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1. 发明授权

US07939536B2 Pyrimidinylisoxazole derivatives 有权
标题翻译：嘧啶基异恶唑衍生物
公开(公告)号：US07939536B2
公开(公告)日：2011-05-10
申请号：US11794180
申请日：2005-12-27
申请人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
发明人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
IPC分类号： C07D413/04 , A61K31/506
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention discloses isoxazole derivatives represented by a formula, in which R1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, R2 stands for substituted or unsubstituted aryl and the like, R3 stands for hydrogen or lower alkyl, R4 stands for substituted or unsubstituted phenyl and the like, and Y stands for —CH2—, —CO—, —CH(CH3)—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action.
摘要翻译：本发明公开了由式表示的异恶唑衍生物，其中R1代表氢，低级烷基，氨基，卤素，低级烷氧基等，R2代表取代或未取代的芳基等，R3代表氢或低级烷基，R4代表代表取代或未取代的苯基等，Y代表具有优异p38MAP激酶的-CH 2 - ， - CO - ， - CH（CH 3） - ， - O-，-NH-等或其药学上可接受的盐抑制作用。

2. 发明申请

US20090192164A1 Treating agent of inflammatory bowel disease 审中-公开
标题翻译：炎症性肠病的治疗剂
公开(公告)号：US20090192164A1
公开(公告)日：2009-07-30
申请号：US12308750
申请日：2007-06-26
申请人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
发明人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
IPC分类号： A61K31/4439 , C07D401/04 , C07D401/14 , C07D413/04 , C07D403/04 , A61K31/444 , A61K31/506 , A61K31/53 , A61P1/00
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/506 , C07D401/14 , C07D413/04
摘要： The invention discloses treating agents of inflammatory bowel disease, which contain p38MAPkinase inhibitor having properties of antedrug as the active ingredient.
摘要翻译：本发明公开了含有作为活性成分的具有特性的p38MAP激酶抑制剂的炎症性肠病治疗剂。

3. 发明授权

US08207203B2 Pyridylisoxazole derivatives 有权
标题翻译：吡啶异恶唑衍生物
公开(公告)号：US08207203B2
公开(公告)日：2012-06-26
申请号：US12308875
申请日：2007-06-26
申请人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
发明人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
IPC分类号： A61K31/4439 , C07D413/04
CPC分类号： C07D413/04 , C07D413/14
摘要： This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.
摘要翻译：本发明提供由下式（I）表示的异恶唑衍生物，其中R 1和R 2各自代表氢，低级烷基，氨基等; R3代表取代或未取代的芳基或杂芳基; R4代表氢或低级烷基; R5代表取代或未取代的苯基，呋喃基等; Y表示具有优异的p38MAP激酶抑制作用的副产物-CH 2 - ， - CO - ， - O-，-NH-等或其药学上可接受的盐，可用于治疗慢性类风湿性关节炎，溃疡性结肠炎等。

4. 发明申请

US20090306145A1 Pyridylisoxazole Derivatives 有权
标题翻译：吡啶基异恶唑衍生物
公开(公告)号：US20090306145A1
公开(公告)日：2009-12-10
申请号：US12308875
申请日：2007-06-26
申请人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
发明人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Jun-ya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
IPC分类号： A61K31/4439 , C07D413/04 , A61P35/00
CPC分类号： C07D413/04 , C07D413/14
摘要： This invention offers isoxazole derivatives represented by the following formula (I) in which R1 and R2 each stands for hydrogen, lower alkyl, amino and the like; R3 stands for substituted or unsubstituted aryl or hetero aryl; R4 stands for hydrogen or lower alkyl; R5 stands for substituted or unsubstituted phenyl, furyl and the like; and Y stands for —CH2—, —CO—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof which exhibit excellent p38MAPkinase-inhibiting action with reduced side-effects, and are useful for treating such diseases as chronic rheumatoid arthritis, ulcerative colitis and the like.
摘要翻译：本发明提供由下式（I）表示的异恶唑衍生物，其中R 1和R 2各自代表氢，低级烷基，氨基等; R3代表取代或未取代的芳基或杂芳基; R4代表氢或低级烷基; R5代表取代或未取代的苯基，呋喃基等; Y表示具有优异的p38MAP激酶抑制作用的副产物-CH 2 - ， - CO - ， - O-，-NH-等或其药学上可接受的盐，可用于治疗慢性类风湿性关节炎，溃疡性结肠炎等。

