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1. 发明申请

US20100168034A1 PEPTIDE HAVING CELL MEMBRANE PENETRATING ACTIVITY 审中-公开
标题翻译：具有细胞膜活化活性的肽
公开(公告)号：US20100168034A1
公开(公告)日：2010-07-01
申请号：US12280077
申请日：2007-02-20
申请人： Kyunglim Lee , Moonhee Kim , Miyoung Kim , Youngjoo Kwon
发明人： Kyunglim Lee , Moonhee Kim , Miyoung Kim , Youngjoo Kwon
IPC分类号： A61K38/08 , C07K7/06 , C12N9/00 , C07H21/00 , A61P43/00
CPC分类号： A61K47/64 , A61K47/65 , A61K48/0008 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/46 , C07K14/47 , C07K16/18
摘要： The present invention provides a peptide having cell membrane penetrating activity, a transmembrane carrier comprising the peptide having cell membrane penetrating activity as an effective component, a transmembrane complex consisting of the peptide having cell membrane penetrating activity combined with a target substance, a transfection kit comprising the peptide having cell membrane penetrating activity and the target substance, use of the peptide having cell membrane penetrating activity for the manufacture of a transmembrane complex, use of the transmembrane complex for the manufacture of a medicament, and a method for delivering a target substance into cell interior which comprises administrating to a subject with a transmembrane complex consisting of the peptide having cell membrane penetrating activity combined with a target substance to induce transduction of the transmembrane complex into cell interior. The peptide having cell membrane penetrating activity of the present invention has a prominent penetrating efficiency as compared with the activities of prior TAT-derived peptides and so the peptide has applications on intracellular delivery in various research fields as well as on therapeutics of specific diseases where targeting of drugs is required at high efficiency. Accordingly, the peptide having cell membrane penetrating activity, the transmembrane complex consisting of the peptide combined with a target substance and the method for delivering a target substance into cell interior using the transmembrane complex of the present invention are very useful as drug delivery systems.
摘要翻译：本发明提供具有细胞膜穿透活性的肽，包含具有细胞膜穿透活性的肽作为有效成分的跨膜载体，由具有与靶物质结合的细胞膜穿透活性的肽组成的跨膜复合物，包含具有细胞膜穿透活性的肽和目标物质，具有细胞膜穿透活性的肽用于制造跨膜复合物的用途，跨膜复合物在制备药物中的用途以及将靶物质递送到细胞内部，其包括用具有与靶物质组合的细胞膜穿透活性的肽组成的跨膜复合物施用于受试者，以诱导跨膜复合物进入细胞内部。与先前的TAT衍生肽的活性相比，具有本发明的细胞膜穿透活性的肽具有突出的穿透效率，因此该肽可用于各种研究领域的细胞内递送以及针对特定疾病的治疗的药物需要高效率。因此，具有细胞膜穿透活性的肽，由靶物质结合的肽组成的跨膜复合物和使用本发明的跨膜复合物将靶物质输送到细胞内部的方法，作为药物递送系统是非常有用的。

2. 发明授权

US07772368B2 Deletion forms of IGE-dependent histamine releasing factor having histamine releasing activity, HRF-binding peptides and the uses thereof 有权
标题翻译：具有组胺释放活性的IGE依赖性组胺释放因子的缺失形式，HRF结合肽及其用途
公开(公告)号：US07772368B2
公开(公告)日：2010-08-10
申请号：US11307141
申请日：2006-01-25
申请人： Kyunglim Lee , Miyoung Kim
发明人： Kyunglim Lee , Miyoung Kim
IPC分类号： C07K1/00
CPC分类号： C07K14/52 , A61K38/00 , Y02A50/411 , Y02A50/473 , Y10S530/862 , Y10S530/868
摘要： The present invention relates to IgE-dependent histamine releasing factor (HRF) and HRF-binding peptides, more precisely, deletion forms of HRF which are able to be formed as dimers containing amino acid sequence represented by SEQ ID NO:3, genes encoding thereof and novel HRF-binding peptides having an activity of inhibiting HRF. The deletion forms of HRF which are able to be formed as dimers of the present invention induces intracellular secretion of histamine and IL-8, making an excellent candidate for a drug for inhibiting allergic reaction triggered by HRF and a kit for detecting HRF in serum of an allergy patient. In addition, novel HFR-binding peptides of the present invention bind to HRF to inhibit the actions of HFR, so they can be effectively used for the prevention and the treatment of allergic diseases of animals including asthma and rhinitis or malaria.
摘要翻译：本发明涉及IgE依赖性组胺释放因子（HRF）和HRF结合肽，更准确地说，能够形成为含有SEQ ID NO：3所示的氨基酸序列的二聚体的HRF的缺失形式，编码其的基因和具有抑制HRF活性的新型HRF结合肽。能够形成为本发明的二聚体的HRF的缺失形式诱导组胺和IL-8的细胞内分泌，成为用于抑制由HRF引发的过敏反应的药物和用于检测血清中HRF的试剂盒的优选候选物过敏患者。此外，本发明的新型HFR结合肽与HRF结合以抑制HFR的作用，因此它们可以有效地用于预防和治疗包括哮喘和鼻炎或疟疾在内的动物的过敏性疾病。

3. 发明授权

US06710165B2 IgE-dependent histamine-releasing factor-binding peptides 有权
标题翻译： IgE依赖性组胺释放因子结合肽
公开(公告)号：US06710165B2
公开(公告)日：2004-03-23
申请号：US09870472
申请日：2001-06-01
申请人： Kyunglim Lee , Junho Chung , Wha Jung Kim , Miyoung Kim , Jaehoon Jung
发明人： Kyunglim Lee , Junho Chung , Wha Jung Kim , Miyoung Kim , Jaehoon Jung
IPC分类号： A61K3800
CPC分类号： C07K14/705 , A61K38/00 , A61K38/03 , G01N33/5008 , Y02A50/411
摘要： Disclosed are IgE-dependent histamine-releasing factor (HRF) receptor, HRF-binding peptides and nucleic acids encoding the same, and uses thereof in the medicinal area.
摘要翻译：公开了IgE依赖性组胺释放因子（HRF）受体，HRF结合肽和编码它们的核酸及其在药物区域中的用途。

4. 发明申请

US20130129726A1 PEPTIDE HAVING CELL MEMBRANE PENETRATING ACTIVITY 审中-公开
公开(公告)号：US20130129726A1
公开(公告)日：2013-05-23
申请号：US13669414
申请日：2012-11-05
申请人： Kyunglim Lee
发明人： Kyunglim Lee
IPC分类号： C07K14/435 , C07K16/18
CPC分类号： A61K47/64 , A61K47/65 , A61K48/0008 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/46 , C07K14/47 , C07K16/18
摘要： Provided are transmembrane complexes that contain a protein transduction domain (PTD) from the N-terminus of IgE-dependent histamine-releasing factor (HRF) and a target substance that is to be delivered into a cell. Also provided are nucleic acid molecules encoding the transmembrane complex, and methods of delivering the target substance into a cell interior by contacting the transmembrane complex with a cell. Also provided are transfection kits containing the PTD and the target substance.

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