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1. 发明授权

US09040693B2 Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof 有权
标题翻译：稠合杂环衍生物，含有它们的药物组合物及其医药用途
公开(公告)号：US09040693B2
公开(公告)日：2015-05-26
申请号：US12089674
申请日：2006-10-17
申请人： Kohsuke Ohno , Takashi Miyagi , Tomonaga Ozawa , Nobuhiko Fushimi
发明人： Kohsuke Ohno , Takashi Miyagi , Tomonaga Ozawa , Nobuhiko Fushimi
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like ; ring B represents aryl or heteroaryl; RB represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E1 and E2 represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO2—Y, —O—(alkylene)—Y, —O—Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.
摘要翻译：本发明提供了可用作预防或治疗性激素依赖性疾病等的药剂的化合物。也就是说，本发明提供由以下通式（I）表示的稠合杂环衍生物，含有该杂环衍生物的药物组合物，其医药用途等。在式（I）中，环A表示5元环状不饱和烃或5元杂芳基; 烷基，烯基，炔基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基等; 环B表示芳基或杂芳基; RB代表卤素，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基等; E1和E2表示氧原子等; U表示单键或亚烷基; X表示Y表示的基团，-SO 2 -Y，-O-（亚烷基）-Y，-O-Z，Y表示Z，氨基等; Z表示环烷基，杂环烷基，芳基，杂芳基等; 或类似物。

2. 发明申请

US20090325900A1 FUSED HETEROCYCLIC DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL USE THEREOF 有权
标题翻译：熔化的杂环衍生物，含有它们的药物组合物及其药物用途
公开(公告)号：US20090325900A1
公开(公告)日：2009-12-31
申请号：US12089674
申请日：2006-10-17
申请人： Kohsuke Ohno , Takashi Miyagi , Tomonaga Ozawa , Nobuhiko Fushimi
发明人： Kohsuke Ohno , Takashi Miyagi , Tomonaga Ozawa , Nobuhiko Fushimi
IPC分类号： A61K31/695 , C07D215/58 , C07D211/72 , C07D311/02 , A61K31/47 , A61K31/44 , C07D223/16 , A61K31/55 , A61P5/24
CPC分类号： C07D495/04
摘要： The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; ring B represents aryl or heteroaryl; RB represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like; E1 and E2 represent an oxygen atom or the like; U represents a single bond or alkylene; X represents a group represented by Y, —SO2—Y, —O— (alkylene)-Y, —O-Z in which Y represents Z, amino or the like; Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like; or the like.
摘要翻译：本发明提供了可用作预防或治疗性激素依赖性疾病等的药剂的化合物。也就是说，本发明提供由以下通式（I）表示的稠合杂环衍生物，含有该杂环衍生物的药物组合物，其医药用途等。在式（I）中，环A表示5元环状不饱和烃或5元杂芳基; 烷基，烯基，炔基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基等; 环B表示芳基或杂芳基; RB代表卤素，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基等; E1和E2表示氧原子等; U表示单键或亚烷基; X表示Y表示的基团，-SO 2 -Y，-O-（亚烷基）-Y，-O-Z，Y表示Z，氨基等; Z表示环烷基，杂环烷基，芳基，杂芳基等; 或类似物。

