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1. 发明授权

US06476197B1 Polypeptides having interferon-&ggr; inducing activity 失效
标题翻译：具有干扰素-γ诱导活性的多肽
公开(公告)号：US06476197B1
公开(公告)日：2002-11-05
申请号：US08982285
申请日：1997-12-01
申请人： Kozo Yamamoto , Iwao Okamoto , Masashi Kurimoto
发明人： Kozo Yamamoto , Iwao Okamoto , Masashi Kurimoto
IPC分类号： C07K100
CPC分类号： C07K14/54 , A61K38/00 , Y02A50/411
摘要： Disclosed are created stable polypeptides which are capable of inducing the production of interferon-gamma by immunocompetent cells. The present polypeptides contain specific amino acid sequences usually derived from the wild-type polypeptides, being capable of the production of interferon-gamma, by replacing the cysteine(s) with different amino acid(s). The present polypeptides possess a stability and an activity of inducing the production of IFN-&ggr; by immunocompetent cells, both of which are significantly higher than those of the wild-type polypeptides. In addition to the activity, the present polypeptides can exhibit remarkable activities of inducing the formation of killer cells and enhancing thier cytotoxicities. The present polypeptides are easily obtainable by the process according to the present invention using recombinant DNA techniques. Thus the present polypeptides are useful for agents to treat and/or prevent susceptive diseases such as viral diseases, infections, malignant tumors, and immunopathies.
摘要翻译：公开了能够通过免疫活性细胞诱导干扰素-γ产生的稳定多肽。本发明的多肽含有通常衍生自野生型多肽的能够产生干扰素-γ的特异性氨基酸序列，通过用不同的氨基酸替代半胱氨酸。本发明的多肽具有通过免疫活性细胞诱导IFN-γ产生的稳定性和活性，两者均明显高于野生型多肽。除了活性之外，本发明的多肽可以表现出显着的诱导杀伤细胞形成的活性和增强其细胞毒性。本发明的多肽可以使用重组DNA技术通过本发明的方法容易地获得。因此，本发明的多肽可用于治疗和/或预防感染性疾病如病毒性疾病，感染，恶性肿瘤和免疫病症的药剂。

2. 发明授权

US07037685B2 DNA encoding loypeptides having interferon-γ inducing activity 失效
标题翻译：编码具有干扰素-γ诱导活性的寡肽的DNA
公开(公告)号：US07037685B2
公开(公告)日：2006-05-02
申请号：US10260576
申请日：2002-10-01
申请人： Kozo Yamamoto , Iwao Okamoto , Masashi Kurimoto
发明人： Kozo Yamamoto , Iwao Okamoto , Masashi Kurimoto
IPC分类号： C12P21/02
CPC分类号： C07K14/54 , A61K38/00 , Y02A50/411
摘要： Disclosed are created stable polypeptides which are capable of inducing the production of interferon-gamma by immunocompetent cells. The present polypeptides contain specific amino acid sequences usually derived from the wild-type polypeptides, being capable of the production of interferon-gamma, by replacing the cysteine(s) with different amino acid(s). The present polypeptides possess a stability and an activity of inducing the production of IFN-γ by immunocompetent cells, both of which are significantly higher than those of the wild-type polypeptides. In addition to the activity, the present polypeptides can exhibit remarkable activities of inducing the formation of killer cells and enhancing thier cytotoxicities. The present polypeptides are easily obtainable by the process according to the present invention using recombinant DNA techniques. Thus the present polypeptides are useful for agents to treat and/or prevent susceptive diseases such as viral diseases, infections, malignant tumors, and immunopathies.
摘要翻译：公开了能够通过免疫活性细胞诱导干扰素-γ产生的稳定多肽。本发明的多肽含有通常衍生自野生型多肽的能够产生干扰素-γ的特异性氨基酸序列，通过用不同的氨基酸替代半胱氨酸。本发明的多肽具有通过免疫活性细胞诱导IFN-γ产生的稳定性和活性，两者均明显高于野生型多肽。除了活性之外，本发明的多肽可以表现出显着的诱导杀伤细胞形成的活性和增强其细胞毒性。本发明的多肽可以使用重组DNA技术通过本发明的方法容易地获得。因此，本发明的多肽可用于治疗和/或预防感染性疾病如病毒性疾病，感染，恶性肿瘤和免疫病症的药剂。

