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1. 发明授权

US5403505A Cleaning and disinfecting agent containing an N-substituted propylene glutamic acid or derivative thereof, and an antimicrobially active compound 失效
标题翻译：包含N-取代的丙烯谷氨酸或其衍生物的清洁和消毒剂和抗微生物活性化合物
公开(公告)号：US5403505A
公开(公告)日：1995-04-04
申请号：US923969
申请日：1992-11-12
申请人： Klaus Hachmann , Karlheinz Disch , Klaus-Peter Bansemir , Hubert Schwidden , Stephanie Kaupp , Carsten Friese , Rudolf Lehmann , Hans T. Leinen
发明人： Klaus Hachmann , Karlheinz Disch , Klaus-Peter Bansemir , Hubert Schwidden , Stephanie Kaupp , Carsten Friese , Rudolf Lehmann , Hans T. Leinen
IPC分类号： A61L2/18 , C11D1/645 , C11D3/48
CPC分类号： C11D3/48 , A61L2/18 , C11D1/645
摘要： An aqueous cleaning and disinfecting concentrate comprisingA) at lease one reaction product ofa) an N-substituted propylene diamine of formula IR.sup.1 --NH--(CH.sub.2).sub.3 --NH.sub.2 (I) in which R.sup.1 is a C.sub.8 -C.sub.18 alkyl group andb) glutamic acid or a glutamic acid derivative of formula IIR.sub.2 --O--CO--(CH.sub.2).sub.2 --CH(NH.sub.2)--COOH (II) in which R.sup.2 is hydrogen or a C.sub.1 -C.sub.4 alkyl group, wherein the said reaction product is optionally ethoxylated and/or propoxylated, and is optionally in the form of a salt with an organic or inorganic acid;B) at least one of the following antimicrobially active compounds:i) a quaternary ammonium compound of formula III ##STR1## in which R.sup.3 and R.sup.4 independently of one another represent alkyl radicals containing 1 to 3 carbon atoms or benzyl radicals, or halogenated or alkylated benzyl radicals containing 6 to 22 carbon atoms, and X.sup.- is an anion;ii) a phenol;iii) a biguanide;(iv) a quaternary phosphonium compound of formula IV ##STR2## in which R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are each independently an alkyl, alkenyl, aryl, or alkaryl group having from 1 to 16 carbon atoms, and Y.sup.- is an anion; andC) at least one low foaming surfactant.The invention also relates to the diluted concentrates, and to the method of use of the diluted concentrates, especially for the disinfection of medical equipment.
摘要翻译： PCT No.PCT / EP91 / 00400 Sec。 371日期：1992年11月12日 102（e）日期1992年11月12日PCT 1991年3月4日PCT公布。出版物WO91 / 日本1991年9月19日。一种水性清洁和消毒浓缩物，其包含A）至少一种反应产物，其a）N-取代的丙二胺，式I R1-NH-（CH2）3-NH2（Ⅰ），其中R1是 C 8 -C 18烷基和b）谷氨酸或式II的R 2 -O-CO-（CH 2）2 -CH（NH 2）-COOH（II）的谷氨酸衍生物，其中R 2是氢或C 1 -C 4烷基基团，其中所述反应产物任选被乙氧基化和/或丙氧基化，并且任选地是与有机或无机酸形式的盐; B）至少一种以下抗微生物活性化合物：i）式III的季铵化合物（III），其中R 3和R 4彼此独立地表示含有1至3个碳原子的烷基或苄基，或含有6-22个碳原子的卤代或烷基化苄基，X-是阴离子; ii）苯酚; iii）双胍; （iv）式IV的季鏻化合物其中R 7，R 8，R 9和R 10各自独立地为具有1至16个碳原子的烷基，烯基，芳基或烷芳基，Y-为阴离子和C）至少一种低发泡表面活性剂。本发明还涉及稀释浓缩物，以及稀释浓缩物的使用方法，特别是用于医疗设备的消毒。