5. 发明申请

US20080114003A1 Pyrimidinylisoxazole Derivatives 有权
标题翻译：嘧啶并异恶唑衍生物
公开(公告)号：US20080114003A1
公开(公告)日：2008-05-15
申请号：US11794180
申请日：2005-12-27
申请人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Junya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
发明人： Koichi Hasumi , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Junya Kato , Jun Sato , Hiroyuki Suzuki , Hajime Asano , Mami Okada , Yasuhiro Matsumoto , Kazuhiko Shirota
IPC分类号： A61K31/506 , C07D413/04 , A61P29/00 , A61P11/00 , A61P35/00 , A61P9/00 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention discloses isoxazole derivatives represented by a formula, in which R1 stands for hydrogen, lower alkyl, amino, halogen, lower alkoxy and the like, R2 stands for substituted or unsubstituted aryl and the like, R3 stands for hydrogen or lower alkyl, R4 stands for substituted or unsubstituted phenyl and the like, and Y stands for —CH2—, —CO—, —CH(CH3)—, —O—, —NH— and the like, or pharmaceutically acceptable salts thereof, which have excellent p38MAPkinase inhibitory action.
摘要翻译：本发明公开了由式表示的异恶唑衍生物，其中R 1代表氢，低级烷基，氨基，卤素，低级烷氧基等，R 2代表取代的或未取代的芳基等，R 3代表氢或低级烷基，R 4代表取代或未取代的苯基等，Y代表-CH

6. 发明授权

US07087624B2 Substituted pyrazole compounds 有权
标题翻译：取代的吡唑化合物
公开(公告)号：US07087624B2
公开(公告)日：2006-08-08
申请号：US10693461
申请日：2003-10-27
申请人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
发明人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
IPC分类号： A61K31/44 , C07D40/00
CPC分类号： C07D231/12 , A61K31/4439 , A61K31/4709 , A61K31/4725 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , Y02A50/411
摘要： Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor α-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases
摘要翻译：公开了由式（I）表示的取代的吡唑化合物或其盐，其中R 1是-CH（OH）-CH（R 4） - （A） -CH（R 4） - （A）n -Y， - CO（CH 2） -B 1 -I 1等（其中A是低级亚烷基; Y是可以被卤素取代的芳基等）; R 4， SUP>是氢原子或低级烷基; B 1是-CH（R 4） - 或-N（R 4） - ;和n为0或1）; R 2是氢原子，可以被羟基等取代的低级烷基或芳烷基; R 3是可以被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用，因此可用于预防或治疗肿瘤坏死因子α相关疾病，白细胞介素1相关疾病，白细胞介素6相关疾病或环氧合酶II相关疾病

7. 发明授权

US06667325B1 Substituted pyrazole compounds 失效
标题翻译：取代的吡唑化合物
公开(公告)号：US06667325B1
公开(公告)日：2003-12-23
申请号：US09980579
申请日：2001-12-03
申请人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
发明人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
IPC分类号： C07D40104
CPC分类号： C07D231/12 , A61K31/4439 , A61K31/4709 , A61K31/4725 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , Y02A50/411
摘要： Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)—(A)n—Y, —CH2—CH(R4)—(A)n—Y, —CO—B1—A—Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.
摘要翻译：公开了由式（I）表示的取代的吡唑化合物或其盐，其中R 1是-CH（OH）-CH（R 4） - （A）n Y，-CH 2 -CH（R 4）） - （A）nY，-CO-B 1 -AY等（其中A是低级亚烷基; Y是可以被卤素取代的芳基等; R 4 >是氢原子或低级烷基; B 1是-CH（R 4） - 或-N（R 4） - ，n是0或1）; R 2是氢原子，可以被羟基等取代的低级烷基或芳烷基; R 3是可被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用，因此可用于预防或治疗肿瘤坏死因子α相关疾病，白细胞介素1相关疾病，白介素6相关疾病或环加氧酶II相关疾病。

8. 发明授权

US06511997B1 Aminopyrazole derivatives 有权
标题翻译：氨基吡唑衍生物
公开(公告)号：US06511997B1
公开(公告)日：2003-01-28
申请号：US09869051
申请日：2001-06-22
申请人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
发明人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
IPC分类号： A61K314409
CPC分类号： C07D401/04 , C07D405/14
摘要： Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1 and X2 are each a hydrogen atom or a halogen atom, or X1 and X2 may be united together to form a lower alkylenedioxy group, Q is a pyridyl group or a quinolyl group, R1 is a hydrogen atom, a substituted or unsubstituted lower alkyl or aryl group, R2 is a hydrogen atom, a lower alkyl group, or an aralkyl group, and R3 represents a hydrogen atom, an organic sulfonyl group, or —C(═Y)—R4 in which R4 is a hydrogen atom or an organic residue and Y is an oxygen or sulfur atom, provided that, when R3 is a hydrogen atom, R1 is a group other than a hydrogen atom and R2 is a hydrogen atom. These amimopyrazole derivatives or their salts have excellent p38MAP kinase inhibiting activities and are hence useful in the prevention or treatment of diseases associated with tumor necrosis sis factor &agr;, interleukin 1, interleukin 6 or cyclooxygenase II.
摘要翻译：式（I）表示的氨基吡唑衍生物或其盐，其中X 1和X 2各自为氢原子或卤素原子，或者X 1和X 2可以一起结合形成低级亚烷基二氧基，Q是吡啶基或喹啉基基团，R 1是氢原子，取代或未取代的低级烷基或芳基，R 2是氢原子，低级烷基或芳烷基，R 3表示氢原子，有机磺酰基或-C（ = Y）-R4，其中R4为氢原子或有机残基，Y为氧或硫原子，条件是当R3为氢原子时，R1为氢原子以外的基团，R2为氢原子。这些酰胺吡唑衍生物或其盐具有优异的p38MAP激酶抑制活性，因此可用于预防或治疗与肿瘤坏死因子α，白细胞介素1，白介素6或环加氧酶II相关的疾病。

