专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130017996A1 MUTEINS OF TEAR LIPOCALIN AND METHODS FOR OBTAINING THE SAME 有权
公开(公告)号：US20130017996A1
公开(公告)日：2013-01-17
申请号：US13616815
申请日：2012-09-14
申请人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
发明人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
IPC分类号： A61K38/17 , C12N15/12 , A61P9/00 , A61P35/00 , A61P27/02 , C12P21/02 , A61P7/10 , A61P9/08 , A61P35/02 , C12N1/21 , C12N1/19 , C12N5/10 , C07K14/475 , A61P9/10
CPC分类号： A61K38/1709 , A61K38/38 , A61K47/60 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521
摘要： The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

2. 发明授权

US09221887B2 Muteins of tear lipocalin and methods for obtaining the same 有权
标题翻译：泪脂蛋白的突变蛋白及其获得方法
公开(公告)号：US09221887B2
公开(公告)日：2015-12-29
申请号：US13616815
申请日：2012-09-14
申请人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
发明人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
IPC分类号： C07K14/47 , C12N5/10 , A61K38/17 , C12N15/12 , G01N33/53 , C07K14/705 , C07K14/435 , G01N33/574 , C12N1/19 , C12N1/21 , C12P21/02
CPC分类号： A61K38/1709 , A61K38/38 , A61K47/60 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521
摘要： The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
摘要翻译：本发明涉及衍生自人类泪液脂质运载蛋白的新型突变蛋白。本发明还涉及编码这种突变蛋白的相应核酸分子及其产生方法。本发明还涉及一种制备这种突变蛋白的方法。最后，本发明涉及包含这种脂质运载蛋白突变蛋白的药物组合物以及突变蛋白的各种用途。

3. 发明申请

US20090305982A1 MUTEINS OF TEAR LIPOCALIN AND METHODS FOR OBTAINING THE SAME 有权
标题翻译：茶碱的灵长类及其制备方法
公开(公告)号：US20090305982A1
公开(公告)日：2009-12-10
申请号：US12309820
申请日：2007-08-01
申请人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
发明人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
IPC分类号： A61K38/17 , C07K14/435 , C07H21/04 , C12N5/10 , C12P21/02 , A61P35/00 , A61P27/00
CPC分类号： A61K38/1709 , A61K38/38 , A61K47/60 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521
摘要： The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
摘要翻译：本发明涉及衍生自人类泪液脂质运载蛋白的新型突变蛋白。本发明还涉及编码这种突变蛋白的相应核酸分子及其产生方法。本发明还涉及一种制备这种突变蛋白的方法。最后，本发明涉及包含这种脂质运载蛋白突变蛋白的药物组合物以及突变蛋白的各种用途。

4. 发明授权

US08313924B2 Muteins of tear lipocalin and methods for obtaining the same 有权
标题翻译：泪脂蛋白的突变蛋白及其获得方法
公开(公告)号：US08313924B2
公开(公告)日：2012-11-20
申请号：US12309820
申请日：2007-08-01
申请人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
发明人： Kristian Jensen , Martin Huelsmeyer , Steffen Schlehuber , Andreas Hohlbaum , Arne Skerra , Eric Boudreau , Richard Jones , Ian Kimber , Rebecca Dearman
IPC分类号： C12P21/02 , C12N5/16 , C07K14/435 , A61K38/17
CPC分类号： A61K38/1709 , A61K38/38 , A61K47/60 , C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , G01N33/57407 , G01N33/57492 , G01N2333/70521
摘要： The present invention relates to novel muteins derived from human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention further refers to a method for producing such a mutein. Finally, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.
摘要翻译：本发明涉及衍生自人类泪液脂质运载蛋白的新型突变蛋白。本发明还涉及编码这种突变蛋白的相应核酸分子及其产生方法。本发明还涉及一种制备这种突变蛋白的方法。最后，本发明涉及包含这种脂质运载蛋白突变蛋白的药物组合物以及突变蛋白的各种用途。

5. 发明授权

US08188053B2 Anti-inflammatory peptides 有权
标题翻译：抗炎肽
公开(公告)号：US08188053B2
公开(公告)日：2012-05-29
申请号：US12086210
申请日：2006-12-04
申请人： Marie Cumberbatch , Rebecca Jane Dearman , Ian Kimber , Russell Colin Viner
发明人： Marie Cumberbatch , Rebecca Jane Dearman , Ian Kimber , Russell Colin Viner
IPC分类号： A61K38/00 , A61K38/04 , A61K38/08 , C07K9/00 , C07K7/00 , C07K7/04 , C07K7/06
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention relates, inter alia, to a method of ameliorating an inflammatory skin condition. Thus, the present invention provides a peptide that includes the amino acid sequence KMIKP (SEQ ID NO: 20), wherein the peptide includes no more than 70 amino acids and wherein the peptide is capable of inhibiting allergen induced Langerhans cell migration, and wherein the peptide is not that depicted in SEQ ID NO. 19. The present invention also relates to the use of a peptide that includes the amino acid sequence KMIKP (SEQ ID NO: 20), wherein the peptide includes no more than 100 amino acids, and wherein the peptide is capable of inhibiting allergen induced Langerhans cell migration, in the manufacture of a topical medicament for the treatment of an inflammatory skin condition.
摘要翻译：本发明尤其涉及一种改善炎性皮肤病症的方法。因此，本发明提供了包含氨基酸序列KMIKP（SEQ ID NO：20）的肽，其中所述肽包含不超过70个氨基酸，并且其中所述肽能够抑制变应原诱导的朗格汉斯细胞迁移，并且其中肽不是SEQ ID NO：本发明还涉及包含氨基酸序列KMIKP（SEQ ID NO：20）的肽的用途，其中所述肽包含不超过100个氨基酸，并且其中所述肽能够抑制变应原诱导的朗格汉斯在制备用于治疗炎性皮肤病症的局部药物中的细胞迁移。

