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1. 发明授权

US06720182B1 Alternative splice variants of CD40 有权
标题翻译： CD40的替代剪接变体
公开(公告)号：US06720182B1
公开(公告)日：2004-04-13
申请号：US09569611
申请日：2000-05-10
申请人： Kinneret Savitzky , Liat Mintz , Sharon Engel , Jeanne Bernstein
发明人： Kinneret Savitzky , Liat Mintz , Sharon Engel , Jeanne Bernstein
IPC分类号： C07H2104
CPC分类号： C07H21/04 , A61K38/00 , C07K14/70578
摘要： The invention concerns novel nucleic acid sequences and amino acid sequences obtained by alternative splicing, expression vectors, host cell and pharmaceutical compositions comprising said sequences.
摘要翻译：本发明涉及通过选择性剪接获得的新型核酸序列和氨基酸序列，表达载体，宿主细胞和包含所述序列的药物组合物。

2. 发明申请

US20060068405A1 Methods and systems for annotating biomolecular sequences 审中-公开
标题翻译：注释生物分子序列的方法和系统
公开(公告)号：US20060068405A1
公开(公告)日：2006-03-30
申请号：US11043860
申请日：2005-01-27
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译：提供多肽序列和多核苷酸序列。还提供了关于这些序列的这些序列和用途的注释信息。

3. 发明申请

US20110183924A1 Methods and systems for annotating biomolecular sequences 审中-公开
标题翻译：注释生物分子序列的方法和系统
公开(公告)号：US20110183924A1
公开(公告)日：2011-07-28
申请号：US12662576
申请日：2010-04-23
申请人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
发明人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
IPC分类号： A61K38/08 , C07K7/00 , C07H21/04 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： G16B40/00 , G16B20/00 , G16B30/00
摘要： A method of annotating biomolecular sequences. The method comprises (a) computationally clustering the biomolecular sequences according to a progressive homology range, to thereby generate a plurality of clusters each being of a predetermined homology of the homology range; and (b) assigning at least one ontology to each cluster of the plurality of clusters, the at least one ontology being: (i) derived from an annotation preassociated with at least one biomolecular sequence of each cluster; and/or (ii) generated from analysis of the at least one biomolecular sequence of each cluster thereby annotating biomolecular sequences.
摘要翻译：注释生物分子序列的方法。该方法包括（a）根据渐进同源范围计算聚集生物分子序列，从而产生多个具有同源范围的预定同源性的簇; 所述至少一个本体是：（i）从与每个簇的至少一个生物分子序列预先相关联的注释导出的;以及（b）将至少一个本体分配给所述多个簇中的每个簇，和/或（ii）从每个簇的至少一个生物分子序列的分析产生，从而注释生物分子序列。

4. 发明申请

US20060147946A1 Novel calcium channel variants and methods of use thereof 审中-公开
标题翻译：新型钙通道变体及其使用方法
公开(公告)号：US20060147946A1
公开(公告)日：2006-07-06
申请号：US11051725
申请日：2005-01-27
申请人： Pinchas Akiva , Alexander Dlber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekhari , Zipi Shaged , Moshe Olshansky , Arial Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanquing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Pinchas Akiva , Alexander Dlber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekhari , Zipi Shaged , Moshe Olshansky , Arial Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanquing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Novel alpha 1 subunit splice variants, including nucleic and amino acid sequences. Methods of use thereof are also described.
摘要翻译：新的α1亚基剪接变体，包括核酸和氨基酸序列。还描述了其使用方法。

5. 发明申请

US20070083334A1 Methods and systems for annotating biomolecular sequences 有权
标题翻译：注释生物分子序列的方法和系统
公开(公告)号：US20070083334A1
公开(公告)日：2007-04-12
申请号：US11443428
申请日：2006-05-31
申请人： Liat Mintz , Hanqing Xie , Dvir Dahari , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Hermesh , Idit Azar , Jeanne Bernstein
发明人： Liat Mintz , Hanqing Xie , Dvir Dahari , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Hermesh , Idit Azar , Jeanne Bernstein
IPC分类号： G06F19/00
CPC分类号： G06F19/24 , G06F19/18 , G06F19/22
摘要： A method of annotating biomolecular sequences. The method comprises (a) computationally clustering the biomolecular sequences according to a progressive homology range, to thereby generate a plurality of clusters each being of a predetermined homology of the homology range; and (b) assigning at least one ontology to each cluster of the plurality of clusters, the at least one ontology being: (i) derived from an annotation preassociated with at least one biomolecular sequence of each cluster; and/or (ii) generated from analysis of the at least one biomolecular sequence of each cluster thereby annotating biomolecular sequences.
摘要翻译：注释生物分子序列的方法。该方法包括（a）根据渐进同源范围计算聚集生物分子序列，从而产生多个具有同源范围的预定同源性的簇; 所述至少一个本体是：（i）从与每个簇的至少一个生物分子序列预先相关联的注释导出的;以及（b）将至少一个本体分配给所述多个簇中的每个簇，和/或（ii）从每个簇的至少一个生物分子序列的分析产生，从而注释生物分子序列。

6. 发明申请

US20110091454A1 METHODS AND SYSTEMS FOR ANNOTATING BIOMOLECULAR SEQUENCES 审中-公开
标题翻译：生物分子序列的方法和系统
公开(公告)号：US20110091454A1
公开(公告)日：2011-04-21
申请号：US12701651
申请日：2010-02-08
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad S. Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , A61P35/00
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译：提供多肽序列和多核苷酸序列。还提供了关于这些序列的这些序列和用途的注释信息。

