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1. 发明授权

US08598541B2 Fluorescent image obtaining device, fluorescent image obtaining method and fluorescent image obtaining program 有权
标题翻译：荧光图像获取装置，荧光图像获取方法和荧光图像获取程序
公开(公告)号：US08598541B2
公开(公告)日：2013-12-03
申请号：US12868187
申请日：2010-08-25
申请人： Koichiro Kishima , Yu Hirono , Nobuhiro Hayashi , Takamichi Yamakoshi , Nobuhiro Kihara , Takashi Yamamoto , Fumiyasu Suzuki , Ryu Narusawa
发明人： Koichiro Kishima , Yu Hirono , Nobuhiro Hayashi , Takamichi Yamakoshi , Nobuhiro Kihara , Takashi Yamamoto , Fumiyasu Suzuki , Ryu Narusawa
IPC分类号： G01J1/58
CPC分类号： G01N21/6458 , G01N21/6428
摘要： A fluorescent image obtaining device includes a light source that irradiates light such that a fluorescent material marked on a target in a biological sample lies in a non-excited state and a fluorescent material marked on a control with the target lies in an excited state, and an imaging unit that takes an image including the entire biological sample.
摘要翻译：荧光图像获取装置包括照射光的光源，使得标记在生物样品中的靶上的荧光物质处于非激发状态，并且标记在靶上的荧光材料处于激发状态，并且拍摄包含整个生物样品的图像的成像单元。

2. 发明申请

US20110049389A1 FLUORESCENT IMAGE OBTAINING DEVICE, FLUORESCENT IMAGE OBTAINING METHOD AND FLUORESCENT IMAGE OBTAINING PROGRAM 有权
标题翻译：荧光图像获取装置，荧光图像获取方法和荧光图像获取程序
公开(公告)号：US20110049389A1
公开(公告)日：2011-03-03
申请号：US12868187
申请日：2010-08-25
申请人： Koichiro Kishima , Yu Hirono , Nobuhiro Hayashi , Takamichi Yamakoshi , Nobuhiro Kihara , Takashi Yamamoto , Fumiyasu Suzuki , Ryu Narusawa
发明人： Koichiro Kishima , Yu Hirono , Nobuhiro Hayashi , Takamichi Yamakoshi , Nobuhiro Kihara , Takashi Yamamoto , Fumiyasu Suzuki , Ryu Narusawa
IPC分类号： G01J1/58
CPC分类号： G01N21/6458 , G01N21/6428
摘要： A fluorescent image obtaining device includes a light source that irradiates light such that a fluorescent material marked on a target in a biological sample lies in a non-excited state and a fluorescent material marked on a control with the target lies in an excited state, and an imaging unit that takes an image including the entire biological sample.
摘要翻译：荧光图像获取装置包括照射光的光源，使得标记在生物样品中的靶上的荧光物质处于非激发状态，并且标记在靶上的荧光材料处于激发状态，并且拍摄包含整个生物样品的图像的成像单元。

3. 发明授权

US09110306B2 Tissue-slice image acquirement and display apparatus, tissue-slice image acquirement and display method, and tissue-slice image acquirement and display program 有权
标题翻译：组织切片图像获取和显示装置，组织切片图像获取和显示方法以及组织切片图像获取和显示程序
公开(公告)号：US09110306B2
公开(公告)日：2015-08-18
申请号：US12862220
申请日：2010-08-24
申请人： Nobuhiro Hayashi , Koichiro Kishima , Takashi Yamamoto , Nobuhiro Kihara , Takamichi Yamakoshi , Fumiyasu Suzuki , Ryu Narusawa
发明人： Nobuhiro Hayashi , Koichiro Kishima , Takashi Yamamoto , Nobuhiro Kihara , Takamichi Yamakoshi , Fumiyasu Suzuki , Ryu Narusawa
IPC分类号： G06K9/00 , G02B21/36 , G06K9/32 , G06T7/00 , G01N1/31 , G02B21/34
CPC分类号： G02B21/367 , G01N1/312 , G02B21/34 , G06K9/00134 , G06K9/3216 , G06K9/3233 , G06T7/11 , G06T7/174 , G06T2207/10056 , G06T2207/30024
摘要： A tissue-slice image acquirement and display apparatus includes: an entire-image acquirer that acquires a bright-field image of an entirety of a first slice of a tissue and a dark-field image of an entirety of a second slice of the tissue; a modifier that modifies a profile shape of a slice portion in the dark-field image on the basis of a profile shape of a slice portion in the bright-field image; a magnified-image acquirer that determines a range encompassing the second slice on the basis of the profile shape of the modified slice portion and that acquires, in a dark field, a magnified image of the second slice in the determined range; and a display controller that causes the bright-field image to be displayed and that causes a portion of the magnified image, the portion corresponding to a position selected in the bright-field image, to be displayed.
摘要翻译：组织切片图像获取和显示装置包括：整体图像获取器，其获取组织的第一切片的整体的亮场图像和组织的第二切片的整体的暗视场图像; 基于亮场图像中的切片部分的轮廓形状来修改暗视场图像中的切片部分的轮廓形状的修改器; 放大图像获取器，其基于修改的切片部分的轮廓形状确定包围第二切片的范围，并且在暗场中获取在所确定的范围内的第二切片的放大图像; 以及显示控制器，其使亮域图像被显示，并且使得显示放大图像的一部分，与亮域图像中选择的位置对应的部分。

