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1. 发明授权

US5902599A Biodegradable polymer networks for use in orthopedic and dental applications 失效
标题翻译：用于矫形和牙科应用的可生物降解聚合物网络
公开(公告)号：US5902599A
公开(公告)日：1999-05-11
申请号：US603171
申请日：1996-02-20
申请人： Kristi S. Anseth , Robert Langer , Venkatram R. Shastri
发明人： Kristi S. Anseth , Robert Langer , Venkatram R. Shastri
IPC分类号： A61F2/28 , A61F2/30 , A61K47/32 , C08F2/46
CPC分类号： C08F2/48 , A61C8/0012 , A61L27/16 , A61L27/58
摘要： Biodegradable polymer networks are provided which are useful in a variety of dental and orthopedic applications. The biodegradable polymer networks can be formed in one embodiment by polymerizing anhydride prepolymers including crosslinkable groups, such as unsaturated moieties. The anhydride prepolymers can be crosslinked, for example in a photopolymerization reaction by irradiation of the prepolymer with light in the presence of a free radical initiator. Suitable anhydride prepolymers include dianhydrides of a dicarboxylic acid and a carboxylic acid molecule comprising a crosslinkable group. For example, methacrylic acid dianhydrides of monomers or oligomers of a diacid such as sebacic acid or 1,3-bis(p-carboxyphenoxy)-hexane can be used. The anhydride prepolymers can be applied in vivo to a site where an orthopedic implant is needed, and then may be crosslinked, for example, by irradiation with U.V. light, to form a biodegradable implant such as a rods, pin or plate. The implants advantageously provide mechanical support and also are capable of slow surface degradation to permit bone ingrowth.
摘要翻译：提供可生物降解的聚合物网络，其可用于各种牙科和矫形应用。可生物降解的聚合物网络可以在一个实施方案中通过聚合包括可交联基团如不饱和部分的酸酐预聚物来形成。酸酐预聚物可以交联，例如通过在自由基引发剂的存在下用光照射预聚物进行光聚合反应。合适的酸酐预聚物包括二羧酸的二酸酐和包含可交联基团的羧酸分子。例如，可以使用二酸的单体或低聚物如癸二酸或1,3-双（对羧基苯氧基） - 己烷的甲基丙烯酸二酐。酸酐预聚物可以在体内应用于需要整形外科植入物的部位，然后可以例如通过用紫外线照射来交联。光，以形成可生物降解的植入物，例如杆，针或板。植入物有利地提供机械支撑并且还能够缓慢的表面退化以允许骨向内生长。

2. 发明授权

US06699505B2 Method of increasing the efficacy of antibiotics by compexing with cyclodextrins 失效
标题翻译：通过与环糊精混合来提高抗生素疗效的方法
公开(公告)号：US06699505B2
公开(公告)日：2004-03-02
申请号：US09981655
申请日：2001-10-17
申请人： Venkatram R. Shastri , Isaac Yue , Patrice Hildgen , Ruben Dario Sinisterra , Robert Langer
发明人： Venkatram R. Shastri , Isaac Yue , Patrice Hildgen , Ruben Dario Sinisterra , Robert Langer
IPC分类号： A61K914
CPC分类号： A61K31/155 , A61K31/65 , A61K31/7036 , A61K47/6951 , B82Y5/00
摘要： The present invention provides methods of increasing the biological activity of a bioactive agent by complexing the bioactive agent with a complexing agent. In one preferred embodiment, the bioactive agent is an antibiotic and the complexing agent is a cyclodextrin. However, the invention may be extended to include any drugs as bioactive agents. In certain preferred embodiments, the bioactive agent fits into a hydrophobic core of a complexing agent.
摘要翻译：本发明提供了通过使生物活性剂与络合剂络合来增加生物活性剂的生物活性的方法。在一个优选的实施方案中，生物活性剂是抗生素，并且络合剂是环糊精。然而，本发明可以扩展到包括任何药物作为生物活性剂。在某些优选的实施方案中，生物活性剂适合于络合剂的疏水核心。

3. 发明授权

US09981068B2 Polymers which resist bacterial attachment 有权
公开(公告)号：US09981068B2
公开(公告)日：2018-05-29
申请号：US14115451
申请日：2012-05-04
申请人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
发明人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
IPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L29/08 , A61L31/14 , A61L31/10 , A61L27/50 , A61L27/34 , A61L29/14 , C08F220/56 , C08F220/24 , C08F220/18 , C08F220/22 , C08F222/10
CPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR (I) [H2C═CR′—C(═O)—NH—]nR (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

4. 发明授权

US09412476B2 Systems, devices, methods, and compositions including fluidized x-ray shielding compositions 有权
公开(公告)号：US09412476B2
公开(公告)日：2016-08-09
申请号：US13373139
申请日：2011-11-03
申请人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
IPC分类号： G21F1/00 , G21F1/06 , G21F1/08 , G21F1/10 , G21F1/02 , G21F3/00 , A61B6/10 , G21F3/02
CPC分类号： G21F1/06 , A61B6/10 , C09D5/32 , G21F1/02 , G21F1/08 , G21F1/10 , G21F3/00 , G21F3/02
摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.