3. 发明授权

US07230079B2 Antiallergic agent 失效
标题翻译：抗过敏剂
公开(公告)号：US07230079B2
公开(公告)日：2007-06-12
申请号：US10525567
申请日：2003-08-26
申请人： Iwao Okamoto , Norie Arai , Keizo Kohno , Masashi Kurimoto , Osamu Sano
发明人： Iwao Okamoto , Norie Arai , Keizo Kohno , Masashi Kurimoto , Osamu Sano
IPC分类号： C07K1/00
CPC分类号： A61K35/644 , A61K8/64 , A61K8/988 , A61K38/00 , A61Q19/00 , C07K14/43572 , A61K2300/00
摘要： It is intended to provide an anti-allergic agent, which efficaciously relieves symptoms accompanying an allergic disease without causing any serious side effect. This object is achieved by providing an anti-allergic agent which contains, as an effective ingredient, proteins collected from royal jelly or purified royal jelly, or royal jelly or purified royal jelly containing the proteins.
摘要翻译：旨在提供一种抗过敏剂，其有效地缓解伴随过敏性疾病的症状，而不引起任何严重的副作用。该目的通过提供一种抗过敏剂来实现，该抗过敏剂含有从蜂王浆或纯化蜂王浆或蜂王浆或含有蛋白质的纯化蜂王浆中收集的蛋白质作为有效成分。

4. 发明申请

US20060134127A1 Antiallergic agent 失效
标题翻译：抗过敏剂
公开(公告)号：US20060134127A1
公开(公告)日：2006-06-22
申请号：US10525567
申请日：2003-08-26
申请人： Iwao Okamoto , Norie Arai , Keizo Kohno , Masashi Kurimoto , Osamu Sano
发明人： Iwao Okamoto , Norie Arai , Keizo Kohno , Masashi Kurimoto , Osamu Sano
IPC分类号： A61K39/00
CPC分类号： A61K35/644 , A61K8/64 , A61K8/988 , A61K38/00 , A61Q19/00 , C07K14/43572 , A61K2300/00
摘要： It is intended to provide an anti-allergic agent, which efficaciously relieves symptoms accompanying an allergic disease without causing any serious side effect. This object is achieved by providing an anti-allergic agent which contains, as an effective ingredient, proteins collected from royal jelly or purified royal jelly, or royal jelly or purified royal jelly containing the proteins.
摘要翻译：旨在提供一种抗过敏剂，其有效地缓解伴随过敏性疾病的症状，而不引起任何严重的副作用。该目的通过提供一种抗过敏剂来实现，该抗过敏剂含有从蜂王浆或纯化蜂王浆或蜂王浆或含有蛋白质的纯化蜂王浆中收集的蛋白质作为有效成分。

5. 发明申请

US20070129430A1 Agent for enhancing the production of collagen, their preparation and use 审中-公开
标题翻译：用于增强胶原蛋白生产的药剂及其制备和用途
公开(公告)号：US20070129430A1
公开(公告)日：2007-06-07
申请号：US10574934
申请日：2003-10-04
申请人： Satomi Miyata , Iwao Okamoto , Shimpei Ushio , Masashi Kurimoto
发明人： Satomi Miyata , Iwao Okamoto , Shimpei Ushio , Masashi Kurimoto
IPC分类号： A61K31/375 , A61K31/22 , A61K31/20
CPC分类号： A61K31/7048 , A23K20/158 , A23K20/174 , A23L33/12 , A23L33/15 , A23V2002/00 , A61K8/65 , A61K8/676 , A61K31/20 , A61K31/201 , A61K31/375 , A61K45/06 , A61Q19/00 , A61Q19/08 , A61K2300/00 , A23V2250/708 , A23V2250/186
摘要： The present invention has an object to provide an agent for enhancing collagen production and use thereof, and solves the object by establishing an agent for enhancing collagen production, which comprises as effective ingredients L-ascorbic acid or its derivative and a fatty acid or its derivative, and use thereof.
摘要翻译：本发明的目的是提供一种用于增强胶原蛋白生产和用途的药剂，并且通过建立包含作为有效成分L-抗坏血酸或其衍生物和脂肪酸或其衍生物的有效成分的胶原蛋白生产增强剂来解决该目的，及其用途。