2. 发明授权

US4652585A N-substituted diaminopropane/glutamic acid reaction products 失效
标题翻译： N-取代二氨基丙烷/谷氨酸反应产物
公开(公告)号：US4652585A
公开(公告)日：1987-03-24
申请号：US713126
申请日：1985-03-15
申请人： Werner Gerhardt , Herbert Fischer , Rudolf Lehmann , Karlheinz Disch , Hans T. Leinen
发明人： Werner Gerhardt , Herbert Fischer , Rudolf Lehmann , Karlheinz Disch , Hans T. Leinen
IPC分类号： A01N37/20 , A01N37/44 , A01N61/00 , C07C101/24 , A01N37/18
CPC分类号： A01N37/44
摘要： Compounds which are the reaction products of a C.sub.12-14 -alkyl N-substituted 1,3-diaminopropane and glutamic acid or its 5-methyl ester, optionally alkoxylated, and optionally their salts, are useful as antimicrobial agents.
摘要翻译：作为任选烷氧基化的C 12-14烷基N-取代的1,3-二氨基丙烷和谷氨酸或其5-甲酯的反应产物和任选的其盐的化合物可用作抗微生物剂。

3. 发明授权

US4900721A Disinfectants and their use for disinfecting the skin and mucous membrane 失效
标题翻译：消毒剂及其用于消毒皮肤和粘膜的用途
公开(公告)号：US4900721A
公开(公告)日：1990-02-13
申请号：US60138
申请日：1987-06-09
申请人： Klaus Bansemir , Karlheinz Disch , Klaus Hachmann , Rudolf Lehmann , Manfred Biermann , Harald Schnegelberger
发明人： Klaus Bansemir , Karlheinz Disch , Klaus Hachmann , Rudolf Lehmann , Manfred Biermann , Harald Schnegelberger
IPC分类号： A01N31/04 , A01N31/10 , A01N33/02 , A01N37/00 , A01N47/44 , A01N59/00 , A01N65/22
CPC分类号： A01N59/00 , A01N65/00 , A01N65/22 , Y10S514/901
摘要： Liquid, aqueous disinfectants based on alcohol and hydrogen peroxide which contain one or more C.sub.2 -C.sub.8 alcohols, hydrogen peroxide or a compound which forms peroxide in aqueous phase, one or more carboxylic acids, one or more microbicidally active nitrogen-containing organic compounds, one or more microbicidally active phenolic compounds, and optionally other active substances and/or auxiliaries typically present in disinfectants, and to the use of such disinfectants for disinfection of the skin and mucous membrane.
摘要翻译：含有一种或多种C 2 -C 8醇，过氧化氢或在水相中形成过氧化物的化合物的基于醇和过氧化氢的液体，水性消毒剂，一种或多种羧酸，一种或多种杀微生物活性的含氮有机化合物，一种或更多的杀微生物活性酚类化合物，以及通常存在于消毒剂中的任选的其它活性物质和/或助剂，以及使用这种消毒剂来消毒皮肤和粘膜。

4. 发明授权

US4746451A Self-decontaminating cleansing preparations 失效
标题翻译：自净化清洁剂
公开(公告)号：US4746451A
公开(公告)日：1988-05-24
申请号：US892023
申请日：1986-07-30
申请人： Klaus Hachmann , Karlheinz Disch , Klaus Bansemir
发明人： Klaus Hachmann , Karlheinz Disch , Klaus Bansemir
IPC分类号： C11D3/32 , C11D3/00 , C11D3/39 , C11D3/48 , C11D3/60 , A61K7/50 , C11D17/08
CPC分类号： C11D3/48 , C11D3/3942 , C11D3/3947
摘要： A microbially self-decontaminating dermatological cleansing concentrate containing at least one washing-active surfactant and at least one standard cleansing concentrate additive, and having a viscosity of about 500 to 5,000 mPas, improved by incorporating hydrogen peroxide, at least one fatty acid alkanolamide, and at least one water soluble alkali salt or ammonium salt; and a method for its use.
摘要翻译：含有至少一种洗涤活性表面活性剂和至少一种标准清洁浓缩添加剂并具有约500至5,000mPas的粘度的微生物自净化皮肤病学清洁浓缩物通过加入过氧化氢，至少一种脂肪酸烷醇酰胺和至少一种水溶性碱金属盐或铵盐; 及其使用方法。

