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1. 发明授权

US5991048A Surface plasmon resonance light pipe sensor 失效
标题翻译：表面等离子体共振光管传感器
公开(公告)号：US5991048A
公开(公告)日：1999-11-23
申请号：US738360
申请日：1996-10-25
申请人： Scott Karlson , Sinclair S. Yee , Kyle Johnston , Ralph Jorgenson
发明人： Scott Karlson , Sinclair S. Yee , Kyle Johnston , Ralph Jorgenson
IPC分类号： G01N21/55 , G01N21/77 , G02B6/10 , G02B6/24 , G02B6/28
CPC分类号： G01N21/553 , G02B6/10 , G02B6/24 , G02B6/2826
摘要： The present invention provides SPR sensors in which the sensing element is a planar lightpipe. The sensors of this invention include configurations which employ multiwavelength light incident on the SPR sensing area at a single angle or at a range of angles. Sensors of this invention also include configurations that employ monochromatic light at a range of angles. Many of the configurations of the SPR lightpipe sensors of this invention involve imaging of input light through the lightpipe. In one embodiment, the invention provides a first order SPR sensor system in which the sensing element is a planar lightpipe. Light coupled into the lightpipe reflects off an SPR sensing area positioned on an external surface planar surface of the lightpipe. Multiwavelength light that is coupled into the lightpipe input face at a range of angles propagates through the lightpipe by total internal reflection (TIR), making multiple reflections, and exits in a series of angular bands each containing spectral information (including SPR features)for a small range of incidence angles. A detector or detectors are positioned to measure the reflection spectrum, including any surface plasmon resonance feature, of one or preferably more than one of the angular bands exiting the lightpipe. SPR sensor configurations include those that have multiple sensing channels and those which can be multiplexed. This invention provides SPR sensors with planar lightpipe sensing elements and method of detecting analytes in samples using these sensors. The invention also provides planar lightpipe that have a plurality of SPR sensing layers on a planar surface.
摘要翻译：本发明提供了SPR传感器，其中感测元件是平面光管。本发明的传感器包括采用在单个角度或角度范围内入射到SPR感测区域的多波长光的配置。本发明的传感器还包括采用角度范围内的单色光的构造。本发明的SPR光管传感器的许多配置涉及通过光管对输入光的成像。在一个实施例中，本发明提供了第一级SPR传感器系统，其中感测元件是平面光管。耦合到光管中的光从位于光管的外表面平面上的SPR感测区域反射出来。以一定范围的角度耦合到光管输入面中的多波长光通过全内反射（TIR）传播通过光管，进行多次反射，并在一系列角频带中退出，每个角带包含光谱信息（包括SPR特征），用于入射角范围小。定位检测器或检测器以测量离开光管的一个或优选多于一个角带的反射光谱，包括任何表面等离子体共振特征。 SPR传感器配置包括具有多个感测通道的那些，以及可复用的那些。本发明提供具有平面光管感测元件的SPR传感器以及使用这些传感器检测样品中的分析物的方法。本发明还提供了在平坦表面上具有多个SPR感测层的平面光管。

2. 发明授权

US5815278A Surface plasmon resonance light pipe sensing probe and related interface optics 失效
标题翻译：表面等离子体共振光管传感探头及相关接口光学元件
公开(公告)号：US5815278A
公开(公告)日：1998-09-29
申请号：US738442
申请日：1996-10-25
申请人： Kyle Johnston , Sinclair S. Yee
发明人： Kyle Johnston , Sinclair S. Yee
IPC分类号： G01N21/55 , G01N21/77 , G02B6/10 , G02B6/24 , G02B6/28 , G01N21/00 , G02B6/02
CPC分类号： G01N21/553 , G02B6/10 , G02B6/24 , G02B6/2826
摘要： The present invention provides SPR sensors in which the sensing element is a planar lightpipe. The sensors of this invention include configurations that employ multi-wavelength light (including broad band and white light) incident on the SPR sensing area at a single angle or at a range of angles. Sensors and probes of this invention also include configurations that employ monochromatic light at a range of angles. Many of the configurations of the SPR lightpipes of this invention involve imaging of input light through the folded lightpipe. In one general embodiment, the invention provides a SPR sensor system in which the sensing element is a folded planar lightpipe.
摘要翻译：本发明提供了SPR传感器，其中感测元件是平面光管。本发明的传感器包括以单个角度或角度范围入射在SPR感测区域上的多波长光（包括宽带和白光）的配置。本发明的传感器和探针还包括采用角度范围内的单色光的构造。本发明的SPR光管的许多构造涉及通过折叠的光管成像输入光。在一个一般实施例中，本发明提供了一种SPR传感器系统，其中感测元件是折叠的平面光管。

