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1. 发明授权

US10300307B2 Focused ultrasound system for small bore imaging 有权
公开(公告)号：US10300307B2
公开(公告)日：2019-05-28
申请号：US14785531
申请日：2014-04-14
申请人： Kullervo Hynynen , Anthony Chau , Rajiv Chopra
发明人： Kullervo Hynynen , Anthony Chau , Rajiv Chopra
IPC分类号： A61B8/00 , A61N7/02 , A61B5/055 , G01R33/48 , A61B6/00 , A61N7/00 , A61B90/00
摘要： A focused ultrasound (“FUS”} system capable of use in a small bore imaging system, such as a small bore magnetic resonance imaging (“MRI”} system is provided. The FUS system generally includes an ultrasound transducer whose position is adjusted by a positioning system. The positioning system is sized to fit within the bore of the small bore imaging system. For instance, the positioning system can fit within a diameter of 150 millimeters or less.

2. 发明申请

US20160067527A1 FOCUSED ULTRASOUND SYSTEM FOR SMALL BORE IMAGING 审中-公开
标题翻译：用于小孔成像的聚焦超声系统
公开(公告)号：US20160067527A1
公开(公告)日：2016-03-10
申请号：US14785531
申请日：2014-04-14
申请人： Kullervo HYNYNEN , Anthony CHAU , Rajiv CHOPRA
发明人： Kullervo Hynynen , Anthony Chau , Rajiv Chopra
IPC分类号： A61N7/02 , A61B5/055 , G01R33/48
CPC分类号： A61N7/02 , A61B5/055 , A61B6/4417 , A61B6/508 , A61B8/4416 , A61B2090/374 , A61B2090/3762 , A61N2007/0091 , G01R33/4814
摘要： A focused ultrasound (“FUS”} system capable of use in a small bore imaging system, such as a small bore magnetic resonance imaging (“MRI”} system is provided. The FUS system generally includes an ultrasound transducer whose position is adjusted by a positioning system. The positioning system is sized to fit within the bore of the small bore imaging system. For instance, the positioning system can fit within a diameter of 150 millimeters or less.
摘要翻译：提供了一种能够在小孔成像系统中使用的聚焦超声（“FUS”）系统，例如小孔磁共振成像（“MRI”）系统.FUS系统通常包括超声换能器，其位置由定位系统，定位系统的尺寸适合小孔成像系统的孔径，例如，定位系统可以安装在150毫米或更小的直径内。

3. 发明申请

US20100125192A1 FOCUSED ULTRASOUND SYSTEM 有权
标题翻译：聚焦超声系统
公开(公告)号：US20100125192A1
公开(公告)日：2010-05-20
申请号：US12618824
申请日：2009-11-16
申请人： Rajiv Chopra , Kullervo Hynynen , Anthony Chau , Adam Christian Waspe
发明人： Rajiv Chopra , Kullervo Hynynen , Anthony Chau , Adam Christian Waspe
IPC分类号： A61B5/055 , A61N7/00
CPC分类号： A61N7/02 , A61B8/0816 , A61B34/70 , A61B2017/00084 , A61B2017/00106 , A61B2017/0084 , A61B2090/374 , A61N2007/0082
摘要： A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.
摘要翻译：聚焦超声系统包括配置成朝向受试者发射聚焦超声能量的超声换能器，以及配置成定位超声换能器以定位目标位置内的聚焦超声能量的定位系统。定位系统包括驱动装置，用于沿着至少一个运动轴平移超声换能器和马达控制器以控制驱动装置。聚焦超声系统还包括连接到电机控制器的控制系统，其被编程为从成像系统接收成像/位置数据，基于成像/位置数据确定目标位置的位置坐标，并且记录目标位置与定位系统。位置坐标通过输入信号发送到电动机控制器，使得电动机控制器控制驱动装置以平移超声换能器。

