专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4716162A Fused 5 ring heterocyclic compounds, their preparation, and their anti-arrhythmic and diuretic use 失效
标题翻译：融合5环杂环化合物，其制备及其抗心律失常和利尿利用
公开(公告)号：US4716162A
公开(公告)日：1987-12-29
申请号：US755474
申请日：1985-07-16
申请人： Kuniyuki Tomita , Yasuo Shimoji , Seiji Kumakura , Hiroyuki Koike , Nobuyoshi Iwata , Yasuhiro Morisawa
发明人： Kuniyuki Tomita , Yasuo Shimoji , Seiji Kumakura , Hiroyuki Koike , Nobuyoshi Iwata , Yasuhiro Morisawa
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/435 , A61K31/475 , A61K31/535 , A61K31/55 , A61P7/10 , A61P9/06 , A61P25/28 , C07D209/18 , C07D209/26 , C07D471/06 , C07D487/04 , C07D487/06 , A61K31/495 , C07D401/14 , C07D471/04
CPC分类号： C07D471/06 , C07D209/26 , C07D487/04 , C07D487/06
摘要： Fused ring compounds of formula (I): ##STR1## (where R.sup.1 -R.sup.4, X.sup.1 and X.sup.2 represent hydrogen or various substituents, n and m are 1-3 and 2-7 respectively, the dotted lines are double or single bonds and Y is one oxygen or two hydrogens) have magnificent anti-arrhythmic activity, diuretic activity and the ability to improve brain function.
摘要翻译：式（I）的稠环化合物：其中R 1 -R 4，X 1和X 2表示氢或各种取代基，n和m分别为1-3和2-7，虚线是双重或单数键和Y是一个氧或两个氢）具有宏伟的抗心律失常活性，利尿活性和改善脑功能的能力。

2. 发明授权

US4007189A Pyrrolotriazolopyrimidine derivatives and process for the preparation thereof 失效
标题翻译：吡咯并三唑并嘧啶衍生物及其制备方法
公开(公告)号：US4007189A
公开(公告)日：1977-02-08
申请号：US683055
申请日：1976-05-04
申请人： Yasunobu Sato , Hiromu Takagi , Yasuo Shimoji , Seiji Kumakura
发明人： Yasunobu Sato , Hiromu Takagi , Yasuo Shimoji , Seiji Kumakura
IPC分类号： A61K31/505 , A61P9/08 , A61P9/12 , A61P29/00 , C07D487/14
CPC分类号： C07D487/14 , Y10S514/929
摘要： Pyrrolotriazolopyrimidine derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms and R.sup.2 represents an alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group having from 5 to 8 carbon atoms, a phenyl group optionally substituted with one or more halogen atoms or a phenylalkyl group having the formula ##STR2## IN WHICH R.sup.3 represents hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R.sup.4 represents halogen atom, an alkyl group having from 1 to 4 carbon atoms or an alkoxy group having from 1 to 4 carbon atoms, m represents an integer from 0 to 2 and n represents an integer from 0 to 3, and pharmacologically acceptable salts thereof. The compounds are useful as vasodilating or hypotensive agents and may be prepared by reacting triazolopyrimidine derivatives having the formula ##STR3## wherein X.sup.1 and X.sup.2 may be the same or different and each represents a halogen atom and R.sup.1 has the same meaning as defined above with an amine having the formulaR.sup.2 - NH.sub.2wherein R.sup.2 has the same meaning as defined above.
摘要翻译：具有式的吡咯并三唑并嘧啶衍生物，其中R 1表示氢原子或具有1至4个碳原子的烷基，R 2表示具有1至4个碳原子的烷基，具有5至8个碳原子的环烷基，任选被一个或多个卤素原子取代的苯基或具有下式的苯基烷基：其中R 3表示氢原子或具有1至4个碳原子的烷基，R 4表示卤素原子，具有1至 4个碳原子或1〜4个碳原子的烷氧基，m表示0〜2的整数，n表示0〜3的整数，以及其药理学上可接受的盐。这些化合物可用作血管扩张剂或降血压剂，并且可以通过使具有式（I）的三唑并嘧啶衍生物反应来制备，其中X 1和X 2可以相同或不同，并且各自表示卤素原子，并且R 1具有与上述相同的含义，具有式R2-NH2的胺，其中R2具有与上述相同的含义。