4. 发明申请

US20110157349A1 STAGE CONTROL DEVICE, STAGE CONTROL METHOD, STAGE CONTROL PROGRAM, AND MICROSCOPE 审中-公开
标题翻译：阶段控制装置，阶段控制方法，阶段控制程序和显微镜
公开(公告)号：US20110157349A1
公开(公告)日：2011-06-30
申请号：US12972030
申请日：2010-12-17
申请人： Takashi Yamamoto , Koichiro Kishima , Ryu Narusawa , Yu Hirono , Fumiyasu Suzuki
发明人： Takashi Yamamoto , Koichiro Kishima , Ryu Narusawa , Yu Hirono , Fumiyasu Suzuki
IPC分类号： H04N7/18 , H04N5/225
CPC分类号： G02B21/26 , G01Q30/20 , G02B21/006 , G02B21/14 , G02B21/24 , G02B21/36 , G02B27/0075
摘要： A stage control device is provided and includes: an obtaining section obtaining a set of images as different visual points in all or a part of a sample set as a photographing object; a distance calculating section calculating a distance between each pixel of one image to be set as a reference in the set of images and a relative pixel in the other image; a tilt angle calculating section calculating a tilt angle of the sample using the distance calculated by the distance calculating section; and an adjusting section adjusting a tilt angle of a stage surface on which the sample is disposed so as to minimize a tilt within an angle of view of a photographed picture on a basis of the tilt angle of the sample.
摘要翻译：提供了一种舞台控制装置，包括：获取部，其在作为拍摄对象的样本集的全部或一部分中获得作为不同视点的一组图像; 距离计算部分，计算要在图像集合中设置为参考的一个图像的每个像素与另一图像中的相对像素之间的距离; 倾斜角计算部，使用由所述距离计算部计算出的距离来计算所述样本的倾斜角度; 以及调整部，其调整配置有所述样本的台面的倾斜角度，以便根据所述样品的倾斜角度使拍摄图像的视角内的倾斜最小化。

5. 发明申请

US20130088634A1 IMAGE ACQUISITION APPARATUS, IMAGE ACQUISITION METHOD, AND COMPUTER PROGRAM 有权
标题翻译：图像采集设备，图像采集方法和计算机程序
公开(公告)号：US20130088634A1
公开(公告)日：2013-04-11
申请号：US13617418
申请日：2012-09-14
申请人： Koichiro Kishima , Ryu Narusawa , Fumiyasu Suzuki
发明人： Koichiro Kishima , Ryu Narusawa , Fumiyasu Suzuki
IPC分类号： H04N5/232
CPC分类号： H04N5/2356 , G02B21/367
摘要： An image acquisition apparatus includes an optical system, an imaging device, a movement controller, and a multiple exposure processing unit. The optical system includes an objective lens for magnifying a portion of an imaging target. The imaging device is capable of performing all-pixel simultaneous exposure and is configured to image the portion magnified by the optical system. The movement controller is configured to move a focal point of the objective lens in a thickness direction of the portion of the imaging target. The multiple exposure processing unit is configured to perform multiple exposure of the imaging device at a plurality of positions such that, for each of ranges sectioned by positions in a direction in which the focal point is movable, an average image that covers each of the ranges is obtained.
摘要翻译：图像采集装置包括光学系统，成像装置，移动控制器和多曝光处理单元。光学系统包括用于放大成像目标的一部分的物镜。成像装置能够执行全像素同时曝光，并且被配置为对由光学系统放大的部分进行成像。移动控制器被配置为沿着成像目标的该部分的厚度方向移动物镜的焦点。多重曝光处理单元被配置为在多个位置执行成像装置的多次曝光，使得对于通过焦点可移动的方向上的位置分割的每个范围，覆盖每个范围的平均图像获得。

