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1. 发明授权

US06514291B1 Artificial dura mater and process for producing dura mater 失效
公开(公告)号：US06514291B1
公开(公告)日：2003-02-04
申请号：US09529073
申请日：2000-04-06
申请人： Koji Yamauchi , Yoshito Ikada , Susumu Miyamoto , Keisuke Yamada , Tomohiko Asahara
发明人： Koji Yamauchi , Yoshito Ikada , Susumu Miyamoto , Keisuke Yamada , Tomohiko Asahara
IPC分类号： A61F202
CPC分类号： A61L27/58 , A61L27/18 , C08L67/04
摘要： The present invention provides an artificial dura mater characterized by comprising at least a sheet of a biodegradable and bioabsorbable synthetic polymer and having a storage modulus at ordinary temperature of from 1×107 to 5×108 (Pa); and a process for producing an artificial dura mater characterized by dissolving a lactide/&egr;-caprolactone copolymer (in a molar ratio ranging from 40/60 to 60/40) in a solvent, filtering the resultant solution and casting the same followed by air drying.

2. 发明授权

US06679919B2 Artificial dura 有权
标题翻译：人造硬膜
公开(公告)号：US06679919B2
公开(公告)日：2004-01-20
申请号：US09529758
申请日：2000-04-19
申请人： Koji Yamauchi , Tomohiko Asahara
发明人： Koji Yamauchi , Tomohiko Asahara
IPC分类号： A61F236
CPC分类号： A61L27/58 , A61L27/18 , C08L67/04
摘要： The present invention provides an artificial dura mater prepared from an biodegradable and bioabsorbable synthetic polymer sheet and having a total light transmittance of 30% or more as defined by JIS K7105, a haze (cloudiness value) of 80% or less as defined by JIS K7105 or a specular glossiness at 60° (Gs 60°) of 10-20% as defined by JIS Z8741.
摘要翻译：本发明提供一种由可生物降解和生物可吸收的合成聚合物片材制备的人造硬膜，其总透光率为JIS K7105定义的30％以上，由JIS K7105定义的雾度（浊度值）为80％以下或由JIS Z8741定义的60°（Gs 60°）的10-20％的镜面光泽度。

3. 发明授权

US07041713B2 Artificial dura mater 失效
标题翻译：人造硬脑膜
公开(公告)号：US07041713B2
公开(公告)日：2006-05-09
申请号：US10019754
申请日：2001-04-27
申请人： Koji Yamauchi , Tomohiko Asahara
发明人： Koji Yamauchi , Tomohiko Asahara
IPC分类号： A61F2/02 , C08K9/00
CPC分类号： A61F2/86 , A61L27/14 , A61L27/16 , A61L27/18 , A61L27/44 , A61L27/50 , A61L27/58 , A61L2430/32 , Y10S623/926 , C08L27/18 , C08L67/04
摘要： The present invention provides an artificial dura mater which comprises an amorphous or low crystallinity polymer as a constituent component and which prevents the cerebrospinal fluid leakage.
摘要翻译：本发明提供一种人造硬膜，其包含无定形或低结晶度聚合物作为构成成分，并且可防止脑脊液泄漏。

4. 发明授权

US06846330B2 Artificial dura mater and process for producing dura mater 失效
标题翻译：人造硬脑膜和硬脑膜生产工艺
公开(公告)号：US06846330B2
公开(公告)日：2005-01-25
申请号：US10310521
申请日：2002-12-05
申请人： Koji Yamauchi , Yoshito Ikada , Susumu Miyamoto , Keisuke Yamada , Tomohiko Asahara
发明人： Koji Yamauchi , Yoshito Ikada , Susumu Miyamoto , Keisuke Yamada , Tomohiko Asahara
IPC分类号： A61L27/18 , A61L27/58 , A61F2/02 , C08L6/08
CPC分类号： A61L27/58 , A61L27/18 , C08L67/04
摘要： The present invention provides an artificial dura mater characterized by comprising at least a sheet of a biodegradable and bioabsorbable synthetic polymer and having a storage modulus at ordinary temperature of from 1×107 to 5×108 (Pa); and a process for producing an artificial dura mater characterized by dissolving a lactide/ε-caprolactone copolymer (in a molar ratio ranging from 40/60 to 60/40) in a solvent, filtering the resultant solution and casting the same followed by air drying.
摘要翻译：本发明提供了一种人造硬膜，其特征在于包括至少一片生物可降解和生物可吸收的合成聚合物，并且在常温下为1×10 7至5×10 8（Pa）的储能模量; 以及用于制备人造硬膜的方法，其特征在于将溶剂中的丙交酯/ε-己内酯共聚物（摩尔比为40/60至60/40）溶解在溶剂中，过滤所得溶液并浇铸，然后进行空气干燥。

