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1. 发明授权

US06743803B2 Medicines for the prevention and treatment of neurodegenerative diseases 失效
标题翻译：用于预防和治疗神经退行性疾病的药物
公开(公告)号：US06743803B2
公开(公告)日：2004-06-01
申请号：US10311932
申请日：2002-12-20
申请人： Kiyoshi Furukawa , Satoshi Kurumiya , Kazuo Okimoto , Kazunori Ohno
发明人： Kiyoshi Furukawa , Satoshi Kurumiya , Kazuo Okimoto , Kazunori Ohno
IPC分类号： A61K314375
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444
摘要： Medicines for the prevention and treatment of neurodegenerative diseases such as Alzheimer's disease and schizophrenia of mammals (including human beings) through the retardation or inhibition of neurodegeneration due to hypofunction of glutamic acid receptor and which contain as an active ingredient 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivatives of the formula (I): wherein Het is oxadiazolyl; R1 is hydrogen, lower alkyl, cyclo-lower alkyl, lower alkenyl, lower alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, etc.; and R2 is hydrogen, lower alkyl, cyclo-lower alkyl, substituted or unsubstituted aryl, etc., or physiologically acceptable acid addition salts thereof.
摘要翻译：通过延迟或抑制谷氨酸受体功能低下的神经退行性疾病，预防和治疗神经变性疾病如阿尔茨海默病和哺乳动物（包括人类）的精神分裂症的药物，其含有作为活性成分的5-取代-3-恶二唑基（I）的-1,6-萘啶-2（1H） - 酮衍生物：其中Het是恶二唑基; R 1是氢，低级烷基，环低级烷基，低级烯基，低级烷氧基，取代或未取代的芳基，取代或未取代的杂芳基等。 R 2为氢，低级烷基，环低级烷基，取代或未取代的芳基等，或其生理上可接受的酸加成盐。

2. 发明授权

US06172079B2 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivatives 失效
标题翻译： 5-取代-3-恶二唑基-1,6-二氮杂萘-2（1H） - 酮衍生物
公开(公告)号：US06172079B2
公开(公告)日：2001-01-09
申请号：US09462412
申请日：2000-01-10
申请人： Kazunori Ohno , Osamu Odai , Kaoru Masumoto , Kiyoshi Furukawa , Makoto Oka
发明人： Kazunori Ohno , Osamu Odai , Kaoru Masumoto , Kiyoshi Furukawa , Makoto Oka
IPC分类号： A61K31435
CPC分类号： C07D471/04
摘要： A 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative of the formula (I): wherein Het is oxadiazolyl, R1 is H, lower alkyl, cyclo-lower alkyl, trifluoromethyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkoxy-lower alkyl, hydroxy-lower alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaromatic group, and R2 is H, lower alkyl, cyclo-lower alkyl, cyclo-lower alkylmethyl, lower alkenyl, cyclo-lower alkenyl, lower alkynyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaromatic group, or a pharmaceutically acceptable acid addition salt thereof, which has high selective affinity to benzodiazepine receptor and is useful particularly as a benzodiazepine inverse agonist, for example, as psychoanaleptic drug or a drug for the treatment of dysmnesia in senile dementia or Alzheimer's disease.
摘要翻译：式（I）的5-取代-3-恶二唑基-1,6-二氮杂萘-2（1H） - 酮衍生物：其中Het是恶二唑基，R 1是H，低级烷基，环低级烷基，三氟甲基，低级烯基低级炔基，低级烷氧基，低级烷氧基 - 低级烷基，羟基 - 低级烷基，取代或未取代的芳基，或取代或未取代的杂芳基，R2是H，低级烷基，环低级烷基，环低级烷基甲基，，环低级烯基，低级炔基，取代或未取代的芳基或取代或未取代的杂芳族基团或其药学上可接受的酸加成盐，其对苯并二氮杂受体具有高选择性亲和力，并且特别用作苯二氮卓反相激动剂，例如作为精神无菌药物或用于治疗老年痴呆或阿尔茨海默氏症的失聪症的药物。

