专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5686251A Naphthyridinium derivatives 失效
标题翻译：萘吡啶衍生物
公开(公告)号：US5686251A
公开(公告)日：1997-11-11
申请号：US510316
申请日：1995-08-02
申请人： Seikoh Horiuchi , Kazuharu Ienaga , Ko Nakamura
发明人： Seikoh Horiuchi , Kazuharu Ienaga , Ko Nakamura
IPC分类号： G01N33/531 , C07D471/04 , C07K14/76 , C07K16/00 , C07K16/44 , G01N33/53 , G01N33/532 , G01N33/68
CPC分类号： G01N33/6842 , C07D471/04 , C07K16/44 , G01N33/5308 , G01N33/68 , Y02P20/55
摘要： The present invention provides naphthyridinium derivatives which are effective, for example, in diagnosis of diabetes, diabetic complications, dialysis-related complications, aging, diseases accompanied by aging, etc. and also provides an antibody prepared from said derivative as a hapten. The naphthyridinium derivatives of the present invention are compounds represented by the general formula (I): ##STR1## wherein R and R' may be the same or different and are alkyl groups optionally substituted with at least one amino group, at least one protected amino group, at least one carboxyl group, or combinations thereof, and their pharmaceutically accepted salts. It is possible to conduct the diagnosis of diabetes, diabetic complications, dialysis-related complications, aging, diseases accompanied by aging, etc. using a compound of the present invention as an indicator. Moreover, it is possible to utilize a compound of the present invention for the evaluation of the pharmaceutical effect of pharmaceuticals effective for treating diabetes-related diseases, dialysis-related complications, aging and diseases accompanied by aging.
摘要翻译：本发明提供了例如糖尿病诊断，糖尿病并发症，透析相关并发症，衰老，老化等疾病等有效的萘啶鎓衍生物，并且还提供由所述衍生物制备的抗体作为半抗原。本发明的萘啶鎓衍生物是由通式（I）表示的化合物：其中R和R'可以相同或不同，并且是任选被至少一个氨基取代的烷基，至少一个保护的氨基，至少一个羧基或其组合，以及它们的药学上可接受的盐。使用本发明化合物作为指标，可以进行糖尿病，糖尿病并发症，透析相关并发症，老化，老化等疾病的诊断。此外，可以利用本发明的化合物来评价有效治疗糖尿病相关疾病，透析相关并发症，老化和伴随衰老的疾病的药物的药效。

2. 发明授权

US5446021A Agricultural and horticultural compositions inducing resistance in plants against salt- and water-stress 失效
标题翻译：农业和园艺组合物在植物中诱导抗盐胁迫和水分胁迫
公开(公告)号：US5446021A
公开(公告)日：1995-08-29
申请号：US240534
申请日：1994-05-10
申请人： Masaharu Kurohashi , Ko Nakamura , Kazuharu Ienaga
发明人： Masaharu Kurohashi , Ko Nakamura , Kazuharu Ienaga
IPC分类号： A01N43/90 , C07K5/12 , A61K38/12
CPC分类号： A01N43/90 , C07K5/12
摘要： The present invention relates to an agricultural and horticultural composition inducing resistance in plants against salt- and water-stresses which comprises as an active ingredient an effective amount of at least one cyclic dipeptide of the following formula (I) or an agriculturally or horticulturally acceptable salt thereof; ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a hydrogen atom or lower alkyl group, or R.sub.1 and R.sub.2 are joined to form pyrrolidine ring which may optionally have hydroxy group, and R.sub.3 is a hydrogen atom or hydroxy group.
摘要翻译：本发明涉及一种诱导植物对抗盐胁迫和水分胁迫的抗性的农业和园艺组合物，其包含作为活性成分的有效量的至少一种下式（I）的环状二肽或农业上或园艺上可接受的盐的; （I）其中R 1和R 2可以相同或不同，其中R 1和R 2各自为氢原子或低级烷基，或R 1和R 2连接形成可任选具有羟基的吡咯烷环，R 3为氢原子或羟基。

3. 发明授权

US4683240A Pharmaceutical composition containing an imidazolidinetrione derivative or pharmaceutically acceptable salt thereof 失效
标题翻译：含有咪唑啉四酮衍生物或其药学上可接受的盐的药物组合物
公开(公告)号：US4683240A
公开(公告)日：1987-07-28
申请号：US826607
申请日：1986-02-06
申请人： Kazuharu Ienaga , Ko Nakamura , Akira Ishii
发明人： Kazuharu Ienaga , Ko Nakamura , Akira Ishii
IPC分类号： A61K31/415 , C07D233/96
CPC分类号： C07D233/96 , A61K31/415 , Y10S514/824 , Y10S514/866
摘要： Pharmaceutical compositions containing imidazolidinetrione derivatives or pharmaceutically acceptable salts thereof having hypoglycemic and hypolipidemic effects. The compositions comprise as an active ingredient at least one imidazolidinetrione derivative of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen, an alkyl group, a cycloalkyl group or ##STR2## and each of R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, halogen, a nitro group, a lower alkyl group or a lower alkoxy group.
摘要翻译：含有具有低血糖和降血脂作用的咪唑烷四酮衍生物或其药学上可接受的盐的药物组合物。所述组合物包含至少一种下式的咪唑烷四酮衍生物作为活性成分：其中R 1和R 2可以相同或不同，分别为氢，烷基，环烷基或者每个可以相同或不同的R 3和R 4是氢，卤素，硝基，低级烷基或低级烷氧基。