5. 发明授权

US4994200A Preparations and processes for cleaning and disinfecting endoscopes 失效
标题翻译：清洁和消毒内窥镜的准备和过程
公开(公告)号：US4994200A
公开(公告)日：1991-02-19
申请号：US224506
申请日：1988-07-26
申请人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
发明人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
IPC分类号： A61B1/12 , A61L2/18 , C11D1/66 , C11D3/386 , C11D3/43 , C11D3/48 , C11D3/60
CPC分类号： C11D3/48 , A61B1/121 , A61L2/18 , C11D11/0064 , C11D3/38618
摘要： In the cleaning and disinfection of endoscopes, the endoscope surfaces to be cleaned are successively(a) brought into contact with a cleaning solution which is heated to 55.degree. to 65.degree. C., kept at that temperature for 1 to 15 minutes and then drained off and which contains a low-foam nonionic surfactant, a proteolytic enzyme, at least one complexing agent and, optionally, other standard detergent constituents, and has a pH value of from 6 to 8;(b) brought into contact with a disinfectant solution which is heated to 55.degree. to 65.degree. C., kept at that temperature for 1 to 15 minutes and then separated off and which contains an aldehyde selected from the group consisting of formaldehyde and aliphatic C.sub.2 -C.sub.8 dialdehydes and at least one complexing agent, and has a pH value of from 6 to 8;(c) washed at least twice with water of which the pH value is adjusted to ph 6-8, the water being heated to 55.degree. to 65.degree. C. at least in the final wash cycle; and(d) dried with sterilized hot air at 55.degree. to 65.degree. C.,water having a hardness of from 3.degree. to 8.degree. Gh being used in steps (a) to (c).

6. 发明授权

US4784790A Preparations and processes for cleaning and disinfecting endoscopes 失效
标题翻译：清洁和消毒内窥镜的准备和过程
公开(公告)号：US4784790A
公开(公告)日：1988-11-15
申请号：US121492
申请日：1987-11-17
申请人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
发明人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
IPC分类号： A61B1/12 , A61L2/18 , C11D1/66 , C11D3/386 , C11D3/43 , C11D3/48 , C11D3/60
CPC分类号： C11D3/48 , A61B1/121 , A61L2/18 , C11D11/0064 , C11D3/38618
摘要： In the cleaning and disinfection of endoscopes, the endoscope surfaces to be cleaned are successively(a) brought into contact with a cleaning solution which is heated to 55.degree. to 65.degree. C., kept at that temperature for 1 to 15 minutes and then drained off and which contains a low-foam nonionic surfactant, a proteolytic enzyme, at least one complexing agent and, optionally, other standard detergent constituents, and has a pH value of from 6 to 8;(b) brought into contact with a disinfectant solution which is heated to 55.degree. to 65.degree. C., kept at that temperature for 1 to 15 minutes and then separated off and which contains an aldehyde selected from the group consisting of formaldehyde and aliphatic C.sub.2 -C.sub.8 dialdehydes and at least one complexing agent, and has a pH value of from 6 to 8;(c) washed at least twice with water of which the pH value is adjusted to pH 6-8, the water being heated to 55.degree. to 65.degree. C. at least in the final wash cycle; and(d) dried with sterilized hot air at 55.degree. to 65.degree. C.,water having a hardness of from 3.degree. to 8.degree.Gh being used in steps (a) to (c).
摘要翻译：在内窥镜的清洗消毒中，将要清洗的内窥镜表面依次（a）与加热至55℃至65℃的清洗溶液接触，在该温度下保持1至15分钟，然后排空并且其含有低泡沫非离子表面活性剂，蛋白水解酶，至少一种络合剂和任选的其它标准洗涤剂组分，并且具有6至8的pH值; （b）与加热至55℃至65℃的消毒溶液接触，在该温度下保持1至15分钟，然后分离，并含有选自甲醛和脂族C2的醛 -C8二醛和至少一种络合剂，并且具有6至8的pH值; （c）至少在最后的洗涤循环中将水至少洗涤至少两次，其中pH值调节至pH6-8，水被加热至55至65℃; （d）用无菌热空气在55〜65℃下干燥，步骤（a）〜（c）中使用硬度为3〜8℃的水。

