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1. 发明授权

US5807858A Compositions and methods for reducing respiratory depression 失效
标题翻译：减少呼吸抑制的组合物和方法
公开(公告)号：US5807858A
公开(公告)日：1998-09-15
申请号：US658726
申请日：1996-06-05
申请人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
发明人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
IPC分类号： A61K31/00 , A61K31/495 , A61K31/496 , C07D295/096 , C07D295/155 , C07D241/04
CPC分类号： C07D295/096 , A61K31/00 , A61K31/495 , A61K31/496 , C07D295/155
摘要： The present invention relates to, inter alia, methods and compositions for reducing, treating or preventing respiratory depression in an animal, using a compound of the formula: ##STR1## wherein: Ar, G, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are as defined in specification, or a pharmaceutically acceptable ester or salt thereof.
摘要翻译：本发明特别涉及用下列化合物降低，治疗或预防动物呼吸抑制的方法和组合物：其中：Ar，G，Z，R 2，R 3，R 4 ，R5，R6和R7如说明书中所定义，或其药学上可接受的酯或其盐。

2. 发明授权

US06300332B1 Methods for reducing respiratory depression and attendant side effects of mu opioid compounds 失效
标题翻译：减少呼吸抑制和阿片样物质副作用的方法
公开(公告)号：US06300332B1
公开(公告)日：2001-10-09
申请号：US09352308
申请日：1999-07-12
申请人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
发明人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
IPC分类号： A61K31495
CPC分类号： A61K31/495 , A61K31/00 , A61K31/40 , A61K31/445 , A61K31/485 , A61K31/496 , A61K31/55 , A61K45/06 , C07D295/096 , C07D295/155 , A61K2300/00
摘要： A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound.
摘要翻译：一种减少，治疗或预防动物中药物介导的呼吸抑制，肌肉僵硬或恶心/呕吐的方法，该方法是向所述动物施用混合的δ/μ阿片样物质激动剂或呼吸抑制介导药物，包括施用给予接受所述药物的动物有效量的δ受体激动剂化合物。

3. 发明授权

US06919350B2 Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds 失效
公开(公告)号：US06919350B2
公开(公告)日：2005-07-19
申请号：US09974004
申请日：2001-10-09
申请人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
发明人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
IPC分类号： A61K45/00 , A61K9/70 , A61K31/00 , A61K31/40 , A61K31/435 , A61K31/445 , A61K31/485 , A61K31/495 , A61K31/496 , A61K31/55 , A61K45/06 , A61P11/00 , A61P11/16 , A61P43/00 , C07D295/096 , C07D295/155 , A61K31/44 , A61K31/4965 , A61K38/00
CPC分类号： A61K31/495 , A61K31/00 , A61K31/40 , A61K31/445 , A61K31/485 , A61K31/496 , A61K31/55 , A61K45/06 , C07D295/096 , C07D295/155 , A61K2300/00
摘要： A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. Preferred examples of such delta receptor agonist compound include diarylmethyl piperazine compounds and diarylmethyl piperidine compounds, and pharmaceutical compositions thereof, having utility in medical therapy for reducing respiratory depression associated with certain analgesics, such as mu opiates.

4. 发明授权

US5985880A Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds 失效
标题翻译：减少呼吸抑制和阿片样物质副作用的组合物和方法
公开(公告)号：US5985880A
公开(公告)日：1999-11-16
申请号：US887312
申请日：1997-07-03
申请人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
发明人： Kwen-Jen Chang , Robert W. McNutt, Jr. , Hugh O. Pettit , Michael J. Bishop
IPC分类号： A61K45/00 , A61K9/70 , A61K31/00 , A61K31/40 , A61K31/435 , A61K31/445 , A61K31/485 , A61K31/495 , A61K31/496 , A61K31/55 , A61K45/06 , A61P11/00 , A61P11/16 , A61P43/00 , C07D295/096 , C07D295/155 , C07D241/04
CPC分类号： A61K31/495 , A61K31/00 , A61K31/40 , A61K31/445 , A61K31/485 , A61K31/496 , A61K31/55 , A61K45/06 , C07D295/096 , C07D295/155
摘要： A method of reducing, treating or preventing drug-mediated respiratory depression in an animal, incident to the administration to said animal of a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a .delta. receptor agonist compound.
摘要翻译：一种减少，治疗或预防动物中药物介导的呼吸抑制的方法，其涉及向所述动物施用呼吸抑制介导药物，包括向接受所述药物的动物施用有效量的δ受体激动剂化合物。

