制备这些环糊精衍生物的方法，以及由新的环糊精衍生物和客体分子组成的包合配合物，以及制备这些材料的方法及相关材料及其使用方法。

5. 发明授权

US06610671B2 Cyclodextrin sulfonates, guest inclusion complexes methods of making the same and related materials 失效
公开(公告)号：US06610671B2
公开(公告)日：2003-08-26
申请号：US10042306
申请日：2002-01-11
申请人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
发明人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
IPC分类号： A61K31724
CPC分类号： G01N30/482 , B01D15/3833 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/29 , B01J2220/54 , C07C309/08 , C08B37/0012 , C08B37/0015 , C08G63/6884
摘要： This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.

6. 发明申请

US20080299166A1 NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新生物材料，其制备和使用
公开(公告)号：US20080299166A1
公开(公告)日：2008-12-04
申请号：US12178934
申请日：2008-07-24
申请人： Lajos Szente , Jozsef Szejtli , Gyorgy L. Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Gyorgy L. Kis , Christian Schoch
IPC分类号： A61K47/30 , A61K47/40 , A61F2/00 , A61K38/02 , A61P17/02 , A61K31/56 , A61K38/43
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选到另外包含所述环糊精组分的相应沉淀物。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

7. 发明申请

US20120040901A1 NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新生物材料，其制备和使用
公开(公告)号：US20120040901A1
公开(公告)日：2012-02-16
申请号：US13281033
申请日：2011-10-25
申请人： Lajos Szente , Jozsef Szejtli , György Lajos Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , György Lajos Kis , Christian Schoch
IPC分类号： A61K38/22 , C12N9/00 , A61K31/4535 , A23L1/48 , A61K31/568 , A61K31/5575 , A61P43/00 , A01P15/00 , A01N25/00 , A61K31/12
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选到另外包含所述环糊精组分的相应沉淀物。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

8. 发明申请

US20070042994A1 Pharmaceutical compositions comprising peranhydrocyclodextrin 审中-公开
标题翻译：药物组合物，包含过氢环糊精
公开(公告)号：US20070042994A1
公开(公告)日：2007-02-22
申请号：US10559524
申请日：2004-07-02
申请人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Kis , Christian Schoch
IPC分类号： A61K31/724
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种药物组合物，其包含一种药物和载体的环糊精糊精，以使用环己烷环糊精作为药物转运增强剂（例如渗透增强剂），以及在制备药物组合物中使用铀氢环糊精作为协同辅助系统。

9. 发明申请

US20050163853A1 Novel biomaterials their preparation and use 审中-公开
标题翻译：新型生物材料的制备和使用
公开(公告)号：US20050163853A1
公开(公告)日：2005-07-28
申请号：US10511075
申请日：2003-04-17
申请人： Lajos Szente , Jozsef Szejtli , Gyorgy Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Gyorgy Kis , Christian Schoch
IPC分类号： A61K47/48 , A23L35/00 , A61K9/00 , A61K9/12 , A61K9/20 , A61K9/70 , A61K47/18 , A61K47/36 , A61K47/40 , A61L27/20 , A61L27/54 , C08L101/16 , A61K9/14 , A01N43/04 , A61K31/724
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anonic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: contacting the anionic polymeric component and an cylcodextrin component in an aqueous medium, and adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said component are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cycxlodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阳离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤：将水性介质中的阴离子聚合物组分和环糊精组分接触，并向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选以相应的沉淀物包括所述环糊精组分。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

10. 发明授权

US5298496A Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same 失效
标题翻译： 3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5298496A
公开(公告)日：1994-03-29
申请号：US793389
申请日：1992-01-02
申请人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
发明人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
IPC分类号： A61K31/41 , A61K31/4245 , A61K31/535 , A61K31/5375 , A61K47/40 , A61K47/48 , A61P9/08 , A61P9/10 , C07D265/28 , C07D271/04 , C07D295/30 , C07D413/04 , C08B37/00 , C08B37/06 , C08B37/16
CPC分类号： C08B37/0015 , C07D271/04 , Y10S514/821 , Y10S514/969
摘要： The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same.The inclusion complex of 3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared bya) reacting the 3-morpholino-sydnonimine or its salt in an aqueous medium with a cyclodextrin derivative and the complex is isolated from the solution by dehydratation, orb) high energy milling of 3-morpholino-sydnonimine or its salt and a cyclodextrin derivative.
摘要翻译： PCT No.PCT / HU91 / 00013 Sec。 371日期1992年1月2日 102（e）日期1992年1月2日PCT 1991年3月28日PCT。本发明涉及3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物。由环糊精衍生物形成的3-吗啉代 - 顺式亚胺或其盐的包合络合物是通过以下步骤制备的：a）使3-吗啉代 - 脱水亚胺或其盐在水性介质中与环糊精衍生物反应，并通过脱水从溶液中分离复合物，或b）3-吗啉代 - 二氢亚胺或其盐和环糊精衍生物的高能研磨。

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