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1. 发明申请

US20130330279A1 NANOPARTICLE MEDIATED GENE THERAPY, DIAGNOSTIC PRODUCTS AND THERAPEUTIC PRODUCTS FOR BREAST CANCER 审中-公开
标题翻译：纳米颗粒介导的基因治疗，诊断产品和用于乳腺癌的治疗产品
公开(公告)号：US20130330279A1
公开(公告)日：2013-12-12
申请号：US13726018
申请日：2012-12-22
申请人： Krishnan Chakravarthy , Robert Spengler , Tracey Ignatowski , Siddhartha Kamisetti
发明人： Krishnan Chakravarthy , Robert Spengler , Tracey Ignatowski , Siddhartha Kamisetti
IPC分类号： C07K17/14 , C12N15/113 , C07K17/08 , A61K49/16 , A61K49/18
CPC分类号： C07K17/14 , A61K47/6855 , A61K49/16 , A61K49/1824 , B82Y5/00 , C07K17/08 , C12N15/1135 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2320/32 , Y10S977/774 , Y10S977/906
摘要： The present disclosure provides compositions and methods of treating Breast Cancer. Disclosed is a nanoparticle paired to at least one of W genetic materials that suppress key regulators of fat synthesis (e.g. Rev-erb) to cause a predefined target cell types apoptosis or X predefined targeting moieties that cause predefined target cell types apoptosis and correspond to Y predefined target parameters associated with Z predefined target cell types in connection with treatment of at least one of the following breast cancer, glioblastoma, head and neck cancer, pancreatic cancer, lung cancer, cancer of the nervous system, gastrointestinal cancer, prostate cancer, ovarian cancer, kidney cancer, retina, cancer, skin cancer, liver cancer, genital.
摘要翻译：本公开提供了治疗乳腺癌的组合物和方法。公开了与抑制脂肪合成的关键调节剂（例如Rev-erb）的W遗传物质中的至少一种的纳米颗粒，以引起预定义的靶细胞类型凋亡或X预定义的靶向部分，其导致预定义的靶细胞类型凋亡并对应于Y 与预定的靶细胞类型相关联的预定目标参数与治疗以下乳腺癌，成胶质细胞瘤，头颈癌，胰腺癌，肺癌，神经系统癌症，胃肠癌，前列腺癌，卵巢中的至少一种有关癌症，肾癌，视网膜，癌症，皮肤癌，肝癌，生殖器。

2. 发明申请

US20120315322A1 NANOPARTICLE MEDIATED GENE THERAPY AND THERAPEUTIC PRODUCTS FOR ALZHEIMERS 审中-公开
标题翻译：纳米颗粒介导的基因治疗和治疗药物
公开(公告)号：US20120315322A1
公开(公告)日：2012-12-13
申请号：US13491785
申请日：2012-06-08
申请人： Krishnan Chakravarthy , Robert Spengler , Tracey Ignatowski , Siddhartha Venkata Kamisetti
发明人： Krishnan Chakravarthy , Robert Spengler , Tracey Ignatowski , Siddhartha Venkata Kamisetti
IPC分类号： A61K9/14 , A61P25/28 , C07H21/02 , A61K48/00 , A61K9/127 , B82Y5/00
CPC分类号： C12N15/87 , A61K48/0075 , B82Y5/00 , C12N2810/00
摘要： The present disclosure provides compositions and methods of treating Alzheimers Disease. In an aspect, a nanoparticle is paired to one or more genetic materials that regulates inflammation in a microenvironment. Such nanoparticles can be used to target predefined target cell types in connection with treatment of at least one of the following Alzheimer's disease, Pick's disease, Lewy Body disease, or Idiopathic dementia.
摘要翻译：本公开提供了治疗阿尔茨海默病的组合物和方法。在一方面，纳米颗粒与在微环境中调节炎症的一种或多种遗传物质配对。结合治疗以下阿尔茨海默氏病，皮克病，路易体病或特发性痴呆中的至少一种，这样的纳米颗粒可用于靶向预定的靶细胞类型。

3. 发明申请

US20070240939A1 Ladder Stabilizers 审中-公开
标题翻译：梯子稳定剂
公开(公告)号：US20070240939A1
公开(公告)日：2007-10-18
申请号：US11799988
申请日：2007-05-03
申请人： Robert Spengler
发明人： Robert Spengler
IPC分类号： E06C7/42
CPC分类号： E06C7/423 , E06C1/39
摘要： A step ladder stabilizer for mounting behind the front step portion and having two adjusting legs which adjust as a slide lock moves vertically within a slot attached to the rear of the ladder steps. When not in use, the ladder stabilizer closes flush against the back of the ladder steps. An alternate embodiment includes a ladder stabilizer for an extension ladder comprising an extending leg and a stabilizer arm with the top of the extending leg attaching to a slide lock that slides along a channel mounted on the side of the ladder. Bolts passing through expansion inserts hold the channel onto each side of the ladder.
摘要翻译：用于安装在前台阶部分后面并且具有两个作为滑动锁定调节的调节腿的阶梯式稳定器在附接到梯子的后部的槽内垂直移动。当不使用时，梯子稳定器与梯子的后面齐平。替代实施例包括用于延伸梯的梯子稳定器，包括延伸腿和稳定臂，其中延伸腿的顶部附接到沿着安装在梯子侧面上的通道滑动的滑动锁。通过膨胀插件的螺栓将通道保持在梯子的每一侧。

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