5. 发明授权

US5574159A Opioid compounds and methods for making therefor 失效
标题翻译：阿片类化合物及其制备方法
公开(公告)号：US5574159A
公开(公告)日：1996-11-12
申请号：US430677
申请日：1995-04-28
申请人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Michael J. Bishop
发明人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Michael J. Bishop
IPC分类号： C07D211/70 , C07D213/38 , C07D213/75 , C07D213/82 , C07D277/28 , C07D295/02 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06 , C07K5/065 , C07D403/10
CPC分类号： C07D213/75 , C07D211/70 , C07D213/38 , C07D213/82 , C07D277/28 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06026 , C07K5/06078 , C07C2101/02
摘要： Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.
摘要翻译：公开了作为用于与诸如δ，mu，σ和/或kappa受体的受体结合的外源受体组合物质的二芳基甲基哌嗪化合物。本发明的化合物可用作激动剂/拮抗剂对中的缀合物用于传导监测和神经递质功能的测定，并且还各种表现出治疗效用，包括介导镇痛，并具有用于治疗腹泻，尿失禁，精神疾病，药物酒精成瘾/过量，肺水肿，抑郁症，哮喘，肺气肿，咳嗽和呼吸暂停，呼吸抑制，认知障碍，呕吐和胃肠道疾病。

6. 发明授权

US5552404A Opioid compounds and methods for using same 失效
标题翻译：阿片类化合物及其使用方法
公开(公告)号：US5552404A
公开(公告)日：1996-09-03
申请号：US431377
申请日：1995-04-28
申请人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Michael J. Bishop
发明人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Michael J. Bishop
IPC分类号： C07D295/14 , A61K31/495 , A61P1/00 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P25/30 , A61P43/00 , C07D213/75 , C07D295/155 , A61K31/445
CPC分类号： C07D213/75 , C07D295/155 , C07C2101/02
摘要： Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.
摘要翻译：公开了作为用于与诸如δ，mu，σ和/或kappa受体的受体结合的外源受体组合物质的二芳基甲基哌嗪化合物。本发明的化合物可用作激动剂/拮抗剂对中的缀合物用于传导监测和神经递质功能的测定，并且还各种表现出治疗效用，包括介导镇痛，并具有用于治疗腹泻，尿失禁，精神疾病，药物酒精成瘾/过量，肺水肿，抑郁症，哮喘，肺气肿，咳嗽和呼吸暂停，呼吸抑制，认知障碍，呕吐和胃肠道疾病。

7. 发明申请

US20080193383A1 COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS 审中-公开
标题翻译：用于减少呼吸系统衰竭和麻醉剂化合物的副作用的组合物和方法
公开(公告)号：US20080193383A1
公开(公告)日：2008-08-14
申请号：US12098899
申请日：2008-04-07
申请人： Kwen-Jen Chang , Robert W. McNutt , Hugh O. Pettit , Michael J. Bishop
发明人： Kwen-Jen Chang , Robert W. McNutt , Hugh O. Pettit , Michael J. Bishop
IPC分类号： A61K49/00
CPC分类号： A61K31/495 , A61K31/00 , A61K31/40 , A61K31/445 , A61K31/485 , A61K31/496 , A61K31/55 , A61K45/06 , C07D295/096 , C07D295/155 , A61K2300/00
摘要： A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. Preferred examples of such delta receptor agonist compound include diarylmethyl piperazine compounds and diarylmethyl piperidine compounds, and pharmaceutical compositions thereof, having utility in medical therapy for reducing respiratory depression associated with certain analgesics, such as mu opiates.
摘要翻译：一种减少，治疗或预防动物中药物介导的呼吸抑制，肌肉僵硬或恶心/呕吐的方法，该方法是向所述动物施用混合的δ/μ阿片样物质激动剂或呼吸抑制介导药物，包括施用给予接受所述药物的动物有效量的δ受体激动剂化合物。这种δ受体激动剂化合物的优选实例包括二芳基甲基哌嗪化合物和二芳基甲基哌啶化合物及其药物组合物，其在医学疗法中具有用于减少与某些镇痛药相关的呼吸抑制作用，例如阿片剂。