5. 发明授权

US5224948A Suturing device for multiposition holding of suture needles 失效
标题翻译：多用途装置保持针脚
公开(公告)号：US5224948A
公开(公告)日：1993-07-06
申请号：US780601
申请日：1991-10-23
申请人： Hiroshi Abe , Tomohiko Asahara
发明人： Hiroshi Abe , Tomohiko Asahara
IPC分类号： A61B17/06 , A61B17/04 , A61B17/28
CPC分类号： A61B17/0469 , A61B17/29
摘要： The present invention provides a deep suturer suitable for suturing a deep portion and a narrow portion which are difficult to be applied by a normal direct hand operation such as transoral operation. The suturer comprises an end needle-holding portion (B) for holding a suture needle, a holder portion (A) for operating the end needle-holding portion (B) and a connection portion (C) for operatively connect the end needle-holding portion (B) and holder portion (B) is provided with a disk head (4) which is rotated integral with a needle-holding portion (5) the holder portion (A) is provided with a handle (2), and the connection portion (C) is provided with a rod (7) having one end connected to the handle (2) through a connecting mechanism (18) and the other end connected to the disk head (4), the rod (7) being axially slidably inserted by of a spring force.

6. 发明申请

US20080107703A1 Hydrogel For Medical Use 审中-公开
标题翻译：水凝胶用于医疗用途
公开(公告)号：US20080107703A1
公开(公告)日：2008-05-08
申请号：US11884239
申请日：2006-02-14
申请人： Yasuhiko Tabata , Tomohiko Asahara
发明人： Yasuhiko Tabata , Tomohiko Asahara
IPC分类号： A61K9/10 , A61P17/00
CPC分类号： C08L101/14 , A61K9/0014 , A61K47/42 , A61L27/222 , A61L27/52 , C08J3/075 , C08J2389/00
摘要： Disclosed is a substantially water-based medical hydrogel having at least 0.010 but no more than 50 crosslink points per molecule, as well as a dried material thereof. The hydrogel is obtained by crosslinking a gelatin having 20 to 30 amino groups per molecule and the same or greater number of carboxyl groups per molecule or a gelatin derivative having 2 to 100 amino groups per molecule and 50 or more carboxyl groups per molecule. According to the present invention, a medical hydrogel with properties appropriate to the intended use can be reliably prepared. In particular a continuous delivery interval can be reliably achieved by using the hydrogel of the invention as a drug delivery vehicle.
摘要翻译：公开了基本上水分的医用水凝胶，其每分子具有至少0.010但不超过50个交联点，以及其干燥材料。水凝胶是通过交联每分子具有20至30个氨基并且每分子具有相同或更多个羧基数的明胶或每分子具有2至100个氨基的明胶衍生物和每个分子具有50个或更多个羧基的明胶获得的。根据本发明，可以可靠地制备具有适合于预期用途的性质的医用水凝胶。特别地，通过使用本发明的水凝胶作为药物递送载体，可以可靠地实现连续输送间隔。

7. 发明授权

US3939636A Mixed yarn 失效
标题翻译：混纺纱
公开(公告)号：US3939636A
公开(公告)日：1976-02-24
申请号：US491273
申请日：1974-07-24
申请人： Yuzaburo Nakayama , Akinori Yamamoto , Tomohiko Asahara , Masaharu Shimamura , Yoshizo Tsuda , Keisuke Igawa , Mitsuhiro Okamoto
发明人： Yuzaburo Nakayama , Akinori Yamamoto , Tomohiko Asahara , Masaharu Shimamura , Yoshizo Tsuda , Keisuke Igawa , Mitsuhiro Okamoto
IPC分类号： D01F6/60 , D02G1/18 , D02G3/04 , D06P5/22 , D02G3/24
CPC分类号： D02G1/18 , D01F6/805 , D06P3/241
摘要： A mixed yarn having a uniform dyeability to an acid dye, which comprises at least two kinds of polyamide filaments differing in shrinkage, each consisting mainly of repeating units represented by the following general formula: ##SPC1##
摘要翻译：对酸性染料具有均匀染色性的混合纱线，其包含至少两种收缩率不同的聚酰胺丝，各自主要由以下通式表示的重复单元组成：