3. 发明申请

US20100130514A1 FUSED HETEROCYCLIC DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE DERIVATIVE, AND USE OF THE COMPOSITION FOR MEDICAL PURPOSES 审中-公开
标题翻译：融合的杂环衍生物，包含衍生物的药物组合物，以及用于医疗用途的组合物的用途
公开(公告)号：US20100130514A1
公开(公告)日：2010-05-27
申请号：US12596301
申请日：2008-04-16
申请人： Takashi Miyagi , Shigeru Yonekubo , Kohsuke Ohno , Mikie Kambara , Nobuhiko Fushimi
发明人： Takashi Miyagi , Shigeru Yonekubo , Kohsuke Ohno , Mikie Kambara , Nobuhiko Fushimi
IPC分类号： A61K31/519 , C07D495/04
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides fused heterocyclic derivatives represented by the following general formula (I), pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A is 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl; RA is halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; ring B is aryl or heteroaryl; RB is halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.; E1 and E2 are oxygen atom, etc.; U is single bond or alkylene; X is a group represented by Y, —O-(alkylene)-Y or —O—Z (in which Y is Z or amino substituted by Z, etc.; Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.
摘要翻译：本发明提供了可用作预防或治疗性激素依赖性疾病等的试剂的化合物。也就是说，本发明提供由以下通式（I）表示的稠合杂环衍生物，含有它们的药物组合物，其药用用途等。在式（I）中，环A是5元环状不饱和烃或5元杂芳基; RA是卤素，烷基，烯基，炔基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基等; 环B是芳基或杂芳基; RB是卤素，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基等; E1和E2是氧原子等; U是单键或亚烷基; X是由Y，-O-（亚烷基）-Y或-O-Z（其中Y是Z或被Z取代的氨基等）表示的基团; Z是环烷基，杂环烷基，芳基，杂芳基等。

4. 发明申请

US20100112090A1 NITROGENATED FUSED RING DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE OF THE SAME FOR MEDICAL PURPOSES 有权
标题翻译：氮化衍生物衍生物，包含其的药物组合物，以及其用于医疗用途的药物组合物
公开(公告)号：US20100112090A1
公开(公告)日：2010-05-06
申请号：US12596313
申请日：2008-04-16
申请人： Shigeru Yonekubo , Takashi Miyagi , Kohsuke Ohno , Mikie Kambara , Nobuhiko Fushimi
发明人： Shigeru Yonekubo , Takashi Miyagi , Kohsuke Ohno , Mikie Kambara , Nobuhiko Fushimi
IPC分类号： A61K31/437 , C07D471/04 , C07D473/28 , C07D473/00 , C07D495/04 , C07D473/04 , A61K31/522 , A61K31/52 , A61K38/09 , A61K31/664 , A61K31/704 , A61K38/14 , A61K31/56 , A61K31/496 , A61P13/08 , A61P15/18 , A61P35/00 , A61P15/00 , A61P5/00 , A61P37/00 , A61P25/28 , A61P15/08 , A61K31/55 , A61K31/4985 , A61K33/24
CPC分类号： C07D471/04 , A61K31/437 , A61K31/52 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/36 , C07D473/40 , C07D487/04
摘要： [Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like.[Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, —OW1, —SW1, —COW2, —NW3W4, —SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, —CO—Y, —SO2—Y, —S-(alkylene)-Y, —O-(alkylene)-Y, —SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.
摘要翻译： [目的]本发明提供可用作预防或治疗性激素依赖性疾病等的药剂的化合物。 [溶液]本发明提供了具有GnRH拮抗活性的下述通式（I）表示的含氮稠环衍生物，前药，盐，含有它们的药物组合物，其药用用途等。在式（I）中，环A和B独立地为芳基或杂芳基; RA和RB独立地是卤素，氰基，烷基，烷基磺酰基，-OW1，-SW1，-COW2，-NW3W4，-SO2NW3W4，芳基等; RC是H或烷基; E是氧原子等; U是单键或亚烷基; 并且X是Y，-CO-Y，-SO 2 -Y，-S-（亚烷基）-Y，-O-（亚烷基）-Y，-SO 2 - （亚烷基）-Y等; Y是Z或氨基等; Z是环烷基，杂环烷基，芳基，杂芳基等。