6. 发明申请

US20050136291A1 Magnetic recording medium, recording method and magnetic storage apparatus 审中-公开
标题翻译：磁记录介质，记录方法和磁存储装置
公开(公告)号：US20050136291A1
公开(公告)日：2005-06-23
申请号：US10975936
申请日：2004-10-28
申请人： Iwao Okamoto , Hisashi Umeda
发明人： Iwao Okamoto , Hisashi Umeda
IPC分类号： G11B5/64 , G11B5/65 , G11B5/66 , G11B5/738 , G11B5/72
CPC分类号： G11B5/66 , G11B5/656
摘要： A magnetic recording medium is provided with first and second ferromagnetic layers which are exchange-coupled via a first nonmagnetic coupling layer and have mutually parallel magnetizations. The second ferromagnetic layer and a magnetic layer are exchange-coupled via a second nonmagnetic coupling layer and have magnetizations which are mutually antiparallel. The first and second ferromagnetic layers and the magnetic layer respectively have dynamic coercivities Hc1′, Hc2′ and Hc3′ which satisfy a relationship Hc1′
摘要翻译：磁记录介质设置有第一和第二铁磁层，其经由第一非磁性耦合层交换耦合并且具有相互平行的磁化。第二铁磁层和磁性层通过第二非磁性耦合层进行交换耦合，并具有相互反平行的磁化。第一和第二铁磁层和磁性层分别具有在记录磁场的切换时间区域中满足关系Hc 1'

7. 发明授权

US06753101B1 Magnetic recording medium, magnetic storage apparatus, recording method and method of producing magnetic recording medium 失效
标题翻译：磁记录介质，磁存储装置，制造磁记录介质的记录方法和方法
公开(公告)号：US06753101B1
公开(公告)日：2004-06-22
申请号：US09588850
申请日：2000-06-06
申请人： E. Noel Abarra , Iwao Okamoto , Yoshifumi Mizoshita , Yuki Yoshida
发明人： E. Noel Abarra , Iwao Okamoto , Yoshifumi Mizoshita , Yuki Yoshida
IPC分类号： G11B566
CPC分类号： G11B5/66 , G11B5/74 , G11B5/82 , G11B2005/0002 , Y10S428/90 , Y10T428/24942 , Y10T428/265
摘要： A magnetic recording medium is provided with at least one exchange layer structure, and a magnetic layer formed on the exchange layer structure. The exchange layer structure includes a ferromagnetic layer and a non-magnetic coupling layer provided on the ferromagnetic layer and under the magnetic layer.
摘要翻译：磁记录介质具有至少一个交换层结构和形成在交换层结构上的磁性层。交换层结构包括铁磁层和设置在铁磁层上和磁层下面的非磁性耦合层。

