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1. 发明授权

US07868145B2 Magnetic particles containing a copolymer core, magnetic layer and silicon layer 有权
标题翻译：含有共聚物芯，磁性层和硅层的磁性颗粒
公开(公告)号：US07868145B2
公开(公告)日：2011-01-11
申请号：US11822958
申请日：2007-07-11
申请人： Kun Chan Wu , Hui-Ju Cho , Pei-Shin Jiang , Hsiang Yuan Huang , Wen-Hsun Kuo , Chi-Min Chau , Chih Hsien Su , Kun Feng Lee
发明人： Kun Chan Wu , Hui-Ju Cho , Pei-Shin Jiang , Hsiang Yuan Huang , Wen-Hsun Kuo , Chi-Min Chau , Chih Hsien Su , Kun Feng Lee
IPC分类号： C07K1/14 , C07K1/22 , C07K17/14 , C07K17/08 , C12P1/00 , C12N11/14 , C12N11/08 , G01N33/553 , G01N33/552 , G01N33/545
CPC分类号： G01N33/5434 , B22F1/02 , B82Y25/00 , C12N13/00 , C22C2202/02 , G01N2446/10 , H01F1/0054 , Y10S435/814 , Y10S530/811 , Y10S530/815 , Y10T428/2993
摘要： A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an active molecule connected to the coupling agent. The magnetic particles provide controllable size, uniform diameter distribution, high magnetization, improved storage stability, and modified surface for targeting biomolecules for biomaterial separation and environmental analysis.
摘要翻译：磁性颗粒及其制造方法。磁性颗粒包括聚合物芯，覆盖聚合物芯的磁性材料层和覆盖磁性材料层的含硅层。此外，磁性颗粒还可以包含在含硅层上的偶联剂和与偶联剂连接的活性分子。磁性颗粒提供可控的尺寸，均匀的直径分布，高磁化强度，改善的储存稳定性，以及用于靶向生物分子用于生物材料分离和环境分析的改性表面。

2. 发明申请

US20090017518A1 Magnetic particles and fabrication method thereof 有权
标题翻译：磁性粒子及其制造方法
公开(公告)号：US20090017518A1
公开(公告)日：2009-01-15
申请号：US11822958
申请日：2007-07-11
申请人： Kun Chan Wu , Hui-Ju Cho , Pei-Shin Jiang , Hsiang Yuan Huang , Wen-Hsun Kuo , Chi-Min Chau
发明人： Kun Chan Wu , Hui-Ju Cho , Pei-Shin Jiang , Hsiang Yuan Huang , Wen-Hsun Kuo , Chi-Min Chau
IPC分类号： C12N13/00 , B05D5/12 , B32B5/16
CPC分类号： G01N33/5434 , B22F1/02 , B82Y25/00 , C12N13/00 , C22C2202/02 , G01N2446/10 , H01F1/0054 , Y10S435/814 , Y10S530/811 , Y10S530/815 , Y10T428/2993
摘要： A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an active molecule connected to the coupling agent. The magnetic particles provide controllable size, uniform diameter distribution, high magnetization, improved storage stability, and modified surface for targeting biomolecules for biomaterial separation and environmental analysis.
摘要翻译：磁性颗粒及其制造方法。磁性颗粒包括聚合物芯，覆盖聚合物芯的磁性材料层和覆盖磁性材料层的含硅层。此外，磁性颗粒还可以包含在含硅层上的偶联剂和与偶联剂连接的活性分子。磁性颗粒提供可控的尺寸，均匀的直径分布，高磁化强度，改善的储存稳定性，以及用于靶向生物分子用于生物材料分离和环境分析的改性表面。