5. 发明授权

US08217069B2 Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes 有权
标题翻译：氮化稠环衍生物，包含其的药物组合物，以及其用于医疗目的
公开(公告)号：US08217069B2
公开(公告)日：2012-07-10
申请号：US12596313
申请日：2008-04-16
申请人： Shigeru Yonekubo , Takashi Miyagi , Kohsuke Ohno , Mikie Kambara , Nobuhiko Fushimi
发明人： Shigeru Yonekubo , Takashi Miyagi , Kohsuke Ohno , Mikie Kambara , Nobuhiko Fushimi
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/52 , C07D473/00 , C07D473/04 , C07D473/30 , C07D473/36 , C07D473/40 , C07D487/04
摘要： [Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like.[Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; RA and RB are independently halogen, cyano, alkyl, alkylsulfonyl, —OW1, —SW1, —COW2, —NW3W4, —SO2NW3W4, aryl, etc.; RC is H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, —CO—Y, —SO2—Y, —S-(alkylene)-Y, —O-(alkylene)-Y, —SO2-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.
摘要翻译： [目的]本发明提供可用作预防或治疗性激素依赖性疾病等的药剂的化合物。 [溶液]本发明提供了具有GnRH拮抗活性的下述通式（I）表示的含氮稠环衍生物，前药，盐，含有它们的药物组合物，其药用用途等。在式（I）中，环A和B独立地为芳基或杂芳基; RA和RB独立地是卤素，氰基，烷基，烷基磺酰基，-OW1，-SW1，-COW2，-NW3W4，-SO2NW3W4，芳基等; RC是H或烷基; E是氧原子等; U是单键或亚烷基; 并且X是Y，-CO-Y，-SO 2 -Y，-S-（亚烷基）-Y，-O-（亚烷基）-Y，-SO 2 - （亚烷基）-Y等; Y是Z或氨基等; Z是环烷基，杂环烷基，芳基，杂芳基等。

6. 发明授权

US09211579B2 Method of producing L-shaped product 有权
标题翻译：生产L型产品的方法
公开(公告)号：US09211579B2
公开(公告)日：2015-12-15
申请号：US13989095
申请日：2011-11-24
申请人： Yasuharu Tanaka , Takashi Miyagi , Misao Ogawa , Shigeru Uchiyama , Takatoshi Sasahara
发明人： Yasuharu Tanaka , Takashi Miyagi , Misao Ogawa , Shigeru Uchiyama , Takatoshi Sasahara
IPC分类号： B21D22/02 , B21D22/26 , B21D53/88
CPC分类号： B21D22/02 , B21D22/26 , B21D53/88
摘要： A method of producing an L-shaped product (10) which includes an L-shaped flat top wall (12), an inside wall (14) extending and connected along an inside edge (12c) of the top wall, and an outside wall (16) extending and connected along an outside edge (12d) of the top wall, each of the inside and outside walls being terminated by flange (18, 20) substantially parallel to the top wall, is disclosed. The method comprises the steps of: providing sheet metal material; providing a drawing die assembly; and stamping the sheet metal material by the drawing die assembly to produce an intermediate product. The method further comprises the steps of: providing a bending die assembly; and stamping the intermediate product by the bending die assembly to produce an L-shaped product completed.
摘要翻译：一种制造L形产品（10）的方法，其包括L形平顶壁（12），沿着顶壁的内边缘（12c）延伸并连接的内壁（14），以及外壁（16）沿着顶壁的外边缘（12d）延伸和连接，每个内壁和外壁由基本上平行于顶壁的凸缘（18,20）端接。该方法包括以下步骤：提供金属板材; 提供拉丝模组件; 并通过拉丝模组件冲压该金属板材以产生中间产品。该方法还包括以下步骤：提供弯曲模具组件; 并通过弯曲模具组件冲压中间产品以产生完成的L形产品。

7. 发明授权

US08589132B2 Method, device, program, and recording medium of analyzing cause of springback 有权
标题翻译：分析回弹原因的方法，设备，程序和记录介质
公开(公告)号：US08589132B2
公开(公告)日：2013-11-19
申请号：US13132637
申请日：2009-06-24
申请人： Takashi Miyagi , Yasuharu Tanaka , Misao Ogawa
发明人： Takashi Miyagi , Yasuharu Tanaka , Misao Ogawa
IPC分类号： G06F7/48
CPC分类号： G06F17/5018 , G06F2217/16 , Y02T10/82
摘要： A method of analyzing a cause of springback of the invention includes: performing a forming analysis to calculate forming data of a formed product; decomposing a component into an in-plane stress component and a bending moment component; generating a before-calculation individual decomposition forming data; performing a calculation to generate an after-calculation individual decomposition forming data; analyzing a first springback configuration and a second springback configuration; obtaining a degree of influence of a stress in each of the areas with respect to springback deformation; and displaying the degree of influence with respect to the springback deformation.
摘要翻译：分析本发明回弹原因的方法包括：进行成形分析以计算成形品的成形数据; 将部件分解成面内应力分量和弯矩分量; 生成计算前个体分解形成数据; 执行计算以生成计算后的个体分解形成数据; 分析第一回弹配置和第二回弹配置; 获得相对于回弹变形的各个区域的应力的影响程度; 并显示相对于回弹变形的影响程度。

