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1. 发明授权

US07829133B2 Surgical suture material with an antimicrobial surface and process for providing an antimicrobial coating on surgical suture material 有权
标题翻译：具有抗微生物表面的手术缝合材料和用于在外科缝合材料上提供抗微生物涂层的方法
公开(公告)号：US07829133B2
公开(公告)日：2010-11-09
申请号：US11877846
申请日：2007-10-24
申请人： Sebastian Vogt , Klaus-Dieter Kuhn , Hubert Buchner
发明人： Sebastian Vogt , Klaus-Dieter Kuhn , Hubert Buchner
IPC分类号： B05D3/00
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A61L2300/802 , B05D1/18 , B05D2256/00
摘要： A surgical suture material with an antimicrobial surface is described, the surface exhibiting a coating containing a) at least one fatty acid, b) octenidine dichloride and/or dequalinium chloride and c) optionally oligomeric lactic acid esters. In addition, a process for coating surgical suture material is described which is characterized by the fact that the thread material is wetted with a homogeneous methanolic solution of octenidine dichloride and/or dequalinium chloride and subsequently the methanol is evaporated, a coating forming on the thread surface.
摘要翻译：描述了具有抗微生物表面的外科缝合材料，所述表面显示包含a）至少一种脂肪酸，b）二氯化奥立芬和/或氯化脱氯化物的涂层，以及c）任选的低聚乳酸酯。另外，描述了用于涂覆外科缝合材料的方法，其特征在于螺纹材料被二氯化二苯胺和/或氯化金合金的均匀甲醇溶液润湿，随后甲醇蒸发，在螺纹上形成涂层表面。

2. 发明申请

US20080213336A1 POLYMETHYLMETHACRYLATE REVISION BONE CEMENT 有权
标题翻译：聚甲基丙烯酸甲酯修饰骨水泥
公开(公告)号：US20080213336A1
公开(公告)日：2008-09-04
申请号：US12017499
申请日：2008-01-22
申请人： Klaus-Dieter Kuhn , Sebastian Vogt , Hubert Buchner
发明人： Klaus-Dieter Kuhn , Sebastian Vogt , Hubert Buchner
IPC分类号： A61F2/28
CPC分类号： A61L24/0015 , A61L24/06 , A61L27/16 , A61L27/54 , A61L2300/406 , A61L2300/45 , A61L2300/622 , A61L2430/02 , C08L33/12
摘要： The invention relates to a PMMA revision bone cement having powder and liquid component, in which the powder component contains two or more granular antibiotics whose grain size distribution is equal in that the main screening fraction each of the individual antibiotics is in the same grain size range, in particular in the range of 100-250 μm or 150-250 μm.
摘要翻译：本发明涉及具有粉末和液体组分的PMMA修复骨水泥，其中粉末组分含有两种或更多种粒度分布相等的粒状抗生素，因为各个抗生素的主要筛选部分具有相同的粒度范围，特别是在100-250μm或150-250μm的范围内。

3. 发明授权

US08012173B2 Surgical suture material with an antimicrobial surface and process for providing an antimicrobial coating on surgical suture material 有权
标题翻译：具有抗微生物表面的手术缝合材料和用于在外科缝合材料上提供抗微生物涂层的方法
公开(公告)号：US08012173B2
公开(公告)日：2011-09-06
申请号：US12889550
申请日：2010-09-24
申请人： Sebastian Vogt , Klaus-Dieter Kuhn , Hubert Büchner
发明人： Sebastian Vogt , Klaus-Dieter Kuhn , Hubert Büchner
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/208 , A61L2300/404 , A61L2300/606 , A61L2300/802 , B05D1/18 , B05D2256/00
摘要： A surgical suture material with an antimicrobial surface is described, the surface exhibiting a coating containing a) at least one fatty acid, b) octenidine dichloride and/or dequalinium chloride and c) optionally oligomeric lactic acid esters. In addition, a process for coating surgical suture material is described which is characterized by the fact that the thread material is wetted with a homogeneous methanolic solution of octenidine dichloride and/or dequalinium chloride and subsequently the methanol is evaporated, a coating forming on the thread surface.
摘要翻译：描述了具有抗微生物表面的外科缝合材料，所述表面显示包含a）至少一种脂肪酸，b）二氯化奥立芬和/或氯化脱氯化物的涂层，以及c）任选的低聚乳酸酯。另外，描述了用于涂覆外科缝合材料的方法，其特征在于螺纹材料被二氯化二苯胺和/或氯化金合金的均匀甲醇溶液润湿，随后甲醇蒸发，在螺纹上形成涂层表面。