3. 发明授权

US5424433A Intermediates for 3-oxadiazoly-1,6-naphthyridine derivatives 失效
标题翻译： 3-恶二唑-1,6-二氮杂萘衍生物的中间体
公开(公告)号：US5424433A
公开(公告)日：1995-06-13
申请号：US260800
申请日：1994-06-16
申请人： Kazunori Ohno , Osamu Odai , Yukio Tominaga , Kiyoshi Furukawa , Makoto Oka
发明人： Kazunori Ohno , Osamu Odai , Yukio Tominaga , Kiyoshi Furukawa , Makoto Oka
IPC分类号： A61K31/4245 , A61K31/435 , A61K31/4375 , C07D271/02 , C07D271/06 , C07D271/10 , C07D471/04
CPC分类号： C07D471/04
摘要： 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I): ##STR1## wherein Het is an oxadiazole ring, R.sub.1 is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: --CH.sub.2 R.sub.1' (in which R.sub.1' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic group), R.sub.2 is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, which are useful as benzodiazepine receptor agonist.
摘要翻译：式（I）的3-恶二唑基-5,6,7,8-四氢-1,6-萘啶衍生物：其中Het是恶二唑环，R 1是氢原子，酰基，低级烷基或式-CH 2 R 1'（其中R 1'为环低级烷基，低级烯基，低级炔基，苄基，芳基或杂芳族基团）的基团，R 2为低级烷基，低级烷基，低级烯基，低级炔基，芳基，杂芳基，卤代低级烷基，低级烷氧基 - 低级烷基，低级烷氧基，低级烷基烯氧基，苯氧基或低级烷硫基，或其药学上可接受的酸加成盐，可用作苯并二氮杂受体激动剂。

4. 发明授权

US5424434A Production on 3-oxadiazolyl-1,6-naphthyridine derivatives 失效
标题翻译： 3-恶二唑基-1,6-二氮杂萘衍生物的制备
公开(公告)号：US5424434A
公开(公告)日：1995-06-13
申请号：US260835
申请日：1994-06-16
申请人： Kazunori Ohno , Osamu Odai , Yukio Tominaga , Kiyoshi Furukawa , Makoto Oka
发明人： Kazunori Ohno , Osamu Odai , Yukio Tominaga , Kiyoshi Furukawa , Makoto Oka
IPC分类号： A61K31/4245 , A61K31/435 , A61K31/4375 , C07D271/02 , C07D271/06 , C07D271/10 , C07D471/04
CPC分类号： C07D471/04
摘要： 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I): ##STR1## wherein Het is an oxadiazole ring, R.sub.1 is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: --CH.sub.2 R.sub.1 ' (in which R.sub.1 ' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic group), R.sub.2 is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, which are useful as benzodiazepine receptor agonist.
摘要翻译：式（I）的3-恶二唑基-5,6,7,8-四氢-1,6-萘啶衍生物：其中Het是恶二唑环，R 1是氢原子，酰基，低级烷基或式-CH 2 R 1'（其中R 1'为环低级烷基，低级烯基，低级炔基，苄基，芳基或杂芳族基团）的基团，R 2为低级烷基，低级烷基，低级烯基，低级炔基，芳基，杂芳基，卤代低级烷基，低级烷氧基 - 低级烷基，低级烷氧基，低级烷基烯氧基，苯氧基或低级烷硫基，或其药学上可接受的酸加成盐，可用作苯并二氮杂受体激动剂。