9. 发明授权

US5067070A Word processor with operator inputted character string substitution 失效
标题翻译：具有操作员字符字符替换的字处理器
公开(公告)号：US5067070A
公开(公告)日：1991-11-19
申请号：US577816
申请日：1990-09-04
申请人： Kouji Miyao , Hajime Asano
发明人： Kouji Miyao , Hajime Asano
IPC分类号： G06F17/24 , G06F17/27
CPC分类号： G06F17/24 , G06F17/2795
摘要： An operator can use a word processor for editing by substituting character strings. The operator can use a designating part of the word processor to identify what portion of a text is to be edited. The portion of the text to be edited is a designated character string. A plurality of substitute strings can be stored in a memory. The substitute character strings can replace the designated character strings. In addition, the designated character string can be placed in a memory to be used later as a substitutive character string.
摘要翻译：操作员可以使用字处理程序进行编辑，替换字符串。操作者可以使用文字处理器的指定部分来识别要编辑文本的哪一部分。要编辑的文本部分是指定的字符串。多个替代串可以存储在存储器中。替代字符串可以替换指定的字符串。此外，指定的字符串可以放置在随后用作替代字符串的存储器中。

10. 发明授权

US4884192A Information processor capable of data transfer among plural digital data processing units by using an active transmission line having locally controlled storage of data 失效
标题翻译：能够通过具有本地控制的数据存储的有源传输线在多个数字数据处理单元之间进行数据传送的信息处理器
公开(公告)号：US4884192A
公开(公告)日：1989-11-28
申请号：US134601
申请日：1987-12-14
申请人： Hiroaki Terada , Katsuhiko Asada , Hiroaki Nishikawa , Souichi Miyata , Hajime Asano , Masahisa Shimizu , Kenji Shima , Shinji Komori
发明人： Hiroaki Terada , Katsuhiko Asada , Hiroaki Nishikawa , Souichi Miyata , Hajime Asano , Masahisa Shimizu , Kenji Shima , Shinji Komori
IPC分类号： G06F15/80
CPC分类号： G06F15/8015 , G06F15/8007
摘要： In an information processor, input interface units (161, 162) are connected to one ring data bus (191) through jointing units (201, 202) and data processing units (181 and 185) are connected to the ring data bus (191) through jointing units (203 through 206) and branching units (221 through 224). Data processing units (183 through 187) are connected to the other ring data bus (192) through jointing units (207 through 210) and branching units (225 through 228) and output interface units (171, 172) are connected to the other ring data bus (192) through branching units (229, 230). The ring data buses (191, 192) propagate the respective in data through the input interface units (161, 162) while storing such data, and processing the data in any of the data processing units to provide outputs to any of the output interface units (171, 172). Thus, since the data is transmitted through the ring data buses ( 191, 192) while being held in the data buses, there is no necessity to provide a memory for temporarily storing the data in each data processing unit. In addition, for a large scale integration of a system, it is easy to integrate each unit in a high density.
摘要翻译：在信息处理器中，输入接口单元（161,162）通过连接单元（201,202）连接到一个环形数据总线（191），数据处理单元（181和185）连接到环形数据总线（191）通过连接单元（203至206）和分支单元（221至224）。数据处理单元（183至187）通过连接单元（207至210）和分支单元（225至228）连接到另一个环形数据总线（192），并且输出接口单元（171,172）连接到另一个环数据总线（192）通过分支单元（229,230）。环形数据总线（191,192）在存储这些数据的同时通过输入接口单元（161,162）传播相应的数据，并且处理数据在任何数据处理单元中以向任何输出接口单元（171,172）。因此，由于数据在被保持在数据总线中时通过环形数据总线（191,192）发送，因此不需要在每个数据处理单元中提供临时存储数据的存储器。另外，对于系统的大规模集成，可以容易地以高密度集成每个单元。

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