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1. 发明授权

US5324855A Preparation of N-acylaminomethylphosphonic acid 失效
标题翻译： N-酰氨基甲基膦酸的制备
公开(公告)号：US5324855A
公开(公告)日：1994-06-28
申请号：US961363
申请日：1992-10-15
申请人： Kohei Morikawa , Toru Sasaki , Kazuhiro Omori , Hideo Miyata , Yoko Suguri
发明人： Kohei Morikawa , Toru Sasaki , Kazuhiro Omori , Hideo Miyata , Yoko Suguri
IPC分类号： C07F9/24 , C07F9/38
CPC分类号： C07F9/3813
摘要： N-acylaminomethylphosphonic acid is prepared from an N-methylolamide compound and a phosphorus trihalide. The starting compounds are mixed and heated in an aprotic solvent in the presence of water in a 0.25 to 2.5 times molar amount relative to the phosphorus trihalide at 60.degree. to 160.degree. C., and the reaction mixture is contacted with water. The N-methylolamide compound is a compound selected from the group consisting of N-methylol-lower alkylamides and N-methylolarylamides. The phosphorus trihalide is preferably phosphorus trichloride. As the aprotic solvent is used one or more of hydrocarbons, halogenated hydrocarbons, ethers, polyethers, nitriles, and aromatic nitro compounds. The mixing may be carried out at a temperature of 60.degree. C. The water present at the initiation of the reaction is in a 1.0 to 1.8 times molar amount relative to the phosphorus trihalide.
摘要翻译： N-酰氨基甲基膦酸由N-羟甲基酰胺化合物和三卤化磷制备。将起始化合物在非质子溶剂中在相对于三卤化磷在0.25至160℃下以0.25至2.5倍摩尔量存在的水中加热，并将反应混合物与水接触。 N-羟甲基酰胺化合物是选自N-羟甲基 - 低级烷基酰胺和N-羟甲基芳基酰胺的化合物。三卤化磷优选为三氯化磷。由于非质子溶剂使用一种或多种烃，卤代烃，醚，聚醚，腈和芳族硝基化合物。混合可以在60℃的温度下进行。反应开始时存在的水相对于三卤化磷的摩尔量为1.0〜1.8倍。

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