7. 发明授权

US07745391B2 Human thrombospondin polypeptide 有权
标题翻译：人类血小板反应蛋白多肽
公开(公告)号：US07745391B2
公开(公告)日：2010-06-29
申请号：US11443428
申请日：2006-05-31
申请人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
发明人： Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Jeanne Bernstein
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： G06F19/24 , G06F19/18 , G06F19/22
摘要： A human thrombospondin 1 protein, polynucleotide encoding the protein, and pharmaceutical composition thereof.
摘要翻译：人类血小板反应蛋白1蛋白，编码蛋白质的多核苷酸及其药物组合物。

8. 发明申请

US20050272050A1 CD40 splice variants, compositions for making and methods of using the same 审中-公开
标题翻译： CD40拼接变体，用于制备的组合物及其使用方法
公开(公告)号：US20050272050A1
公开(公告)日：2005-12-08
申请号：US10924074
申请日：2004-08-23
申请人： Liat Mintz , Jeanne Bernstein , Dani Eshel , Amir Toporik , Aviva Chen
发明人： Liat Mintz , Jeanne Bernstein , Dani Eshel , Amir Toporik , Aviva Chen
IPC分类号： A61K48/00 , C07H21/04 , C07K14/705 , C07K14/74 , C07K16/28 , C12N15/12 , C12Q1/68
CPC分类号： C07K16/2878 , A61K48/00 , C07K14/70578 , C12N2799/026
摘要： Provided are substantially pure CD40 splice variants that include altered internal sequences and unique tail sequences relative to previously described CD40 protein sequences. Also provided are fragments of the CD40 splice variants comprising at least 10 amino acids including at least 4 amino acids of the unique tail sequence; the unique tail sequences, and homologues thereof having at least 10 amino acids and 90% identity and antibodies which bind to an epitope on such proteins are disclosed. Pharmaceutical compositions comprising the protein, antibodies, isolated nucleic acid molecule that encode such proteins and pharmaceutical composition comprising such nucleic acid molecules are also disclosed. The present invention additionally relates to recombinant expression vectors that include the nucleic acid molecules and host cells which comprise such recombinant expression vectors are disclosed. In vitro methods of detecting in a sample the presence and/or quantity of such proteins or transcript which encodes such proteins are disclosed as are kits and reagents for performing the methods. Methods of modulating CD40-CD154 interactions in an individual are disclosed.
摘要翻译：提供基本上纯的CD40剪接变体，其包括相对于先前描述的CD40蛋白序列的改变的内部序列和唯一的尾部序列。还提供了CD40剪接变体的片段，其包含至少10个氨基酸，包括唯一尾部序列的至少4个氨基酸; 公开了具有至少10个氨基酸和90％同一性的独特的尾部序列及其同源物，并且与这些蛋白质上的表位结合的抗体。还公开了包含蛋白质，抗体，编码这种蛋白质的分离的核酸分子和包含此类核酸分子的药物组合物的药物组合物。本发明还涉及包含核酸分子和包含这种重组表达载体的宿主细胞的重组表达载体。在样本中检测体外的方法，公开了编码这种蛋白质的这些蛋白质或转录物的存在和/或数量，作为用于进行该方法的试剂盒和试剂。公开了调节个体中CD40-CD154相互作用的方法。

9. 发明申请

US20050158740A1 Variants of human glycoprotein hormone alpha chain: compositions and uses thereof 审中-公开
标题翻译：人类糖蛋白激素α链的变体：其组成及用途
公开(公告)号：US20050158740A1
公开(公告)日：2005-07-21
申请号：US10984379
申请日：2004-11-08
申请人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary
发明人： Ronen Shemesh , Jeanne Bernstein , Dvir Dahary
IPC分类号： A61K38/00 , C07H21/04 , C07K14/59 , C07K14/72 , C12Q1/68
CPC分类号： C07K14/59 , A61K38/00
摘要： The present invention provides human glycoprotein hormone (hGPH) α-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the diagnosis, prevention and treatment of symptoms, diseases and disorders related to glycoprotein hormones.
摘要翻译：本发明提供人糖蛋白激素（hGPH）α链剪接变体，包括编码这些变体的分离的核酸和编码的氨基酸序列，以及包含这些序列的抗体，反义寡核苷酸，表达载体和宿主细胞。本发明还公开了这些序列用于诊断，预防和治疗与糖蛋白激素相关的症状，疾病和病症的用途。

10. 发明申请

US20060052301A1 Splice variants of peptide YY, neuropeptide Y, pancreatic peptide Y and Amylin, and uses thereof 审中-公开
标题翻译：肽YY，神经肽Y，胰肽Y和胰岛淀粉样多肽的剪接变体及其用途
公开(公告)号：US20060052301A1
公开(公告)日：2006-03-09
申请号：US11145463
申请日：2005-06-02
申请人： Ronen Shemesh , Yossef Kliger , Lewis Neville , Jeanne Bernstein , Dani Eshel
发明人： Ronen Shemesh , Yossef Kliger , Lewis Neville , Jeanne Bernstein , Dani Eshel
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K14/57545 , C07K16/26 , C07K2319/00
摘要： The present invention relates to alternative splice variants of Amylin and members of the Pancreatic Polypeptide family, namely PYY, NPY, and PPY, vectors and compositions that include the same, and methods of use thereof. This invention provides peptides, nucleic acid sequences which encode same, analogs and derivatives thereof, antibodies which specifically recognize the variant sequences, compositions that include the same and methods of use thereof.
摘要翻译：本发明涉及胰岛淀粉样多肽的选择性剪接变体和胰腺多肽家族的成员，即PYY，NPY和PPY，包含其的载体和组合物及其使用方法。本发明提供肽，其编码相同的核酸序列，其类似物和衍生物，特异性识别变体序列的抗体，包括其的组合物及其使用方法。

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