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1. 再颁专利

USRE36374E 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists 失效
公开(公告)号：USRE36374E
公开(公告)日：1999-11-02
申请号：US648240
申请日：1996-05-13
申请人： Klaus Peter Bogeso , Klaus Gundertofte , Ejner Knud Moltzen , Henrik Pedersen
发明人： Klaus Peter Bogeso , Klaus Gundertofte , Ejner Knud Moltzen , Henrik Pedersen
IPC分类号： A61K31/4427 , A61K31/445 , A61P21/00 , A61P25/02 , A61P25/28 , C07D401/04 , C07D413/04 , C07D417/04
CPC分类号： C07D401/04 , C07D413/04 , C07D417/04
摘要： The present invention relates to novel compounds of the following formula, where the dotted line designates in optional bond: ##STR1## wherein "het" designates a five membered heterocyclic ring which may include 1 or 2 double bonds and 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, provided that "het" may not designate a 1,4- or 1,3,4-oxadiazole,R.sup.1 is selected from hydrogen, lower alkyl, optionally substituted with phenyl which may be substituted with halogen, lower alkyl, or lower alkoxy, or a group R.sup.6 --CO--NH--CH.sub.2 -- or R.sup.6 --O--CO--, wherein R.sup.6 is lower alkyl, branched or unbranched, or phenyl optionally substituted with halogen, trifuoromethyl, lower alkyl, hydroxy, lower alkoxy, or lower acyloxy;R.sup.2 and R.sup.3 are the same or different, each representing hydrogen, lower alkyl, cycloalkyl (3-6 C-atoms), lower alkenyl, lower alkadienyl, lower alkynyl, optionally substituted with hydroxy, halogen or phenyl, in which the phenyl group may be substituted with halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy; R.sup.2 and R.sup.3 may further, respectively, be selected from trifluoromethyl or phenyl optionally substituted with halogen, trifluoromethyl, lower alkyl, hydroxy, lower alkoxy or lower acyloxy, or R.sup.2 and R.sup.3 may, respectively, be a group OR.sup.7 or SR.sup.7 wherein R.sup.7 is defined as R.sup.2 or R.sup.3, andif "het" includes 2 or more carbon atoms R.sup.4 and R.sup.5 are the same or different, and each is defined as R.sup.2 or R.sup.3, and if "het" includes only one carbon atom, there is only one substituent, R.sup.4, on the heterocyclic ring, and R.sup.4 is defined as R.sup.2 or R.sup.3,as well as individual stereo isomers and pharmaceutically acceptable acid addition salts thereof.The invention moreover relates to methods for the preparation of the compounds of formula 1, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of formula I.

2. 发明授权

US5703087A Phenyl indole compounds 失效
标题翻译：苯基吲哚化合物
公开(公告)号：US5703087A
公开(公告)日：1997-12-30
申请号：US635905
申请日：1996-11-27
申请人： Jens Kristian Perregaard , Ejner Knud Moltzen , Kim Andersen , Henrik Pedersen , Klaus Peter B.o slashed.ges.o slashed. , Andre Pernet , Barbara Bopp , Darcy Mulford , Kiyoshi Sakamoto
发明人： Jens Kristian Perregaard , Ejner Knud Moltzen , Kim Andersen , Henrik Pedersen , Klaus Peter B.o slashed.ges.o slashed. , Andre Pernet , Barbara Bopp , Darcy Mulford , Kiyoshi Sakamoto
IPC分类号： A61K31/4427 , A61K31/445 , A61P9/12 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D401/14
CPC分类号： C07D401/14
摘要： The present invention relates to phenylindole compounds of formula I: ##STR1## related to atypical neuroleptic sertindole.
摘要翻译： PCT No.PCT / DK94 / 00407 Sec。 371日期：1996年11月27日 102（e）日期1996年11月27日PCT 1994年10月28日PCT公布。第WO95 / 12591号公报日期：1995年5月11日本发明涉及式I的苯基吲哚化合物：与非典型精神抑制索吲哚有关的（I）。

