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1. 发明授权

US07442302B2 Highly water-permeable blood purifier of hollow-fiber membrane type 有权
标题翻译：高透水性中空纤维膜型血液净化器
公开(公告)号：US07442302B2
公开(公告)日：2008-10-28
申请号：US10559398
申请日：2004-08-26
申请人： Kimihiro Mabuchi , Noriyuki Tamamura , Hidehiko Sakurai , Noriko Monden , Shinya Koyama , Hiroshi Shibano , Katsuaki Kuze , Katsuhiko Nose
发明人： Kimihiro Mabuchi , Noriyuki Tamamura , Hidehiko Sakurai , Noriko Monden , Shinya Koyama , Hiroshi Shibano , Katsuaki Kuze , Katsuhiko Nose
IPC分类号： B01D33/21 , B01D39/00 , B01D39/14 , B01D71/06 , B01D71/28
CPC分类号： B01D69/08 , A61M1/16 , B01D67/0083 , B01D67/0088 , B01D69/02 , B01D69/087 , B01D71/44 , B01D71/68 , B01D2323/02 , B01D2323/08 , B01D2323/12 , B01D2323/30 , B01D2325/02 , B01D2325/04 , B01D2325/20 , B01D2325/24
摘要： The present invention provides a highly water permeable hollow fiber membrane type blood purifier for medical use, which is excellent in safety and module-assembling ease and which has a high water permeability suitable for use in therapy of chronic renal failure.The present invention relates to a highly water-permeable hollow fiber type blood purifier comprising hydrophobic polymer hollow fiber membranes each of which contains a hydrophilic polymer, characterized in that the amount of the hydrophilic polymer eluted from the hollow fiber membrane is 10 ppm or less; in that the ratio of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %; in that the burst pressure of the hollow fiber membrane is 0.5 MPa or higher; and in that the coefficient of water permeability of the blood purifier is 150 ml/m2/hr./mmHg or higher.
摘要翻译：本发明提供一种用于医疗用途的高水溶性中空纤维膜式血液净化器，其安全性和组装方便性优异，并且具有适用于慢性肾功能衰竭治疗的高透水性。本发明涉及含有亲水性聚合物的疏水性聚合物中空纤维膜的高透水性中空纤维型血液净化剂，其特征在于，从中空纤维膜洗出的亲水性聚合物的量为10ppm以下，因为中空丝膜的外表面的亲水性聚合物的比例为25〜50质量％。中空纤维膜的爆破压力为0.5MPa以上; 血液净化器的透水系数为150ml / m 2 / hr./mmHg以上。

2. 发明申请

US20060191844A1 Highly water-permeable blood purifier of hollow-fiber membrane type 有权
标题翻译：高透水性中空纤维膜型血液净化器
公开(公告)号：US20060191844A1
公开(公告)日：2006-08-31
申请号：US10559398
申请日：2004-08-26
申请人： Kimihiro Mahuchi , Noriyuki Tamamura , Hidehiko Sakurai , Noriko Monden , Shinya Koyama , Hiroshi Shibano , Katsuaki Kuze , Katsuhiko Nose
发明人： Kimihiro Mahuchi , Noriyuki Tamamura , Hidehiko Sakurai , Noriko Monden , Shinya Koyama , Hiroshi Shibano , Katsuaki Kuze , Katsuhiko Nose
IPC分类号： B01D69/08
CPC分类号： B01D69/08 , A61M1/16 , B01D67/0083 , B01D67/0088 , B01D69/02 , B01D69/087 , B01D71/44 , B01D71/68 , B01D2323/02 , B01D2323/08 , B01D2323/12 , B01D2323/30 , B01D2325/02 , B01D2325/04 , B01D2325/20 , B01D2325/24
摘要： The present invention provides a highly water permeable hollow fiber membrane type blood purifier for medical use, which is excellent in safety and module-assembling ease and which has a high water permeability suitable for use in therapy of chronic renal failure. The present invention relates to a highly water-permeable hollow fiber type blood purifier comprising hydrophobic polymer hollow fiber membranes each of which contains a hydrophilic polymer, characterized in that the amount of the hydrophilic polymer eluted from the hollow fiber membrane is 10 ppm or less; in that the ratio of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %; in that the burst pressure of the hollow fiber membrane is 0.5 MPa or higher; and in that the coefficient of water permeability of the blood purifier is 150 ml/m2/hr./mmHg or higher.
摘要翻译：本发明提供一种用于医疗用途的高水溶性中空纤维膜式血液净化器，其安全性和组装方便性优异，并且具有适用于慢性肾功能衰竭治疗的高透水性。本发明涉及含有亲水性聚合物的疏水性聚合物中空纤维膜的高透水性中空纤维型血液净化剂，其特征在于，从中空纤维膜洗出的亲水性聚合物的量为10ppm以下，因为中空丝膜的外表面的亲水性聚合物的比例为25〜50质量％。中空纤维膜的爆破压力为0.5MPa以上; 血液净化器的透水系数为150ml / m 2 / hr./mmHg以上。