5. 发明授权

US09144488B2 Breast implant with analyte sensors responsive to external power source 有权
标题翻译：具有响应外部电源的分析物传感器的乳房植入物
公开(公告)号：US09144488B2
公开(公告)日：2015-09-29
申请号：US13495252
申请日：2012-06-13
申请人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
IPC分类号： A61F2/12 , A61B5/07 , A61B5/00 , A61B5/145
CPC分类号： A61F2/12 , A61B5/0031 , A61B5/076 , A61B5/14546 , A61B5/4312 , A61B5/686 , A61B5/6867 , A61B2560/0219 , A61F2250/0085 , A61F2250/0096
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the plurality of sensor modules oriented to detect one or more analytes in a fluid adjacent to the shell, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.
摘要翻译：本文描述了包括传感器模块和相关方法的乳房植入物。乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，多个传感器模块中的每一个被定向成检测与壳体相邻的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括唯一的标识符并被配置为利用从外部源发送的能量。

6. 发明授权

US09061075B2 Bone delivery device 有权
公开(公告)号：US09061075B2
公开(公告)日：2015-06-23
申请号：US11900776
申请日：2007-09-12
申请人： Ed Harlow , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/00 , C12N5/02 , C12N11/00 , C12N11/16 , A61K47/48 , A61K9/00 , C12N5/077 , A61K35/12
CPC分类号： A61K47/48776 , A61K9/0024 , A61K47/6901 , A61K2035/126 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.

7. 发明授权

US09006694B2 Systems, devices, methods, and compositions including fluidized x-ray shielding compositions 有权
标题翻译：包括流化X射线屏蔽组合物的系统，装置，方法和组合物
公开(公告)号：US09006694B2
公开(公告)日：2015-04-14
申请号：US13373135
申请日：2011-11-03
申请人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
IPC分类号： G21F3/02 , A61B6/10 , G21F1/02 , G21F3/00
CPC分类号： G21F3/02 , A61B6/10 , G21F1/02 , G21F3/00
摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.
摘要翻译：描述了用于提供包括柔性层的x射线屏蔽系统的系统，装置，方法和组合物，所述柔性层包括具有多个互连的间隙空间的支撑结构，所述多个互连间隙空间提供用于x射线屏蔽流体组合物的循环网络。

8. 发明授权

US09005943B2 Bone cell delivery device 有权
标题翻译：骨细胞递送装置
公开(公告)号：US09005943B2
公开(公告)日：2015-04-14
申请号：US11906580
申请日：2007-10-02
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N11/00 , A61F13/00 , A61K9/52 , A61L27/36 , A61K9/00 , A61K47/48 , A61L27/38 , C12N5/077 , A61K35/12
CPC分类号： A61F2/00 , A61K9/0024 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译：公开了骨笼，包括用于生物相容性植入的装置。骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。

9. 发明授权

US08968274B2 Acoustically controlled substance delivery device 有权
公开(公告)号：US08968274B2
公开(公告)日：2015-03-03
申请号：US12217873
申请日：2008-07-08
申请人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61K9/22 , A61M5/142 , A61M5/145 , A61M5/172
CPC分类号： A61M5/14276 , A61M5/145 , A61M5/172 , A61M5/1723 , A61M2005/14513 , A61M2205/0266 , A61M2205/0288 , A61M2205/3507 , A61M2205/3523 , A61M2205/3569 , A61M2205/36
摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.

10. 发明授权

US08962316B2 Choroid plexus device 有权
标题翻译：脉络丛装置
公开(公告)号：US08962316B2
公开(公告)日：2015-02-24
申请号：US11451994
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/071 , C12N5/00 , C12N5/02 , A61K47/48 , A61K9/00 , A61L27/36 , A61L27/38 , C12N5/079 , C12N5/077 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译：公开了骨笼，包括用于生物相容性植入的装置。骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。

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