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1. 发明申请

US20080208962A1 Real time automatic update system and method for disaster damage investigation using wireless communication and web-gis 审中-公开
标题翻译：使用无线通信和网络通信的实时自动更新系统和灾害损害调查方法
公开(公告)号：US20080208962A1
公开(公告)日：2008-08-28
申请号：US11802620
申请日：2007-05-24
申请人： Kyehyun Kim , Jongkook Lee
发明人： Kyehyun Kim , Jongkook Lee
IPC分类号： G06F15/16
CPC分类号： G01S19/14 , H04L67/12 , H04L67/18 , H04W4/029 , H04W4/90 , H04W64/00 , H04W76/50
摘要： Disclosed are a real time automatic update system and method for disaster damage investigation using wireless communication and a web-GIS (Geographic Information System), which are able to prevent disaster recurrence by effectively acquiring various data associated with a disaster area in disaster investigation, quickly establish a disaster register and enable easy searching by loading corresponding data on the web. The system includes a field equipment kit which is comprised of various kinds of equipments for capturing the location of a damaged area, damage cause information, damage images and moving images, and voice information and transmitting them to a server; a damage investigation information receiving server which receives data that is created in the field equipment kit and transmitted therefrom through wireless communication, analyzes/stores disaster data, and classifies/processes the disaster data; a web server which receives data classified suitably for a homepage, a disaster register, a web-GIS, etc. and establishes a disaster register DB and a web DB; a web-GIS server which updates and stores geographical information and geographical property information linked with the web server; and a client terminal which connects to the web server and the web-GIS server to generate a retrieval signal of disaster information and displays the information on the screen.
摘要翻译：公开了一种使用无线通信进行的灾害损害调查的实时自动更新系统和方法，以及能够通过有效地获取与灾区相关的各种数据进行灾害调查的Web-GIS（地理信息系统），能够预防灾害复发建立灾难登记册，并通过在网络上加载相应的数据实现轻松搜索。该系统包括一个现场设备套件，包括用于捕获损坏区域的位置的各种设备，损坏原因信息，损坏图像和运动图像以及语音信息并将其发送到服务器; 损害调查信息接收服务器，其接收在现场设备套件中创建并通过无线通信从其发送的数据，分析/存储灾害数据，并对灾害数据进行分类/处理; 接收适用于主页，灾难登记册，web-GIS等分类的数据的网络服务器，建立灾难登记DB和Web DB; web-GIS服务器，其更新并存储与web服务器链接的地理信息和地理属性信息; 以及连接到web服务器和web-GIS服务器以生成灾难信息的检索信号并在屏幕上显示信息的客户终端。

2. 发明申请

US20050009765A1 Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against rna targets and its preparation 失效
标题翻译：具有增强的rna靶标特异性的新霉素 - 氯霉素的异二聚体结合物及其制备
公开(公告)号：US20050009765A1
公开(公告)日：2005-01-13
申请号：US10496275
申请日：2001-12-05
申请人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
发明人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
IPC分类号： C07H5/10 , C07H15/232 , A61K31/704 , C07H15/20 , C07H15/22
CPC分类号： C07H5/10 , C07H15/232
摘要： The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol of formula 1, their preparation and their use. Because of their heterodimeric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, the can be effectively used as an antiviral agent, an antibacterial agent or an anti cancer drugs.
摘要翻译：本发明涉及式1的新霉素 - 氯霉素的异二聚体缀合物，其制备及其用途。由于它们的异二聚体结构，它们可以识别RNA基序的茎和环，并且显示出对某些RNA的结合能力，使得它们具有增强的药物功效并且可以由非特异性药物引起的副作用降低。由于这些原因，可以有效地用作抗病毒剂，抗菌剂或抗癌药物。

3. 发明授权

US07022839B2 Heterodimeric conjugates of neomycin-chloramphenicol having an enhanced specificity against RNA targets and its preparation 失效
标题翻译：具有增强的RNA靶标特异性的新霉素氯霉素的异二聚体结合物及其制备
公开(公告)号：US07022839B2
公开(公告)日：2006-04-04
申请号：US10496275
申请日：2001-12-05
申请人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
发明人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Kye-Jung Shin
IPC分类号： C07H1/00
CPC分类号： C07H5/10 , C07H15/232
摘要： The present invention relates to heterodimeric conjugates of neomycin-chloramphenicol, of formula 1, their preparation and their use. Because of their heterodmieric structure, they can recognize both stem and loop of RNA motif and show binding ability to a certain RNA such that they have an enhanced pharmaceutical efficacy and reduced side effect which can be caused by non-specific drugs. For these reasons, they can be effectively used as an antiviral agent, an antibacterial agent or an anticancer drugs.
摘要翻译：本发明涉及式1的新霉素 - 氯霉素的异二聚体缀合物，其制备及其用途。由于其异质结构，它们可以识别RNA基序的茎和环，并且显示出对某些RNA的结合能力，使得它们具有增强的药物功效并且可以由非特异性药物引起的副作用降低。由于这些原因，它们可以有效地用作抗病毒剂，抗菌剂或抗癌药物。

4. 发明申请

US20050222055A1 Heterodimeric conjugates of neomycin-oxazolidinone, their preparation and their use 审中-公开
标题翻译：新霉素 - 恶唑烷酮的异二聚体共轭物，其制备及其应用
公开(公告)号：US20050222055A1
公开(公告)日：2005-10-06
申请号：US10502539
申请日：2002-07-04
申请人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Ae Pae , Hun Koh
发明人： Jaehoon Yu , Jongkook Lee , Miyun Kwon , Ae Pae , Hun Koh
IPC分类号： C07H15/22 , C07H15/232 , C07H15/20 , A61K31/704
CPC分类号： C07H15/232
摘要： The present invention relates to novel oxazolidinone derivatives represented as following compound I and a process for the preparation thereof. The compounds of the present invention have wide antibacterial spectrums superior antibacterial activity and low toxicity. Therefore, it can be expected to use as novel antibacterial agent. wherein, R1 is alkylcarboxyl group or —CH2R2 (wherein, R2 is OH, argido group, —OR3 (wherein, R3 is C1-4 alkyl, methansulfonyl, p-toluensulfonyl, carboxyl, C1-4 alkylcarboxyl, C1-4 alkylcarbonyl, benzyloxycarbonyl, or imidazolylcarbonyl), or —NHR4).
摘要翻译：本发明涉及以下述化合物I表示的新型恶唑烷酮衍生物及其制备方法。本发明的化合物具有广泛的抗菌谱，抗菌活性和毒性低。因此，可以预期用作新型抗菌剂。其中R 1是烷基羧基或-CH 2 R 2 R 2（其中R 2是OH，argido 基团，-OR 3（其中R 3是C 1-4烷基，甲磺酰基，对甲苯磺酰基，羧基，C 1 -C 4烷基， 1-4烷基羧基，C 1-4烷基羰基，苄氧基羰基或咪唑基羰基）或-NHR 4）。

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