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1. 发明授权

US4918012A Method for producing carnitine, L-carnitinamide hydrolase and method for producing same 失效
标题翻译：肉碱生产方法，L-肉毒碱水解酶及其制备方法
公开(公告)号：US4918012A
公开(公告)日：1990-04-17
申请号：US89454
申请日：1987-08-26
申请人： Kiyoshi Nakayama , Haruo Honda , Yukie Ogawa , Tatsuya Ozawa , Tetsuo Ohta
发明人： Kiyoshi Nakayama , Haruo Honda , Yukie Ogawa , Tatsuya Ozawa , Tetsuo Ohta
IPC分类号： C12N9/80 , C12P13/00
CPC分类号： C12P13/007 , C12N9/80 , Y10S435/874
摘要： This invention relates to a method for producing carnitine comprising contacting, in a reaction medium, carnitinamide with (A) an amidase capable of hydrolyzing carnitinamide to form carnitine or (B) a microorganism containing said amidase, carnitinamide hydrolase and a method for producing same.
摘要翻译：本发明涉及一种生产肉碱的方法，包括在反应介质中使肉毒碱与（A）能够水解肉毒碱的酰胺酶形成肉碱或（B）含有所述酰胺酶，肉毒杆菌素水解酶的微生物及其制备方法在反应介质中接触。

2. 发明授权

US5041375A Method of producing carnitine 失效
标题翻译：生产肉碱的方法
公开(公告)号：US5041375A
公开(公告)日：1991-08-20
申请号：US279004
申请日：1988-12-02
申请人： Kiyoshi Nakayama , Haruo Honda , Yukie Ogawa , Tetsuo Ohta , Tatsuya Ozawa
发明人： Kiyoshi Nakayama , Haruo Honda , Yukie Ogawa , Tetsuo Ohta , Tatsuya Ozawa
IPC分类号： C12N9/14 , C12P13/00 , C12P41/00 , C12R1/15
CPC分类号： C12P13/007 , C12N9/14 , C12P41/006 , Y10S435/843
摘要： This invention relates to a method for producing carnitine comprising contacting, in a reaction medium, carnitinenitrile with (A) a nitrilase capable of hydrolyzing carnitinenitrile to form carnitine or (B) a microorganism containing said nitrilase.

3. 发明申请

US20120287262A1 IN-VEHICLE INFORMATION APPARATUS 有权
标题翻译：车内信息装置
公开(公告)号：US20120287262A1
公开(公告)日：2012-11-15
申请号：US13318376
申请日：2011-01-26
申请人： Kiyoshi Nakayama , Masato Takahashi
发明人： Kiyoshi Nakayama , Masato Takahashi
IPC分类号： H04N7/18
CPC分类号： G01C21/3688 , B60K35/00 , B60K37/06 , B60K2350/1004 , B60K2350/1032 , B60K2350/1096
摘要： An in-vehicle information apparatus according to the invention includes a main unit having a display device, and a navigation unit providing a navigation function to the main unit. The navigation unit includes a navigation processing unit which executes a process concerning the navigation function, a sub unit providing an addition function to the navigation unit, and a navigation unit screen generating unit which generates a navigation unit screen for displaying information concerning a function which the navigation unit provides. The main unit includes an operation unit which receives an input for selecting a function from a user, a main unit screen generating unit which generates a main unit screen for displaying information concerning a function which the main unit provides, and a video selector which selects one of the navigation unit screen and the main unit screen and provides the selected one to the display device. The addition function provided by the sub unit is executed by an interruption process, and the video selector selects one of the navigation unit screen and the main unit screen based on the function inputted to the operation unit and the addition function executed by the interruption process.
摘要翻译：根据本发明的车载信息装置包括具有显示装置的主单元和向主单元提供导航功能的导航单元。导航单元包括执行与导航功能有关的处理的导航处理单元，向导航单元提供加法功能的子单元，以及导航单元画面生成单元，其生成导航单元屏幕，用于显示有关功能的信息，导航单位提供。主单元包括接收用户选择功能的输入的操作单元，产生用于显示与主单元提供的功能有关的信息的主单元屏幕的主单元屏幕生成单元，以及选择一个的导航单元屏幕和主单元屏幕，并将所选择的屏幕提供给显示设备。由子单元提供的附加功能通过中断处理执行，并且视频选择器基于输入到操作单元的功能和通过中断处理执行的加法函数来选择导航单元屏幕和主单元屏幕中的一个。