3. 发明申请

US20210230381A1 DESIGN OF COMPOSITE MATERIALS WITH DESIRED CHARACTERISTICS 有权
公开(公告)号：US20210230381A1
公开(公告)日：2021-07-29
申请号：US17158665
申请日：2021-01-26
申请人： Mikkel Dybro Lundorf , Henrik Pedersen , NANOCORE APS
发明人： Mikkel Dybro Lundorf , Henrik Pedersen , Tore Dehli
IPC分类号： C08J5/00 , B82Y30/00 , B82Y40/00 , C08K9/04 , C08K9/08 , C01B32/05 , C01B32/174 , C01B32/194 , C04B35/565 , C04B35/58 , C04B35/50 , C04B35/10 , C04B35/56 , C04B35/48 , C04B28/02 , C01B32/156 , C01B32/168 , C04B14/38 , C04B16/06 , C04B35/80 , C08F292/00 , C08J5/06 , C09D5/24 , C09D11/03 , C09D11/04 , C09D11/107 , C09D11/52 , C09D133/14
摘要： A type of composite material where the matrix material and additive are held together by covalently or non-covalently bound ligands is described. A particularly useful composite material covered by the present invention is a carbon nanotube-reinforced composite material where the matrix consists of a polymer, covalently attached to a linker, where said linker is non-covalently attached to the carbon nanotube.
Methods for the preparation of such composite materials are provided.

4. 发明授权

US10336808B2 MHC peptide complexes and uses thereof in infectious diseases 有权
公开(公告)号：US10336808B2
公开(公告)日：2019-07-02
申请号：US13482472
申请日：2012-05-29
申请人： Jøgen Schøller , Henrik Pedersen , Liselotte Brix
发明人： Jøgen Schøller , Henrik Pedersen , Liselotte Brix
IPC分类号： C07K14/74 , A61K47/64 , G01N33/569 , A61K49/18 , G01N33/574 , A61K47/61 , A61K38/00
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.

5. 发明申请

US20180298154A1 DESIGN OF COMPOSITE MATERIALS WITH DESIRED CHARACTERISTICS 审中-公开
公开(公告)号：US20180298154A1
公开(公告)日：2018-10-18
申请号：US15525741
申请日：2015-11-11
申请人： Mikkel Dybro Lundorf , Henrik Pedersen , NANOCORE APS
发明人： Mikkel Dybro Lundorf , Henrik Pedersen , Tore Dehli
IPC分类号： C08J5/00 , C08F292/00 , C08J5/06 , C01B32/156 , C01B32/168 , C01B32/194 , C09D11/52 , C09D11/107 , C09D11/04 , C09D11/03 , C09D5/24 , C09D133/14 , C04B16/06 , C04B14/38 , C04B35/80
CPC分类号： C08J5/005 , B82Y30/00 , B82Y40/00 , C01B32/05 , C01B32/152 , C01B32/156 , C01B32/168 , C01B32/174 , C01B32/194 , C04B14/386 , C04B16/0675 , C04B35/80 , C04B2235/48 , C08F292/00 , C08F2810/20 , C08J5/06 , C08J2323/06 , C08J2363/00 , C08J2367/00 , C08J2369/00 , C08J2375/04 , C08J2377/06 , C08K3/041 , C08K3/042 , C08K9/04 , C08K9/08 , C08K2201/001 , C08K2201/011 , C09D5/24 , C09D11/03 , C09D11/04 , C09D11/107 , C09D11/52 , C09D133/14 , C22C26/00 , C22C2026/001 , H01B1/04 , C08L23/04
摘要： Composite material, where the matrix material and the additive are held together by covalently or non-covalently bound ligands. The linker unit between matrix and additive has the structure Ligand1-LinkerL-Ligand 2, wherein Ligand1 and Ligand2 are a bond or a chemical entity that is capable of binding covalently or non-covalently to a structural entity, such as a polymer matrix or the additive (ex. CNT, graphene, carbon nanofiber, etc), and LinkerL is a chemical bond or entity that links Ligand1 and Ligand2.

6. 发明授权

US08426183B2 Glucoamylase variants 失效
公开(公告)号：US08426183B2
公开(公告)日：2013-04-23
申请号：US13329550
申请日：2011-12-19
申请人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Roenfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
IPC分类号： C12N9/34 , C12P19/20 , C07H21/04 , C07K1/00
CPC分类号： C12N9/2428 , C12P19/14 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.