3. 发明授权

US5002942A 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders 失效
标题翻译： 1,5-苯并硫氮因衍生物，其制备及其在治疗心血管疾病中的应用
公开(公告)号：US5002942A
公开(公告)日：1991-03-26
申请号：US384261
申请日：1989-07-21
申请人： Hiroaki Yanagisawa , Koichi Fujimoto , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Hiroshi Nishino
发明人： Hiroaki Yanagisawa , Koichi Fujimoto , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Hiroshi Nishino
IPC分类号： C07D281/10 , C07D417/04 , C07D417/06
CPC分类号： C07D417/04 , C07D281/10 , C07D417/06
摘要： Compounds of formula (I): ##STR1## in which: R.sup.1 is aryl or aromatic heterocyclic; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C.sub.1 -C.sub.6 alkylthio, phenylthio, C.sub.1 -C.sub.6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R.sup.4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R.sup.5 and R.sup.6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R.sup.4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.

4. 发明授权

US5459148A Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease 失效
标题翻译：联苯衍生物及其用于治疗高血压和心脏病的用途
公开(公告)号：US5459148A
公开(公告)日：1995-10-17
申请号：US331356
申请日：1994-10-27
申请人： Hiroaki Yanagisawa , Yoshiya Amemiya , Takuro Kanazaki , Yasuo Shimoji , Hiroyuki Koike , Toshio Sada
发明人： Hiroaki Yanagisawa , Yoshiya Amemiya , Takuro Kanazaki , Yasuo Shimoji , Hiroyuki Koike , Toshio Sada
IPC分类号： A61K31/415 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/4188 , A61K31/435 , A61K31/44 , A61K31/4418 , A61K31/4427 , A61K31/505 , A61P9/00 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/80 , C07D233/58 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/88 , C07D233/90 , C07D233/92 , C07D235/04 , C07D235/08 , C07D235/14 , C07D235/26 , C07D239/42 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/12 , C07D471/04
CPC分类号： C07D213/80 , C07D233/90 , C07D235/08 , C07D235/26 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/12 , C07D471/04 , Y02P20/55 , Y02P20/582
摘要： Compounds of formula (I): ##STR1## [wherein: A represents a group (IIa), (IIb) or (IIc): ##STR2## R.sup.1 is alkyl, alkenyl, cycloalkyl or a group of formula R.sup.4 --Y--R.sup.5 --, where: R.sup.4 is hydrogen, alkyl, or cycloalkyl, R.sup.5 is a single bond or alkylene, and Y is oxygen, sulfur or imino group; R.sup.2 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted cycloalkyl, hydroxy, amino, alkylamino, dialkylamino, formyl, alkylcarbonyl, alkoxy, alkylthio, cyano or nitro; R.sup.3 is hydrogen, alkyl, carboxy, protected carboxy, carbamoyl or tetrazol-5-yl; X is of formula --CH.dbd., --N.dbd. or --C(COOR.sup.6).dbd., where R.sup.6 is hydrogen or a carboxy-protecting group; Z is a single bond, alkylene or vinylene; and B is carboxy, protected carboxy or tetrazol-5-yl]; and pharmaceutically acceptable salts and esters thereof have the ability to inhibit the action of angiotensin II and thus can be used for the treatment and prophylaxis of hypertension and cardiac diseases.
摘要翻译：（II）化合物：其中：A表示基团（IIa），（IIb）或（IIc）：（IIa）（IIc）（IIc） R1是烷基，烯基，环烷基或式R4-Y-R5-基团，其中：R4是氢，烷基或环烷基，R5是单键或亚烷基，Y是氧，硫或亚氨基; R 2是氢，卤素，任选取代的烷基，任选取代的烯基，任选取代的环烷基，羟基，氨基，烷基氨基，二烷基氨基，甲酰基，烷基羰基，烷氧基，烷硫基，氰基或硝基; R3是氢，烷基，羧基，被保护的羧基，氨基甲酰基或四唑-5-基; X为式-CH =，-N =或-C（COOR 6）=，其中R 6为氢或羧基保护基; Z是单键，亚烷基或亚乙烯基; 和B是羧基，保护的羧基或四唑-5-基]; 其药学上可接受的盐和酯具有抑制血管紧张素II作用的能力，因此可用于治疗和预防高血压和心脏病。

