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    • 9. 发明授权
    • Preparation of 2-chloro-5- methyl-pyridine
    • 2-氯-5-甲基 - 吡啶的制备
    • US5103011A
    • 1992-04-07
    • US644702
    • 1991-01-23
    • Klaus JelichDieter KaufmannBernd GallenkampReinhard Lantzsch
    • Klaus JelichDieter KaufmannBernd GallenkampReinhard Lantzsch
    • C07D213/61
    • C07D213/61
    • In the preparation of 2-chloro-5-methyl-pyridine of the formula ##STR1## by reacting 3-methyl-pyridine-1-oxide of the formula ##STR2## with a chlorinating agent, the improvement which comprises effecting the reaction in the presence of a chlorinating agent of the formula ##STR3## in which A represents oxygen or the grouping ##STR4## in which R.sup.2 and R.sup.3 individually represent alkyl, cycloalkyl or aryl or together represent alkanediyl or oxaalkanediyl andR.sup.1 represents hydrogen, chlorine, alkyl, cycloalkyl, aryl or the grouping ##STR5## in which R.sup.2 and R.sup.3 have the abovementioned meanings,and where, if R.sup.1 represents aryl, A must represent the grouping ##STR6## in the presence of a basic organic nitrogen compound and in the presence of a diluent at a temperature between about -20.degree. C. and +120.degree. C. The product is known to be useful in the systhesis of pharmaceuticals and insecticides.
    • 在通式(Ⅰ)的3-甲基 - 吡啶-1-氧化物与氯化剂反应制备式(Ⅰ)的2-氯-5-甲基 - 吡啶时,其改进是 包括在其中A表示氧的分子式(III)的氯化剂或其中R 2和R 3各自表示烷基,环烷基或芳基或一起代表烷二基或氧杂烷二基的基团的组合的存在下进行反应,以及 R 1表示氢,氯,烷基,环烷基,芳基或其中R 2和R 3具有上述含义的基团,其中,如果R 1表示芳基,则A在碱性有机物存在下必须代表“IMAGE” 氮化合物和稀释剂存在下,在约-20℃至+ 120℃之间的温度下进行。已知该产物可用于药物和杀虫剂的合成。