3. 发明授权

US5822073A Optical lightpipe sensor based on surface plasmon resonance 失效
标题翻译：基于表面等离子体共振的光学光管传感器
公开(公告)号：US5822073A
公开(公告)日：1998-10-13
申请号：US736157
申请日：1996-10-25
申请人： Sinclair S. Yee , Kyle Johnston , Shuai Shen
发明人： Sinclair S. Yee , Kyle Johnston , Shuai Shen
IPC分类号： G01N21/55 , G01N21/77 , G02B6/10 , G02B6/24 , G02B6/28 , G01N21/17
CPC分类号： G01N21/553 , G02B6/10 , G02B6/24 , G02B6/2826
摘要： The present invention relates in general to SPR sensors in which the sensing element is a planar lightpipe. More specifically, a planar lightpipe sensor configuration for measurement of SPR at a single angle operation is provided. The lightpipe of this sensor is beveled to facilitate coupling of substantially collimated white light, preferably TM polarized white light, at a selected single angle that excites SPR at the sensing area. Angle of incidence on the SPR sensing area is determined by bevel angle used. This embodiment is a zero order sensor in the sense that it allows measurement for a given analyte at only a single angle of incidence. In this embodiment, however, the lightpipe can have a plurality of SPR sensing area across its width to provide for multichannel sensing. Refractive index sensitivity of this configuration is estimated as 4.times.10.sup.-5 RI units.
摘要翻译：本发明一般涉及SPR传感器，其中感测元件是平面光管。更具体地，提供了用于在单角度操作中测量SPR的平面光管传感器配置。该传感器的光管是斜面的，以便于以感测区域激发SPR的选定的单个角度耦合基本上准直的白光，优选TM偏振白光。 SPR感应区域的入射角由所使用的斜角决定。该实施例是一种零级传感器，其意义在于它允许仅在单个入射角度对给定分析物进行测量。然而，在该实施例中，光管可以在其宽度上具有多个SPR感测区域以提供多通道感测。该配置的折射率灵敏度估计为4×10 -5 RI单位。

4. 发明授权

US07334947B2 Alignment system and method 失效
标题翻译：校准系统和方法
公开(公告)号：US07334947B2
公开(公告)日：2008-02-26
申请号：US11549702
申请日：2006-10-16
申请人： Andreas Rose , Guenter Herr , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Kyle Johnston
IPC分类号： G02B6/36
CPC分类号： G02B6/4292 , G02B6/4204 , G02B6/4234 , G02B6/4236
摘要： The present invention provides an alignment system comprising a base having a feature that accepts a first optical element, a first eccentric element having a through hole that accepts an eccentric assembly comprising a second eccentric element having a feature that accepts a second optical element and is attached to the second optical element via second attachment means, wherein the first eccentric element is engaged with the base via first attachment means and axial alignment between optical axis of the first optical element and optical axis of the second optical element is achieved by rotationally adjusting at least one of the eccentric elements relative to the base. The present invention also provides methods to make and use this alignment system.
摘要翻译：本发明提供了一种对准系统，其包括具有接受第一光学元件的特征的基座，具有通孔的第一偏心元件，该偏心元件接收偏心组件，该偏心组件包括具有接受第二光学元件的特征的第二偏心元件，通过第二附接装置到达第二光学元件，其中第一偏心元件通过第一附接装置与基座接合，并且通过至少旋转地调节第一光学元件的光轴和第二光学元件的光轴之间的轴向对准来实现相对于基地的偏心元素之一。本发明还提供了制造和使用该对准系统的方法。

