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1. 发明申请

US20160220166A1 Methodology for Discriminating Concussion Subjects from Normal Subjects by Identifying and Using QEEG correlates of concussion across 4 cognitive tasks and eyes closed condition. 审中-公开
标题翻译：通过识别和使用QEEG四个认知任务和闭眼条件之间的脑震荡相关的正常受试者辨别受试者的方法。
公开(公告)号：US20160220166A1
公开(公告)日：2016-08-04
申请号：US14608330
申请日：2015-01-29
申请人： Kirtley Elliott Thornton
发明人： Kirtley Elliott Thornton
IPC分类号： A61B5/00 , A61B5/0484 , A61B5/04 , A61B5/048
CPC分类号： A61B5/4064 , A61B5/04014 , A61B5/048 , A61B5/04842 , A61B5/04845 , A61B5/6803 , A61B5/7246 , A61B5/7282
摘要： Previous patents and research have focused on the problem of determining whether the quantitative EEG (QEEG) can discriminate a traumatic brain injury (TBI) subject from a normal individual. The patents and research have had varying degree of specificity in defining the variables involved in obtaining a high degree of discriminant ability. However, all research has limited its approach to the collection of eyes closed data and most confine themselves to under 32 Hertz. The present patent employs 4 cognitive activation tasks, an eyes closed task, 19 locations, the high frequency 32-64 Hz range (Spectral Correlation Coefficient (SCC) and phase algorithms) and frontal relative power of beta2 (32-64 Hz) to obtain 100% correct identification in a group of over 195 subjects (normal and traumatic brain injured (TBI)) across the 4 cognitive activation tasks and eyes closed condition. The approach is validated on a sample of 50 misclassified participants which the discriminant correctly identifies as misclassified.
摘要翻译：以前的专利和研究集中在确定定量脑电图（QEEG）是否可以区分来自正常个体的创伤性脑损伤（TBI）受试者的问题。专利和研究在确定获得高度判别能力所涉及的变量方面具有不同程度的特异性。然而，所有的研究都限制了收集眼睛闭合数据的方法，而且绝大部分限制在32赫兹以下。本专利采用4个认知激活任务，闭眼任务，19个位置，高频32-64Hz范围（频谱相关系数（SCC）和相位算法）以及β2（32-64Hz）的正相关功率来获得在一组超过195个受试者（正常和创伤性脑损伤（TBI））中的100％正确识别在4个认知激活任务和闭眼状态。该方法对50个错误分类参与者的样本进行验证，判别正确识别为错误分类。

2. 发明申请

US20140187994A1 Methodology for Discriminating Concussion Subjects from Normal Subjects by Identifying and Using QEEG correlates of concussion across 4 cognitive tasks. 审中-公开
标题翻译：通过识别和使用四个认知任务中的脑震荡的QEEG相关性来区分来自正常受试者的脑震荡受试者的方法。
公开(公告)号：US20140187994A1
公开(公告)日：2014-07-03
申请号：US13585712
申请日：2012-08-14
申请人： Kirtley Elliott Thornton
发明人： Kirtley Elliott Thornton
IPC分类号： A61B5/048
CPC分类号： A61B5/048 , A61B5/4064
摘要： Previous patents and research have focused on the problem of determining whether the quantitative EEG (QEEG) can discriminate a traumatic brain injury (TBI) subject from a normal individual. The patents and research have had varying degree of specificity in defining the variables involved in obtaining a high degree of discriminant ability. However, all research has limited its approach to the collection of eyes closed data and most confine themselves to under 32 Hertz. The present patent employs 4 cognitive activation tasks, an eyes closed task, 19 locations, the high frequency 32-64 Hz range, Spectral Correlation Coefficient (SCC) and phase algorithms to obtain 100% correct identification in a group of over 195 subjects (normal and traumatic brain injured (TBI)) across the 4 cognitive activation tasks and eyes closed task and was successful in correct identification of 50 participants randomly misclassified as normal or brain injured across the five tasks (10 per task).
摘要翻译：以前的专利和研究集中在确定定量EEG（QEEG）是否可以区分来自正常个体的创伤性脑损伤（TBI）受试者的问题。专利和研究在确定获得高度判别能力所涉及的变量方面具有不同程度的特异性。然而，所有的研究都限制了收集眼睛闭合数据的方法，而且绝大部分限制在32赫兹以下。本专利采用4个认知激活任务，闭眼任务，19个位置，高频32-64Hz范围，光谱相关系数（SCC）和相位算法，以获得一组超过195个受试者的100％正确识别（正常和创伤性脑损伤（TBI）），通过4个认知激活任务和闭眼眼睛的任务，并成功地正确识别50名参与者在五个任务中的正常或脑损伤（10个每个任务）随机错误分类。