6. 发明授权

US09386233B2 Image acquisition apparatus, image acquisition method, and computer program 有权
标题翻译：图像采集装置，图像采集方法和计算机程序
公开(公告)号：US09386233B2
公开(公告)日：2016-07-05
申请号：US13617418
申请日：2012-09-14
申请人： Koichiro Kishima , Ryu Narusawa , Fumiyasu Suzuki
发明人： Koichiro Kishima , Ryu Narusawa , Fumiyasu Suzuki
IPC分类号： H04N5/235 , G02B21/36
CPC分类号： H04N5/2356 , G02B21/367
摘要： An image acquisition apparatus includes an optical system, an imaging device, a movement controller, and a multiple exposure processing unit. The optical system includes an objective lens for magnifying a portion of an imaging target. The imaging device is capable of performing all-pixel simultaneous exposure and is configured to image the portion magnified by the optical system. The movement controller is configured to move a focal point of the objective lens in a thickness direction of the portion of the imaging target. The multiple exposure processing unit is configured to perform multiple exposure of the imaging device at a plurality of positions such that, for each of ranges sectioned by positions in a direction in which the focal point is movable, an average image that covers each of the ranges is obtained.
摘要翻译：图像采集装置包括光学系统，成像装置，移动控制器和多曝光处理单元。光学系统包括用于放大成像目标的一部分的物镜。成像装置能够执行全像素同时曝光，并且被配置为对由光学系统放大的部分进行成像。移动控制器被配置为沿着成像目标的该部分的厚度方向移动物镜的焦点。多重曝光处理单元被配置为在多个位置执行成像装置的多次曝光，使得对于通过焦点可移动的方向上的位置分割的每个范围，覆盖每个范围的平均图像获得。

7. 发明授权

US08576483B2 Microscope and focusing method 有权
标题翻译：显微镜和聚焦法
公开(公告)号：US08576483B2
公开(公告)日：2013-11-05
申请号：US13157718
申请日：2011-06-10
申请人： Norihiro Tanabe , Takashi Yamamoto , Nobuhiro Hayashi , Ryu Narusawa
发明人： Norihiro Tanabe , Takashi Yamamoto , Nobuhiro Hayashi , Ryu Narusawa
IPC分类号： G02B21/00
CPC分类号： G02B21/0032 , G02B21/06
摘要： Disclosed herein is a microscope, including: an illumination optical system; a first image creation optical system; a second image creation optical system; an illumination-field-diaphragm focus adjustment section; and a characteristic-quantity computation block, wherein the illumination-field-diaphragm focus adjustment section adjusts the image creation position for the illumination field diaphragm on the basis of the characteristic quantity computed by the characteristic-quantity computation block.
摘要翻译：本文公开了一种显微镜，包括：照明光学系统; 第一图像创建光学系统; 第二图像创建光学系统; 照明场光阑聚焦调节部; 以及特征量计算块，其中，所述照明场光阑聚焦调整部基于由所述特征量计算块计算的特征量来调整所述照明场光阑的图像创建位置。