5. 发明申请

US20070255357A1 NASAL DECOLONIZATION OF MICROBES 审中-公开
标题翻译：微生物的NASAL分解
公开(公告)号：US20070255357A1
公开(公告)日：2007-11-01
申请号：US11741627
申请日：2007-04-27
申请人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
发明人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0605 , A61N2005/0607 , A61N2005/0644 , A61N2005/0645 , A61N2005/0662
摘要： The present invention presents devices, kits, systems and methods that can be used for nasal decolonization of microbes and treatment of MRSA, E. coli, and E. fecalis. For example, it includes a method for nasal decolonization of microbes comprising: applying a photosensitizing composition comprising methylene blue to anterior nares; inserting at least a portion of a light delivery device into the nasal cavity; and applying light to the anterior nares at a wavelength ranges from about 650 nm to 680 nm; wherein the light is delivered by the light delivery device to the anterior nares; the light delivery device is in light communication with a light source via a waveguide; and over 90% of the microbes at the anterior nares is eliminated by the nasal decolonization.
摘要翻译：本发明提供了可用于微生物鼻非殖民化和MRSA，大肠杆菌和E.粪便的治疗的装置，试剂盒，系统和方法。例如，它包括一种用于微生物鼻腔非殖民化的方法，包括：将包含亚甲蓝的光敏组合物施用于前鼻孔; 将光输送装置的至少一部分插入鼻腔中; 并在约650nm至680nm的波长范围内向前鼻孔施加光; 其中所述光由所述光输送装置输送到所述前鼻孔; 光输送装置经由波导与光源光连通; 前鼻孔的超过90％的微生物被鼻非殖民化所消除。

6. 发明申请

US20080119914A1 TREATMENT FOR OTITIS EXTERNA 有权
标题翻译： OTITIS EXTERNA治疗
公开(公告)号：US20080119914A1
公开(公告)日：2008-05-22
申请号：US11741604
申请日：2007-04-27
申请人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
发明人： Andreas Rose , Nicolas G. Loebel , Guenter Herr , Kyle Johnston , Cale Street , Roger Andersen
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61B2018/2261 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0605 , A61N2005/0607 , A61N2005/0644 , A61N2005/0645 , A61N2005/0662
摘要： The present invention presents devices, kits, systems and methods that can be used to otitis externa. For example, a method of present invention includes applying a photosensitizing composition to treatment site within ear cavity where microbes causing otitis externa are located; inserting at least a portion of a light delivery device into the cavity; and applying light to the treatment site at a wavelength absorbed by the photosensitizing composition so as to inhibit or eliminate the microbes and/or to reduce inflammation at the treatment site but without causing physiological damage to host tissue within the ear cavity; wherein the light is delivered by the light delivery device to the treatment site and the light delivery device is in light communication with a light source via a waveguide.
摘要翻译：本发明提供了可用于外耳炎的装置，试剂盒，系统和方法。例如，本发明的方法包括将光敏组合物施用于引起耳外耳道微生物的耳腔内的治疗部位; 将光输送装置的至少一部分插入空腔中; 并以由光敏组合物吸收的波长对处理部位施加光，以抑制或消除微生物和/或减少治疗部位的炎症，但不会对耳腔内的宿主组织造成生理损伤; 其中所述光被所述光输送装置输送到所述处理部位，并且所述光输送装置经由波导与光源光连通。

7. 发明申请

US20080035049A1 Boating safety apparatus 审中-公开
标题翻译：划船安全装置
公开(公告)号：US20080035049A1
公开(公告)日：2008-02-14
申请号：US11105110
申请日：2005-04-13
申请人： Kyle Johnston , Leonard Johnston
发明人： Kyle Johnston , Leonard Johnston
IPC分类号： G09F17/00
CPC分类号： G09F17/00
摘要： A boating safety apparatus comprises a support body, a flag attachment member and a flag. The support body includes an attachment device configured for attaching the support body to another body. The flag attachment member is movably mounted at a first end thereof to the support body. The flag attachment member is movable between a displayed position and a stowed position. The flag is attached to the flag attachment member adjacent the second end of the flag attachment member. The flag is configured for designating an active water sport activity.
摘要翻译：划船安全装置包括支撑体，标志附接构件和标志。支撑体包括被配置为将支撑体附接到另一主体的附接装置。标志附接构件在其第一端可移动地安装到支撑体。标志附接构件可在显示位置和收起位置之间移动。标志附接到与标志附接构件的第二端相邻的标志附接构件。该标志被配置为指定活动的水上运动活动。