8. 发明申请

US20100149242A1 IMAGE FORMING APPARATUS 有权
标题翻译：图像形成装置
公开(公告)号：US20100149242A1
公开(公告)日：2010-06-17
申请号：US12635939
申请日：2009-12-11
申请人： Wataru TAKAHASHI , Takashi Miyagi , Naoki Okazaki , Yoshinari Suzuki
发明人： Wataru TAKAHASHI , Takashi Miyagi , Naoki Okazaki , Yoshinari Suzuki
IPC分类号： B41J29/38
CPC分类号： B41J29/393 , B41J2/16585 , B41J11/007
摘要： An image forming apparatus includes an ink discharge unit including nozzles to discharge ink and to form an image on a recording medium; a conveyer belt to convey the recording medium so that the recording medium passes through an area facing the ink discharge unit, the conveyor belt including blank discharge holes to let the ink for a blank discharge through; a control unit to control an ink discharge operation of the ink discharge unit; a blank discharge receiver to receive the ink for the blank discharge, provided at a position facing the ink discharge unit across the conveyor belt; and a belt position detection unit to detect a position in a direction perpendicular to a belt moving direction of the conveyor belt, wherein the control unit controls the blank discharge operation of the ink discharge unit based on a detection result detected by the belt position detection unit.
摘要翻译：图像形成装置包括：排墨单元，其包括用于排出墨水并在记录介质上形成图像的喷嘴; 输送带，用于输送记录介质，使得记录介质通过面向排墨单元的区域，该输送带包括用于使墨水排出的墨水的空白排出孔; 控制单元，用于控制排墨单元的排墨操作; 一个空白放电接收器，用于接收用于空白放电的墨水，设置在面向喷墨单元的位置穿过传送带; 以及带位置检测单元，用于检测与传送带的带移动方向垂直的方向上的位置，其中，所述控制单元基于由所述带位置检测单元检测到的检测结果来控制所述排墨单元的空白排出操作。

9. 发明授权

US07532364B2 Image processing device, image output apparatus, and storage medium storing image processing program 有权
标题翻译：图像处理装置，图像输出装置和存储图像处理程序的存储介质
公开(公告)号：US07532364B2
公开(公告)日：2009-05-12
申请号：US11076002
申请日：2005-03-09
申请人： Takashi Miyagi , Naosuke Ino
发明人： Takashi Miyagi , Naosuke Ino
IPC分类号： G06K15/00 , H04N1/405 , H04N1/40
CPC分类号： H04N1/405 , H04N1/4052
摘要： An image processing device converts multi-gradation image data to low-gradation image data for outputting an image of a dot pattern that is formed by a high-density first part formed in a band shape by dots connected in a predetermined direction and a low-density second part formed by randomly arranged dots.
摘要翻译：图像处理装置将多灰度级图像数据转换为低灰度级图像数据，以输出通过以预定方向连接的点形成的带状形状的高密度第一部分形成的点图案的图像，密度第二部分由随机排列的点形成。

10. 发明申请

US20060050318A1 Image processing device, image output apparatus, and storage medium storing image processing program 有权
公开(公告)号：US20060050318A1
公开(公告)日：2006-03-09
申请号：US11076002
申请日：2005-03-09
申请人： Takashi Miyagi , Naosuke Ino
发明人： Takashi Miyagi , Naosuke Ino
IPC分类号： H04N1/405
CPC分类号： H04N1/405 , H04N1/4052
摘要： An image processing device converts multi-gradation image data to low-gradation image data for outputting an image of a dot pattern that is formed by a high-density first part formed in a band shape by dots connected in a predetermined direction and a low-density second part formed by randomly arranged dots.

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