5. 发明授权

US5367078A 3-oxadiazolyl-1,6-naphthyridine derivatives 失效
标题翻译： 3-恶二唑基-1,6-二氮杂萘衍生物
公开(公告)号：US5367078A
公开(公告)日：1994-11-22
申请号：US112660
申请日：1993-08-27
申请人： Kazunori Ohno , Osamu Odai , Yukio Tominaga , Kiyoshi Furukawa , Makoto Oka
发明人： Kazunori Ohno , Osamu Odai , Yukio Tominaga , Kiyoshi Furukawa , Makoto Oka
IPC分类号： A61K31/4245 , A61K31/435 , A61K31/4375 , C07D271/02 , C07D271/06 , C07D271/10 , C07D471/04
CPC分类号： C07D471/04
摘要： 3-Oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphthyridine derivative of the formula (I): ##STR1## wherein Het is an oxadiazole ring, R.sub.1 is hydrogen atom, an acyl group, a lower alkyl group or a group of the formula: --CH.sub.2 R.sub.1 ' (in which R.sub.1 ' is a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, benzyl group, aryl group or a heteroaromatic groups), R.sub.2 is a lower alkyl group, a cyclo-lower alkyl group, a lower alkenyl group, a lower alkynyl group, aryl group, a heteroaromatic group, a halogeno-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkoxy group, a lower alkenyloxy group, a phenoxy group, or a lower alkylthio group, or a pharmaceutically acceptable acid addition salt thereof, which are useful as benzodiazedine receptor agonist.
摘要翻译：式（I）的3-恶二唑基-5,6,7,8-四氢-1,6-萘啶衍生物：其中Het是恶二唑环，R 1是氢原子，酰基，低级烷基或式-CH 2 R 1'（其中R 1'为环低级烷基，低级烯基，低级炔基，苄基，芳基或杂芳族基团）的基团，R 2为低级烷基，低级烷基，低级烯基，低级炔基，芳基，杂芳基，卤代低级烷基，低级烷氧基 - 低级烷基，低级烷氧基，低级烷基烯氧基，苯氧基或低级烷硫基，或其药学上可接受的酸加成盐，其可用作苯并二嗪二受体激动剂。

6. 发明授权

US06277993B1 Intermediates for 5-substituted-3-oxadiazolyl-1,6-Naphthyridin-2(1H)-one derivatives 失效
标题翻译： 5-取代-3-恶二唑基-1,6-萘啶-2（1H） - 酮衍生物的中间体
公开(公告)号：US06277993B1
公开(公告)日：2001-08-21
申请号：US09654782
申请日：2000-09-01
申请人： Kazunori Ohno , Osamu Odai , Kaoru Masumoto , Kiyoshi Furukawa , Makoto Oka
发明人： Kazunori Ohno , Osamu Odai , Kaoru Masumoto , Kiyoshi Furukawa , Makoto Oka
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： A 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative of the formula (I): wherein Het is oxadiazolyl, R1 is H, lower alkyl, cyclo-lower alkyl, trifluoromethyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkoxy-lower alkyl, hydroxy-lower alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaromatic group, and R2 is H, lower alkyl, cyclo-lower alkyl, cyclo-lower alkylmethyl, lower alkenyl, cyclo-lower alkenyl, lower alkynyl, substituted or unsubstituted aryl, or substituted or unsubstituted hetero-aromatic group, or a pharmaceutically acceptable acid addition salt thereof, which has high selective affinity to benzodiazepine receptor and is useful particularly as a benzodiazepine inverse agonist, for example, as psychoanaleptic drug or a drug for the treatment of dysmnesia in senile dementia or Alzheimer's disease.
摘要翻译：式（I）的5-取代-3-恶二唑基-1,6-二氮杂萘-2（1H） - 酮衍生物：其中Het是恶二唑基，R 1是H，低级烷基，环低级烷基，三氟甲基，低级烯基低级炔基，低级烷氧基，低级烷氧基 - 低级烷基，羟基 - 低级烷基，取代或未取代的芳基，或取代或未取代的杂芳基，R2是H，低级烷基，环低级烷基，环低级烷基甲基，，环低级烯基，低级炔基，取代或未取代的芳基，或取代或未取代的杂芳族基团或其药学上可接受的酸加成盐，其对苯并二氮杂受体具有高选择性亲和力，并且特别用作苯二氮卓反相激动剂，例如，作为精神无菌药物或用于治疗老年痴呆或阿尔茨海默病的失聪症的药物。

7. 发明授权

US08014077B2 Variable power optical system and imaging device 有权
标题翻译：可变功率光学系统及成像装置
公开(公告)号：US08014077B2
公开(公告)日：2011-09-06
申请号：US12647245
申请日：2009-12-24
申请人： Kazunori Ohno
发明人： Kazunori Ohno
IPC分类号： G02B15/14
CPC分类号： G02B15/177
摘要： On condition that a first lens group adopts at least one plastic lens; a second lens group adopts at least any two adjacent plastic lenses; the first lens group monotonously moves from an object side to an image plane side in a zooming; the second lens group monotonously moves from the image plane side to the object side; wherein fw/fpi represents a ratio of refractive power of the entire system achieved at a wide angle end to refractive power of the respective lenses; P1 represents a total of fw/fpi of the plastic lenses of the first lens group; and P2 represents a total of fw/fpi of the plastic lenses of the second lens group, the following conditional expressions −0.22
摘要翻译：在第一透镜组采用至少一个塑料透镜的条件下; 第二透镜组采用至少两个相邻的塑料透镜; 第一透镜组在变焦中从物体侧单调地移动到像面侧; 第二透镜组从图像平面侧单调地移动到物体侧; 其中fw / fpi表示在广角端实现的整个系统的屈光力与各个透镜的屈光力之比; P1表示第一透镜组的塑料透镜的fw / fpi的总和; P2表示第二透镜组的塑料透镜的fw / fpi的总和，满足以下条件式-0.22

