专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130064791A1 Interferon Analogs 有权
标题翻译：干扰素类似物
公开(公告)号：US20130064791A1
公开(公告)日：2013-03-14
申请号：US13519808
申请日：2010-12-30
申请人： Klaas Poelstra , Jai Prakash , Eleonora Beljaars , Ruchi Bansal
发明人： Klaas Poelstra , Jai Prakash , Eleonora Beljaars , Ruchi Bansal
IPC分类号： C07K14/57 , C12N15/63 , A61K38/21 , A61P29/00 , A61P1/00 , C12N5/10 , A61P7/00 , A61P31/12 , A61P31/16 , A61P31/14 , A61P35/00 , C12N1/21 , C12N15/23 , A61P13/12
CPC分类号： C07K14/57 , A61K38/00 , A61K38/12 , A61K38/21 , A61K38/217 , C07K5/0808 , C07K5/081 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K7/06 , C07K14/555 , C07K2319/09 , C07K2319/74
摘要： The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.
摘要翻译：本发明涉及医学领域。其中，它涉及显示较少不希望的副作用及其治疗用途的干扰素（IFN）的生物活性类似物。提供的是IFN类似物，其中介导其与其天然受体的结合的部分至少在功能上被破坏，并且其中该类似物包含能够介导细胞内IFN活性的信号传导部分，所述信号传导部分在其N-末端，任选地通过连接体，其中至少一个靶向结构域能够结合除IFN受体以外的细胞表面受体。

2. 发明授权

US09381230B2 Interferon analogs 有权
标题翻译：干扰素类似物
公开(公告)号：US09381230B2
公开(公告)日：2016-07-05
申请号：US13519808
申请日：2010-12-30
申请人： Klaas Poelstra , Jai Prakash , Eleonora Beljaars , Ruchi Bansal
发明人： Klaas Poelstra , Jai Prakash , Eleonora Beljaars , Ruchi Bansal
IPC分类号： A61K38/21 , C07K14/555 , C07K14/57 , A61K38/12 , C07K5/083 , C07K5/09 , C07K5/093
CPC分类号： C07K14/57 , A61K38/00 , A61K38/12 , A61K38/21 , A61K38/217 , C07K5/0808 , C07K5/081 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K7/06 , C07K14/555 , C07K2319/09 , C07K2319/74
摘要： The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (IFNs) which show less unwanted side-effects and to the therapeutic uses thereof. Provided is an IFN analog, wherein the moiety mediating binding to its natural receptor is at least functionally disrupted and wherein the analog comprises a signaling moiety capable of mediating intracellular IFN activity, said signaling moiety being provided at its N-terminus, optionally via a linker, with at least one targeting domain capable of binding to a cell surface receptor other than the IFN receptor.
摘要翻译：本发明涉及医学领域。其中，它涉及显示较少不希望的副作用及其治疗用途的干扰素（IFN）的生物活性类似物。提供的是IFN类似物，其中介导其与其天然受体的结合的部分至少在功能上被破坏，并且其中该类似物包含能够介导细胞内IFN活性的信号传导部分，所述信号传导部分在其N-末端，任选地通过连接体，其中至少一个靶向结构域能够结合除IFN受体以外的细胞表面受体。

