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1. 发明授权

US5332734A Oxazinone derivative 失效
标题翻译：恶嗪酮衍生物
公开(公告)号：US5332734A
公开(公告)日：1994-07-26
申请号：US956029
申请日：1992-12-10
申请人： Koji Kobayashi , Shunichi Manabe , Yoshihiro Watanabe , Kazuhide Hayakawa , Itsuo Uchida
发明人： Koji Kobayashi , Shunichi Manabe , Yoshihiro Watanabe , Kazuhide Hayakawa , Itsuo Uchida
IPC分类号： C07D265/22 , C07D413/12 , C07D417/12 , C07D471/04 , C07D239/95 , A61K31/535 , A61K31/54 , C07D239/72
CPC分类号： C07D265/22 , C07D413/10 , C07D417/12 , C07D471/04
摘要： Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibitor: ##STR1## where A includes, for example, ##STR2## in which W is --O--, --S--, --CH.dbd.CH-- or --NR.sup.9 -- or means that (CH.sub.2).sub.n is directly bonded to (CH.sub.2).sub.n,V.sup.2 is .dbd.CR.sup.12 -- or .dbd.N--, andD is 5 to 7-membered carbon ring or hetero ring;X is --O--, --S--, --CO--, or --NR.sup.15 or means that A is directly bonded to (CH.sub.2).sub.l ;Y is --O--, --CH.dbd.CH-- or --NR.sup.16 -- or means that (CH.sub.2).sub.l is directly bonded to Z;Z is --CH.sub.2 -- or --CO--; andl is an integer of 0 to 4.Further, R and R.sup.1 to R.sup.16 are hydrogen atom, lower alkyl group, etc.
摘要翻译： PCT No.PCT / JP92 / 00444 Sec。 371日期：1992年12月10日 102（e）日期1992年12月10日PCT提交1992年4月9日PCT公布。出版物WO92 / 18488 日期：1992年10月29日。公开是由下述式（I）表示的新型恶嗪酮衍生物或其药学上可接受的酸加成盐，其可用作抗炎剂，抑制嗜中性粒细胞浸润的药剂丝氨酸蛋白酶抑制剂：其中A包括例如其中W是-O - ， - S - ， - CH = CH-或-NR 9 - 的，或意味着（CH 2）n直接键合到（CH 2）n，V 2是= CR 12 - 或= N-，D是5至7元碳环或杂环; X是-O - ， - S - ， - CO-或-NR 15或意指A直接键合到（CH 2）l; Y是-O - ， - CH = CH-或-NR 16 - 或意指（CH 2）l直接键合到Z上; Z是-CH 2 - 或-CO-; l为0〜4的整数。另外，R和R 1〜R 16为氢原子，低级烷基等。

2. 发明授权

US5204462A 4H-3,1-benzoxazin-4-one derivative 失效
标题翻译： 4H-3,1-苄氧基-4-酮衍生物
公开(公告)号：US5204462A
公开(公告)日：1993-04-20
申请号：US776372
申请日：1991-11-27
申请人： Koji Kobayashi , Koichi Ozawa , Masashi Sasabuchi , Itsuo Uchida
发明人： Koji Kobayashi , Koichi Ozawa , Masashi Sasabuchi , Itsuo Uchida
IPC分类号： A61K38/00 , C07D207/16 , C07D413/12 , C07K5/062 , C07K5/065 , C07K5/083 , C07K5/087
CPC分类号： C07D413/10 , C07D207/16 , C07K5/06052 , C07K5/06078 , C07K5/06165 , C07K5/0806 , C07K5/0812 , A61K38/00
摘要： 4H-3,1-benzoxazin-4-one derivatives represented by formula (I) below: ##STR1## wherein R.sup.1 represents a lower alkyl group, R.sup.2 represents a lower alkyl group, a lower alkylthioalkyl group, or a lower alkanesulfinylalkyl group, R.sup.3 represents a hydrogen atom a hydroxyl group, a lower alkoxy group, or a lower acyloxy group, X represents an amino acid residue selected from the group consisting of alanine, valine, and phenylalanine, n represents an integer of 0, 1, or 2, and Y means a substituent selected from the group consisting of an alkanoyl group having 2 to 6 carbon atoms which may be substituted by a phenyl group, a benzyloxycarbonyl group, a lower alkoxycarbonyl group, a cinnamoyl group, and a methoxysuccinyl group. These derivatives exhibit a strong serine protease inhibiting effect, and are useful as effective components of agents for preventing and curing diseases caused by the excessive effect of serine proteases, e.g., pneumonia, pulmonary emphysema, fibroid lung, bronchitis, arthritis, pancreatitis, nephritis, shock, sepsis, and arteriosclerosis.