8. 发明授权

US5745302A Inverted Galilean type zoom finder lens system 失效
标题翻译：倒置伽利略式变焦距镜头系统
公开(公告)号：US5745302A
公开(公告)日：1998-04-28
申请号：US829821
申请日：1997-03-25
申请人： Kazunori Ohno
发明人： Kazunori Ohno
IPC分类号： G02B15/17 , G02B23/14 , G03B13/02 , G02B15/14 , G02B17/08
CPC分类号： G03B13/02 , G02B15/17 , G02B23/14
摘要： An inverted Galilean zoom view finder equipped with a framing mark projection feature comprises in order from the object side to the image side a positive power objective lens L.sub.1 which is a by-convex singlet having a strong curvature of object side surface, a negative power lens L.sub.2 which is a by-concave singlet having a strong curvature of image side surface, and a negative power eye piece lens L.sub.3 which is a meniscus singlet having a strong curvature of concave surface at the object side. The negative power lens L.sub.2 is movable relative to both positive power objective lens L.sub.1 and negative power eye piece lens L.sub.3 along the optical axis X to vary the magnitude of the finder lens system, and the eye piece lens is formed with a reflective surface around a half transparent surface at the image side for reflecting back an image of framing mark and directing the image into the view of the zoom view finder.
摘要翻译：具有框架标记投影特征的倒置的伽利略变焦取景器包括从物体侧到像侧的顺序为具有物体侧表面的强曲率的凸面单重态的正光焦度物镜L1，负光焦度透镜 L2，其是具有强烈的图像侧表面曲率的逐个凹陷的单线态，以及作为在物体侧具有强凹曲面的弯月形单线态的负功率眼镜片L3。负功率透镜L2可以沿着光轴X相对于正功率物镜L1和负功率眼镜透镜L3移动，以改变取景器透镜系统的大小，并且眼片透镜形成有围绕在图像侧的半透明表面反射成帧标记的图像并将图像引导到变焦取景器的视图中。

9. 发明授权

US5739965A Wide angle lens system for camera 失效
标题翻译：广角镜头系统
公开(公告)号：US5739965A
公开(公告)日：1998-04-14
申请号：US655901
申请日：1996-05-31
申请人： Kazunori Ohno
发明人： Kazunori Ohno
IPC分类号： G02B9/04 , G02B13/18 , G02B13/04
CPC分类号： G02B13/18 , G02B9/04
摘要： A wide angle lens comprises in order from the object end an aperture stop, a first meniscus lens .sub.L1 having a convex object end surface and a second positive power lens element L.sub.2, the lens satisfying the following conditions: -0.10
摘要翻译：广角镜头从物体端开始依次具有孔径光阑，具有凸面物体端面的第一弯液面透镜L1和第二正光透镜元件L2，该透镜满足以下条件：-0.10

10. 发明授权

US5657167A Focal length changeable lens system 失效
标题翻译：焦距可变透镜系统
公开(公告)号：US5657167A
公开(公告)日：1997-08-12
申请号：US420343
申请日：1995-04-11
申请人： Kazunori Ohno
发明人： Kazunori Ohno
IPC分类号： G02B15/177 , G02B15/14 , G02B13/18
CPC分类号： G02B15/177
摘要： A lens system comprises a stationary negative power singlet and a positive power singlet which is changed between two specific axial positions so as to yield a short focal length suitable for wide angle photography and a long focal length suitable for a tele-photography, respectively, and satisfies the following condition:-2.0
摘要翻译：透镜系统包括固定负功率单线态和正功率单线圈，其在两个特定轴向位置之间改变，以产生适合于广角摄影的短焦距和适合于远摄摄影的长焦距，以及满足以下条件：-2.0

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