4. 发明授权

US5013750A Glycocyamidine derivatives 失效
标题翻译：糖胞苷衍生物
公开(公告)号：US5013750A
公开(公告)日：1991-05-07
申请号：US551375
申请日：1990-07-11
申请人： Ko Nakamura , Kazuharu Ienaga
发明人： Ko Nakamura , Kazuharu Ienaga
IPC分类号： C07D233/88
CPC分类号： C07D233/88
摘要： The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, is hydrogen or a lower alkyl group, preferably a straight or branched alkyl group having 1 to 3 carbon atoms, such as methyl, ethyl, propyl or isopropyl, and R represents hydrogen or an acetyl group,which are useful as test reagents for diagnosis of renal failure.
摘要翻译：本发明的甘氨酰胺衍生物由下式（I）表示：其中R 1，R 2和R 3可以相同或不同，为氢或低级烷基，优选直链或甲基，乙基，丙基，异丙基等碳原子数1〜3的支链烷基，R表示氢或乙酰基，可用作肾功能衰竭的诊断试剂。

5. 发明授权

US4708961A Acylindole derivatives and their use in pharmaceutical compositions 失效
标题翻译：丁醛衍生物及其在药物组合物中的应用
公开(公告)号：US4708961A
公开(公告)日：1987-11-24
申请号：US919746
申请日：1986-10-16
申请人： Kazuharu Ienaga , Ko Nakamura
发明人： Kazuharu Ienaga , Ko Nakamura
IPC分类号： C07D209/12 , A61K31/40
CPC分类号： C07D209/12
摘要： The present invention is concerned with novel acylindole derivatives of the formula (I) and platelet-aggregation inhibiting agents containing them as an active ingredient. ##STR1## In the formula (I), either R.sub.1 and R.sub.2 is hydrogen, an alkyl group having 1 to 5 carbon atoms, an alkyl group substituted by at least one hydroxy group and having 1 to 5 carbon atoms, or a group of the formula ##STR2## in which R.sub.3 is an alkyl group having 1 to 5 carbon atoms, and --OR.sub.2 is a substituent at the ortho or para position.The compounds of the invention are useful as preventive medicine or remedy for various diseases or symptoms caused by platelet-aggregation, as well as inhibitors of platelet-aggregation on vascular walls during or after an operation.
摘要翻译：本发明涉及式（I）的新型丙烯酰基吲哚衍生物和含有它们作为活性成分的血小板聚集抑制剂。（I）在式（I）中，R 1和R 2是氢，具有1至5个碳原子的烷基，被至少一个羟基取代且具有1至5个碳原子的烷基，或其中R 3是具有1至5个碳原子的烷基的式“IMAGE”的基团，-OR 2是邻位或对位的取代基。本发明的化合物可用作预防药物或由血小板聚集引起的各种疾病或症状的补救剂，以及在手术期间或手术后在血管壁上血小板聚集的抑制剂。

6. 发明授权

US4957936A Glycocyamidine derivatives 失效
标题翻译：糖胞苷衍生物
公开(公告)号：US4957936A
公开(公告)日：1990-09-18
申请号：US472494
申请日：1990-01-30
申请人： Ko Nakamura , Kazuharu Ienaga
发明人： Ko Nakamura , Kazuharu Ienaga
IPC分类号： G01N33/50 , A61K31/415 , A61K49/00 , A61P9/08 , A61P9/10 , C07D233/88
CPC分类号： C07D233/88 , Y02P20/55
摘要： The glycocyamidine derivatives of the present invention are represented by the following formula (I): ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, is hydrogen or a lower alkyl group, preferably a straight or branched alkyl group having 1 to 3 carbon atoms, such as methyl, ethyl, propyl or isopropyl, and R represents hydrogen or an acetyl group.which are useful as test reagents for diagnosis of renal failure.
摘要翻译：本发明的糖胞苷衍生物由下式（I）表示：其中R 1，R 2和R 3可以相同或不同，为氢或低级烷基，优选直链或支链具有1至3个碳原子的烷基，例如甲基，乙基，丙基或异丙基，R代表氢或乙酰基。其用作诊断肾衰竭的测试试剂。