4. 发明申请

US20100130492A1 MORPHOLINOPURINE DERIVATIVES 有权
标题翻译：多环芳烃衍生物
公开(公告)号：US20100130492A1
公开(公告)日：2010-05-27
申请号：US12579175
申请日：2009-10-14
申请人： Kiyoshi Nakayama , Kazuyuki Sugita , Masaki Setoguchi , Yuichi Tominaga , Masanori Saitou , Takashi Odagiri
发明人： Kiyoshi Nakayama , Kazuyuki Sugita , Masaki Setoguchi , Yuichi Tominaga , Masanori Saitou , Takashi Odagiri
IPC分类号： A61K31/5377 , C07D487/04 , A61P43/00 , A61P35/00
CPC分类号： C07D473/34
摘要： There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.
摘要翻译：提供抑制磷脂酰肌醇3-激酶（PI3K）和/或雷帕霉素（mTOR）的哺乳动物靶标并表现出抗肿瘤活性的新型化合物。本发明提供具有抑制PI3K和/或mTOR的各种取代基并表现出抗肿瘤活性的下述式（1）表示的化合物：其中R1，R2，R3，R4，Ra，Rb，Rc和X各自具有与本说明书中定义的含义相同。

5. 发明授权

US06823859B2 Flat heating surface type gas stove 失效
标题翻译：平面加热表面式燃气灶
公开(公告)号：US06823859B2
公开(公告)日：2004-11-30
申请号：US10602723
申请日：2003-06-25
申请人： Yutaka Yamada , Kiyoshi Nakayama
发明人： Yutaka Yamada , Kiyoshi Nakayama
IPC分类号： F24C300
CPC分类号： F24C3/067 , Y02B40/166
摘要： There is disclosed a novel flat heating surface type gas stove which is capable of heating a heating substance across a heat resistance glass at practically applicable heating efficiency, overcoming any inconvenience resulting from the exposure of flame and facilitating the cleaning of the gas stove. This gas stove 10 comprises a heat resistance glass top plate 12 which is disposed over a burner 15, wherein a gas-permeable porous body 40 is disposed below said top plate 12, and a space between said top plate 12 and a surface of said gas-permeable porous body 40 is assigned to a combustion space S. Combustion gas generated is designed to be discharged through said gas-permeable porous body 40. As high-temperature combustion gas passes through said gas-permeable porous body 40, radiant heat B is generated from the surface of said gas-permeable porous body 40. Since the heating substance 4 is heated by both of heat conduction and radiation, high heating efficiency can be achieved.
摘要翻译：公开了一种新颖的平面加热表面式燃气灶，其能够以实际可用的加热效率加热加热物质穿过耐热玻璃，克服了由于火焰的暴露而导致的任何不便，并且便于清洁燃气灶。该气体炉10包括设置在燃烧器15上方的耐热性玻璃顶板12，其中透气性多孔体40设置在所述顶板12的下方，并且所述顶板12与所述气体的表面之间的空间将透气性多孔体40分配给燃烧空间S.产生的燃烧气体被设计成通过所述透气性多孔体40排出。当高温燃烧气体通过所述透气性多孔体40时，辐射热B为从所述透气性多孔体40的表面产生。由于加热物质4被热传导和辐射两者加热，因此可以实现高的加热效率。

