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1. 发明公开

US20230147364A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR RNA VIRUS-RELATED DISEASES 审中-公开
公开(公告)号：US20230147364A1
公开(公告)日：2023-05-11
申请号：US17917197
申请日：2021-04-28
申请人： Kyoto University , NAGASAKI UNIVERSITY
发明人： Haruhisa INOUE , Keiko IMAMURA , Jiro YASUDA , Yasuteru SAKURAI
IPC分类号： A61K31/496 , A61K31/4535 , A61K31/41 , A61K31/4439 , A61K31/381 , A61P31/14 , A61K31/138
CPC分类号： A61K31/496 , A61K31/4535 , A61K31/41 , A61K31/4439 , A61K31/381 , A61P31/14 , A61K31/138
摘要： A a prophylactic or therapeutic agent for RNA virus-related diseases is provided, the prophylactic or therapeutic agent containing, as an active ingredient, at least one compound selected from the group consisting of a selective estrogen receptor modulator, an anti-tuberculosis drug, a CysLT1 receptor antagonist, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, an arachidonate 5-lipoxygenase (5-LOX) inhibitor, a derivative thereof, a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable solvate thereof.

2. 发明申请

US20220215543A1 Information Processing Device, Screening Device, Information Processing Method, Screening Method, and Program 有权
公开(公告)号：US20220215543A1
公开(公告)日：2022-07-07
申请号：US17614218
申请日：2020-05-28
申请人： Kyoto University
发明人： Haruhisa INOUE , Takayuki KONDO , Yuichiro YADA
IPC分类号： G06T7/00 , G16H30/20 , G16H50/30 , G16H50/70 , G16H50/20 , A61B5/00 , G06N20/20
摘要： An information processing device includes: an acquirer configured to acquire images obtained by imaging cells differentiated from pluripotent stem cells derived from a subject; and a predictor configured to input the images acquired by the acquirer to a model trained on data in which information indicating at least a neurodegenerative disease is associated with the image obtained by imaging the cells of the neurodegenerative disease differentiated from the pluripotent stem cells, and predict an onset of the neurodegenerative disease of the subject or effects of drugs on the neurodegenerative disease, based on output results of the model to which the images were input.

3. 发明申请

US20190008860A1 AGENT FOR PREVENTING AND/OR TREATING ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：US20190008860A1
公开(公告)日：2019-01-10
申请号：US16066946
申请日：2016-12-29
申请人： KYOTO UNIVERSITY
发明人： Haruhisa INOUE , Takayuki KONDO
IPC分类号： A61K31/4985 , A61K31/4709 , A61K31/353 , A61K31/405 , A61K31/095 , A61K31/357 , A61P25/28
摘要： The present invention provides a prophylactic or therapeutic agent for Alzheimer's disease (AD) containing a combination of two or more compounds selected from the group consisting of compounds shown by compound Nos. 1 to 130. Since these compounds are existing drugs that have already been confirmed actually for safety and pharmacokinetics in human, they can be a means for a pre-emptive treatment of people at risk of AD and in a stage before developing mild cognitive impairment (MCI).

4. 发明申请

US20200222443A1 COMPOSITION FOR PREVENTION OR TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 36 审中-公开
公开(公告)号：US20200222443A1
公开(公告)日：2020-07-16
申请号：US16614644
申请日：2018-05-17
申请人： KYOTO UNIVERSITY
发明人： Haruhisa INOUE , Keiko IMAMURA , Kosuke MATSUZONO
IPC分类号： A61K31/7088 , A61K48/00 , C12N15/113
摘要： An object of the present invention is to provide ASO that can effectively suppress a formation of RNA foci spontaneously occurring in neurons having SCA36 mutation, without inducing the cleavage of NOP56 pre-mRNA. The present invention provides an oligonucleotide comprising a nucleotide sequence in which one or more nucleotide sequences represented by SEQ ID NO: 2 are consecutively connected and is complementary to pre-mRNA of NOP56 gene, wherein a structure formed by the hybridization of the oligonucleotide to the pre-mRNA is resistant to RNaseH.

5. 发明申请

US20180209962A1 SCREENING METHOD USING INDUCED NEURONS 审中-公开
公开(公告)号：US20180209962A1
公开(公告)日：2018-07-26
申请号：US15526192
申请日：2015-11-13
申请人： KYOTO UNIVERSITY
发明人： Haruhisa INOUE , Keiko IMAMURA
IPC分类号： G01N33/50 , C12N5/0793
CPC分类号： G01N33/5058 , C07K14/47 , C12N5/0619 , C12N15/09 , C12N2506/45 , C12N2510/00 , C12Q1/02 , G01N33/6896
摘要： An object of the present invention is to provide a method for screening for a prophylactic or therapeutic agent for tauopathy capable of blocking the propagation of tau-mediated neurodegeneration.A method for screening for a prophylactic or therapeutic agent for tauopathy, comprising the following steps (1) to (3): (1) contacting neurons having a mutant MAPT gene with a test substance; (2) measuring any one index selected from the group consisting of the following (a) to (e) in the neurons: (a) the amount of a tau oligomer in a culture supernatant. (b) the amount of an intracellular tau oligomer, (c) the frequency of depolarization, (d) an intracellular calcium ion concentration, and (e) the number of living cells; and (3) selecting the test substance as a prophylactic or therapeutic agent for tauopathy when the value of (a), (b), (c), or (d) measured in the step (2) after the contact with the test substance in the step (1) is lower than the value obtained without the contact with the test substance in the step (1), and/or when the value of (e) measured in the step (2) after the contact with the test substance in the step (1) is higher than the value obtained without the contact with the test substance in the step (1).

