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    • 9. 发明授权
    • Pyridine compounds and their pharmaceutical use
    • 吡啶化合物及其药物用途
    • US06521643B1
    • 2003-02-18
    • US09913715
    • 2001-08-17
    • Masaki TomishimaKazuhiko Take
    • Masaki TomishimaKazuhiko Take
    • A61K3144
    • C07D401/04C07D213/58C07D213/61C07D213/63C07D213/73C07D213/85C07D417/04C07D417/06C07D417/12
    • A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.
    • 式(I)的化合物,其中每个符号如说明书中所定义,及其药学上可接受的盐。 本发明的化合物(I)及其药学上可接受的盐对一氧化氮(NO)的产生具有很强的抑制活性,可用于预防和/或治疗NOS(一氧化氮合酶)介导的疾病,例如 成人呼吸窘迫综合征,心肌炎,滑膜炎,脓毒性休克,胰岛素 - 后遗症糖尿病,溃疡性结肠炎,脑梗死,类风湿性关节炎,骨关节炎,骨质疏松症,系统性红斑狼疮,器官移植排斥反应,哮喘,疼痛,溃疡等 人类和动物。