3. 发明授权

US5536737A Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof 失效
标题翻译：具有脯氨酰内肽酶抑制活性的化合物及其药物用途
公开(公告)号：US5536737A
公开(公告)日：1996-07-16
申请号：US446592
申请日：1995-05-24
申请人： Koji Kobayashi , Minoru Akamatsu , Shinji Yata , Hiroyuki Abe , Katsuo Toide , Motohiro Kogayu , Itsuo Uchida
发明人： Koji Kobayashi , Minoru Akamatsu , Shinji Yata , Hiroyuki Abe , Katsuo Toide , Motohiro Kogayu , Itsuo Uchida
IPC分类号： C07D207/16 , C07D277/06 , C07D417/06 , C07D403/06 , A61K31/40 , A61K31/425
CPC分类号： C07D417/06 , C07D207/16 , C07D277/06
摘要： Compounds of the formula ##STR1## wherein R is a hydrogen atom or an acyl; U is --O--, --CHR.sup.1 -- or --NR.sup.2 -- wherein R.sup.1 is a hydrogen atom or a hetero ring, and R.sup.2 is a hydrogen atom or a lower alkoxycarbonyl lower alkyl; V is --O--, --S--, --CHR.sup.3 -- or --NR.sup.4 -- wherein R.sup.3 is a hydrogen atom or a lower alkoxycarbonyl, and R.sup.4 is a hydrogen atom, a lower alkyl or an acyl; W is methyl, a hetero ring or optionally substituted phenyl; X and Y are the same or different and each is --CH.sub.2 -- or --S--; m is an integer of 0 to 6; and n is an integer of 1 to 4, and pharmaceutically acceptable salts thereof.The compounds of the present invention have specifically strong inhibitory activity against prolyl endopeptidase, and suppress decomposition and inactivation of TRH, substance P, neurotensin, vasopressin and the like. Accordingly, the compounds can be used for the prophylaxis and/or treatment of dementia and amnesia including Alzheimer's disease.
摘要翻译： PCT No.PCT / JP93 / 01687 Sec。 371日期：1995年5月24日 102（e）日期1995年5月24日PCT提交1993年11月17日PCT公布。公开号WO94 / 12474 日期：1997年11月17日。式（I）的化合物，其中R是氢原子或酰基; U是-O-，-CHR1-或-NR2-，其中R1是氢原子或杂环，R2是氢原子或低级烷氧基羰基低级烷基; V是-O - ， - S - ， - CH 3 - 或-NR 4 - ，其中R 3是氢原子或低级烷氧基羰基，R 4是氢原子，低级烷基或酰基。 W是甲基，杂环或任选取代的苯基; X和Y相同或不同，各自为-CH 2 - 或-S-; m为0〜6的整数。 n为1〜4的整数，及其药学上可接受的盐。本发明的化合物对脯氨酰内肽酶具有特异的强抑制活性，抑制TRH，物质P，神经降压素，加压素等的分解失活。因此，该化合物可用于预防和/或治疗包括阿尔茨海默病在内的痴呆和遗忘。

4. 发明授权

US5506256A Proline derivatives possessing prolyl endopeptidase-inhibitory activity 失效
标题翻译：具有脯氨酰内肽酶抑制活性的脯氨酸衍生物
公开(公告)号：US5506256A
公开(公告)日：1996-04-09
申请号：US26311
申请日：1993-02-26
申请人： Koji Kobayashi , Kazuhiko Nishii , Kunio Iwata , Itsuo Uchida
发明人： Koji Kobayashi , Kazuhiko Nishii , Kunio Iwata , Itsuo Uchida
IPC分类号： C07D207/08 , C07D207/16 , C07D405/12 , C07D417/06 , A61K31/40 , C07D403/06 , C07D403/14
CPC分类号： C07D207/08 , C07D207/16 , C07D405/12 , C07D417/06
摘要： Novel proline derivatives of the following formula (I) ##STR1## wherein each symbol is as defined in the specification, which specifically inhibit prolyl endopeptidase activity and can be used for the prevention and/or treatment of dementia and amnesia as agents which act directly on the central symptoms of dementia.
摘要翻译：下式（I）的新型脯氨酸衍生物：其中每个符号如说明书中所定义，其特异性抑制脯氨酰内肽酶活性，并且可用于（I）或（I）预防和/或治疗痴呆症和遗忘症作为直接作用于痴呆症的中枢症状的药剂。