4. 发明申请

US20060293407A1 Polymethylmethacrylate bone cement 有权
标题翻译：聚甲基丙烯酸甲酯骨水泥
公开(公告)号：US20060293407A1
公开(公告)日：2006-12-28
申请号：US11447807
申请日：2006-06-06
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K6/08
CPC分类号： A61L27/50 , A61L24/001 , A61L24/06 , A61L27/16 , A61L2430/02 , C08L33/12
摘要： A polymethylmethacrylate bone cement with a liquid monomer component and a solid component contains in the monomer liquid, for example, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, for example, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer for the dye or dye mixture. The solubilizer preferably is liquid or pasty at room temperature. The monomer liquid is translucent at room temperature. Preferably, 0.001-1.00 mass percent of a dye or dye mixture that is insoluble or poorly soluble in methacrylic acid methylester and, preferably, 0.001-2.00 mass percent of a synthetically produced, protein-free, hydrophobic, low molecular or oligomeric solubilizer that is liquid or pasty at room temperature are homogeneously dissolved in the polymethacrylate or polymethylacrylate of the powder component.
摘要翻译：具有液体单体组分和固体组分的聚甲基丙烯酸甲酯骨粘固剂在单体液体中含有例如0.001-1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，例如，用于染料或染料混合物的合成产生的无蛋白质，疏水性，低分子或低聚增溶剂的2.00质量％。增溶剂在室温下优选为液体或糊状。单体液体在室温下是半透明的。优选0.001〜1.00质量％的不溶于或难溶于甲基丙烯酸甲酯的染料或染料混合物，优选0.001-2.00质量％的合成产生的无蛋白质，疏水性，低分子或低聚物的增溶剂，其为液体或糊状物均匀地溶解在粉末组分的聚甲基丙烯酸酯或聚甲基丙烯酸甲酯中。

5. 发明授权

US08758827B2 Local system for the release of active principle and process for its manufacture 失效
标题翻译：释放本地系统的主动原理及其制造过程
公开(公告)号：US08758827B2
公开(公告)日：2014-06-24
申请号：US12949260
申请日：2010-11-18
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K9/50
CPC分类号： A61K9/0024 , A61J2200/20 , A61K9/1611 , A61K9/1635 , A61L27/16 , A61L27/54 , A61L2300/406 , C08L33/12
摘要： A local system for the release of active principle is described which consists of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerization, radical polymerization activators effective in the temperature range of 10-80° C. or residues of these polymerization activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein.A process for the production of the local system for the release of active principle in the case of which a) a paste is produced by mixing methyl methacrylate, polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulphate, one or more pharmaceutical active principles and a thermally decomposing radical initiator, the paste having a viscosity such that it cannot be deformed at room temperature by the effect of gravity; b) the paste is injection molded by an injection molding device without heating at room temperature into approximately spherical or rotation-symmetrical bodies or the approximately spherical or rotation symmetrical bodies are injection-molded onto a wire; c) the bodies are heated to a temperature at which the polymerization initiator decomposes.
摘要翻译：描述了用于释放有效原理的局部系统，其由大致球形或旋转对称的主体组成，其主要由聚甲基丙烯酸甲酯或聚甲基丙烯酸甲酯共聚甲基丙烯酸酯，二氧化锆或硫酸钡组成，以及一种或多种药物活性成分，特别是抗生素，其通过自由基聚合制备，在10-80℃的温度范围内有效的自由基聚合活化剂或不含有芳族胺，重金属盐和巴比妥类的这些聚合活化剂的残基。制备用于释放活性成分的局部体系的方法，其中a）通过混合甲基丙烯酸甲酯，聚甲基丙烯酸甲酯或聚甲基丙烯酸甲酯共聚丙烯酸甲酯，二氧化锆和/或硫酸钡，或更多的药物活性成分和热分解性自由基引发剂，所述糊具有使其在室温下不受重力的影响而不能变形的粘度; b）浆料通过注射成型装置注射成型，而不在室温下加热成近似球形或旋转对称的体，或将近似球形或旋转的对称体注射到线上; c）将物体加热至聚合引发剂分解的温度。