5. 发明授权

US5646171A Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use 失效
标题翻译：血管紧张素II拮抗剂1-联苯甲基咪唑化合物及其治疗用途
公开(公告)号：US5646171A
公开(公告)日：1997-07-08
申请号：US465369
申请日：1995-06-05
申请人： Hiroaki Yanagisawa , Yoshiya Amemiya , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Toshio Sada
发明人： Hiroaki Yanagisawa , Yoshiya Amemiya , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Toshio Sada
IPC分类号： C07D233/90 , C07D403/10 , C07D405/12 , C07D405/14 , C07F7/18 , C07D405/08 , C07D257/04 , A61K31/415 , A61K31/41
CPC分类号： C07D403/10 , C07D233/90 , C07D405/12 , C07D405/14 , C07F7/1856
摘要： An angiotensin II antagonist of the formula: ##STR1## in which: R.sub.p.sup.1 represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl or C.sub.1 -C.sub.6 alkanoyl; R.sub.p.sup.2 represents a single bond, C.sub.1 -C.sub.4 alkylene or C.sub.1 -C.sub.4 alkylidene; R.sub.p.sup.3 and R.sub.p.sup.4 are independently selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl; R.sub.p.sup.5 represents hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl, naphthyl, benzyl, diphenylmethyl, naphthylmethyl, alkanoyloxyalkyl, cycloalkanecarbonyloxyalkyl, alkoxycarbonyloxyalkyl, cycloalkyloxycarbonyloxyalkyl, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methyl, (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl or phthalaidyl; R.sub.p.sup.6 represents a carboxy or a tetrazol-5-yl; and X.sub.p represents an oxygen or sulfur, and pharmaceutically acceptable salts thereof. The compounds have hypotensive activity and can thus be used for the treatment and prophylaxis of hypertension.
摘要翻译：一种下式的血管紧张素II拮抗剂：其中：Rp1表示氢，C1-C6烷基，C3-C6环烷基或C1-C6烷酰基; Rp2表示单键，C1-C4亚烷基或C1-C4亚烷基; Rp3和Rp4独立地选自氢和C1-C6烷基; R 5表示氢，C 1 -C 4烷基，苯基，萘基，苄基，二苯基甲基，萘基甲基，烷酰氧基烷基，环烷基羰氧基烷基，烷氧基羰氧基烷基，环烷氧基羰基氧基烷基，（5-苯基-2-氧代-1,3-二氧杂环戊烯-4-基） - 烷基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基或邻苯二甲酰基; Rp6表示羧基或四唑-5-基; Xp表示氧或硫，以及其药学上可接受的盐。这些化合物具有降血压活性，因此可用于治疗和预防高血压。