3. 发明申请

US20070187320A1 Polysulfone-base permselective hollow fiber membrane bundle and process for producing the same 审中-公开
标题翻译：聚砜碱选择性中空纤维膜束及其制备方法
公开(公告)号：US20070187320A1
公开(公告)日：2007-08-16
申请号：US10599167
申请日：2005-03-22
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
IPC分类号： B01D71/28
CPC分类号： B01D69/08 , B01D63/02 , B01D67/0011 , B01D67/0016 , B01D67/009 , B01D67/0093 , B01D67/0095 , B01D69/02 , B01D71/68 , B01D2323/30 , B01D2323/34 , B01D2325/28
摘要： The present invention relates to a polysulfone permselective hollow fiber membrane bundle which has high safety and high reliability in performance and which is particularly suitable for use in a blood purifier or the like, a process for manufacturing the same, and a blood purifier comprising the same.
摘要翻译：本发明涉及一种具有高安全性和高可靠性的聚砜选择性中空纤维膜束，其特别适用于血液净化器等，其制造方法和含有该聚砜的血液净化器。

4. 发明授权

US07922007B2 Separation membrane with selective permeability and process for producing the same 有权
标题翻译：具有选择性渗透性的分离膜及其制造方法
公开(公告)号：US07922007B2
公开(公告)日：2011-04-12
申请号：US10599128
申请日：2005-03-18
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
IPC分类号： B01D63/02 , B01D71/68 , B01D61/00
CPC分类号： B01D69/08 , B01D67/0011 , B01D67/0013 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2323/02 , B01D2323/12 , B01D2325/20 , B01D2325/28 , D01D5/24 , D01F6/94
摘要： The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.
摘要翻译：本发明涉及可用于血液净化处理的选择性选择性分离膜。更具体地说，本发明涉及具有良好平衡的分离性能，高度稳定的安全性和性能的聚砜类选择性分离膜，并且也可以顺利地组装到模块中，及其制造方法。

5. 发明申请

US20070199891A1 Separation Membrane With Selective Permeability And Process For Producing The Same 有权
标题翻译：具有选择性渗透性的分离膜及其生产方法
公开(公告)号：US20070199891A1
公开(公告)日：2007-08-30
申请号：US10599128
申请日：2005-03-18
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriyuki Tamamura , Makoto Ono , Noriko Monden , Noriaki Kato , Hiroshi Shibano , Katsuhiko Nose
IPC分类号： B01D69/00 , B01D71/28
CPC分类号： B01D69/08 , B01D67/0011 , B01D67/0013 , B01D69/085 , B01D69/087 , B01D71/68 , B01D2323/02 , B01D2323/12 , B01D2325/20 , B01D2325/28 , D01D5/24 , D01F6/94
摘要： The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.
摘要翻译：本发明涉及可用于血液净化处理的选择性选择性分离膜。更具体地说，本发明涉及具有良好平衡的分离性能，高度稳定的安全性和性能的聚砜类选择性分离膜，并且也可以顺利地组装到模块中，及其制造方法。

