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1. 发明授权

US5859867A Microlaser 失效
标题翻译：微型激光
公开(公告)号：US5859867A
公开(公告)日：1999-01-12
申请号：US565344
申请日：1995-11-30
申请人： Kyungwon An , James J. Childs , Ramachandra Rao Dasari , Michael S. Feld
发明人： Kyungwon An , James J. Childs , Ramachandra Rao Dasari , Michael S. Feld
IPC分类号： H01S3/06 , H01S3/091
CPC分类号： H01S3/08031 , H01S3/0604 , H01S3/10
摘要： In a single-atom microlaser, a pair of opposed reflectors define a high-finesse or "high-Q" optical cavity therebetween. A source delivers a stream of multiple-energy-level atoms or particles into the cavity. Each individual atom in the stream is excited by a pump from a lower energy level to an upper energy level before injection into the cavity. The cavity resonance frequency is substantially matched to the frequency of a photon emitted by each atom as it enters the cavity. The photon is emitted due to a transition in energy between the upper level and lower level of each atom. In this manner, upon entry of a sequence of individual atoms into the cavity for example, the average number of photons resonating in the cavity exceeds one and the average number of atoms in the cavity is less than one. The photons are sustained in the high-Q cavity for a long enough time period such that the photon field interacts with the next atom in the stream. A beam of coherent light in the optical frequency spectrum is emitted from the cavity.
摘要翻译：在单原子微激光器中，一对相对的反射器在它们之间限定高精度或“高Q”光学腔。源将多能级原子或颗粒流输送到空腔中。流中的每个单独的原子在注入空腔之前被泵从较低的能级激发到较高的能级。空腔谐振频率基本上与每个原子在进入腔体时发射的光子的频率相匹配。光子由于每个原子的上层和下层之间的能量过渡而被发射。以这种方式，例如，当单个原子序列进入空腔时，在空腔中谐振的光子的平均数量超过1，并且空腔中的平均原子数小于1。光子在高Q空穴中持续足够长的时间段，使得光子场与流中的下一个原子相互作用。光学频谱中的相干光束从腔体发射出来。

2. 发明授权

US08466286B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08466286B2
公开(公告)日：2013-06-18
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： C07F5/02 , A61K49/00 , A61B5/00 , A61B8/00 , A61B10/00 , C07D471/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

3. 发明申请

US20120052018A1 SMMR (SMALL MOLECULE METABOLITE REPORTERS) FOR USE AS IN VIVO GLUCOSE BIOSENSORS 有权
标题翻译：用于葡萄糖生物传感器的SMMR（小分子代谢报告物）
公开(公告)号：US20120052018A1
公开(公告)日：2012-03-01
申请号：US13215061
申请日：2011-08-22
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07F5/02
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

4. 发明授权

US08008088B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
标题翻译： SMMR（小分子代谢物记者）用作体内葡萄糖生物传感器
公开(公告)号：US08008088B2
公开(公告)日：2011-08-30
申请号：US11475784
申请日：2006-06-26
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： G01N33/00 , A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

5. 发明申请

US20120116271A1 CELLULITE TREATMENT 审中-公开
标题翻译：纤维素处理
公开(公告)号：US20120116271A1
公开(公告)日：2012-05-10
申请号：US13325028
申请日：2011-12-13
申请人： Joseph P. Caruso , Andrei V. Belikov , Gregory B. Altshuler , James J. Childs
发明人： Joseph P. Caruso , Andrei V. Belikov , Gregory B. Altshuler , James J. Childs
IPC分类号： A61H7/00 , A61B18/18 , A61B18/04
CPC分类号： A61N7/02 , A61B18/14 , A61B18/1815 , A61B18/203 , A61B90/04 , A61B2018/00023 , A61B2018/00458 , A61B2090/378 , A61N2007/0008 , A61N2007/0039
摘要： A method and apparatus are provided for treating connective tissue. The method and apparatus can be used for treating and/or reducing the appearance of cellulite.
摘要翻译：提供了一种治疗结缔组织的方法和装置。该方法和装置可用于治疗和/或减少脂肪团的外观。

6. 发明授权

US08029765B2 SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors 有权
公开(公告)号：US08029765B2
公开(公告)日：2011-10-04
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