4. 发明授权

US09101752B2 Computer controlled focused ultrasound positioning system for sequential beam emitting to sonicate discrete and interleaved tissue locations 有权
标题翻译：用于连续光束发射的计算机控制的聚焦超声定位系统以超声离散离散和交织的组织位置
公开(公告)号：US09101752B2
公开(公告)日：2015-08-11
申请号：US12618824
申请日：2009-11-16
申请人： Rajiv Chopra , Kullervo Hynynen , Anthony Chau , Adam Christian Waspe
发明人： Rajiv Chopra , Kullervo Hynynen , Anthony Chau , Adam Christian Waspe
IPC分类号： A61B5/055 , A61N7/02 , A61B19/00 , A61B17/00 , A61N7/00 , A61B8/08
CPC分类号： A61N7/02 , A61B8/0816 , A61B34/70 , A61B2017/00084 , A61B2017/00106 , A61B2017/0084 , A61B2090/374 , A61N2007/0082
摘要： A focused ultrasound system includes an ultrasound transducer configured to emit focused ultrasound energy toward a subject and a positioning system configured to position the ultrasound transducer to localize the focused ultrasound energy within a target location. The positioning system includes a drive apparatus to translate the ultrasound transducer along at least one axis of motion and a motor controller to control the drive apparatus. The focused ultrasound system also includes a control system connected to the motor controller that is programmed to receive imaging/location data from an imaging system, determine positional coordinates of the target location based on the imaging/location data, and register the positional coordinates of the target location with the positioning system. The positional coordinates are sent to the motor controller via an input signal to cause the motor controller to control the drive apparatus so as to translate the ultrasound transducer.
摘要翻译：聚焦超声系统包括配置成朝向受试者发射聚焦超声能量的超声换能器，以及配置成定位超声换能器以定位目标位置内的聚焦超声能量的定位系统。定位系统包括驱动装置，用于沿着至少一个运动轴平移超声波换能器和马达控制器以控制驱动装置。聚焦超声系统还包括连接到电机控制器的控制系统，其被编程为从成像系统接收成像/位置数据，基于成像/位置数据确定目标位置的位置坐标，并且记录目标位置与定位系统。位置坐标通过输入信号发送到电动机控制器，使得电动机控制器控制驱动装置以平移超声换能器。

5. 发明授权

US09387515B2 Impedance matching for ultrasound phased array elements 有权
标题翻译：用于超声相控阵列元件的阻抗匹配
公开(公告)号：US09387515B2
公开(公告)日：2016-07-12
申请号：US11600301
申请日：2006-11-15
申请人： Kullervo Hynynen
发明人： Kullervo Hynynen
IPC分类号： B06B1/06
CPC分类号： B06B1/0655 , H01L41/053 , H01L41/09
摘要： A system includes a transducer configured to emit ultrasound in response to receiving an electrical signal from a driving circuit. The transducer includes a first dimension that determines a frequency of the ultrasound and a second dimension that determines an impedance of the transducer. The frequency is independent of the second dimension.
摘要翻译：系统包括响应于从驱动电路接收电信号而被配置为发射超声的换能器。换能器包括确定超声频率的第一维度和确定换能器阻抗的第二维度。频率与第二维无关。

6. 发明授权

US07344509B2 Shear mode therapeutic ultrasound 有权
标题翻译：剪切模式治疗超声
公开(公告)号：US07344509B2
公开(公告)日：2008-03-18
申请号：US10822019
申请日：2004-04-09
申请人： Kullervo Hynynen , Gregory T. Clement
发明人： Kullervo Hynynen , Gregory T. Clement
IPC分类号： A61H1/00
CPC分类号： A61B8/54 , A61B8/0808 , A61B8/485 , A61B17/22004 , A61N7/00 , A61N2007/0078
摘要： A method of delivering ultrasound signals using shear waves includes applying a portion of at least a first ultrasound beam to a subject at at least a first incident angle relative to the surface of the subject to induce shear waves in the subject, energy in the shear waves forming a substantial part of energy of first ultrasound waves at a desired region in the subject at a therapeutic level.
摘要翻译：使用剪切波输送超声信号的方法包括：至少第一超声波束的一部分相对于受试者的表面以至少第一入射角施加到受试者，以在受试者中引起剪切波，剪切波中的能量在治疗水平上在受试者的期望区域形成第一超声波的大部分能量。

7. 发明申请

US20060052706A1 Phased array ultrasound for cardiac ablation 审中-公开
标题翻译：心脏消融相控阵超声
公开(公告)号：US20060052706A1
公开(公告)日：2006-03-09
申请号：US11208353
申请日：2005-08-19
申请人： Kullervo Hynynen , Laurence Epstein , Ferenc Jolesz
发明人： Kullervo Hynynen , Laurence Epstein , Ferenc Jolesz
IPC分类号： A61B8/14
CPC分类号： A61N7/022 , A61B2017/00243 , A61N2007/0078
摘要： A system is provided for performing ablation of target tissue. The system includes an ultrasound phased array having a plurality of ultrasonic transducers and drive circuitry that is configured to generate signals that cause the ultrasonic transducers to focus ultrasound radiation at the target tissue. The system also includes a diagnostic system configured to collect diagnostic data that is indicative of a condition of the target tissue and computational circuitry that is configured to control the drive circuitry based on the diagnostic data.
摘要翻译：提供用于进行靶组织消融的系统。该系统包括具有多个超声波换能器和驱动电路的超声相控阵，该超声换能器和驱动电路经配置以产生使超声波换能器将超声辐射聚焦在靶组织上的信号。该系统还包括被配置为收集指示目标组织的状况的诊断数据和被配置为基于诊断数据来控制驱动电路的计算电路的诊断系统。