6. 发明申请

US20090272686A1 BLOOD PURIFIER 审中-公开
标题翻译：血液净化器
公开(公告)号：US20090272686A1
公开(公告)日：2009-11-05
申请号：US11910627
申请日：2006-04-03
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriko Monden , Noriaki Kato , Makoto Ohno , Mitsuru Suzuki
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriko Monden , Noriaki Kato , Makoto Ohno , Mitsuru Suzuki
IPC分类号： B01D69/08
CPC分类号： B01D69/02 , A61M1/16 , A61M2209/06 , B01D67/0011 , B01D67/009 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2325/20 , B01D2325/28 , C02F1/44 , C02F2103/026
摘要： [Purpose] To provide a blood purifier which has high levels of blood compatibility, performance-retaining property when in contact with blood, and safety, and which shows an excellent water permeability-exhibiting rate after a priming treatment and has high reliability in long-term storage.[Solution] A blood purifier assembled using a polyvinyl pyrrolidone-containing polysulfone-based permselective hollow fiber membrane bundle, characterized in that the amount of polyvinyl pyrrolidone which elutes from the hollow fiber membrane bundle is 10 ppm or less, the amounts of hydrogen peroxide which elute from extracts from all the sites of the hollow fiber membrane bundle are 5 ppm or less, when the hollow fiber membrane bundle is divided into 10 portions in the lengthwise direction to test the sites of all the 10 portions according to the method regulated in the Approval Standard for Dialysis-Type Artificial Kidney Apparatus, and the water permeability of the blood purifier found at a point of time when 10 minutes has passed since the priming treatment of the blood purifier is 90% or more of the water permeability of the same found at a point of time when 24 hours has passed since the priming treatment thereof.
摘要翻译： [目的]提供一种具有高血液相容性，与血液接触时的性能保持性和安全性的血液净化器，并且在预处理后显示出优异的透水性，并且在长期使用中具有高可靠性，长期存储。 [解决方案]使用含聚乙烯吡咯烷酮的聚砜系渗透性中空纤维膜束组装的血液净化器，其特征在于，从中空纤维膜束洗出的聚乙烯吡咯烷酮的量为10ppm以下，过氧化氢的量从中空纤维膜束的所有位置的提取物中洗脱出的浓度为5ppm以下，将中空纤维膜束沿长度方向分割成10份，按照本发明的方法透析型人造肾器的认可标准和自血液净化器起动处理10分钟后发现的血液净化器的透水性为同一发现的透水性的90％以上在自启动处理24小时后的时间点。

7. 发明申请

US20080000830A1 Highly Water Permeable Hollow Fiber Membrane Type Blood Purifier and Process for Manufacturing the Same 审中-公开
标题翻译：高透水中空纤维膜型血液净化器及其制造方法
公开(公告)号：US20080000830A1
公开(公告)日：2008-01-03
申请号：US11573339
申请日：2005-08-08
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Noriko Monden , Shinya Koyama , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Noriko Monden , Shinya Koyama , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
IPC分类号： A61M1/18 , B01D69/08 , B01D71/68 , D01D5/24
CPC分类号： B01D69/02 , A61L2/081 , A61L2/186 , A61L2202/24 , B01D67/009 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2323/12 , B01D2323/30 , B01D2323/34 , B01D2325/02 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to a highly water-permeable hollow fiber membrane type blood purifier which comprises hydrophobic polymer hollow fiber membranes each containing a hydrophilic polymer, wherein the hollow fiber membrane has a hydrophilic polymer content of 25 to 50 mass % and a ratio of hole areas of 8 to 25% at its outer surface, and has a thickness non-uniformity degree of 0.6 or more, a thickness of 10 to 60 μm and a burst pressure of 0.5 to 2 MPa, and which is characterized in that the blood purifier has a water permeability of 150 to 2,000 ml/m2/hr/mmHg, and in that said blood purifier is exposed to radioactive rays on conditions that the oxygen concentration of an ambient atmosphere around the hollow fiber membranes is from 0.001% inclusive to 0.1% inclusive, and that the moisture content of the hollow fiber membrane to its weight is from 0.2 mass % inclusive to 7 mass % inclusive. The present invention also relates to a process for manufacturing the same-blood purifier.
摘要翻译：本发明涉及一种高透水性中空纤维膜型血液净化器，其包含各自含有亲水性聚合物的疏水性聚合物中空纤维膜，其中，中空纤维膜的亲水性聚合物含量为25〜50质量％，孔的比例其外表面的面积为8〜25％，厚度不均匀度为0.6以上，厚度为10〜60μm，爆破压力为0.5〜2MPa，其特征在于，所述血液净化器具有150-2,000ml / m 2 / hr / mmHg的透水性，并且在中空纤维膜周围环境气氛的氧气浓度的条件下将所述血液净化器暴露于放射线为0.001〜0.1％，中空纤维膜的水分含量为0.2质量％以上7质量％以下。本发明还涉及同一血液净化器的制造方法。