7. 发明申请

US20100286673A1 METHOD AND APPARATUS FOR TREATMENT OF TISSUE 审中-公开
标题翻译：用于治疗组织的方法和装置
公开(公告)号：US20100286673A1
公开(公告)日：2010-11-11
申请号：US12754551
申请日：2010-04-05
申请人： Gregory B. Altshuler , Andrei Belikov , James J. Childs , Andrei V. Erofeev , Ilya Yaroslavsky , Henry H. Zenzie
发明人： Gregory B. Altshuler , Andrei Belikov , James J. Childs , Andrei V. Erofeev , Ilya Yaroslavsky , Henry H. Zenzie
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B90/98 , A61B2018/00005 , A61B2018/00452 , A61B2018/00458 , A61B2018/0047 , A61B2018/00476 , A61B2090/065 , A61B2090/0811 , A61N5/0616 , A61N5/0617 , A61N5/062 , A61N2005/0643
摘要： Devices and methods of treatment of tissue, such as skin tissue, with electromagnetic radiation (EMR) are disclosed that employ local deformation of tissue in small areas. Devices and methods employing local deformation are used to produce fractional lattices of EMR-treated islets in tissue for application including hair growth management.
摘要翻译：公开了利用电磁辐射（EMR）处理组织（例如皮肤组织）的装置和方法，其在小区域中采用局部组织变形。使用局部变形的装置和方法用于在包括毛发生长管理在内的组织中产生EMR处理的胰岛的分数晶格。

8. 发明申请

US20100145321A1 METHODS AND PRODUCTS FOR PRODUCING LATTICES OF EMR-TREATED ISLETS IN TISSUES, AND USES THEREFOR 审中-公开
标题翻译：用于生产组织中EMR处理小鼠的细胞的方法和产品及其用途
公开(公告)号：US20100145321A1
公开(公告)日：2010-06-10
申请号：US12625824
申请日：2009-11-25
申请人： Gregory B. Altshuler , Ilya Yaroslavsky , Andrei V. Erofeev , David Tabatadze , Mikhail Z. Smirnov , James J. Childs
发明人： Gregory B. Altshuler , Ilya Yaroslavsky , Andrei V. Erofeev , David Tabatadze , Mikhail Z. Smirnov , James J. Childs
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2017/00765 , A61B2018/00005 , A61B2018/00452 , A61B2018/0047 , A61B2018/00476 , A61B2018/2023 , A61B2018/20355 , A61H39/002 , A61H2201/10 , A61N1/00 , A61N2/00
摘要： Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.
摘要翻译：公开了用电磁辐射（EMR）处理组织以在组织中产生EMR处理的胰岛的晶格的方法。还公开了用于在组织中产生经EMR处理的胰岛的晶格的装置和系统，以及这种装置和系统的美容和医疗应用。

9. 发明申请

US20090004108A1 Smmr (Small Molecule Metabolite Reporters) For Use As In Vivo Glucose Biosensors 有权
标题翻译： Smmr（小分子代谢记录）用作体内葡萄糖生物传感器
公开(公告)号：US20090004108A1
公开(公告)日：2009-01-01
申请号：US10584821
申请日：2004-12-23
申请人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
发明人： Emile M. Bellott , Dongsheng Bu , James J. Childs , Christopher Lambert , Hubert A. Nienaber , Shirley J. Shi , Zhaolin Wang , Jerome J. Workman , Alex R. Zelenchuk
IPC分类号： A61K49/00 , C07D311/78
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07F5/025 , C07F7/1804 , Y10T436/144444
摘要： Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
摘要翻译：描述了用作体内葡萄糖生物传感器，传感器组合物和使用方法的小分子代谢记录（SMMR）。 SMMR包括含有硼酸的呫吨，香豆素，喹诺酮和基于非花叶粉的小分子，其用于体内，有利地在皮肤上监测葡萄糖。

10. 发明授权

US06219132B1 Method and apparatus for performing spectroscopic analysis with applicability to samples with turbidity and absorption 有权
标题翻译：用于对具有浊度和吸收性的样品进行光谱分析的方法和装置
公开(公告)号：US06219132B1
公开(公告)日：2001-04-17
申请号：US09159944
申请日：1998-09-24
申请人： Ronald S. Scharlack , James J. Childs
发明人： Ronald S. Scharlack , James J. Childs
IPC分类号： G01N3348
CPC分类号： G01N21/31
摘要： A method of performing analysis of samples having turbidity and/or high absorbance is disclosed. The analysis utilizes information from multiple factors, which affect transmittance or absorbance. These factors include: absorbance as measured in a non-turbid sample, scattering losses due to particles and limitations of the measurement device as measured in a non-absorbing sample, additional scattering losses due to sample absorbance, variable path length effects due to the sample, variable path length effects due to the measurement device, and additional nonlinear effects. By taking into account additional factors that affect transmittance or absorbance, a more accurate analysis is achieved.
摘要翻译：公开了对具有浊度和/或高吸光度的样品进行分析的方法。分析利用多因素的信息，影响透光率或吸光度。这些因素包括：在非混浊样品中测量的吸光度，由于颗粒引起的散射损失和在非吸收样品中测量的测量装置的限制，由于样品吸光度引起的附加散射损失，由于样品导致的可变路径长度影响，由测量装置引起的可变路径长度影响，以及额外的非线性效应。通过考虑影响透光率或吸光度的其他因素，可以获得更准确的分析。

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