6. 发明申请

US20090253631A1 Anti-Inflammatory Peptides 有权
标题翻译：抗炎肽
公开(公告)号：US20090253631A1
公开(公告)日：2009-10-08
申请号：US12086210
申请日：2006-12-04
申请人： Marie Cumberbatch , Rebecca Jane Dearman , Ian Kimber , Russell Colin Viner
发明人： Marie Cumberbatch , Rebecca Jane Dearman , Ian Kimber , Russell Colin Viner
IPC分类号： A61K38/08 , C07K7/06 , C07K7/08 , A61K38/10 , A61P17/02
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention relates, inter alia, to a method of ameliorating an inflammatory skin condition. Thus, the present invention provides a peptide that includes the amino acid sequence KMIKP (SEQ ID NO: 20), wherein the peptide includes no more than 70 amino acids and wherein the peptide is capable of inhibiting allergen induced Langerhans cell migration, and wherein the peptide is not that depicted in SEQ ID NO. 19. The present invention also relates to the use of a peptide that includes the amino acid sequence KMIKP (SEQ ID NO: 20), wherein the peptide includes no more than 100 amino acids, and wherein the peptide is capable of inhibiting allergen induced Langerhans cell migration, in the manufacture of a topical medicament for the treatment of an inflammatory skin condition.
摘要翻译：本发明尤其涉及一种改善炎性皮肤病症的方法。因此，本发明提供了包含氨基酸序列KMIKP（SEQ ID NO：20）的肽，其中所述肽包含不超过70个氨基酸，并且其中所述肽能够抑制变应原诱导的朗格汉斯细胞迁移，并且其中肽不是SEQ ID NO：本发明还涉及包含氨基酸序列KMIKP（SEQ ID NO：20）的肽的用途，其中所述肽包含不超过100个氨基酸，并且其中所述肽能够抑制变应原诱导的朗格汉斯在制备用于治疗炎性皮肤病症的局部药物中的细胞迁移。

7. 发明申请

US20090203586A1 METHOD FOR AMELIORATING AN INFLAMMATORY SKIN CONDITION 审中-公开
标题翻译：用于调节炎症性皮肤病症的方法
公开(公告)号：US20090203586A1
公开(公告)日：2009-08-13
申请号：US11570148
申请日：2005-06-10
申请人： Rebecca Jane Dearman , Marie Cumberbatch , Ian Kimber , Gregorio Del Val
发明人： Rebecca Jane Dearman , Marie Cumberbatch , Ian Kimber , Gregorio Del Val
IPC分类号： A61K38/17 , C07K14/00
CPC分类号： C12N9/0036
摘要： The present invention relates to the use of thioredoxin in the manufacture of a medicament suitable for application to a skin surface for ameliorating an inflammatory skin condition. The present invention further relates to a method of ameliorating an inflammatory skin condition comprising applying to a skin surface an effective amount of a composition comprising thioredoxin. The invention further relates to a pharmaceutical composition suitable for ameliorating an inflammatory skin condition comprising from 0.0001 to 0.5 w/v thioredoxin.
摘要翻译：本发明涉及硫氧还蛋白在制备适用于皮肤表面以改善炎性皮肤病症的药物中的应用。本发明还涉及一种改善炎性皮肤病症的方法，包括向皮肤表面施用有效量的包含硫氧还蛋白的组合物。本发明还涉及适于改善包含0.0001至0.5w / v硫氧还蛋白的炎性皮肤病症的药物组合物。

8. 发明授权

US06716010B2 Bearing arrangement 有权
标题翻译：轴承安排
公开(公告)号：US06716010B2
公开(公告)日：2004-04-06
申请号：US10172800
申请日：2002-06-14
申请人： Mark Stephen Eaton , Ian Kimber
发明人： Mark Stephen Eaton , Ian Kimber
IPC分类号： F03C0200
CPC分类号： F01C21/02 , F04C2/18 , F04C15/0026 , Y10T29/49636
摘要： A bearing arrangement for a gear pump comprises first and second separate bearing blocks each having a respective block housing. The first and second bearing blocks together defining an axially directed bearing surface including a bridge region formed from an erosion resistant material which acts to separate inlet and outlet ports of the pump and a second region formed from a reduced friction material. The bridge region is defined by first and second insert members cast within respective ones of the block housings. The first and second bearing blocks are arranged such that respective surfaces of the first and second insert members mate with one another, and the first and second insert members are arranged such that the bridge region of the bearing surface is flush with the second region.
摘要翻译：用于齿轮泵的轴承装置包括第一和第二分离的轴承座，每个轴承座具有相应的车厢外壳。所述第一和第二轴承座一起限定轴向定向的支承表面，所述轴承表面包括由抗侵蚀材料形成的桥接区域，所述桥接区域用于分离所述泵的入口和出口以及由减摩擦材料形成的第二区域。桥接区由第一和第二插入构件限定，该第一和第二插入构件在相应的块体外壳内铸造。第一和第二轴承座布置成使得第一和第二插入件的相应表面彼此配合，并且第一和第二插入构件布置成使得支承表面的桥接区域与第二区域齐平。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式