6. 发明授权

US5739201A Two-pack crosslinking aqueous adhesive 失效
标题翻译：双组份交联水性胶粘剂
公开(公告)号：US5739201A
公开(公告)日：1998-04-14
申请号：US795309
申请日：1997-02-04
申请人： Masaki Ugai , Kiyoshi Nakayama , Masahito Mori
发明人： Masaki Ugai , Kiyoshi Nakayama , Masahito Mori
IPC分类号： C09J201/02 , C09J11/06 , C09J201/04 , C09J201/08 , C08L83/00
CPC分类号： C09J201/04 , C09J201/08
摘要： A two-pack, crosslinking aqueous adhesive, which comprises (A) an adhesive component comprising an aqueous liquid of a polymer containing at least one of a halogen atom, a carboxyl group or an ester bond in the backbone chain or side chain of the polymer molecule and (B) a curing component comprising an active silyl compound containing at least one of an amino group or an imino group in the molecule, which has excellent emulsion stability after mixing the components, long pot-life and excellent heat resistance and is suitable for adhesion of materials which require heat resistance such as interior automotive trims.
摘要翻译：一种双组分交联水性粘合剂，其包含（A）粘合剂组分，其包含聚合物的水性液体，所述聚合物含有聚合物的主链或侧链中的至少一个卤素原子，羧基或酯键分子和（B）包含在分子中含有氨基或亚氨基中的至少一个的活性甲硅烷基化合物的固化组分，其在混合组分后具有优异的乳液稳定性，长的适用期和优异的耐热性，并且是合适的用于粘附需要耐热性的材料，例如内部汽车饰件。

7. 发明授权

US5270190A Method for producing (R)-malic acid from maleic acid using microbial maleate hydratase 失效
标题翻译：使用微生物马来酸盐水解酶从马来酸生产（R） - 马来酸的方法
公开(公告)号：US5270190A
公开(公告)日：1993-12-14
申请号：US821197
申请日：1992-01-15
申请人： Kiyoshi Nakayama , Yukie Kobayashi
发明人： Kiyoshi Nakayama , Yukie Kobayashi
IPC分类号： C12N9/88 , C12P7/46
CPC分类号： C12P7/46 , C12N9/88 , Y10S435/822 , Y10S435/911
摘要： This invention relates to a method for producing (R)-malic acid comprising contacting, in a reaction medium, maleic acid with (A) a microbial maleate hydratase capable of hydrating maleic acid to form (R)-malic acid or (B) a microorganism containing the maleate hydratase, microbial maleate hydratase and a method for producing same. In accordance with the present invention (R)-malic acid with high optical purity is supplied efficiently and economically.
摘要翻译：本发明涉及一种制备（R） - 马来酸的方法，包括在反应介质中使马来酸与（A）能够水合马来酸形成（R） - 马来酸的微生物马来酸盐水合酶或（B）含有马来酸盐水合酶的微生物，马来酸微生物水合酶及其制备方法。根据本发明，高效且经济地提供了具有高光学纯度的（R） - 丙二酸。

8. 发明授权

US4798967A Control system for foldable outside rearview mirror 失效
标题翻译：可折叠外部后视镜控制系统
公开(公告)号：US4798967A
公开(公告)日：1989-01-17
申请号：US173154
申请日：1988-03-24
申请人： Tohru Yamana , Kiyoshi Nakayama , Kazuhiko Sato
发明人： Tohru Yamana , Kiyoshi Nakayama , Kazuhiko Sato
IPC分类号： B60R1/074 , G02B7/182 , G02B7/18 , G05B19/10
CPC分类号： G02B7/1827 , B60R1/074
摘要： A control system for a foldable outside rearview mirror comprises an electric motor having an electric motor circuit, an operation switch, trigger element connected with the operation switch for outputting a trigger pulse in response to actuation of the operation switch, timer element connected with the trigger element for outputting a pulse of a predetermined pulse width to drive the electric motor only for a set time upon receipt of the trigger pulse from the trigger element, polarity changing element having a pair of outputs of high and low level and formed for reversely switching the electric motor by inverting the pair of the outputs upon receipt of the trigger pulse from the trigger element, and switching element for switching a voltage applied to the electric motor to react or fold a rearview mirror upon receipt of the output of the polarity changing element.
摘要翻译：一种用于可折叠的外部后视镜的控制系统包括具有电动机电路的电动机，操作开关，与操作开关连接的触发元件，用于响应于操作开关的致动而输出触发脉冲，与触发器连接的定时器元件元件，用于输出预定脉冲宽度的脉冲，以便在从触发元件接收到触发脉冲时只设定一定时间来驱动电动机，极性改变元件具有一对高电平和低电平的输出，并形成用于反向切换电动机通过在从触发元件接收到触发脉冲时反转一对输出，以及用于切换施加到电动机的电压的开关元件，以在接收到极性改变元件的输出时反应或折叠后视镜。