8. 发明申请

US20070260231A1 Optical probe for delivery of light 审中-公开
标题翻译：用于发光的光学探头
公开(公告)号：US20070260231A1
公开(公告)日：2007-11-08
申请号：US11397768
申请日：2006-04-04
申请人： Andreas Rose , Guenter Herr , Joe Ridge , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Joe Ridge , Kyle Johnston
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/2238 , A61B2018/2261 , A61N5/06 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/0644 , A61N2005/066 , A61N2005/0661
摘要： The present invention discloses an optical probe employed for the delivery of light. More particularly, the present invention relates to an optical probe, a probe tip or combination thereof and its uses for delivery of light to upon surfaces of tissue and other portions of the human body or other organisms.
摘要翻译：本发明公开了一种用于发光的光探头。更具体地，本发明涉及光学探针，探针尖端或其组合，以及其用于将光传递到人体或其他生物体的组织和其它部分的表面上的用途。

9. 发明申请

US20110043683A1 IMAGE DIVERSION SYSTEMS & METHODS FOR IMAGE CAPTURE DEVICES 审中-公开
标题翻译：用于图像捕获设备的图像分流系统和方法
公开(公告)号：US20110043683A1
公开(公告)日：2011-02-24
申请号：US12744456
申请日：2010-04-16
申请人： Kirk W. Beach , Jonathan D. Cowles , Kyle Johnston , Ai Thi-Khiem Cowles
发明人： Kirk W. Beach , Jonathan D. Cowles , Kyle Johnston , Ai Thi-Khiem Cowles
IPC分类号： H04N5/225
CPC分类号： G02B17/008 , G02B6/06 , G02B13/001 , G02B13/0065 , G02B17/026 , G02B17/045 , G02B27/0172 , G02B2027/0123 , G02B2027/0138 , G02B2027/0154
摘要： Disclosed herein are systems and methods that divert images for image capture devices. An image diversion system includes a housing, at least one reflective surface within the housing, and a mounting mechanism. The housing is adapted to mount onto an existing image capture device. The at least one reflective surface can divert the image that is captured by the image capture device when the housing is mounted on the image capture device. Another image diversion system also includes at least one total internal reflection (TIR) element that can divert the image that is captured by the image capture device when the housing is mounted on the image capture device. A method provides a housing, at least one reflective and/or refractive surface within the housing, and a mounting mechanism.
摘要翻译：这里公开了用于转移用于图像捕获设备的图像的系统和方法。图像转向系统包括壳体，壳体内的至少一个反射表面和安装机构。壳体适于安装到现有的图像捕获装置上。当壳体安装在图像捕获装置上时，至少一个反射表面可以转移由图像捕获装置捕获的图像。另一个图像分流系统还包括至少一个全内反射（TIR）元件，当外壳安装在图像捕获装置上时，可以转移由图像捕获装置捕获的图像。一种方法提供壳体，壳体内的至少一个反射和/或折射表面以及安装机构。

10. 发明申请

US20070165985A1 ALIGNMENT SYSTEM AND METHOD 失效
标题翻译：对准系统和方法
公开(公告)号：US20070165985A1
公开(公告)日：2007-07-19
申请号：US11549702
申请日：2006-10-16
申请人： Andreas Rose , Guenter Herr , Kyle Johnston
发明人： Andreas Rose , Guenter Herr , Kyle Johnston
IPC分类号： G02B6/36
CPC分类号： G02B6/4292 , G02B6/4204 , G02B6/4234 , G02B6/4236
摘要： The present invention provides an alignment system comprising a base having a feature that accepts a first optical element, a first eccentric element having a through hole that accepts an eccentric assembly comprising a second eccentric element having a feature that accepts a second optical element and is attached to the second optical element via second attachment means, wherein the first eccentric element is engaged with the base via first attachment means and axial alignment between optical axis of the first optical element and optical axis of the second optical element is achieved by rotationally adjusting at least one of the eccentric elements relative to the base. The present invention also provides methods to make and use this alignment system.
摘要翻译：本发明提供了一种对准系统，其包括具有接受第一光学元件的特征的基座，具有通孔的第一偏心元件，该偏心元件接收偏心组件，该偏心组件包括具有接受第二光学元件的特征的第二偏心元件，通过第二附接装置到达第二光学元件，其中第一偏心元件通过第一附接装置与基座接合，并且通过至少旋转地调节第一光学元件的光轴和第二光学元件的光轴之间的轴向对准来实现相对于基地的偏心元素之一。本发明还提供了制造和使用该对准系统的方法。

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