3. 发明授权

US06755964B1 Process for the fixed bed sweetening of petroleum distillates using halogenated metal phthalocyanine as a catalyst 有权
标题翻译：使用卤化金属酞菁作为催化剂的石油馏分固定床脱色方法
公开(公告)号：US06755964B1
公开(公告)日：2004-06-29
申请号：US09804993
申请日：2001-03-13
申请人： Brij Bahadur Agrawal , Som Nath Puri , Gautam Das , Bir Sain , Bhagwati Prasad Balodi , Sunil Kumar , Anil Kumar , Pushpa Gupta , Jai Prakash , Onkar Singh Tyagi , Turuga Sundara Rama Prasada Rao , Gur Pratap Rai
发明人： Brij Bahadur Agrawal , Som Nath Puri , Gautam Das , Bir Sain , Bhagwati Prasad Balodi , Sunil Kumar , Anil Kumar , Pushpa Gupta , Jai Prakash , Onkar Singh Tyagi , Turuga Sundara Rama Prasada Rao , Gur Pratap Rai
IPC分类号： C10G1900
CPC分类号： C10G27/10
摘要： A process for fixed bed sweetening of petroleum distillates using halogenating metal phthalocyanine as a catalyst comprising impregnating the catalyst on activated charcoal bed by circulating alcoholic alkaline solution of the catalyst through charcoal bed till colorless bed solution is obtained in the effluent, passing the petroleum distillate through the said catalyst loaded charcoal bed along with air or oxygen at a temperature and pressure with liquid hourly space velocity with continuous or intermittent injection of alkali solution such as sodium hydroxide of concentration to obtain the desired low mercaptan level petroleum distillates. The alkaline solution used is selected from methanolic and ethanolic solution of sodium hydroxide. The halogenated metal phthalocyanine catalyst used is selected from dichloro cobalt phthalocyanine and dibromo cobalt phthalocyanine. The petroleum fraction used is selected from diesel, kerosene and FCC gasoline.
摘要翻译：一种使用卤化金属酞菁作为催化剂的石油馏分的固定床脱色方法，包括通过将催化剂的醇碱性溶液循环通过木炭床将催化剂浸渍在活性炭床上，直到在流出物中得到无色的床溶液，使石油馏出物通过所述催化剂负载的活性炭床与空气或氧气一起在温度和压力下具有液时空速，连续或间歇地注入浓度如氢氧化钠的碱溶液以获得所需的低硫醇水平的石油馏分。使用的碱性溶液选自氢氧化钠的甲醇和乙醇溶液。所用的卤化金属酞菁催化剂选自二氯钴酞菁和二溴钴酞菁。所使用的石油馏分选自柴油，煤油和FCC汽油。

4. 发明授权

US06696381B2 Process for the preparation of a novel catalyst useful for sweetening of sour petroleum distillates 有权
标题翻译：制备用于酸性石油馏出物甜化的新型催化剂的方法
公开(公告)号：US06696381B2
公开(公告)日：2004-02-24
申请号：US09804985
申请日：2001-03-13
申请人： Brij Bahadur Agrawal , Som Nath Puri , Gautam Das , Bir Sain , Bhagwati Prasad Balodi , Sunil Kumar , Anil Kumar , Pushpa Gupta , Jai Prakash , Onkar Singh Tyagi , Turuga Sundara Rama Prasada Rao , Gur Pratap Rai
发明人： Brij Bahadur Agrawal , Som Nath Puri , Gautam Das , Bir Sain , Bhagwati Prasad Balodi , Sunil Kumar , Anil Kumar , Pushpa Gupta , Jai Prakash , Onkar Singh Tyagi , Turuga Sundara Rama Prasada Rao , Gur Pratap Rai
IPC分类号： C07D48722
CPC分类号： C10G27/10 , B01J31/183 , B01J2531/025 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847
摘要： A process for the preparation of a supported catalyst comprising a Halogenated Phthalocyanine of cobalt, iron or manganese of formula 1 which comprises: mixing a phthalocyanine of cobalt, iron or manganese with a halogenating agent in a stoichiometric ratio ranging between 1:1 to 1:20 optionally in an inert organic solvent, refluxing or heating and stirring for a time period ranging between 1-6 hrs, distilling the excess halogenating agent from the mixture, filtering and washing the residual mass by known method to obtain the desired halogenated phthalocyanine and impregnating a support material with the desired halogenated phthalocyanine.
摘要翻译：一种制备载体催化剂的方法，其包括式1的钴，铁或锰的卤代酞菁，其包括：将化学计量比为1：1至1:20的钴，铁或锰的酞菁与卤化剂混合任选地在惰性有机溶剂中，回流或加热和搅拌1-6小时的时间，从混合物中蒸馏出过量的卤化剂，通过已知方法过滤和洗涤残余物质，得到所需的卤代酞菁并浸渍支持材料与所需的卤代酞菁。