6. 发明申请

US20070141157A1 Method for producing antibiotic/antibiotics and their use 审中-公开
标题翻译：生产抗生素/抗生素的方法及其应用
公开(公告)号：US20070141157A1
公开(公告)日：2007-06-21
申请号：US11441656
申请日：2006-05-26
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K9/14
CPC分类号： A61K9/1688 , A61K31/70
摘要： A method for producing antibiotic/antibiotics-particles characterized in that an aqueous solution of an amino glycoside-antibiotic or an aqueous solution comprising two or more amino glycoside-antibiotics is mixed under agitation with a solvent mixture comprising isopropanol and at least one additional alcohol, with the volume ratio of the solvent mixture to the aqueous solution being at least 3 to 1 and with the suspension developed being agitated until the primarily yielded coarse antibiotic/antibiotics aggregates disintegrate into particles, which have a grain size smaller than 400 μm.
摘要翻译：一种生产抗生素/抗生素颗粒的方法，其特征在于将氨基糖苷 - 抗生素的水溶液或包含两种或更多种氨基糖苷 - 抗生素的水溶液在搅拌下与包含异丙醇和至少一种另外的醇的溶剂混合物混合，溶剂混合物与水溶液的体积比至少为3:1，搅拌悬浮液直到主要产生的粗抗生素/抗生素聚集体分解成粒度小于400μm的颗粒。

7. 发明申请

US20050031664A1 Porous body with antibiotic coating, method for production, and use 审中-公开
标题翻译：多孔体用抗生素涂层，生产和使用方法
公开(公告)号：US20050031664A1
公开(公告)日：2005-02-10
申请号：US10831680
申请日：2004-04-23
申请人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kuhn
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kuhn
IPC分类号： A61L27/00 , A61L27/54 , A61L27/56 , A61K31/56
CPC分类号： A61L27/56 , A61L27/54 , A61L2300/21 , A61L2300/406 , A61L2300/45 , A61L2300/606
摘要： The production and use of a porous body with an antibiotic coating is described. A coating composed of at least one antibiotic salt, sparingly soluble in water or in an aqueous environment, from the group comprising fusidic acid-antibiotics, for example, fusidic acid-gentamicin, fusidic acid-sisomicin, fusidic acid-netilmicin, fusidic acid-streptomycin, fusidic acid-tobramycin, fusidic acid-spectinomycin, fusidic acid-vancomycin, fusidic acid-ciprofloxacin, fusidic acid-moxifloxacin, fusidic acid-clindamycin, fusidic acid-lincomycin, fusidic acid-tetracycline, fusidic acid-chlorotetracycline, fusidic acid-oxytetracycline, and fusidic acid-rolitetracycline is introduced into the pore system of nonmetallic porous bodies and metallic porous bodies. The antibiotically coated porous bodies are used as implants.
摘要翻译：描述了具有抗生素涂层的多孔体的生产和使用。由包含夫西地酸 - 抗生素，例如夫西地酸 - 庆大霉素，夫西地酸 - 西沙米星，夫西地酸 - 西米立霉素，夫西地酸 - 抗生素的组中的至少一种抗微生物盐，微溶于水或在水性环境中，链霉素，夫西地酸妥布霉素，夫西地酸壮观霉素，夫西地酸万古霉素，夫西地酸环丙沙星，夫西地酸莫西沙星，夫西地酸克林霉素，夫西地酸 - 林可霉素，夫西地酸四环素，夫西地酸 - 氯四环素，夫西地酸 - 土霉素和夫西地酸四环素引入非金属多孔体和金属多孔体的孔体系中。抗菌涂层多孔体用作植入物。

