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1. 发明申请

US20080139541A1 Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权
标题翻译：治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法
公开(公告)号：US20080139541A1
公开(公告)日：2008-06-12
申请号：US12015735
申请日：2008-01-17
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： A61K31/542 , A61P25/28
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid D peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译：治疗或预防与淀粉样蛋白β肽（Abeta）的异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或与含有淀粉样蛋白D肽的斑块形成（ Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。

2. 发明申请

US20060040928A1 Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权
标题翻译：治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法
公开(公告)号：US20060040928A1
公开(公告)日：2006-02-23
申请号：US11132815
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Edward Lazer , Clara Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Edward Lazer , Clara Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： C07D279/16 , A61K31/5415
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译：治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。

3. 发明授权

US07534787B2 Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权
标题翻译：治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法
公开(公告)号：US07534787B2
公开(公告)日：2009-05-19
申请号：US12015735
申请日：2008-01-17
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： C07D513/04 , A61K31/542
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译：治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3，R 5，R 6，L 1和i如权利要求1中所定义。

4. 发明授权

US07375220B2 Method of treating diseases and conditions associated with an altered level of amyloid β peptides and new enolcarboxamide compounds 有权
标题翻译：治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法
公开(公告)号：US07375220B2
公开(公告)日：2008-05-20
申请号：US11132815
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Edward S. Lazer , Clara K. Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Edward S. Lazer , Clara K. Miao , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： C07D279/16 , A61K31/5415
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译：治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。

5. 发明申请

US20050277635A1 Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds 有权
标题翻译：治疗与淀粉样蛋白β肽和新的烯醇酰胺化合物水平变化相关的疾病和病症的方法
公开(公告)号：US20050277635A1
公开(公告)日：2005-12-15
申请号：US11132482
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Ciossek , Marcus Kostka
IPC分类号： A61K31/541 , C07D279/02 , C07D513/04 , A61K31/54
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
摘要翻译：治疗或预防与淀粉样蛋白β肽（Abeta）异构体水平升高相关的疾病或病症的方法和/或具有改变的Abeta同种型水平和/或形成含有淀粉状蛋白β肽的噬菌斑 Abeta）同种型，其包括向所述哺乳动物施用治疗有效量的选自式Ia，Ib的化合物，其中V，W，Y，R 2，R 3， >，R 5，R 6，L 1和i如权利要求1中所定义。

6. 发明授权

US07393843B2 Method of treating diseases and conditions associated with an altered level of amyloid β peptides and new enolcarboxamide compounds 有权
公开(公告)号：US07393843B2
公开(公告)日：2008-07-01
申请号：US11132482
申请日：2005-05-19
申请人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Clossek , Marcus Kostka
发明人： Klaus Bornemann , Guenter Trummlitz , Bernd Beck , Frank Sams-Dodd , Dagmar Kugler , Klaus Klinder , Cornelia Dorner-Clossek , Marcus Kostka
IPC分类号： A61K31/54 , C07D279/18
CPC分类号： C07D513/04 , A61K31/541 , C07D279/02
摘要： A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid β peptides (Aβ) and/or with a changed ratio of levels of Aβ isoforms and/or with the formation of plaques containing amyloid β peptide (Aβ) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.