5. 发明授权

US6023151A Method and device for enhancing smart battery performance 失效
标题翻译：提高智能电池性能的方法和装置
公开(公告)号：US6023151A
公开(公告)日：2000-02-08
申请号：US39528
申请日：1998-03-16
申请人： Richard Hudson , Syed Rahman , Thorfinn Thayer , Jai Prakash , Nate Banes
发明人： Richard Hudson , Syed Rahman , Thorfinn Thayer , Jai Prakash , Nate Banes
IPC分类号： H02J7/00 , H01M10/44 , H01H35/00
CPC分类号： H01M10/44 , H01M10/448 , Y10T307/858
摘要： The subject invention pertains to a method and device for implementing a dynamic End of Discharge Voltage (EODV) for rechargeable batteries and battery packs (batteries/packs). This dynamic EODV can be adjusted based on, for example, environment, operating conditions, temperature, residual capacity, cell chemistry, cell size, form factor, discharge rate, and/or the number of charge/discharge cycles the battery has undergone. The subject invention can provide for enhanced run time from each discharge cycle of the battery/pack. In addition, the subject invention can provide for more accurate save-to-disk alarms, while ensuring adequate energy for the actual save to disk operation. Furthermore, the subject invention can also extend the useful life of the battery/pack.
摘要翻译：本发明涉及用于实现用于可再充电电池和电池组（电池/组件）的动态终止电压（EODV）结束的方法和装置。该动态EODV可以基于例如环境，操作条件，温度，剩余容量，电池化学，电池尺寸，外形尺寸，放电率和/或电池已经经历的充电/放电循环次数进行调整。本发明可以提供来自电池/组件的每个放电循环的增强的运行时间。此外，本发明可以提供更准确的保存到磁盘的警报，同时确保实际保存到磁盘操作的足够的能量。此外，本发明还可以延长电池/包的使用寿命。

6. 发明授权

US5536593A Electrochemical cell 失效
标题翻译：电化学电池
公开(公告)号：US5536593A
公开(公告)日：1996-07-16
申请号：US211554
申请日：1994-12-05
申请人： Laszlo I. Redey , Donald R. Vissers , Jai Prakash
发明人： Laszlo I. Redey , Donald R. Vissers , Jai Prakash
IPC分类号： H01M4/02 , H01M4/58 , H01M10/39 , H01M4/36
CPC分类号： H01M4/02 , H01M10/39 , H01M4/582
摘要： An electrochemical cell having a bimodal positive electrode, a negative electrode of an alkali metal, and a compatible electrolyte including an alkali metal salt molten at the cell operating temperature. The positive electrode has an electrochemically active layer of at least one transition metal chloride at least partially present as a charging product, and additives of bromide and/or iodide and sulfur in the positive electrode or the electrolyte. Electrode volumetric capacity is in excess of 400 Ah/cm.sup.3 ; the cell can be 90% recharged in three hours and can operate at temperatures below 160.degree. C. There is also disclosed a method of reducing the operating temperature and improving the overall volumetric capacity of an electrochemical cell and for producing a positive electrode having a BET area greater than 6.times.10.sup.4 cm.sup.2 /g of Ni.
摘要翻译： PCT No.PCT / US92 / 08599 Sec。 371日期1994年12月5日第 102（e）日期1994年12月5日PCT提交1992年10月8日PCT公布。公开号WO93 / 07650 日期：1993年04月15日。具有双峰正电极，碱金属负极的电化学电池和在电池工作温度下熔融的碱金属盐的相容电解质。正电极具有至少一种至少部分作为充电产物存在的至少一种过渡金属氯化物的电化学活性层，以及正极或电解质中的溴化物和/或碘化物和硫的添加剂。电极体积容量超过400 Ah / cm3; 电池可以在三小时内充电90％，并且可以在低于160℃的温度下工作。还公开了一种降低电化学电池的工作温度和提高总体积容量的方法，并且制造具有BET 面积大于6×10 4 cm 2 / g的Ni。