8. 发明授权

US06929608B1 Apparatus for deposition of ultrasound energy in body tissue 失效
标题翻译：用于在身体组织中沉积超声能量的装置
公开(公告)号：US06929608B1
公开(公告)日：2005-08-16
申请号：US09692294
申请日：2000-10-19
申请人： Erin Hutchinson , Mark Buchanan , Kullervo Hynynen
发明人： Erin Hutchinson , Mark Buchanan , Kullervo Hynynen
IPC分类号： A61B17/22 , A61B17/225 , A61M37/00 , A61N7/00 , A61N7/02 , B06B1/06 , A61B8/00
CPC分类号： B06B1/0633 , A61B2017/22028 , A61M37/0092 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095 , B06B1/0622 , B06B1/0629
摘要： An apparatus for providing ultrasonic energy for deposition in body tissue including an array of elements having at least two different sizes and at least one element being aperiodically spaced with the respect to other elements in the array. Excitation of the elements produces a beam of ultrasonic energy having reduced grating lobes. Reduced grating lobe magnitude permits improved ultrasonic beam focusing and/or the use of larger element sizes.
摘要翻译：一种用于提供用于在身体组织中沉积的超声能量的装置，包括具有至少两个不同尺寸的元件阵列，并且至少一个元件与阵列中的其它元件非周期性地间隔开。元件的激发产生具有减小的栅瓣的超声波能量束。减小的光栅大小允许改进的超声波束聚焦和/或使用更大的元件尺寸。

9. 发明授权

US6135971A Apparatus for deposition of ultrasound energy in body tissue 失效
标题翻译：用于在身体组织中沉积超声能量的装置
公开(公告)号：US6135971A
公开(公告)日：2000-10-24
申请号：US747033
申请日：1996-11-08
申请人： Erin Hutchinson , Mark Buchanan , Kullervo Hynynen
发明人： Erin Hutchinson , Mark Buchanan , Kullervo Hynynen
IPC分类号： A61B17/22 , A61B17/225 , A61M37/00 , A61N7/00 , A61N7/02 , B06B1/06
CPC分类号： B06B1/0633 , A61N7/02 , B06B1/0622 , B06B1/0629 , A61B2017/22028 , A61M37/0092 , A61N2007/0065 , A61N2007/0078 , A61N2007/0095
摘要： An apparatus for providing ultrasonic energy for deposition in body tissue including an array of elements having at least two different sizes and at least one element being aperiodically spaced with the respect to other elements in the array. Excitation of the elements produces a beam of ultrasonic energy having reduced grating lobes. Reduced grating lobe magnitude permits improved ultrasonic beam focusing and/or the use of larger element sizes.
摘要翻译：一种用于提供用于在身体组织中沉积的超声能量的装置，包括具有至少两个不同尺寸的元件阵列，并且至少一个元件与阵列中的其它元件非周期性地间隔开。元件的激发产生具有减小的栅瓣的超声波能量束。减小的光栅大小允许改进的超声波束聚焦和/或使用更大的元件尺寸。

10. 发明授权

US6074352A Method for the treatment of joint diseases characterized by unwanted pannus 失效
标题翻译：治疗以不需要的血管diseases病为特征的关节疾病的方法
公开(公告)号：US6074352A
公开(公告)日：2000-06-13
申请号：US48866
申请日：1998-03-26
申请人： Kullervo Hynynen , Karoly Foldes , Ferenc A. Jolesz , Carl Winalski , Sonya Shortkroff
发明人： Kullervo Hynynen , Karoly Foldes , Ferenc A. Jolesz , Carl Winalski , Sonya Shortkroff
IPC分类号： A61N7/00 , A61B17/00
CPC分类号： A61N7/00
摘要： The present invention describes methods for the treatment of joint diseases characterized by unwanted pannus, e.g., arthritis. The method involves the introduction of ultrasound energy into the inflamed cells or pannus of the joint to be treated resulting in destruction and/or modification of the pannus.
摘要翻译：本发明描述了治疗以不需要的血管us diseases（例如关节炎）为特征的关节疾病的方法。该方法涉及将超声能量引入待治疗的关节的发炎细胞或血管treated，导致砧骨的破坏和/或修饰。

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