3. 发明授权

US09901279B2 QEEG correlates of effective cognitive functioning—memory and problem solving—in diverse clinical conditions and normal populations 有权
公开(公告)号：US09901279B2
公开(公告)日：2018-02-27
申请号：US14608278
申请日：2015-01-29
申请人： Kirtley Elliott Thornton
发明人： Kirtley Elliott Thornton
IPC分类号： A61B5/0482 , A61B5/00
CPC分类号： A61B5/0482 , A61B5/7246
摘要： Mental abilities are labeled with terms such as memory & problem solving and corresponding performance measures (recall score, # correct) can be obtained. The quantitative EEG (QEEG) measure of brain functioning reflects the electrophysiology of the gray & white matter of the brain underlying the scalp. A database of clinical and non-clinical participants underwent a cognitive activation QEEG to determine the relations between the QEEG measures and cognitive performance for memory (auditory and reading) and problem solving. The analysis revealed correlative (positive and negative) relationships between cognitive performance and the Quantitative EEG (QEEG) measures (coherence, phase, magnitude, etc.) during these cognitive activation conditions. An individual can undergo an evaluation and the subject's values on the relevant (and all) variables can be determined. The deficient QEEG variables can be effectively changed with an operant biofeedback conditioning methodology called EEG biofeedback. The method has been shown to improve memory functioning.

4. 发明申请

US20160220141A1 QEEG Correlates of Effective Cognitive Functioning - memory and problem solving- in Diverse Clinical Conditions & Normal Populations 审中-公开
标题翻译： QEEG在多种临床条件和正常人群中有效的认知功能 - 记忆和问题解决相关
公开(公告)号：US20160220141A1
公开(公告)日：2016-08-04
申请号：US14608278
申请日：2015-01-29
申请人： Kirtley Elliott Thornton
发明人： Kirtley Elliott Thornton
IPC分类号： A61B5/0482 , A61B5/00
CPC分类号： A61B5/0482 , A61B5/7246
摘要： Mental abilities are labeled with terms such as memory & problem solving and corresponding performance measures (recall score, # correct) can be obtained. The quantitative EEG (QEEG) measure of brain functioning reflects the electrophysiology of the gray & white matter of the brain underlying the scalp. A database of clinical and non-clinical participants underwent a cognitive activation QEEG to determine the relations between the QEEG measures and cognitive performance for memory (auditory and reading) and problem solving. The analysis revealed correlative (positive and negative) relationships between cognitive performance and the Quantitative EEG (QEEG) measures (coherence, phase, magnitude, etc.) during these cognitive activation conditions. An individual can undergo an evaluation and the subject's values on the relevant (and all) variables can be determined. The deficient QEEG variables can be effectively changed with an operant biofeedback conditioning methodology called EEG biofeedback. The method has been shown to improve memory functioning.
摘要翻译：精神能力被标记为记忆和问题解决等术语，并且可以获得相应的绩效指标（回忆分数，＃正确）。脑功能的定量脑电图（QEEG）测量反映了头皮下脑部灰白质的电生理学。临床和非临床参与者的数据库进行认知激活QEEG，以确定QEEG测量与记忆（听觉和阅读）和解决问题的认知表现之间的关系。分析显示在认知激活条件下，认知表现与定量脑电图（QEEG）测量（相干性，相位，幅度等）之间的相关（正和负）关系。个人可以进行评估，并且可以确定相关（和全部）变量的主题值。可以通过称为EEG生物反馈的操作性生物反馈调理方法有效地改变缺陷型QEEG变量。该方法已被证明可以改善记忆功能。

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