6. 发明授权

US5616599A Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use 失效
标题翻译：血管紧张素II拮抗剂1-联苯甲基咪唑化合物及其治疗用途
公开(公告)号：US5616599A
公开(公告)日：1997-04-01
申请号：US378650
申请日：1995-01-26
申请人： Hiroaki Yanagisawa , Koichi Fujimoto , Yoshiya Amemiya , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Toshio Sada
发明人： Hiroaki Yanagisawa , Koichi Fujimoto , Yoshiya Amemiya , Yasuo Shimoji , Takuro Kanazaki , Hiroyuki Koike , Toshio Sada
IPC分类号： C07D233/90 , C07D403/10 , C07D405/12 , C07D405/14 , C07F7/18 , C07D257/04 , A61K31/41 , A61K31/415
CPC分类号： C07D403/10 , C07D233/90 , C07D405/12 , C07D405/14 , C07F7/1856
摘要： Compounds of the following formula (I) or the formula (I).sub.p : ##STR1## wherein R.sup.1 is alkyl or alkenyl; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R.sup.4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula --SiR.sup.a R.sup.b R.sup.c, in which R.sup.a, R.sup.b and R.sup.c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R.sup.5 is carboxy or --CONR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 hydrogens or alkyl, or R.sup.8 and R.sup.9 together form alkylene; R.sup.6 is hydrogen, alkyl, alkoxy or halogen; R.sup.7 is carboxy or tetrazol-5-yl; R.sub.p.sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R.sub.p.sup.2 is a single bond, alkylene or alkylidene; R.sub.p.sup.3 and R.sub.p.sup.4 are each hydrogen or alkyl; R.sub.p.sup.6 is carboxy or tetrazol-5-yl; and X.sub.p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.
摘要翻译：下式（I）或式（I）的化合物p：其中R 1是烷基或链烯基; R2和R3是与环烷基稠合的氢，烷基，烯基，环烷基，芳烷基，芳基或芳基; R4是氢，烷基，烷酰基，烯酰基，芳基羰基，烷氧基羰基，四氢吡喃基，四氢噻喃基，四氢噻吩基，四氢呋喃基，式-SiRaRbRc的基团，其中R a，R b和R c是烷基或芳基，烷氧基甲基，（烷氧基烷氧基）甲基，卤代烷氧基甲基，芳烷基，芳基或烷酰氧基甲氧基羰基; R5是羧基或-CONR8R9，其中R8和R9的氢或烷基，或R8和R9一起形成亚烷基; R6是氢，烷基，烷氧基或卤素; R7是羧基或四唑-5-基; Rp1为氢，烷基，环烷基或烷酰基; Rp2是单键，亚烷基或亚烷基; Rp3和Rp4各自为氢或烷基; Rp6是羧基或四唑-5-基; Xp为氧或硫; 及其药学上可接受的盐和酯。化合物是AII受体拮抗剂，因此具有低血压活性，可用于治疗和预防高血压。该化合物可以通过使联苯甲基化合物与咪唑化合物反应来制备。

7. 发明授权

US4527915A Sealed multi-row roller bearing device for rolling mills 失效
标题翻译：用于轧机的密封多列滚子轴承装置
公开(公告)号：US4527915A
公开(公告)日：1985-07-09
申请号：US615901
申请日：1984-05-29
申请人： Koichi Ikariishi , Toshiaki Kitano , Masanori Shinohara , Yasuo Shimoji
发明人： Koichi Ikariishi , Toshiaki Kitano , Masanori Shinohara , Yasuo Shimoji
IPC分类号： B21B31/07 , F16C19/38 , F16C33/80 , F16J15/447
CPC分类号： F16C19/388 , B21B31/07 , F16C13/02 , F16C33/768 , F16C33/7813 , F16C33/80
摘要： A sealed multi-row roller bearing device for rolling mills, wherein the opposite ends of the inner race are extended, and a plurality of inner annular bodies which are of one of the groups of elements defining labyrinths are fitted on the extension of the inner race, while outer annular bodies which are of the other group of elements defining labyrinths are removably connected to the end of the outer race.
摘要翻译：一种用于轧机的密封多列滚子轴承装置，其中内圈的相对端延伸，并且具有限定迷宫的元件组中的一组的多个内环形体安装在内圈的延伸部而另一组元件限定迷宫的外部环形体可拆卸地连接到外圈的端部。