7. 发明申请

US20120264161A1 MHC PEPTIDE COMPLEXES AND USES THEREOF IN INFECTIOUS DISEASES 审中-公开
标题翻译： MHC肽复合物及其在感染性疾病中的应用
公开(公告)号：US20120264161A1
公开(公告)日：2012-10-18
申请号：US13482472
申请日：2012-05-29
申请人： Jørgen Schøller , Henrik Pedersen , Liselotte Brix
发明人： Jørgen Schøller , Henrik Pedersen , Liselotte Brix
IPC分类号： C07K19/00 , C12N5/0783 , C12Q1/02
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K49/1896 , G01N33/56905 , G01N33/56911 , G01N33/56972 , G01N33/56977 , G01N33/574 , G01N2333/70539 , G01N2800/24 , Y02A50/401 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要： Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules are disclosed. The affinity and specificity of the MHC-peptide complexes are surprisingly high. The possibility of presenting to the target cells a plurality of MHC-peptide complexes makes the MHC complexes according to the present invention an extremely powerful tool e.g. in the field of therapy and diagnosis. The invention generally relates to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC complexes and MHC multimers.
摘要翻译：公开了携带能够结合相关靶细胞上的对受体的配体的新型化合物。这些化合物具有许多有利的特征，使得它们非常适用于广泛的应用，包括用作检测系统，相关靶细胞的检测以及许多其它方法。特别地，公开了包含一种或多种MHC分子的新型MHC复合物。 MHC-肽复合物的亲和性和特异性惊人地高。向靶细胞呈递多个MHC-肽复合物的可能性使得根据本发明的MHC复合物成为非常强大的工具，例如，在治疗和诊断领域。本发明一般涉及治疗领域，包括治疗方法和治疗组合物。本发明还包括MHC复合物和MHC多聚体的样品安装用途。

8. 发明授权

US08012732B2 Fungal lypolytic and amylase enzyme composition and methods using the same 有权
标题翻译：真菌溶血酶和淀粉酶组成及使用方法
公开(公告)号：US08012732B2
公开(公告)日：2011-09-06
申请号：US12552572
申请日：2009-09-02
申请人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
发明人： Janne Brunstedt , Jørn Dalgaard Mikkelsen , Henrik Pedersen , Jørn Borch Søe
IPC分类号： C12P1/00 , C12N9/00 , C12N9/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： A21D8/042 , A23C19/0328 , A23D7/02 , A23K20/189 , A23K50/75 , A23L7/107 , A23L7/109 , A23L7/111 , A23L27/60 , A23L29/06 , C11B3/003 , C12N9/18 , C12P7/62 , C12P19/44 , C12Y301/01
摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.
摘要翻译：与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂：甘油三酯水解活性比至少为1.5。在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列，与其具有至少90％的同一性。本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸第7号（b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

9. 发明申请

US20100248257A1 Compiled Methods for Analysing and Sorting Samples 审中-公开
标题翻译：分析和分类样品的编译方法
公开(公告)号：US20100248257A1
公开(公告)日：2010-09-30
申请号：US12647747
申请日：2009-12-28
申请人： Kivin Jacobsen , Henrik Pedersen , Liselotte Brix , Jesper Lohse , Jørgen Schøller , Tina Jakobsen
发明人： Kivin Jacobsen , Henrik Pedersen , Liselotte Brix , Jesper Lohse , Jørgen Schøller , Tina Jakobsen
IPC分类号： G01N33/53
CPC分类号： C07K14/70539 , A61K38/00 , A61K47/61 , A61K47/6425 , A61K47/665 , B82Y5/00
摘要： The present invention relates to the fields of analysis, diagnostics, prognostics, standardization, characterization and enumeration of entities such as biological cells, as well as therapeutical applications. Accordingly, the present invention in preferred aspects is directed to methods for the detection and/or analysis and/or isolation and optionally further manipulation of entities, such as cells, particles, and supra-molecular structures.
摘要翻译：本发明涉及诸如生物细胞的实体以及治疗应用的分析，诊断，预测，标准化，表征和计数的领域。因此，本发明在优选方面涉及用于检测和/或分析和/或分离和任选地进一步操纵诸如细胞，颗粒和超分子结构的实体的方法。

10. 发明授权

US07354753B2 Glucoamylase variants 失效
标题翻译：葡糖淀粉酶变体
公开(公告)号：US07354753B2
公开(公告)日：2008-04-08
申请号：US10421586
申请日：2003-04-23
申请人： Bjarne Ronfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
发明人： Bjarne Ronfeldt Nielsen , Allan Svendsen , Henrik Pedersen , Jesper Vind , Hanne Vang Hendriksen , Torben Peter Frandsen
IPC分类号： C12N9/34 , C07H21/04
CPC分类号： C12N9/2428 , C12P19/20 , Y02E50/17
摘要： The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
摘要翻译：本发明涉及亲本真菌葡糖淀粉酶的变体，其具有改变的性质，特别是改进的热稳定性和/或增加的比活性。

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