7. 发明授权

US5190724A Process for disinfecting medical molding materials 失效
标题翻译：消毒医疗模具材料的工艺
公开(公告)号：US5190724A
公开(公告)日：1993-03-02
申请号：US663818
申请日：1991-05-17
申请人： Klaus Hachmann , Klaus Bansemir , Karlheinz Disch
发明人： Klaus Hachmann , Klaus Bansemir , Karlheinz Disch
IPC分类号： A01N31/02 , A01N35/02 , A61C9/00 , A61L2/18
CPC分类号： A61L2/18 , A01N35/02 , A61C9/00
摘要： In the process disclosed, medical molding materials are treated with an aqueous solution of a disinfectant which contains, in addition, 0.1 to 15 wt.% of a soluble alcohol. This ensures high dimensional stability and good surface quality of the mold, even in the case of critical molding materials as alginates.
摘要翻译： PCT No.PCT / EP89 / 01052 Sec。 371日期1991年5月17日 102（e）日期1991年5月17日PCT提交1989年9月11日PCT公布。 WO90 / 03191 PCT出版物日期为1990年4月5日。在所公开的方法中，医疗模塑材料用消毒剂的水溶液处理，另外还含有0.1至15重量％的可溶性醇。这确保了模具的高尺寸稳定性和良好的表面质量，即使在作为藻酸盐的关键成型材料的情况下也是如此。

8. 发明授权

US5234832A Process for cleaning and disinfecting heat and corrosion sensitive medical instruments 失效
标题翻译：清洁和消毒热和腐蚀敏感性医疗仪器的方法
公开(公告)号：US5234832A
公开(公告)日：1993-08-10
申请号：US353291
申请日：1989-05-17
申请人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
发明人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
IPC分类号： A61B1/12 , A61L2/18 , C11D1/66 , C11D1/72 , C11D3/386 , C11D3/48 , C11D3/60
CPC分类号： C11D11/0064 , A61L2/18 , C11D1/721 , C11D3/38618 , C11D3/48 , Y10S516/07
摘要： The invention is a process for cleaning and disinfection of heat and corrosion sensitive medical instruments, particularly endoscopes in which the surfaces of the medical instruments are contacted with a detergent and disinfectant solution. The solution has a pH of from 6 to 8 and contains a low foaming nonionic surfactant, a proteolytic enzyme, a complexing agent, and an aldehyde selected from the group consisting of formaldehyde and aliphatic dialdehydes containing 2 to 8 carbon atoms and, optionally, other standard detergent and disinfectant constituents. The cleaning solution is heated to 55.degree. to 65.degree. C. and kept at that temperature for 1 to 15 minutes during contact with the surfaces of a medical instrument. The surfaces are rinsed at least twice with water, the water being heated to 55.degree. to 65.degree. C. at least in the last rinse cycle and the medical instruments are dried with sterilized hot air at a temperature of 40.degree. to 60.degree. C. Water having a hardness of 3.degree. to 8.degree. Gh is used.
摘要翻译：本发明是用于清洁和消毒热和腐蚀敏感的医疗器械，特别是其中医疗器械的表面与洗涤剂和消毒剂溶液接触的内窥镜的方法。该溶液具有6至8的pH，并且含有低泡沫非离子表面活性剂，蛋白水解酶，络合剂和选自甲醛和含有2至8个碳原子的脂族二醛的醛，以及任选的其它标准洗涤剂和消毒剂成分。将清洁溶液加热至55℃至65℃，并在与医疗器械表面接触的同时在该温度下保持1至15分钟。将表面用水冲洗至少两次，至少在最后一个漂洗循环中将水加热至55℃至65℃，并将医疗器械用无菌热空气在40至60℃的温度下干燥。使用硬度为3〜8°Gh的水。