9. 发明授权

US4724090A Additive fabric softening composition for granular detergent 失效
标题翻译：颗粒洗涤剂用添加剂织物柔软组合物
公开(公告)号：US4724090A
公开(公告)日：1988-02-09
申请号：US59176
申请日：1987-06-12
申请人： Shigeru Suzuki , Hiroshi Nakaya , Kiyoshi Nakayama
发明人： Shigeru Suzuki , Hiroshi Nakaya , Kiyoshi Nakayama
IPC分类号： C11D1/62 , C11D3/37 , D06M13/46
CPC分类号： C11D3/3769 , C11D1/62
摘要： An additive composition for a granular detergent comprising:(a) a cationic surfactant having the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 independently represent an alkyl group having 12 to 26 carbon atoms, R.sub.3 and R.sub.4 independently represent an alkyl group having 1 to 4 carbon atoms, a benzyl group, a hydroxyalkyl group having 2 to 4 carbon atoms, or a polyoxyalkylene group having 1 to 10 mole oxyalkylene units, and X represents a halogen atom, CH.sub.3 SO.sub.4, C.sub.2 H.sub.5 SO.sub.4, or ##STR2## , and(b) (i) a polymer of an acrylamide monomer having the general formula (II) ##STR3## wherein R.sub.5 represents hydrogen or methyl, and R.sub.6 and R.sub.7 independently represent hydrogen, an alkyl group having 1 to 10 carbon atoms, a hydroxy alkyl group having 1 to 10 carbon atoms, or the substituted alkyl group having 2 to 15 carbon atoms or (ii) a copolymer of the acrylamide monomer (II) with an anionic monomer. The ratio of component (a)/component (b) in a weight basis is 99.9/0.1 to 50/50.
摘要翻译：一种用于颗粒洗涤剂的添加剂组合物，其包含：（a）具有通式（I）的阳离子表面活性剂：其中R 1和R 2独立地表示具有12至26个碳原子的烷基，R 3和R 4独立地表示具有1至4个碳原子的烷基，苄基，具有2至4个碳原子的羟烷基或具有1至10摩尔氧化烯单元的聚氧化烯基，X表示卤素原子，CH 3 SO 4，C 2 H 5 SO 4或和（b）（i）具有通式（II）的丙烯酰胺单体的聚合物（II）其中R5表示氢或甲基，R6和R7独立地表示氢，具有1至10个碳原子，具有1-10个碳原子的羟基烷基或具有2至15个碳原子的取代的烷基，或（ii）丙烯酰胺单体（II）与阴离子单体的共聚物。组分（a）/组分（b）的重量比为99.9 / 0.1至50/50。

10. 发明授权

US4183786A Process for production of L-serine 失效
标题翻译：生产L-丝氨酸的方法
公开(公告)号：US4183786A
公开(公告)日：1980-01-15
申请号：US855328
申请日：1977-11-28
申请人： Kiyoshi Nakayama , Kazumi Araki , Yoshitake Tanaka
发明人： Kiyoshi Nakayama , Kazumi Araki , Yoshitake Tanaka
IPC分类号： C12P13/06 , C12D13/06
CPC分类号： C12P13/06 , Y10S435/872
摘要： A process for converting glycine to L-serine is effected by the use of an aqueous medium containing glycine and microbial cells of a mutant belonging to the genus Nocardia. The mutant is capable of converting glycine to L-serine and has no or lowered ability to decompose L-serine and/or a resistance to at least one metabolic antagonist selected from those of glycine, serine, methionine, glutamine, histidine, leucine, isoleucine, valine, purine, pyrimidine or folic acid. The L-serine is accumulated in the aqueous medium and is recovered therefrom.
摘要翻译：将甘氨酸转化为L-丝氨酸的方法通过使用含有甘氨酸的水性培养基和属于诺卡氏菌属的突变体的微生物细胞来实现。突变体能够将甘氨酸转化为L-丝氨酸，并且没有或降低分解L-丝氨酸的能力和/或对至少一种选自甘氨酸，丝氨酸，甲硫氨酸，谷氨酰胺，组氨酸，亮氨酸，异亮氨酸的代谢拮抗剂的抗性，缬氨酸，嘌呤，嘧啶或叶酸。 L-丝氨酸在水性介质中积聚并从中回收。

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