7. 发明授权

US5532078A Electrochemical cell 失效
标题翻译：电化学电池
公开(公告)号：US5532078A
公开(公告)日：1996-07-02
申请号：US312053
申请日：1994-09-26
申请人： Laszlo I. Redey , Kevin M. Myles , Donald R. Vissers , Jai Prakash
发明人： Laszlo I. Redey , Kevin M. Myles , Donald R. Vissers , Jai Prakash
IPC分类号： H01M4/02 , H01M4/58 , H01M10/39 , H01M6/20
CPC分类号： H01M4/582 , H01M10/39 , H01M4/02
摘要： An electrochemical cell with a positive electrode having an electrochemically active layer of at least one transition metal chloride. A negative electrode of an alkali metal and a compatible electrolyte including an alkali metal salt molten at cell operating temperature is included in the cell. The electrolyte is present at least partially as a corrugated .beta." alumina tube surrounding the negative electrode interior to the positive electrode. The ratio of the volume of liquid electrolyte to the volume of the positive electrode is in the range of from about 0.1 to about 3. A plurality of stacked electrochemical cells is disclosed each having a positive electrode, a negative electrode of an alkali metal molten at cell operating temperature, and a compatible electrolyte. The electrolyte is at least partially present as a corrugated .beta." alumina sheet separating the negative electrode and interior to the positive electrodes. The alkali metal is retained in a porous electrically conductive ceramic, and seals for sealing the junctures of the electrolyte and the adjacent electrodes at the peripheries thereof.
摘要翻译：一种具有正电极的电化学电池，其具有至少一种过渡金属氯化物的电化学活性层。在电池中包括碱金属的负极和包含在电池工作温度下熔融的碱金属盐的相容电解质。电解质至少部分地存在于围绕正极的负极内部的波纹β“氧化铝管。液体电解质的体积与正极的体积的比例在约0.1至约3的范围内。公开了多个层叠的电化学电池，其具有正极，碱金属的负极熔化在电池工作温度和兼容的电解液。电解质至少部分地以波纹状β“氧化铝片形式存在，将负极和内部分隔成正极。碱金属保留在多孔导电陶瓷中，并且密封用于在其周边处密封电解质和相邻电极的接合处。

8. 发明公开

US20240025965A1 INTEGRIN BINDING PEPTIDES AND USES THEREOF 审中-公开
公开(公告)号：US20240025965A1
公开(公告)日：2024-01-25
申请号：US18295068
申请日：2023-04-03
申请人： Jai Prakash , Universiteit Twente
发明人： Jai Prakash
IPC分类号： C07K14/705 , A61K49/00 , C07K14/78 , C07K7/08 , C07K7/06 , A61K47/62 , A61K47/60 , A61P1/16
CPC分类号： C07K14/70546 , A61K49/0045 , C07K14/78 , C07K7/08 , C07K7/06 , A61K47/62 , A61K47/60 , A61P1/16 , A61K49/0056 , A61K38/00
摘要： The disclosure relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.

9. 发明授权

US11634470B2 Integrin binding peptides and uses thereof 有权
公开(公告)号：US11634470B2
公开(公告)日：2023-04-25
申请号：US15770105
申请日：2016-10-21
申请人： Universiteit Twente , Jai Prakash
发明人： Jai Prakash
IPC分类号： A61K38/00 , C07K14/705 , A61K49/00 , C07K14/78 , C07K7/08 , C07K7/06 , A61K47/62 , A61K47/60 , A61P1/16
摘要： The disclosure relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.

10. 发明申请

US20180312567A1 INTEGRIN BINDING PEPTIDES AND USES THEREOF 审中-公开
公开(公告)号：US20180312567A1
公开(公告)日：2018-11-01
申请号：US15770105
申请日：2016-10-21
申请人： Jai Prakash , Universiteit Twente
发明人： Jai Prakash
IPC分类号： C07K14/705 , A61K47/62 , A61K47/60 , A61P1/16 , A61K49/00
CPC分类号： A61K49/0045 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/70546 , C07K14/78
摘要： The invention relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式