8. 发明授权

US5681830A Opioid compounds 失效
标题翻译：阿片类化合物
公开(公告)号：US5681830A
公开(公告)日：1997-10-28
申请号：US285313
申请日：1994-08-03
申请人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Mark A. Collins , Michael J. Bishop
发明人： Kwen-Jen Chang , Dulce G. Bubacz , Ann O. Davis , Robert W. McNutt, Jr. , Mark A. Collins , Michael J. Bishop
IPC分类号： C07D211/70 , C07D213/38 , C07D213/75 , C07D213/82 , C07D277/28 , C07D295/02 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06 , C07K5/065 , A61K31/495 , A61K31/675 , C07D241/04 , C07D401/12
CPC分类号： C07D211/70 , C07D213/38 , C07D213/75 , C07D213/82 , C07D277/28 , C07D295/03 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/192 , C07D333/20 , C07D333/28 , C07D333/38 , C07K5/06026 , C07K5/06078 , C07C2101/02
摘要： Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.
摘要翻译：公开了作为用于与诸如δ，mu，σ和/或kappa受体的受体结合的外源受体组合物质的二芳基甲基哌嗪化合物。本发明的化合物可用作激动剂/拮抗剂对中的缀合物用于传导监测和神经递质功能的测定，并且还各种表现出治疗效用，包括介导镇痛，并具有用于治疗腹泻，尿失禁，精神疾病，药物酒精成瘾/过量，肺水肿，抑郁症，哮喘，肺气肿，咳嗽和呼吸暂停，呼吸抑制，认知障碍，呕吐和胃肠道疾病。

9. 发明申请

US20120115909A1 TAZAROTENE DERIVATIVES 审中-公开
公开(公告)号：US20120115909A1
公开(公告)日：2012-05-10
申请号：US13383869
申请日：2010-07-16
申请人： Xue Ge , Hansen Wong , Wendy Huang Chern , Hans Hofland , Michael J. Bishop , Xin Frank Cai , Alan Colborn
发明人： Xue Ge , Hansen Wong , Wendy Huang Chern , Hans Hofland , Michael J. Bishop , Xin Frank Cai , Alan Colborn
IPC分类号： A61K31/4436 , A61P17/10 , A61P17/06 , A61K31/4545 , A61P17/12 , A61P17/00 , C07D409/14 , A61K31/444 , C07D409/10 , A61P17/08
CPC分类号： C07D409/14 , A61K9/0014 , A61K31/05 , A61K31/327 , A61K31/38 , A61K31/4436 , A61K31/444 , A61K31/593 , A61K45/06 , C07D409/06 , A61K2300/00
摘要： The presently described subject matter relates to new derivatives of tazarotene that also exhibit retinoid activity, pharmaceutical compositions comprising the derivatives, method of treating skin disorders with the pharmaceutical compositions, and process of making the derivatives.
摘要翻译：目前描述的主题涉及也表现类视黄醇活性的他扎罗汀的新衍生物，包含衍生物的药物组合物，用药物组合物治疗皮肤病症的方法，以及制备衍生物的方法。

10. 发明授权

US08602919B2 Pitching cage 有权
标题翻译：投球笼
公开(公告)号：US08602919B2
公开(公告)日：2013-12-10
申请号：US13220755
申请日：2011-08-30
申请人： Michael J. Bishop
发明人： Michael J. Bishop
IPC分类号： A63B67/00 , A63B69/00
CPC分类号： A63B69/0002 , A63B63/00 , A63B71/022 , A63B2063/002 , A63B2069/0006 , A63B2208/12 , A63B2209/10
摘要： A training cage for throwing practice, comprises a frame having a height, width and depth. The training cage also comprises a strike zone indicator that defines the boundaries of a strike zone and a pitch locator. The pitch locator is configured such that when the pitch locator is in cooperation with the strike zone indicator, the strike zone is defined by at least one strike area pass through that defines an area that allows a ball thrown within the strike zone to pass through the strike zone indicator and at least one strike area barricade that defines an area that obstructs the ball thrown within the strike zone from passing through the strike zone indicator. Moreover, the pitching cage comprises a target having a target surface that is suspended in a second designated position located behind the strike zone indicator.
摘要翻译：用于投掷练习的训练笼包括具有高度，宽度和深度的框架。训练笼还包括限定击打区域和沥青定位器的边界的撞击区域指示器。俯仰定位器构造成使得当俯仰定位器与撞击区域指示器配合时，击打区域由通过的至少一个击打区域限定，该区域限定了允许在击球区域内抛出的球通过击打区域指示器和至少一个撞击区域路障，其限定阻挡在撞击区域内抛出的球穿过撞击区域指示器的区域。此外，俯仰笼包括具有悬挂在位于击打区域指示器后面的第二指定位置的目标表面的目标。

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