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1. 发明授权

US08133912B2 Methyl aquocobyrinic acid derivative, alkylation composition, and method for detoxifying a harmful compound by utilizing the composition 失效
标题翻译：甲基aquocobyrinic酸衍生物，烷基化组合物和利用该组合物使有害化合物解毒的方法
公开(公告)号：US08133912B2
公开(公告)日：2012-03-13
申请号：US12309511
申请日：2007-07-24
申请人： Koichiro Nakamura , Yoshio Hisaeda , Ling Pan
发明人： Koichiro Nakamura , Yoshio Hisaeda , Ling Pan
IPC分类号： A61K31/409
CPC分类号： C07F9/70 , C07F9/72 , C07F15/06
摘要： The composition for the alkylation according to the present disclosure is characterized in that the composition contains the following cobalt complex. The method of detoxifying the harmful compound according to the present disclosure is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present disclosure.
摘要翻译：根据本公开的用于烷基化的组合物的特征在于所述组合物含有以下钴络合物。根据本公开的对有害化合物进行解毒的方法的特征在于，在组合物存在下，通过有机化合物的烷基化将含有选自砷，锑和硒中的至少一种元素的有害化合物解毒根据本公开。

2. 发明申请

US20090306362A1 METHYL AQUOCOBYRINIC ACID DERIVATIVE, ALKYLATION COMPOSITION, AND METHOD FOR DETOXIFYING A HARMFUL COMPOUND BY UTILIZING THE COMPOSITION 失效
标题翻译：甲基芳烃酸衍生物，烷基化组合物和利用组合物去除有害化合物的方法
公开(公告)号：US20090306362A1
公开(公告)日：2009-12-10
申请号：US12309511
申请日：2007-07-24
申请人： Koichiro Nakamura , Yoshio Hisaeda , Ling Pan
发明人： Koichiro Nakamura , Yoshio Hisaeda , Ling Pan
IPC分类号： C07F9/70 , C07D487/22 , C07F9/72 , C07H23/00 , B01J31/12
CPC分类号： C07F9/70 , C07F9/72 , C07F15/06
摘要： The composition for the alkylation according to the present invention is characterized in that the composition contains a cobalt complex. The method of detoxifying the harmful compound according to the present invention, is characterized in that a harmful compound containing at least one element selected from the groups comprising arsenic, antimony and selenium is detoxified by the alkylation of the harmful compound, in the presence of the composition according to the present invention.
摘要翻译：根据本发明的用于烷基化的组合物的特征在于组合物含有钴络合物。根据本发明的有害化合物的解毒方法的特征在于，在有害化合物的烷基化的情况下，含有选自砷，锑和硒中的至少一种元素的有害化合物在根据本发明的组合物。

3. 发明授权

US09115053B2 Activators of class I histone deacetlyases (HDACS) and uses thereof 有权
标题翻译： I组蛋白脱乙酰酶（HDACS）的活化剂及其用途
公开(公告)号：US09115053B2
公开(公告)日：2015-08-25
申请号：US13554670
申请日：2012-07-20
申请人： Li-Huei Tsai , Ling Pan , Stephen J. Haggarty , Debasis Patnaik
发明人： Li-Huei Tsai , Ling Pan , Stephen J. Haggarty , Debasis Patnaik
IPC分类号： C07D487/04 , C07C219/28 , C07D307/52 , C07D405/12 , C07D409/12 , C07C217/58 , C07D411/12 , C07D307/40
CPC分类号： C07D405/12 , C07C217/58 , C07C219/28 , C07D307/40 , C07D307/52 , C07D409/12 , C07D411/12 , C07D487/04
摘要： The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and kits thereof. The present invention further provides methods of using the compounds to treat or prevent neurological disorders. In one aspect, the methods include administering to a subject in need of treatment for a neurological disorder a therapeutically effective amount of DAC-001, DAC-002, DAC-003, DAC-009, or DAC-012, or a compound of Formula (A), (B), (C), or (D).
摘要翻译：本发明提供式（A），（B），（C）和（D）的药学上可接受的盐，溶剂合物，水合物，多晶型物，共晶体，互变异构体，立体异构体，同位素标记的衍生物及其前药的化合物，其药物组合物及其试剂盒。本发明还提供使用该化合物治疗或预防神经障碍的方法。在一个方面，所述方法包括向需要治疗神经障碍的受试者施用治疗有效量的DAC-001，DAC-002，DAC-003，DAC-009或DAC-012或式（A），（B），（C）或（D）。

4. 发明申请

US20220288295A1 Nasal aspirator suction bin assembly 有权
公开(公告)号：US20220288295A1
公开(公告)日：2022-09-15
申请号：US17827831
申请日：2022-05-30
申请人： Ling Pan
发明人： Ling Pan
IPC分类号： A61M1/00
摘要： A nasal aspirator suction bin assembly comprises a suction bin base, which has a first connecting end connected with a host and a second connecting end connected with a suction bin cover; after the suction bin base is connected with the suction bin cover, a cavity is formed therein; the middle of the suction bin base is provided with an outlet tube, which runs through the suction bin base and extends into the cavity; the upper end of the suction bin cover is provided with a suction tube, which runs through the suction bin cover and extends into the cavity; a bracket is arranged in the cavity, and the bracket comprises a bracket tube which can be inserted on the outlet tube and a baffle arranged at the other free end of the bracket tube, and at least one air hole is arranged on the bracket tube to keep the suction tube and the outlet tube in communication all the time; the cavity is used to store the inhaled nasal fluid. Because of the umbrella-shaped bracket, the nasal fluid cannot touch the position of the air hole during normal use and small-angle inclined use, so the nasal fluid cannot enter the host and cause pollution.

5. 发明申请

US20130096129A1 ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF 有权
标题翻译：第一类组蛋白活化剂（HDACS）的激活剂及其用途
公开(公告)号：US20130096129A1
公开(公告)日：2013-04-18
申请号：US13554670
申请日：2012-07-20
申请人： Li-Huei Tsai , Ling Pan , Stephen J. Haggarty , Debasis Patnaik
发明人： Li-Huei Tsai , Ling Pan , Stephen J. Haggarty , Debasis Patnaik
IPC分类号： C07C219/28 , C07D487/04 , C07D405/12 , C07D307/52 , C07D409/12
CPC分类号： C07D405/12 , C07C217/58 , C07C219/28 , C07D307/40 , C07D307/52 , C07D409/12 , C07D411/12 , C07D487/04
摘要： The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and kits thereof. The present invention further provides methods of using the compounds to treat or prevent neurological disorders. In one aspect, the methods include administering to a subject in need of treatment for a neurological disorder a therapeutically effective amount of DAC-001, DAC-002, DAC-003, DAC-009, or DAC-012, or a compound of Formula (A), (B), (C), or (D).
摘要翻译：本发明提供式（A），（B），（C）和（D）的药学上可接受的盐，溶剂合物，水合物，多晶型物，共晶体，互变异构体，立体异构体，同位素标记的衍生物及其前药的化合物，其药物组合物及其试剂盒。本发明还提供使用该化合物治疗或预防神经障碍的方法。在一个方面，所述方法包括向需要治疗神经障碍的受试者施用治疗有效量的DAC-001，DAC-002，DAC-003，DAC-009或DAC-012或式（A），（B），（C）或（D）。

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