7. 发明授权

US07373826B2 Method for manufacturing a fluid pressure measurement unit and a component for being used in a fluid pressure measurement unit 失效
标题翻译：用于制造流体压力测量单元的方法和用于流体压力测量单元中的部件
公开(公告)号：US07373826B2
公开(公告)日：2008-05-20
申请号：US11458961
申请日：2006-07-20
申请人： Joerg Weber , Bernd Beck
发明人： Joerg Weber , Bernd Beck
IPC分类号： A61B5/02
CPC分类号： G01L19/0023 , A61M5/16854 , A61M39/22 , A61M2205/3344 , A61M2230/30 , Y10T29/49144 , Y10T29/49146 , Y10T29/49171
摘要： A fluid pressure measurement unit is manufactured by steps of providing a measurement element with a measurement chip arranged on a first chip carrier side and a plurality of socket-shaped terminal contacts for contacting contact terminals of the measurement chip, the socket-shaped terminal contacts protruding from a second chip carrier side opposite from the chip carrier first side; providing a housing element comprising a plurality of receiving holes in a housing element first side which are implemented to receive the socket-shaped terminal contacts when combining the housing element with the measurement element, wherein the receiving holes extend from the housing element first side to a housing element second side opposite from the housing element first side; and combining the measurement element and the housing element, wherein the second chip carrier side is opposite from the housing element first side and the socket-shaped terminal contacts are arranged in the receiving holes.
摘要翻译：流体压力测量单元通过以下步骤来制造：测量元件具有布置在第一芯片载体侧上的测量芯片和用于接触测量芯片的接触端子的多个插座形状的端子触头，插座形状的端子触头突出从与芯片载体第一侧相反的第二芯片载体侧; 提供壳体元件，其包括在壳体元件第一侧中的多个接收孔，当将所述壳体元件与所述测量元件组合时，所述多个接收孔被实现为接收所述插座形接线端子，其中所述接收孔从所述壳体元件第一侧延伸到壳体元件第二侧与壳体元件第一侧相对; 以及组合测量元件和壳体元件，其中第二芯片载体侧与壳体元件第一侧相对，并且插座形端子触头布置在接收孔中。

8. 发明申请

US20070209449A1 METHOD FOR MANUFACTURING A FLUID PRESSURE MEASUREMENT UNIT AND A COMPONENT FOR BEING USED IN A FLUID PRESSURE MEASUREMENT UNIT 失效
标题翻译：制造流体压力测量单元的方法和用于流体压力测量单元的组件
公开(公告)号：US20070209449A1
公开(公告)日：2007-09-13
申请号：US11458961
申请日：2006-07-20
申请人： Joerg Weber , Bernd Beck
发明人： Joerg Weber , Bernd Beck
IPC分类号： G01F1/56 , H05K3/30 , H05K3/34
CPC分类号： G01L19/0023 , A61M5/16854 , A61M39/22 , A61M2205/3344 , A61M2230/30 , Y10T29/49144 , Y10T29/49146 , Y10T29/49171
摘要： A method for manufacturing a component of a fluid pressure measurement unit includes the step of providing a measurement element with a measurement chip arranged on a first side of the chip carrier and a plurality of socket-shaped terminal contacts for contacting contact terminals of the measurement chip, wherein the socket-shaped terminal contacts protrude from a second side of the chip carrier opposite from the first side of the chip carrier. Further, the inventive method comprises a step of providing a housing element comprising a plurality of receiving holes in a first side of the housing element which are implemented to receive the socket-shaped terminal contacts when combining the housing element with the measurement element, wherein the receiving holes extend from the first side of the housing element to a second side of the housing element opposite from the first side of the housing element, wherein the step of providing the housing element includes spraying on a sealing element to the first side of the housing element and/or spraying on a closing element to the second side of the housing element for closing the receiving holes on the second side of the housing element. Finally, the inventive method includes a step of combining the measurement element and the housing element such that the second side of the chip carrier is opposite from the first side of the housing element and the socket-shaped terminal contacts are arranged in the receiving holes to manufacture the component of the fluid pressure measurement unit.
摘要翻译：一种制造流体压力测量单元的部件的方法包括以下步骤：向芯片载体的第一侧设置测量芯片和测量芯片，用于接触测量芯片的接触端子，其中所述插座形端子触点从所述芯片载体的与所述芯片载体的第一侧相对的第二侧突出。此外，本发明的方法包括提供壳体元件的步骤，该壳体元件包括在壳体元件的第一侧中的多个接收孔，其在将壳体元件与测量元件组合时被实施为接收插座形接线端子，其中接收孔从壳体元件的第一侧延伸到与壳体元件的第一侧相对的壳体元件的第二侧，其中提供壳体元件的步骤包括在密封元件上喷涂到壳体的第一侧元件和/或在封闭元件上喷射到壳体元件的第二侧，用于封闭壳体元件的第二侧上的接收孔。最后，本发明的方法包括将测量元件和壳体元件组合以使得芯片承载件的第二侧与壳体元件的第一侧相对的步骤，并且插座形端子触头布置在接收孔中制造流体压力测量单元的部件。