8. 发明申请

US20110317259A1 MICROSCOPE AND FOCUSING METHOD 有权
标题翻译：显微镜和聚焦方法
公开(公告)号：US20110317259A1
公开(公告)日：2011-12-29
申请号：US13157718
申请日：2011-06-10
申请人： Norihiro Tanabe , Takashi Yamamoto , Nobuhiro Hayashi , Ryu Narusawa
发明人： Norihiro Tanabe , Takashi Yamamoto , Nobuhiro Hayashi , Ryu Narusawa
IPC分类号： G02B21/06
CPC分类号： G02B21/0032 , G02B21/06
摘要： Disclosed herein is a microscope, including: an illumination optical system; a first image creation optical system; a second image creation optical system; an illumination-field-diaphragm focus adjustment section; and a characteristic-quantity computation block, wherein the illumination-field-diaphragm focus adjustment section adjusts the image creation position for the illumination field diaphragm on the basis of the characteristic quantity computed by the characteristic-quantity computation block.
摘要翻译：本文公开了一种显微镜，包括：照明光学系统; 第一图像创建光学系统; 第二图像创建光学系统; 照明场光阑聚焦调节部; 以及特征量计算块，其中，所述照明场光阑聚焦调整部基于由所述特征量计算块计算出的特征量来调整所述照明场光阑的图像创建位置。

9. 发明授权

US09100532B2 Image processing apparatus and method for generating an image 有权
标题翻译：用于产生图像的图像处理装置和方法
公开(公告)号：US09100532B2
公开(公告)日：2015-08-04
申请号：US13159067
申请日：2011-06-13
申请人： Ryu Narusawa , Koichiro Kishima
发明人： Ryu Narusawa , Koichiro Kishima
IPC分类号： H04N9/083 , H04N3/14 , H04N5/335 , H04N9/04 , H04N5/228 , H04N9/73
CPC分类号： H04N9/045 , H04N9/735
摘要： An image processing apparatus includes an output signal obtaining unit that is connected to a pixel group having a first pixel, a second pixel, and a third pixel and obtains a first output signal, a second output signal, and a third output signal, a spectral sensitivity determination unit that determines a first spectral sensitivity, a second spectral sensitivity, and a third spectral sensitivity, which are spectral sensitivities of the first, second, and third output signals, respectively, with respect to a wavelength of incident light entering the pixel group, an output signal amplification unit that amplifies the first, second, and third output signals based on the first, second, and third spectral sensitivities, respectively, and an image generation unit calculates pixel values of the first pixel, the second pixel, and the third pixel from the first output signal, the second output signal, and the third output signal amplified, and generates an image.
摘要翻译：一种图像处理装置，包括输出信号获取单元，其连接到具有第一像素，第二像素和第三像素的像素组，并获得第一输出信号，第二输出信号和第三输出信号，光谱灵敏度确定单元，其分别确定第一，第二和第三输出信号相对于入射到像素组的入射光的波长的光谱灵敏度，第二光谱灵敏度和第三光谱灵敏度输出信号放大单元，其分别基于第一，第二和第三光谱灵敏度放大第一，第二和第三输出信号，并且图像生成单元计算第一像素，第二像素和从第一输出信号，第二输出信号和第三输出信号放大第三像素，并产生图像。

10. 发明授权

US08942417B2 Method for detection of specimen region, apparatus for detection of specimen region, and program for detection of specimen region 有权
标题翻译：检测样本区域的方法，检测样本区域的装置以及检测区域的程序
公开(公告)号：US08942417B2
公开(公告)日：2015-01-27
申请号：US13303279
申请日：2011-11-23
申请人： Koichiro Kishima , Ryu Narusawa , Goh Matsunobu
发明人： Koichiro Kishima , Ryu Narusawa , Goh Matsunobu
IPC分类号： G06K9/00 , G02B21/36 , G02B21/16 , G06T7/00
CPC分类号： G02B21/365 , G02B21/16 , G06T7/11 , G06T7/174 , G06T2207/10056 , G06T2207/20221 , G06T2207/30024
摘要： A method for detecting the specimen region includes the first step for the first region detecting unit to detect the first region which is a region with contrast in the first image of an object for observation which is photographed under illumination with visible light, the second step for the second region detecting unit to detect the second region which is a region with contrast in the second image of the object for observation which is photographed under illumination with ultraviolet light, and the third step for the specimen region defining unit to define, based on the first and second regions mentioned above, the specimen region where there exists the specimen in the object for observation.
摘要翻译：用于检测样本区域的方法包括：第一区域检测单元检测第一区域的第一步骤，第一区域是在可见光照射下拍摄的观察对象的第一图像中的对比区域，第二步骤第二区域检测单元，用于检测在用紫外光照射下拍摄的用于观察的对象的第二图像中具有对比度的区域的第二区域，以及用于样本区域定义单元的第三步骤，基于第一和第二区域，在观察对象物中存在标本的样本区域。

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