7. 发明授权

US4708954A Hypogylcemic oxaluric acid derivatives 失效
标题翻译：低血糖草酸衍生物
公开(公告)号：US4708954A
公开(公告)日：1987-11-24
申请号：US826997
申请日：1986-02-07
申请人： Kazuharu Ienaga , Ko Nakamura , Akira Ishii
发明人： Kazuharu Ienaga , Ko Nakamura , Akira Ishii
IPC分类号： C07D295/20 , A61K31/445 , A61P3/08 , A61P3/10 , C07C67/00 , C07C239/00 , C07C275/50 , C07D295/10 , C07D295/215 , A61K31/535
CPC分类号： C07D295/215 , C07C275/50 , C07C2101/08 , C07C2101/14
摘要： Pharmaceutical compositions containing an oxaluric acid derivative of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is hydrogen; an alkyl group or a cycloalkyl group; or R.sub.1 and R.sub.2 are joined to form a heterocyclic ring with the nitrogen atom to which they are both attached; and R.sub.3 is hydrogen or an alkyl group. These compounds have excellent hypoglycemic effects with low toxcicity and safety.
摘要翻译：含有下式的草酸衍生物的药物组合物：其中R1和R2可以相同或不同，为氢; 烷基或环烷基; 或者R 1和R 2连接形成与它们相连的氮原子的杂环; 并且R 3是氢或烷基。这些化合物具有优异的低血糖作用，具有低毒性和安全性。

8. 发明授权

US4647574A Hypoglycemic hydantoin derivatives 失效
标题翻译：低血糖乙内酰脲衍生物
公开(公告)号：US4647574A
公开(公告)日：1987-03-03
申请号：US709861
申请日：1985-03-08
申请人： Kazuharu Ienaga , Ko Nakamura
发明人： Kazuharu Ienaga , Ko Nakamura
IPC分类号： C07D233/66 , C07D233/72 , C07D233/74 , A61K31/415
CPC分类号： C07D233/72
摘要： The present invention relates to novel hydantoin derivatives represented by the general formula (I) and pharmaceutical compositions containing them as an active ingredient. ##STR1## In the formula (I), X is hydrogen or a group having the formula --OR.sub.4, and each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, is hydrogen, an alkyl group or a cycloalkyl group.Hydantoin derivatives and pharmaceutically acceptable salts thereof of the present invention have excellent hypoglycemic, hypolipidemic and diuretic effects, as well as low toxicity and great safety. Therefore, the compounds of the present invention are not only useful as antidiabetics but also as drugs for hyperlipidemia.
摘要翻译：本发明涉及由通式（I）表示的新型乙内酰脲衍生物和含有它们作为有效成分的药物组合物。（I）在式（I）中，X是氢或具有式-OR 4的基团，R 1，R 2，R 3和R 4可以相同或不同，为氢，烷基或环烷基。本发明的乙内酰脲衍生物及其药学上可接受的盐具有优异的降血糖，降血脂和利尿作用，并且毒性低，安全性高。因此，本发明的化合物不仅可用作抗糖尿病药，还可用作高脂血症药物。

9. 发明授权

US5084473A Method for preventing or treating renal failure 失效
标题翻译：预防或治疗肾功能衰竭的方法
公开(公告)号：US5084473A
公开(公告)日：1992-01-28
申请号：US564520
申请日：1990-08-09
申请人： Hiroki Mikami , Kazuharu Ienaga
发明人： Hiroki Mikami , Kazuharu Ienaga
IPC分类号： C07D233/72 , A61K31/415 , A61K31/4166 , A61P13/02 , A61P15/00
CPC分类号： A61K31/415
摘要： The present invention relates to a method for preventing or treating renal failure in a mannal which comprises administering the mammal an effective amount for renal failure of at least one hydantoin derivative of the following formula (I) or a pharmaeutically acceptable salt thereof. ##STR1##

10. 发明授权

US06451831B1 Agent for hypoalbuminaemia 有权
标题翻译：低白蛋白血症的代理
公开(公告)号：US06451831B1
公开(公告)日：2002-09-17
申请号：US10074772
申请日：2002-02-12
申请人： Kazuharu Ienaga , Hiroki Mikami , Ryoji Nishibata
发明人： Kazuharu Ienaga , Hiroki Mikami , Ryoji Nishibata
IPC分类号： A61K31415
CPC分类号： A61K31/4166
摘要： A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, a hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. Administration of the compounds substantially increases the serum albumin value of patients suffering from hypoalbuminaemia from abnormal values, and significantly improves the condition of hypoalbuminaemia.
摘要翻译：用于低白蛋白血症的高度安全和有用的治疗剂含有由式（I）表示的乙内酰脲衍生物或其药学上可接受的盐作为有效成分：其中R 1和R 2可以相同或不同，表示氢，烷基或环烷基; X和Y各自可以相同或不同，表示氢，羟基，烷基或烷氧基，或X和Y一起表示氧代基。化合物的施用显着提高了患有低蛋白血症的患者的血清白蛋白值异常值，并显着改善了低白蛋白血症的状况。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式