8. 发明授权

US09050410B2 Blood purifier and blood purifier package 有权
标题翻译：血液净化器和血液净化器包装
公开(公告)号：US09050410B2
公开(公告)日：2015-06-09
申请号：US11577209
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
IPC分类号： B01D39/00 , B01D39/14 , A61M1/16 , A61L2/08 , B01D65/02 , B01D67/00 , B01D71/68
CPC分类号： A61M1/168 , A61L2/087 , A61L2202/22 , A61M1/16 , A61M1/1682 , A61M1/169 , A61M2209/06 , B01D65/022 , B01D67/0011 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2321/34 , B01D2323/34 , B01D2325/36 , B01D2325/38
摘要： The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis.The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.
摘要翻译：本发明提供了一种血液净化器，其显示从其选择性渗透性分离膜中提取的过氧化氢的量减少，因此在其半胱氨酸用途的安全性方面是高度可靠的。本发明涉及一种血液净化器，其包括选择性渗透性分离膜作为主要成分，其特征在于，经过3个月以上从血液净化器除去的选择性渗透性分离膜中提取的过氧化氢的量已经过去由于通过暴露于放射线和/或电子射线对血液净化器的灭菌不大于10ppm。

9. 发明申请

US20080044643A1 Polysulfone Type Selectively Permeable Hollow Fiber Membrane Module and Process for Manufacturing the Same 有权
标题翻译：聚砜型选择性渗透中空纤维膜模块及其制造方法
公开(公告)号：US20080044643A1
公开(公告)日：2008-02-21
申请号：US11573333
申请日：2005-08-09
申请人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
IPC分类号： C08J7/18 , B32B5/14
CPC分类号： B01D63/021 , A61M2209/06 , B01D65/022 , B01D65/10 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2313/23 , B01D2321/346 , B01D2323/34 , B01D2325/022 , Y10T428/249958
摘要： The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.
摘要翻译：本发明涉及一种包含聚砜型选择性渗透性中空纤维膜的中空纤维膜组件，其包含聚砜基树脂和亲水性聚合物作为主要成分，其中（A）亲水性聚合物在内表面最上层中的含量的中空纤维膜的至少比膜的内表面的邻近层中的亲水性聚合物的含量大至少1.1倍，（B）亲水性聚合物在外表面的最上层中的含量中空纤维膜比膜的内表面的最上层中的亲水性聚合物的含量大至少1.1倍。中空纤维膜组件暴露于放射线，条件是中空纤维膜周围的环境气氛的氧浓度为0.001〜0.1％，中空纤维膜的水分含量为 0.2〜7质量％。

10. 发明授权

US09056280B2 Method for sterilizing blood purifier and blood purifier package 有权
标题翻译：灭菌方法和血液净化器包装
公开(公告)号：US09056280B2
公开(公告)日：2015-06-16
申请号：US11577235
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
IPC分类号： A61L2/00 , B01D65/02 , A61L2/08 , B01D67/00 , A61M1/16
CPC分类号： A61M1/169 , A61L2/087 , A61L2202/22 , A61M1/168 , A61M1/1682 , B01D61/28 , B01D63/02 , B01D65/022 , B01D67/0097 , B01D2321/28 , B01D2321/34
摘要： The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package.The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.
摘要翻译：本发明提供了一种对血液净化器进行灭菌的方法，该方法有效地减少归因于选择性渗透性分离膜的劣化的血液净化器的提取物的量随着放射线或电子射线暴露期间和之后的时间而变化，哪种方法在用于血液渗透治疗时安全性高度可靠。本发明还提供一种血液净化器包装。本发明涉及一种用于对通过将相同的血液净化器暴露于放射线和/或电子射线的基本干燥的选择性渗透性分离膜作为主要成分的血液净化器进行灭菌的方法，该方法是其特征在于，将血液净化器与除氧剂和保湿剂一起密封在包装袋中，或与能够释放水分的除氧剂一起密封，然后通过上述曝光在这样的密封状态下灭菌。

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