6. 发明申请

US20150266937A1 VACCINE FOR TREATMENT OF TAUTOPATHY 有权
标题翻译：用于治疗胃肠病的疫苗
公开(公告)号：US20150266937A1
公开(公告)日：2015-09-24
申请号：US14585922
申请日：2014-12-30
申请人： Kyoto University , National Institute of Radiological Sciences
发明人： Haruhisa INOUE , Hiroki TAKEUCHI , Ryosuke TAKAHASHI , Makoto HIGUCHI , Bin JI , Tetsuya SUHARA
IPC分类号： C07K14/47 , A61K39/00
CPC分类号： C07K14/4711 , A61K39/0005 , A61K39/0007 , A61K2039/5256 , A61K2039/53 , C07K2319/02 , C12N2799/021
摘要： This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要翻译：本发明涉及用于预防或治疗tau蛋白病的疫苗，其包含作为活性成分的载体，其包含编码与分泌信号序列连接的突变型tau蛋白的核酸，其中所述疫苗能够诱导针对（任选地磷酸化）tau蛋白在与直接施用突变型tau蛋白的情况相比更持续的方式。

7. 发明申请

US20200368267A1 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
公开(公告)号：US20200368267A1
公开(公告)日：2020-11-26
申请号：US16766675
申请日：2018-11-22
申请人： KYOTO UNIVERSITY
发明人： Haruhisa INOUE , Keiko IMAMURA
IPC分类号： A61K31/7088 , A61P19/04 , C07K16/18
摘要： The present invention provides a prophylactic and/or therapeutic agent for ALS containing a Src/c-Abl pathway inhibitor.

8. 发明申请

US20160046905A1 PLURIPOTENT STEM CELL FOR NEURONAL DIFFERENTIATION INDUCTION 审中-公开
标题翻译：用于神经元差异诱导的大脑干细胞
公开(公告)号：US20160046905A1
公开(公告)日：2016-02-18
申请号：US14778670
申请日：2014-03-24
申请人： KYOTO UNIVERSITY
发明人： Haruhisa INOUE , Keiko IMAMURA , Takayuki KONDO
IPC分类号： C12N5/0793 , C12N5/074 , C12N5/078 , G01N33/569
摘要： The present invention aims to provide a method of producing motor neurons/neurons that sufficiently reproduce intrinsic properties of motor neurons/neurons, especially of the motor neurons/neurons in patients, from pluripotent stem cells promptly and synchronically, and a pluripotent stem cell capable of differentiating into a neuron or a motor neuron promptly and synchronically after a drug treatment.A method of generating a motor neuron from a pluripotent stem cell, comprising the following steps in order from (1) to (2): (1) introducing one or more nucleic acids encoding Lhx3, Ngn2, and Isl1 into a pluripotent stem cell; and (2) maintaining expression of the Lhx3, Ngn2, and Isl1 for three days or more.
摘要翻译：本发明的目的在于提供一种产生运动神经元/神经元的方法，其能够迅速和同步地从多能干细胞中充分再现运动神经元/神经元，特别是运动神经元/神经元的运动神经元/神经元的内在特性，以及多能干细胞在药物治疗后迅速和同步地分化为神经元或运动神经元。一种从多能干细胞产生运动神经元的方法，包括以下步骤：（1）至（2）：（1）将一种或多种编码Lhx3，Ngn2和Isl1的核酸引入多能干细胞; 和（2）维持Lhx3，Ngn2和Isl1表达三天以上。

9. 发明申请

US20220215544A1 Information Processing Device, Screening Device, Information Processing Method, Screening Method, and Program 有权
公开(公告)号：US20220215544A1
公开(公告)日：2022-07-07
申请号：US17614243
申请日：2020-05-29
申请人： Kyoto University
发明人： Haruhisa INOUE , Keiko IMAMURA , Yuichiro YADA
IPC分类号： G06T7/00 , G16H50/20
摘要： An information processing device includes: an acquirer configured to acquire images obtained by imaging cells differentiated from pluripotent stem cells derived from a subject; and a predictor configured to input the images acquired by the acquirer to a model trained on data in which information indicating at least an intractable neurological disease is associated with an image obtained by imaging the cells of the intractable neurological disease differentiated from the pluripotent stem cells, and predict an onset of the intractable neurological disease of the subject based on output results of the model to which the images were input.

10. 发明申请

US20200222386A1 AGENT FOR PREVENTING AND/OR TREATING ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：US20200222386A1
公开(公告)日：2020-07-16
申请号：US16626686
申请日：2018-06-27
申请人： KYOTO UNIVERSITY
发明人： Haruhisa INOUE , Takayuki KONDG
IPC分类号： A61K31/48 , A61P25/28
摘要： The present invention provides a prophylactic and/or therapeutic agent for Alzheimer's disease containing a compound represented by the formula (I) or the formula (II) or a salt thereof. Each symbol in the formulas (I) and (II) are as described in the attached DESCRIPTION:

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