3. 发明授权

US07740759B2 Magnetic separation device 失效
标题翻译：磁选机
公开(公告)号：US07740759B2
公开(公告)日：2010-06-22
申请号：US11736555
申请日：2007-04-17
申请人： Chih Hsien Su , Hsiao Cheng Lin , Chi-Min Chau , Yuh-Jiuan Lin , Wen-Hsun Kuo
发明人： Chih Hsien Su , Hsiao Cheng Lin , Chi-Min Chau , Yuh-Jiuan Lin , Wen-Hsun Kuo
IPC分类号： B01D35/06 , B03C1/02 , B01L9/06
CPC分类号： B03C1/288 , B01L9/06 , B01L2200/0668 , B03C2201/18
摘要： A magnetic separation device separating magnetic material from a working fluid of a container is disclosed. The magnetic separation device includes a first element, a second element and a magnetic assembly structure including a plurality of magnetic units. The first element includes a first body, a plurality of first main positioning portions disposed on the first body, and a plurality of first sub-positioning portions disposed on the first body and next to the first main positioning portions to receive the container. The second element includes a second body, a plurality of second main positioning portions disposed on the second body, and a plurality of second sub-positioning portions disposed on the second body and next to the second main positioning portions to receive the container. The magnetic units disposed on the first main positioning portions and the second main positioning portions absorb magnetic material from the working fluid.
摘要翻译：公开了一种将磁性材料与容器的工作流体分离的磁选机。磁分离装置包括第一元件，第二元件和包括多个磁性单元的磁性组件结构。第一元件包括第一主体，设置在第一主体上的多个第一主定位部以及设置在第一主体上并靠近第一主定位部分以接收容器的多个第一副定位部。第二元件包括第二主体，设置在第二主体上的多个第二主定位部分和设置在第二主体上并与第二主定位部分相邻以接收容器的多个第二副定位部分。设置在第一主定位部分上的磁性单元和第二主定位部分吸收来自工作流体的磁性材料。

4. 发明申请

US20080156714A1 MAGNETIC SEPARATION DEVICE 失效
标题翻译：磁选分离装置
公开(公告)号：US20080156714A1
公开(公告)日：2008-07-03
申请号：US11736555
申请日：2007-04-17
申请人： Chih Hsien Su , Hsiao Cheng Lin , Chi-Min Chau , Yuh-Jiuan Lin , Wen-Hsun Kuo
发明人： Chih Hsien Su , Hsiao Cheng Lin , Chi-Min Chau , Yuh-Jiuan Lin , Wen-Hsun Kuo
IPC分类号： B01D35/06
CPC分类号： B03C1/288 , B01L9/06 , B01L2200/0668 , B03C2201/18
摘要： A magnetic separation device separating magnetic material from a working fluid of a container is disclosed. The magnetic separation device includes a first element, a second element and a magnetic assembly structure including a plurality of magnetic units. The first element includes a first body, a plurality of first main positioning portions disposed on the first body, and a plurality of first sub-positioning portions disposed on the first body and next to the first main positioning portions to receive the container. The second element includes a second body, a plurality of second main positioning portions disposed on the second body, and a plurality of second sub-positioning portions disposed on the second body and next to the second main positioning portions to receive the container. The magnetic units disposed on the first main positioning portions and the second main positioning portions absorb magnetic material from the working fluid.
摘要翻译：公开了一种将磁性材料与容器的工作流体分离的磁选机。磁分离装置包括第一元件，第二元件和包括多个磁性单元的磁性组件结构。第一元件包括第一主体，设置在第一主体上的多个第一主定位部以及设置在第一主体上并靠近第一主定位部分以接收容器的多个第一副定位部。第二元件包括第二主体，设置在第二主体上的多个第二主定位部分和设置在第二主体上并与第二主定位部分相邻以接收容器的多个第二副定位部分。设置在第一主定位部分上的磁性单元和第二主定位部分吸收来自工作流体的磁性材料。

5. 发明申请

US20080020471A1 Blood sugar detecting system 审中-公开
标题翻译：血糖检测系统
公开(公告)号：US20080020471A1
公开(公告)日：2008-01-24
申请号：US11703190
申请日：2007-02-07
申请人： Chi-Min Chau , Chih-Hsien Su , Hsiang-Yuan Huang , Yuh-Jiuan Lin
发明人： Chi-Min Chau , Chih-Hsien Su , Hsiang-Yuan Huang , Yuh-Jiuan Lin
IPC分类号： G01N33/49
CPC分类号： G01N33/49
摘要： A blood sugar detecting system using emission quantum dots is provided. A non-cyclodextran carbohydrate-containing molecule and a glucose-recognizing molecule respectively bind to an emission quantum dot and a light-absorbing molecule to form the blood sugar measuring system. When the non-cyclodextran carbohydrate-containing molecule and the glucose-recognizing molecule bind together to bring the emission quantum dot very close to the light-absorbing molecule, a fluorescence resonance energy transfer effect is happened between them. Glucose can compete with the non-cyclodextran carbohydrate-containing molecule for the binding site of the glucose-recognizing molecule to detect glucose concentration variation.
摘要翻译：提供了使用发射量子点的血糖检测系统。含有非环糊精碳水化合物的分子和葡萄糖识别分子分别结合发射量子点和光吸收分子以形成血糖测量系统。当含有非环糊精碳水化合物的分子和葡萄糖识别分子结合在一起使得发光量子点非常接近光吸收分子时，它们之间发生荧光共振能量转移效应。葡萄糖可以与含葡萄糖识别分子的结合位点的含有非环糊精碳水化合物的分子竞争，以检测葡萄糖浓度变化。