5. 发明授权

US5118811A Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities 失效
标题翻译：氨基酸衍生物与PROLYL内含子抑制活性相关
公开(公告)号：US5118811A
公开(公告)日：1992-06-02
申请号：US613737
申请日：1990-12-12
申请人： Itsuo Uchida , Koji Kobayashi , Kazuhiko Nishii , Kunio Iwata , Shin Hara , Koretake Anami
发明人： Itsuo Uchida , Koji Kobayashi , Kazuhiko Nishii , Kunio Iwata , Shin Hara , Koretake Anami
IPC分类号： C07D207/09 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/27 , C07D277/04 , C07D277/06 , C07D417/06 , C07D417/14
CPC分类号： C07D207/27 , C07D207/09 , C07D207/16 , C07D277/04 , C07D277/06 , C07D417/06 , C07D417/14
摘要： Amino acid derivatives of the formula ##STR1## wherein: Q is W--(CH.sub.2).sub.m --(A).sub.n --CO--B-- whereinA is oxygen atom or --NH--;B is ##STR2## or --(CH.sub.2).sub.l -- wherein X is sulfur atom or --CH.sub.2 --, and l is an integer from 1 to 3;W is ##STR3## wherein Hal is halogen atom; n is an integer of 0 or 1; andm is an integer from 0 to 3;Y is sulfur atom or --CH.sub.2 --; andR is hydrogen atom, formyl group, C.sub.1-5 alkoxycarbonyl group, --C.tbd.N or ##STR4## wherein R.sup.1 is hydrogen atom, andR.sup.2 is hydroxyl group, C.sub.1-5 alkylcarboxy group, phenylcarboxy group, C.sub.1-5 alkoxy group or phenyl C.sub.1-5 alkoxy group; with the proviso that when R is hydrogen atom, formyl group or C.sub.1-5 alkoxycarbonyl group, W is ##STR5## The compounds mentioned above specifically inhibit prolyl endopeptidase activity and are useful as agents for the treatment and prevention of dementia and amnesia.

6. 发明授权

US11712853B2 Three-dimensional apparatus and method outputting quality information of fabricated three-dimensional objects 有权
公开(公告)号：US11712853B2
公开(公告)日：2023-08-01
申请号：US17219968
申请日：2021-04-01
申请人： Koji Kobayashi , Hanae Itabashi
发明人： Koji Kobayashi , Hanae Itabashi
IPC分类号： G05B19/4099 , B29C64/393
CPC分类号： B29C64/393 , G05B19/4099
摘要： A data output apparatus includes first circuitry configured to acquire predetermined information used for a three-dimensional fabrication; and second circuitry configured to output quality information for a three-dimensional object fabricated during the three-dimensional fabrication based on the predetermined information.

7. 发明授权

US09307109B2 Image processing apparatus, image processing system, and image processing method 有权
标题翻译：图像处理装置，图像处理系统和图像处理方法
公开(公告)号：US09307109B2
公开(公告)日：2016-04-05
申请号：US14316359
申请日：2014-06-26
申请人： Hirohisa Inamoto , Koji Kobayashi , Yuka Kihara
发明人： Hirohisa Inamoto , Koji Kobayashi , Yuka Kihara
IPC分类号： H04N1/04 , G06K9/20 , H04N1/00 , G06K9/18 , G06K9/00
CPC分类号： H04N1/04 , G06K9/00449 , G06K9/18 , G06K9/2063 , G06K2209/01 , H04N1/00968
摘要： An image processing apparatus is disclosed, including a marking position detection part and a first character recognition part. The marking position detection part detects a marking position with respect to a first sheet based on first image data scanned from the first sheet. The first character recognition part conducts a first character recognition with respect to an area specified based on the marking position, for second image data scanned from a second sheet.
摘要翻译：公开了一种图像处理装置，包括标记位置检测部分和第一字符识别部分。标记位置检测部分基于从第一片材扫描的第一图像数据来检测相对于第一片材的标记位置。第一字符识别部分对于从第二片材扫描的第二图像数据，相对于基于标记位置指定的区域进行第一字符识别。