8. 发明申请

US20070031469A1 Dyed polymethyl methacrylate bone cement and process for its production 有权
标题翻译：染色聚甲基丙烯酸甲酯骨水泥及其生产工艺
公开(公告)号：US20070031469A1
公开(公告)日：2007-02-08
申请号：US11483339
申请日：2006-07-07
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K31/74 , A61F2/28
CPC分类号： A61L24/001 , A61L24/06 , A61L27/16 , A61L27/50 , A61L2430/02 , C08L33/12
摘要： A dyed polymethyl methacrylate bone cement is described which is characterised by at least the surface of the polymer particles of the powder component being coated partially or completely with a mixture of one or several dyes and a hydrophobic, low molecular or oligomeric organic coupling agent, such a quantity of coupling agent being present that the polymer particles can be visually recognised as not having swollen.
摘要翻译：描述了染色的聚甲基丙烯酸甲酯骨粘固剂，其特征在于粉末组分的聚合物颗粒的至少表面部分或完全被一种或多种染料和疏水性，低分子或低聚有机偶联剂的混合物部分或完全涂覆，存在一定量的偶联剂，使得聚合物颗粒可以在视觉上被认为不具有溶胀。

9. 发明申请

US20060292199A1 PMMA bone cement containing antibiotic/antibiotics 审中-公开
标题翻译：含抗生素/抗生素的PMMA骨水泥
公开(公告)号：US20060292199A1
公开(公告)日：2006-12-28
申请号：US11234034
申请日：2005-09-23
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K38/14 , A61K31/7034 , A61K31/545 , A61K31/496 , A61K9/14 , A61F13/00
CPC分类号： A61L24/06 , A61L24/0015 , A61L27/16 , A61L27/54 , A61L2300/404 , A61L2430/02 , C08L33/12
摘要： A PMMA bone cement containing an antibiotic/antibiotics is described which is characterized in that, in the powder component, 0.1-5.0% by weight of water soluble, glasstype antibiotic/antibiotics granules with a particle diameter in the region of 50-1000 μm are contained which are built up of glass-type antibiotic/antibiotics primary particles bonded to each other which have a particle diameter in the region of 1-70 μm.
摘要翻译：描述了含有抗生素/抗生素的PMMA骨水泥，其特征在于，在粉末组分中，0.1-5.0重量％的粒径在50-1000μm的水溶性，glasstype抗生素/抗生素颗粒是由玻璃型抗生素/抗生素一次粒子构成，其中粒子直径在1-70μm之间。

10. 发明申请

US20060127444A1 Antibiotic/s containing bone substitute material with sustained active substance release 有权
标题翻译：含有持久活性物质释放的骨替代材料的抗生素
公开(公告)号：US20060127444A1
公开(公告)日：2006-06-15
申请号：US11294001
申请日：2005-12-05
申请人： Klaus-Dieter Kuhn , Sebastian Vogt
发明人： Klaus-Dieter Kuhn , Sebastian Vogt
IPC分类号： A61K33/42 , A61F2/00
CPC分类号： A61L27/025 , A61L27/54 , A61L2300/404 , A61L2300/406 , A61L2430/02
摘要： Antibiotic/s containing bone substitute material is described which is characterized in that it is composed of a compacted mixture of granules of calcium sulfate dihydrate, calcium carbonate and at least one representative of the aminoglycoside antibiotics, lincosamide antibiotics, glycopeptide antibiotics, macrolide antibiotics, ketolide antibiotics, the nitroimidazoles, the fluorochinolone antibiotics and the oxazolidinone antibiotics, the steroid antibiotics, the antiseptic agents and the fungicidal/fungistatic antibiotics which are partly or entirely sheathed with a layer of glycerol tripalmitate and/or glycerol tristearate and/or glycerol trilaurate and/or 1-hexadecyl alcohol which connects the granules with each other.
摘要翻译：描述了含有抗生素的骨替代材料，其特征在于其由硫酸钙二水合物，碳酸钙和至少一种氨基糖苷类抗生素代谢物的压实混合物，氯胺素抗生素，糖肽抗生素，大环内酯类抗生素，酮内酯抗生素，硝基咪唑，氟喹诺酮抗生素和恶唑烷酮抗生素，类固醇抗生素，防腐剂和杀真菌/抑菌抗生素，其部分或全部用三层棕榈酸甘油酯和/或甘油三硬脂酸酯和/或甘油三月桂酸酯和/ 或将该颗粒彼此连接的1-十六烷基醇。

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