6. 发明申请

US20060286563A1 Analytical method and device utilizing magnetic materials 失效
标题翻译：利用磁性材料的分析方法和装置
公开(公告)号：US20060286563A1
公开(公告)日：2006-12-21
申请号：US11320659
申请日：2005-12-30
申请人： Yuh-Jiuan Lin , Kun-Feng Lee , Chi-Min Chau , Hui-Ju Cho
发明人： Yuh-Jiuan Lin , Kun-Feng Lee , Chi-Min Chau , Hui-Ju Cho
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/553
CPC分类号： G01N33/54326 , G01N33/54373 , Y10S436/805
摘要： The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external magnetic field to draw the magnetic material to an sensing region of an acoustics sensor, and then converts an effect occurred on a surface of the sensing region to an amount of the substance in the sample, wherein the effect is caused by a contact of the surface with the magnetic material and the substance.
摘要翻译：本发明涉及利用磁性材料和声学传感器的分析方法和装置。本发明采用用特定可识别分子修饰的磁性材料来捕获样品中的物质，并提供外部磁场以将磁性材料吸引到声学传感器的感测区域，然后转换在感测表面上发生的影响区域相对于样品中物质的量，其中效果是由表面与磁性材料和物质的接触引起的。

7. 发明申请

US20070148095A1 Fluorescent magnetic nanoparticles with specific targeting functions 审中-公开
标题翻译：具有特定靶向功能的荧光磁性纳米颗粒
公开(公告)号：US20070148095A1
公开(公告)日：2007-06-28
申请号：US11430894
申请日：2006-05-10
申请人： Ming-Yao Chen , Chi-Min Chau , Hsiang Huang , Cheng-Yi Chen , Pei-Shin Jiang , Chin-I Lin
发明人： Ming-Yao Chen , Chi-Min Chau , Hsiang Huang , Cheng-Yi Chen , Pei-Shin Jiang , Chin-I Lin
IPC分类号： A61K49/10 , C07K16/46
CPC分类号： A61K49/0002 , A61K41/00 , A61K49/0032 , A61K49/0052 , A61K49/0054 , A61K49/0093
摘要： Magnetic nanoparticles with fluorescent properties and specific targeting functions. The fluorescent magnetic nanoparticle includes a magnetic nanoparticle, a biocompatible polymer chemically modifying the magnetic nanoparticle, a fluorescent dye coupled to the biocompatible polymer, and a specific targeting agent coupled to the biocompatible polymer. The fluorescent and magnetic properties of the nanoparticles provide different types of signal sources and therefore, prompt imaging using different types of imaging techniques to reconfirm foci is feasible.
摘要翻译：具有荧光性质和特异性靶向功能的磁性纳米颗粒。荧光磁性纳米颗粒包括磁性纳米颗粒，化学修饰磁性纳米颗粒的生物相容性聚合物，与生物相容性聚合物偶联的荧光染料和与生物相容性聚合物偶联的特异性靶向剂。纳米颗粒的荧光和磁性能提供不同类型的信号源，因此，使用不同类型的成像技术进行即时成像，以重新确认病灶是可行的。

8. 发明申请

US20060140865A1 Nano-micelle carrier used in near infrared image detection and detection method thereof 审中-公开
标题翻译：用于近红外图像检测的纳米胶束载体及其检测方法
公开(公告)号：US20060140865A1
公开(公告)日：2006-06-29
申请号：US11317077
申请日：2005-12-27
申请人： Wen Chang , Chao-Hung Kao , Chi-Min Chau , Chin-I Lin , Shian-Jy Wang
发明人： Wen Chang , Chao-Hung Kao , Chi-Min Chau , Chin-I Lin , Shian-Jy Wang
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K49/0082
摘要： A nano-micelle carrier used in near infrared image detection. The carrier includes a nano-micelle comprising a plurality of block copolymers having critical micelle concentration (CMC) and a near infrared dye grafted onto the micelle surface, wherein the carrier has a hydrophobic interior and a hydrophilic surface. The invention also provides a method of detecting a near infrared image.
摘要翻译：用于近红外图像检测的纳米胶束载体。载体包括纳米胶束，其包含具有临界胶束浓度（CMC）的多种嵌段共聚物和接枝到胶束表面上的近红外染料，其中载体具有疏水性内部和亲水性表面。本发明还提供一种检测近红外图像的方法。

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