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    • 1. 发明申请
    • AGENT FOR TREATING ATRIAL FIBRILLATION
    • 用于治疗ATRIAL FIBRILLATION的代理
    • US20090247572A1
    • 2009-10-01
    • US12064148
    • 2006-08-22
    • Koichi WadaNoriyuki MasudaKeiichi Taniguchi
    • Koichi WadaNoriyuki MasudaKeiichi Taniguchi
    • A61K31/4725A61P9/00
    • C07D401/06A61K31/4725
    • It is intended to provide an agent for treating atrial fibrillation, comprising an If current inhibitor as an active ingredient. In the present invention, the means for resolution comprises an agent for treating atrial fibrillation, comprising an If current inhibitor as an active ingredient. In particular, it comprises an agent for treating atrial fibrillation comprising (−)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide monophosphate as an active ingredient. The active ingredient according to the present invention has more preferred properties for use as an agent for treating atrial fibrillation compared to Verapamil (a Ca antagonist) and Atenolol (a β-blocker) which have been conventionally used as the agents for treating atrial fibrillation.
    • 本发明提供一种治疗心房颤动的药剂,其包含If电流抑制剂作为活性成分。 在本发明中,解决方法包括用于治疗心房颤动的药剂,其包含If电流抑制剂作为活性成分。 特别地,其包含用于治疗房颤的药剂,其包含( - ) - N- {2 - [(R)-3-(6,7-二甲氧基-1,2,3,4-四氢异喹啉-2-羰基)哌啶子基 ]乙基} -4-氟苯甲酰胺单磷酸酯作为活性成分。 与通常用作治疗心房颤动的药物的维拉帕米(Ca拮抗剂)和阿替洛尔(β-阻断剂)相比,本发明的活性成分具有更优选的用作治疗心房颤动的药剂的性质。
    • 4. 发明申请
    • RUBBER COMPOSITION AND CROSSLINKED OBJECT
    • 橡胶组合物和交联物体
    • US20100152368A1
    • 2010-06-17
    • US12067821
    • 2006-09-21
    • Yoshio HirayamaKei HirataKoichi WadaKenji Shachi
    • Yoshio HirayamaKei HirataKoichi WadaKenji Shachi
    • C08L47/00
    • C08L21/00C08K3/36C08K5/548C08L9/00C08L13/00C08L15/00C08L2666/02
    • The present invention relates to a rubber composition comprising 100 parts by mass of a solid diene-based rubber (1), 5 to 150 parts by mass of silica (2), 0.1 to 50 parts by mass of a liquid diene-based rubber (3) which is modified with an unsaturated carboxylic acid and/or derivative thereof and has a number average molecular weight of 5000 to 100000, and further 0,1 to 50 parts by mass of an unmodified liquid diene-based rubber (4) having a number average molecular weight of 5000 to 100000 with respect to 100 parts by mass of the solid diene-based rubber (1) and/or 1.5 to 14.0 parts by mass of water (5) with respect to 100 parts by mass of silica (2), and a crosslinked product obtained by crosslinking the rubber composition.A rubber composition obtained by the present invention is improved in processability when silica is added and mixed with a diene-based rubber and is excellent in dynamic properties after crosslinking.
    • 本发明涉及一种橡胶组合物,其包含100质量份固体二烯系橡胶(1),5〜150质量份二氧化硅(2),0.1〜50质量份液态二烯系橡胶( 3),其用不饱和羧酸和/或其衍生物改性,数均分子量为5000〜100000,进一步为0.1〜50质量份未改性的液体二烯类橡胶(4),其具有 相对于100质量份的固体二烯系橡胶(1),数均分子量为5000〜100000,和/或相对于100质量份的二氧化硅(2)为1.5〜14.0质量份的水(5) )和通过使橡胶组合物交联而得到的交联物。 通过本发明获得的橡胶组合物在加入二氧化硅并与二烯系橡胶混合时的加工性提高,交联后的动态性能优异。
    • 7. 发明申请
    • Filter device
    • 过滤装置
    • US20080117000A1
    • 2008-05-22
    • US11984639
    • 2007-11-20
    • Koichi Wada
    • Koichi Wada
    • H03H9/64H03H9/54
    • H03H9/009
    • A lattice-type filter circuit includes first and second balanced signal terminals; first and second balanced signal terminals; a first resonator connected to a series arm between the first balanced signal terminal on the input side and the first balanced signal terminal on the output side; a second resonator connected to a series arm between the second balanced signal terminal on the input side and the second balanced signal terminal on the output side; a first resonant circuit including impedance elements, being connected to a lattice arm between the first balanced signal terminal on the output side and the second balanced signal terminal on the input side; and a second resonant circuit including impedance elements, being connected to a lattice arm between the second balanced signal terminal on the output side and the first balanced signal terminal on the input side.
    • 格子型滤波电路包括第一和第二平衡信号端子; 第一和第二平衡信号端子; 连接到输入侧的第一平衡信号端子与输出侧的第一平衡信号端子之间的串联臂的第一谐振器; 连接到输入侧的第二平衡信号端子与输出侧的第二平衡信号端子之间的串联臂的第二谐振器; 包括阻抗元件的第一谐振电路,连接到输出侧的第一平衡信号端子与输入侧的第二平衡信号端子之间的格子臂; 以及包括阻抗元件的第二谐振电路,连接到输出侧的第二平衡信号端子与输入侧的第一平衡信号端子之间的格子臂。