8. 发明授权

US5464405A Bipolar surgical tweezers 失效
标题翻译：双极手术镊子
公开(公告)号：US5464405A
公开(公告)日：1995-11-07
申请号：US182610
申请日：1994-01-18
申请人： Kazuhiko Fujitsu , Tomohiko Asahara , Nobuhiro Kagaminuma , Kohichi Iwai
发明人： Kazuhiko Fujitsu , Tomohiko Asahara , Nobuhiro Kagaminuma , Kohichi Iwai
IPC分类号： A61B17/30 , A61B18/12 , A61B18/14 , A61M1/00 , A61B17/39
CPC分类号： A61B18/1442 , A61M1/0058 , A61M1/0084
摘要： Embedding a perfusion passage pipe in the surface at the inside of one of the arms of a tweezers partially or entirely and concurrently, fastening a housing portion in the rear of the grip portion in a range of 90.degree. to 170.degree. angled from the tip portion to the central axis of the grip portion of an arm.
摘要翻译：将灌注通道管部分地或全部并入并入镊子的一个臂的内侧的表面内，将手柄部分的后部的壳体部分从尖端部分成90度到170度的范围内到臂的把手部分的中心轴线。

9. 发明授权

US5364409A Endoscopic needle holder 失效
标题翻译：内窥镜针架
公开(公告)号：US5364409A
公开(公告)日：1994-11-15
申请号：US57235
申请日：1993-05-04
申请人： Masayoshi Kuwabara , Tomohiko Asahara , Noboru Ujiie , Nobuhiro Kagaminuma
发明人： Masayoshi Kuwabara , Tomohiko Asahara , Noboru Ujiie , Nobuhiro Kagaminuma
IPC分类号： B63J3/02 , A61B17/04 , A61B17/12 , A61B17/28 , A62C29/00 , B63H11/08
CPC分类号： A61B17/0469 , A61B17/0483 , A61B17/062 , A61B17/12013 , A61B2017/2837 , A61B2017/2901 , A61B2017/2926
摘要： The invention provides a needle holding arrangement for only the gripping of a needle within the body cavity. There is provided a suture fixing means for gripping or fixing a suture with a needle on an outer peripheral surface of the needle-holder shaft. After piercing and passing of the needle through the tissue in the body, a knot of the suture can be made within the body cavity, and saturation and ligation of tissues in the body and end closure and ligation of blood vessel and gall duct can also be performed.
摘要翻译：本发明提供一种用于仅在体腔内夹持针的针保持装置。提供了一种缝合线固定装置，用于在针架轴的外周表面上用针夹持或固定缝合线。穿刺穿过身体组织后，缝合线可以在体腔内形成，体内组织的饱和和结扎以及血管和胆管结扎也可以是执行。

10. 发明授权

US07867230B2 Bipolar forceps 有权
标题翻译：双极镊子
公开(公告)号：US07867230B2
公开(公告)日：2011-01-11
申请号：US11278622
申请日：2006-04-04
申请人： Tomohiko Asahara , Takeshi Mikami , Kiyohiro Houkin
发明人： Tomohiko Asahara , Takeshi Mikami , Kiyohiro Houkin
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00077 , A61B2018/00107 , A61B2018/0013 , A61B2018/00148 , A61B2018/1415
摘要： This invention provides bipolar forceps that are used for coagulation, dissection or similar surgical manipulation by the application of a high-frequency current in a surgical operation, which suppresses attachment and sticking of burned protein to arm tip end portions irrespective of the properties of the metal material forming the arms. The bipolar forceps according to the present invention have on each of opposed surfaces 1a of the tip end portions 1 of a pair of arms a composite plating film 3 composed of a noble metal material 3a and nonconductive fine particles 3b, and a laminate plating film 4 of a noble metal material formed on the composite plating film 3.
摘要翻译：本发明提供了双极镊子，其用于通过在外科手术中应用高频电流进行凝固，解剖或类似手术操作，其抑制燃烧的蛋白质与臂末端部分的附着和粘附，而与金属的性质无关形成手臂的材料。根据本发明的双极钳具有在一对臂的末端部1的相对表面1a上的由贵金属材料3a和非导电细颗粒3b构成的复合镀膜3和层压电镀膜4 形成在复合镀膜3上的贵金属材料。

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