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1. 发明申请

US20100140112A1 Nanoparticle Marker, Diagnostic Methods Using the Same and Diagnostic Kit and Apparatus Using the Same 审中-公开
公开(公告)号：US20100140112A1
公开(公告)日：2010-06-10
申请号：US11993715
申请日：2006-06-23
申请人： Kyoung-Sik Seo , Jeong-Whan Kim
发明人： Kyoung-Sik Seo , Jeong-Whan Kim
IPC分类号： G01N27/26 , C08F290/14 , C08G63/91 , C07F1/08 , C07F1/00 , C07F3/00 , C07F7/24 , C07F3/06 , C07F3/08 , C07F15/04 , G01N33/553
CPC分类号： G01N33/54346 , B82Y15/00 , B82Y30/00 , G01N33/54373
摘要： A diagnostic kit disclosed herein comprises a nanoparticle-biomaterial complex, an extraction solution, a collection electrode, and a current peak measurement unit. The nanoparticle-biomaterial complex comprises: one or more nanoparticles selected from a metal group consisting of zinc, cadmium, lead, copper, gallium, arsenic, thallium, nickel, manganese and bismuth; one or more biomaterial-binding materials binding to the nanoparticles through a binding-stabilizing agent and binding specifically to the biomaterials to be detected; and a binding-stabilizing agent forming bonds between the nanoparticles and the biomaterial-binding materials. The extraction solution serves to isolate and extract the nanoparticles from the nanoparticle-biomaterial complex. The collection electrode serves to collect the nanoparticles from the extraction solution. The current peak measurement unit serves to measure current peaks corresponding to the nanoparticles collected from the collection electrode. A diagnostic kit disclosed herein comprises a nanoparticle-biomaterial complex, an extraction solution, a collection electrode and a current peak measurement unit. The nanoparticle-biomaterial complex comprises in the diagnostic kit: one or more nanoparticles selected from a metal group consisting of zinc, cadmium, lead, copper, gallium, arsenic, thallium, nickel, manganese and bismuth; one or more biomaterial-binding materials binding to the nanoparticles through a binding-stabilizing agent and binding specifically to the biomaterials to be detected; and a binding-stabilizing agent inducing the binding between the nanoparticles and the biomaterial-binding materials. The extraction solution serves to isolate and extract the nanoparticles from the nanoparticle-biomaterial complex. The collection electrode serves to collect the nanoparticles from the extraction solution. The current peak measurement unit serves to measure current peaks corresponding to the nanoparticles collected from the collection electrode. A diagnostic device disclosed herein is an information technology-integrated, miniaturized electrochemical biosensor, which comprises a disposable tip, an electrode, a container for storing a diagnostic reagent, and a unit for performing electric measurement or optical measurement, is in the form of a pipette or syringe, and has a container stopper in which the electrode is included.

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