9. 发明授权

US5223166A Preparations and processes for cleaning and disinfecting endoscopes 失效
标题翻译：清洁和消毒内窥镜的准备和过程
公开(公告)号：US5223166A
公开(公告)日：1993-06-29
申请号：US618144
申请日：1990-11-26
申请人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
发明人： Karlheinz Disch , Klaus Hachmann , Klaus Bansemir
IPC分类号： A61B1/12 , A61L2/18 , C11D3/386
CPC分类号： C11D3/48 , A61B1/121 , A61L2/18 , C11D3/2072 , C11D3/33 , C11D3/361 , C11D3/364 , C11D3/365 , C11D3/38618 , C11D3/43
摘要： In the cleaning and disinfection of endoscopes, the endoscope surfaces to be cleaned are successivelya) brought into contact with a cleaning solution which is heated to 55.degree. to 65.degree. C., kept at that temperature for 1 to 15 minutes and then drained off and which contains a low-foam nonionic surfactant, a proteolytic enzyme, at least one complexing agent and, optionally, other standard detergent constituents, and has a pH value of from 6 to 8;b) brought into contact with a disinfectant solution which is heated to 55.degree. to 65.degree. C., kept at that temperature for 1 to 15 minutes and then separated off and which contains an aldehyde selected from the group consisting of formaldehyde and aliphatic C.sub.2 -C.sub.8 dialdehydes and at least one complexing agent, and has a pH value of from 6 to 8;c) washed at least twice with water of which the pH value is adjusted to pH 6-8, the water being heated to 55.degree. to 65.degree. C. at least in the final wash cycle; andd) dried with sterilized hot air at 55.degree. to 65.degree. C.,water having a hardness of from 3.degree. to 8.degree. Gh being used in steps a) to c).
摘要翻译：在内窥镜的清洁和消毒中，待清洁的内窥镜表面依次a）与加热至55℃至65℃的清洁溶液接触，在该温度下保持1至15分钟，然后排出并且其含有低泡沫非离子表面活性剂，蛋白水解酶，至少一种络合剂和任选的其它标准洗涤剂组分，并且具有6至8的pH值; b）与加热至55℃至65℃的消毒剂溶液接触，在该温度下保持1至15分钟，然后分离，并含有选自甲醛和脂族C2- C8二醛和至少一种络合剂，pH值为6〜8; c）至少在最后的洗涤循环中将水至少洗涤至少两次，其中pH值被调节至pH6-8，水被加热至55℃至65℃; 和d）在55至65℃的无菌热空气中干燥，在步骤a）至c）中使用硬度为3至8°Gh的水。

10. 发明授权

US5030659A Disinfectant compositions 失效
标题翻译：消毒剂组合物
公开(公告)号：US5030659A
公开(公告)日：1991-07-09
申请号：US477159
申请日：1990-02-08
申请人： Klaus Bansemir , Karlheinz Disch , Klaus Hachmann
发明人： Klaus Bansemir , Karlheinz Disch , Klaus Hachmann
IPC分类号： A01N31/08 , A01N31/12 , A01N31/16 , A01N33/12 , A01N47/44 , C11D3/48
CPC分类号： C11D3/48 , A01N47/44
摘要： Liquid, aqueous disinfectant preparations containing a combination of(a) at least one microbicidal quaternary ammonium compound(b) at least one microbicidal biguanide compound and(c) at least one microbicidal phenolic compound,components (a) and (b) being present in a ratio by weight a:b of (16 - 2); 1 while components (a) and (c) are present in a ratio by weight a:c of (16 - 2):1.
摘要翻译：含有（a）至少一种杀微生物季铵化合物（b）至少一种杀微生物双胍化合物和（c）至少一种杀微生物酚化合物，组分（a）和（b））的组合的液体消毒剂制剂（16-2）的重量比a：b; 1，而组分（a）和（c）以（16-2）：1的重量比a：c存在。

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