8. 发明授权

US06740383B2 Magnetic recording medium possessing a ratio of Hc(perpendicular) to Hc(horizontal) that is not more than 0.22 and magnetic recording disk device 失效
标题翻译：具有Hc（垂直）与Hc（水平）之比不大于0.22的磁记录介质和磁记录盘装置
公开(公告)号：US06740383B2
公开(公告)日：2004-05-25
申请号：US09275578
申请日：1999-03-24
申请人： Masayoshi Shinohara , Kenji Sato , Yuki Yoshida , Iwao Okamoto , Yasuji Ikeda , Kiyoshi Yamaguchi
发明人： Masayoshi Shinohara , Kenji Sato , Yuki Yoshida , Iwao Okamoto , Yasuji Ikeda , Kiyoshi Yamaguchi
IPC分类号： G11B573
CPC分类号： B82Y25/00 , B82Y10/00 , G11B5/012 , G11B5/4886 , G11B5/656 , G11B5/72 , G11B5/7325 , G11B2005/3996 , Y10T428/24355 , Y10T428/24975
摘要： A magnetic recording medium and a magnetic disk device using the same. The magnetic recording medium comprising a nonmagnetic substrate having applied thereon, through two or more chromium-based underlayers, a magnetic recording layer having a circumferential direction of easy magnetization and containing cobalt as a principal component thereof, and also containing chromium and platinum in combination with tantalum or tantalum and niobium. Using the magnetic recording medium, a reproducing output and S/N ratio can be increased without causing an increase in noise.
摘要翻译：磁记录介质及使用其的磁盘装置。该磁记录介质包括通过两个或多个铬基底层施加在其上的非磁性基底，具有容易磁化的圆周方向并且含有钴作为其主要成分的磁记录层，并且还含有铬和铂与钽或钽和铌。使用磁记录介质，可以增加再现输出和S / N比，而不会增加噪声。

9. 发明授权

US06677051B1 Magnetic recording medium with dual magnetic layers having specific composition requirements and a magnetic storage apparatus 失效
标题翻译：具有特定组成要求的双磁性层的磁记录介质和磁存储装置
公开(公告)号：US06677051B1
公开(公告)日：2004-01-13
申请号：US09648097
申请日：2000-08-25
申请人： B. Ramamurthy Acharya , Iwao Okamoto
发明人： B. Ramamurthy Acharya , Iwao Okamoto
IPC分类号： G11B566
CPC分类号： G11B5/656 , G11B5/66 , Y10T428/12646 , Y10T428/12861 , Y10T428/12931 , Y10T428/26
摘要： A magnetic recording medium is constructed to include a substrate, and a magnetic layer disposed above the substrate, wherein the magnetic layer has an initial layer on a side closer to the substrate and a final layer on a side opposite from the substrate with respect to the initial layer. The initial layer is made of a CoCrB-based alloy having a thickness of 1 to 10 nm, and the final layer is made of a Co-based alloy having a thickness of 5 to 30 nm.
摘要翻译：磁记录介质被构造成包括基板和设置在基板上方的磁性层，其中磁性层在靠近基板的一侧具有初始层，并且相对于基板在与基板相反的一侧具有最终层初始层。初始层由厚度为1〜10nm的CoCrB系合金构成，最终层由厚度为5〜30nm的Co系合金构成。

10. 发明授权

US06645646B1 Magnetic recording medium and magnetic storage apparatus 失效
标题翻译：磁记录介质和磁存储装置
公开(公告)号：US06645646B1
公开(公告)日：2003-11-11
申请号：US09587842
申请日：2000-06-06
申请人： Hisashi Umeda , E. Noel Abarra , Iwao Okamoto , Yoshifumi Mizoshita
发明人： Hisashi Umeda , E. Noel Abarra , Iwao Okamoto , Yoshifumi Mizoshita
IPC分类号： G11B566
CPC分类号： G11B5/66 , G11B5/74 , G11B5/82 , G11B2005/0002 , Y10S428/90 , Y10T428/12465 , Y10T428/12861 , Y10T428/2495 , Y10T428/265
摘要： A magnetic recording medium is constructed to include at least one exchange layer structure and a magnetic layer provided on the exchange layer structure, where the exchange layer structure includes a ferromagnetic layer and a non-magnetic coupling layer provided on the ferromagnetic layer, and a magnetic bonding layer provided between the ferromagnetic layer and the non-magnetic coupling layer and/or between the non-magnetic coupling layer and the magnetic layer, wherein the magnetic bonding layer has a magnetization direction parallel to the ferromagnetic layer and the magnetic layer.
摘要翻译：磁记录介质被构造成包括至少一个交换层结构和设置在交换层结构上的磁性层，其中交换层结构包括强磁性层和设置在铁磁层上的非磁性耦合层，以及磁性层粘结层设置在铁磁层和非磁性耦合层之间和/或非磁性耦合层与磁性层之间，其中磁性结合层具有平行于铁磁性层和磁性层的磁化方向。

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