8. 发明授权

US5086057A Method of treating cachexia and certain new compounds for use in this method 失效
标题翻译：在本方法中使用的方法来处理高速公路和某些新化合物
公开(公告)号：US5086057A
公开(公告)日：1992-02-04
申请号：US691542
申请日：1991-04-25
申请人： Kazuhiko Sasagawa , Yo Takiguchi , Jun Ohsuri , Yasuo Shimoji
发明人： Kazuhiko Sasagawa , Yo Takiguchi , Jun Ohsuri , Yasuo Shimoji
IPC分类号： A61K31/505 , A61K31/535 , A61P1/00 , A61P1/14 , A61P7/06 , C07D487/14
CPC分类号： C07D487/14 , A61K31/505 , A61K31/535
摘要： Compounds of formula (I): ##STR1## [in which: Y represents a group of formula ##STR2## the dotted line is a double of single bond; R.sup.1 is hydrogen, alkyl or aryl; R.sup.2 is hydrogen or halogen; R.sup.3 is alkyl or cycloalkyl; R.sup.4 is hydrogen, alkyl, hydroxy or halogen; and R.sup.6 is hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or aralkyl;]and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia. Certain of these compounds are novel.

9. 发明授权

US6090802A 1- Methylcarbapenem derivatives 失效
标题翻译： 1-甲基碳青霉烯衍生物
公开(公告)号：US6090802A
公开(公告)日：2000-07-18
申请号：US95925
申请日：1998-06-12
申请人： Isao Kawamoto , Yasuo Shimoji , Katsuya Ishikawa , Katsuhiko Kojima , Hiroshi Yasuda , Satoshi Ohya , Yukio Utsui
发明人： Isao Kawamoto , Yasuo Shimoji , Katsuya Ishikawa , Katsuhiko Kojima , Hiroshi Yasuda , Satoshi Ohya , Yukio Utsui
IPC分类号： C07D477/20 , A61K31/409
CPC分类号： C07D477/20
摘要： A 1-methylcarbapenem compound represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 represents hydrogen or an ester residue; and A represents a group of the formula (A1) ##STR2## wherein n is 0, 1 or 2, P is 0, 1 or 2, R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sup.4 is a group (Q2) ##STR3## wherein B is phenylene, phenylene(C.sub.1 -C.sub.3)alkyl, cyclohexylene, cyclohexylene(C.sub.1 -C.sub.3)alkyl or C.sub.1 -C.sub.5 alkylene, R.sup.7 is hydrogen or C.sub.1 -C.sub.4 alkyl, and R.sup.14 is a group --C(.dbd.NH)R.sup.8, wherein R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl or a group --NR.sup.9 R.sup.10, wherein R.sup.9 and R.sup.10 are the same or different and are hydrogen or C.sub.1 -C.sub.4 alkyl; or a pharmacologically acceptable salt thereof.
摘要翻译：由下式（I）表示的1-甲基碳青霉烯化合物：其中R1表示氢或C1-C4烷基; R2代表氢或酯残基; 并且A表示式（A1）的基团，其中n为0,1或2，P为0,1或2，R3为氢或C1-C4烷基，R4为基团（Q2），其中B为亚苯基，亚苯基（C1-C3）烷基，亚环己基，亚环己基（C1-C3）烷基或C1-C5亚烷基，R7是氢或C1-C4烷基，R14是基团-C（= NH）R8，其中R8是氢或C1 -C4烷基或-NR9R10基团，其中R9和R10相同或不同，为氢或C1-C4烷基; 或其药理学上可接受的盐。

10. 发明授权

US5055479A Method of treating cachexia 失效
标题翻译：治疗CACHEXIA的方法
公开(公告)号：US5055479A
公开(公告)日：1991-10-08
申请号：US365851
申请日：1989-06-14
申请人： Yo Takiguchi , Jun Ohsumi , Yasuo Shimoji , Kazuhiko Sasagawa
发明人： Yo Takiguchi , Jun Ohsumi , Yasuo Shimoji , Kazuhiko Sasagawa
IPC分类号： A61K31/505 , A61K31/535 , A61P1/00 , A61P1/14 , A61P7/06 , C07D487/14
CPC分类号： C07D487/14 , A61K31/505 , A61K31/535
摘要： Compounds of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式