9. 发明申请

US20050203350A1 Patient monitoring apparatus 审中-公开
标题翻译：病人监护仪
公开(公告)号：US20050203350A1
公开(公告)日：2005-09-15
申请号：US11064338
申请日：2005-02-23
申请人： Bernd Beck
发明人： Bernd Beck
IPC分类号： A61B5/00 , A61B5/0215 , G06F19/00 , G08C17/00 , A61B5/02 , A61B5/08 , A61B10/00 , G06F17/00
CPC分类号： A61B5/0002 , A61B5/0215 , G06F19/3418
摘要： A patient monitoring apparatus includes at least one transducer for a patient, a transmission device for the patient and a reception device which is remote therefrom and to which an evaluation unit is connected. The transmission and reception devices each have at least one memory. The memory in the transmission unit stores an explicit or unique unalterable identification code. The reception unit has a keypad which can be used to input an identification code into its memory. A radio link between the transmission and reception units is set up only if the two stored identification codes are identical. If the radio link is interrupted for a prescribed period, the identification code in the reception unit is automatically erased, and a connection can be set up again only after the appropriate identification code has been input on the reception unit again. The radio link operates on the basis of the Bluetooth protocol.
摘要翻译：患者监视装置包括至少一个用于患者的换能器，用于患者的传输装置和远离其的接收装置，并且连接有评估单元。发送和接收设备各具有至少一个存储器。传输单元中的存储器存储显式或唯一的不可更改的识别码。接收单元具有可用于将识别码输入其存储器中的小键盘。发送和接收单元之间的无线电链路仅在两个存储的识别码相同时被建立。如果无线链路在规定时间内中断，接收单元中的识别码将被自动擦除，并且只有在再次在接收单元上输入适当的识别码之后，才能再次建立连接。无线电链路基于蓝牙协议进行操作。

10. 发明申请

US20060278293A1 PRESSURE MEASURING LINE, PARTICULARLY FOR INVASIVE BLOOD PRESSURE MEASUREMENT 审中-公开
标题翻译：压力测量线，特别是用于入血的血压测量
公开(公告)号：US20060278293A1
公开(公告)日：2006-12-14
申请号：US11423858
申请日：2006-06-13
申请人： Jorg Weber , Bernd Beck
发明人： Jorg Weber , Bernd Beck
IPC分类号： F16L9/14
CPC分类号： A61M39/08 , A61B5/0215 , A61M25/0045 , A61M2205/3331 , G01L19/0007
摘要： The invention relates to a pressure measuring line, particularly for invasive blood pressure measurement, which presents a wall made of a flexible material, which surrounds a passageway. The wall consists particularly of at least one inner hose and an outer hose enveloping the former, where the material of the inner hose is harder than the material of the outer hose, and the wall thickness of the inner hose is less than the wall thickness of the outer hose. The inner side of the outer hose is in full-surface contact with the outer side of the inner hose.
摘要翻译：本发明涉及一种压力测量线，特别是对于侵入性血压测量，该测量线呈现围绕通道的由柔性材料制成的壁。该壁特别包括至少一个内部软管和一个包围前者的外部软管，其中内部软管的材料比外部软管的材料更硬，并且内部软管的壁厚小于外软管。外软管的内侧与内软管的外侧全表面接触。

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