8. 发明申请

US20140049788A1 IMAGE PROCESSING APPARATUS, IMAGE PROCESSING SYSTEM, AND IMAGE PROCESSING METHOD 审中-公开
标题翻译：图像处理设备，图像处理系统和图像处理方法
公开(公告)号：US20140049788A1
公开(公告)日：2014-02-20
申请号：US14065015
申请日：2013-10-28
申请人： Hirohisa INAMOTO , Koji Kobayashi , Yuka Kihara
发明人： Hirohisa INAMOTO , Koji Kobayashi , Yuka Kihara
IPC分类号： H04N1/00
CPC分类号： H04N1/04 , G06K9/00449 , G06K9/18 , G06K9/2063 , G06K2209/01 , H04N1/00968
摘要： An image processing apparatus is disclosed, including a marking position detection part and a first character recognition part. The marking position detection part detects a marking position with respect to a first sheet based on first image data scanned from the first sheet. The first character recognition part conducts a first character recognition with respect to an area specified based on the marking position, for second image data scanned from a second sheet.
摘要翻译：公开了一种图像处理装置，包括标记位置检测部分和第一字符识别部分。标记位置检测部分基于从第一片材扫描的第一图像数据来检测相对于第一片材的标记位置。第一字符识别部分对于从第二片材扫描的第二图像数据，相对于基于标记位置指定的区域进行第一字符识别。

9. 发明授权

US08508563B2 Image display apparatus and control method thereof 失效
标题翻译：图像显示装置及其控制方法
公开(公告)号：US08508563B2
公开(公告)日：2013-08-13
申请号：US13204216
申请日：2011-08-05
申请人： Koji Kobayashi
发明人： Koji Kobayashi
IPC分类号： G09G5/02
CPC分类号： G09G3/20 , G09G2320/0209
摘要： An image display apparatus has a correction unit that performs a correction process on image signals so as to suppress luminance fluctuation caused by capacitive coupling between adjacent column wirings. The correction unit includes: a correction value generation unit that determines a correction value for a pixel to be corrected on the basis of a combination of a signal value of the pixel to be corrected and signal values of adjacent pixels which are on a column wiring next to a column wiring on which the pixel to be corrected is, and on the basis of a position of the pixel to be corrected in a column direction; and a correction operation unit that corrects a signal of the pixel to be corrected using the correction value generated by the correction value generation unit.
摘要翻译：图像显示装置具有对图像信号执行校正处理的校正单元，以便抑制由相邻列布线之间的电容耦合引起的亮度波动。校正单元包括：校正值生成单元，其基于要校正的像素的信号值和下一列列线上的相邻像素的信号值的组合来确定要校正的像素的校正值到要校正的像素的列布线，并且基于要在列方向上校正的像素的位置; 以及校正操作单元，其使用由校正值生成单元生成的校正值来校正要校正的像素的信号。

10. 发明授权

US08295618B2 Image processing apparatus, image processing method, and computer program product 有权
标题翻译：图像处理装置，图像处理方法和计算机程序产品
公开(公告)号：US08295618B2
公开(公告)日：2012-10-23
申请号：US12507984
申请日：2009-07-23
申请人： Tamon Sadasue , Akio Matsubara , Hiroyuki Sakuyama , Koji Kobayashi , Junichi Hara , Taku Kodama , Maiko Takenaka
发明人： Tamon Sadasue , Akio Matsubara , Hiroyuki Sakuyama , Koji Kobayashi , Junichi Hara , Taku Kodama , Maiko Takenaka
IPC分类号： G06K9/36
CPC分类号： H04N19/86 , H04N19/42 , H04N19/44
摘要： In an image processing apparatus, an encoding unit encodes a processed image; a determining unit determines whether a reference pixel has been subjected to the image processing; and a decoding unit decodes, when the determining unit determines that the reference pixel has been subjected to the image processing, a piece of rectangular block code data of a rectangular block thereby acquiring a second decoded image. The encoding unit refers to, when the determining unit determines that the reference pixel has been subjected to the image processing, the processed image and encodes the second decoded image.
摘要翻译：在图像处理装置中，编码单元对经处理的图像进行编码; 确定单元确定参考像素是否已经经过图像处理; 并且当确定单元确定参考像素已经经过图像处理时，解码单元解码矩形块的矩形块码数据，从而获取第二解码图像。编码单元是指当确定单元确定参考像素已经经过图像处理时，处理后的图像并对第二解码图像进行编码。

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