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1. 发明申请

US20160198989A1 IMPLANTABLE DEVICES AND METHODS FOR THE EVALUATION OF ACTIVE AGENTS 审中-公开
标题翻译：用于评估活性剂的可植入装置和方法
公开(公告)号：US20160198989A1
公开(公告)日：2016-07-14
申请号：US15077300
申请日：2016-03-22
申请人： Kibur Medical, Inc.
发明人： Robert I. Tepper , Jason Fuller , Oliver Jonas , John Santini
IPC分类号： A61B5/1473 , A61B17/34 , A61B5/00 , G01N33/50
CPC分类号： G01N33/5008 , A61B5/0017 , A61B5/0084 , A61B5/4848 , A61B5/6851 , A61B5/6861 , A61B10/0266 , A61B2010/045 , A61B2562/12 , A61K9/0097 , A61M5/00 , B33Y80/00 , F04C2270/041
摘要： Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure. The microwells contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility (such as WiFi) to provide for in situ retrieval of information and modification of device release properties. In the most preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.
摘要翻译：描述了将一个或多个微量剂量的一种或多种活性剂单独或组合地以一种或多种剂量递送给患者的选定组织的装置。这些装置通常包括布置在支撑结构上或内部的多个微孔。微孔剂含有一种或多种活性剂，单独或组合使用一种或多种剂量和/或释放药代动力学。在一个示例性实施例中，该装置具有圆柱形形状，在装置的外侧上具有对称的孔，每个孔含有一种或多种药物，其一个或多个浓度，尺寸允许使用导管，插管或探针放置。可选地，该设备具有导丝，以及光纤，传感器和/或交互功能，例如远程可访问性（例如WiFi），以提供信息的原位检索和设备释放属性的修改。在最优选的实施例中，光纤和/或传感器可以单独访问分立的孔。

2. 发明申请

US20160256670A1 IMPLANTABLE DEVICES AND METHODS FOR EVALUATION OF ACTIVE AGENTS 审中-公开
公开(公告)号：US20160256670A1
公开(公告)日：2016-09-08
申请号：US15158344
申请日：2016-05-18
申请人： Kibur Medical, Inc. , Massachusetts Institute of Technology
发明人： Robert I. Tepper , Jason Fuller , Oliver Jonas , John Santini
IPC分类号： A61M31/00 , A61B17/34 , A61B5/00 , A61B10/02
CPC分类号： A61M31/002 , A61B5/0084 , A61B5/145 , A61B5/4848 , A61B5/6861 , A61B10/0233 , A61B10/0266 , A61B10/0275 , A61B17/3468 , A61K9/0024 , A61K9/0097 , A61M37/0069 , A61M2202/06 , A61M2205/04 , A61M2207/00 , G01N1/31
摘要： Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility to provide for in situ retrieval of information and modification of device release properties. In a preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.

3. 发明授权

US10183155B2 Implantable devices and methods for evaluation of active agents 有权
公开(公告)号：US10183155B2
公开(公告)日：2019-01-22
申请号：US15158344
申请日：2016-05-18
申请人： Kibur Medical, Inc. , Massachusetts Institute of Technology
发明人： Robert I. Tepper , Jason Fuller , Oliver Jonas , John Santini
IPC分类号： A61M31/00 , A61B5/00 , A61B10/02 , A61B17/34 , A61B5/145 , A61K9/00 , A61M37/00 , G01N1/31
摘要： Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility to provide for in situ retrieval of information and modification of device release properties. In a preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.

4. 发明申请

US20130184593A1 Implantable Devices And Methods For The Evaluation of Active Agents 审中-公开
标题翻译：可植入设备和方法评估活性剂
公开(公告)号：US20130184593A1
公开(公告)日：2013-07-18
申请号：US13729738
申请日：2012-12-28
申请人： Kibur Medical, Inc.
发明人： Robert I. Tepper , Jason Fuller , Oliver Jonas , John Santini
IPC分类号： G01N33/50 , A61M5/00
CPC分类号： G01N33/5008 , A61B5/0017 , A61B5/0084 , A61B5/4848 , A61B5/6851 , A61B5/6861 , A61B10/0266 , A61B2010/045 , A61B2562/12 , A61K9/0097 , A61M5/00 , B33Y80/00 , F04C2270/041
摘要： Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure. The microwells contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility (such as WiFi) to provide for in situ retrieval of information and modification of device release properties. In the most preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.
摘要翻译：描述了将一个或多个微量剂量的一种或多种活性剂单独或组合地以一种或多种剂量递送给患者的选定组织的装置。这些装置通常包括布置在支撑结构上或内部的多个微孔。微孔剂含有一种或多种活性剂，单独或组合使用一种或多种剂量和/或释放药代动力学。在一个示例性实施例中，该装置具有圆柱形形状，在装置的外侧上具有对称的孔，每个孔含有一种或多种药物，其一个或多个浓度，尺寸允许使用导管，插管或探针放置。可选地，该设备具有导丝，以及光纤，传感器和/或交互功能，例如远程可访问性（例如WiFi），以提供信息的原位检索和设备释放属性的修改。在最优选的实施例中，光纤和/或传感器可以单独访问分立的孔。

5. 发明授权

US10390702B2 Implantable devices and methods for the evaluation of active agents 有权
公开(公告)号：US10390702B2
公开(公告)日：2019-08-27
申请号：US15077300
申请日：2016-03-22
申请人： Kibur Medical, Inc.
发明人： Robert I. Tepper , Jason Fuller , Oliver Jonas , John Santini
IPC分类号： A61B5/00 , B33Y80/00 , A61K9/00 , A61M5/00 , G01N33/50 , A61B10/02 , A61B10/04
摘要： Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure. The microwells contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility (such as WiFi) to provide for in situ retrieval of information and modification of device release properties. In the most preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.

6. 发明申请

US20150005595A1 IMPLANTABLE DEVICES AND METHODS FOR EVALUATION OF ACTIVE AGENTS 审中-公开
标题翻译：用于评估活性剂的可植入装置和方法
公开(公告)号：US20150005595A1
公开(公告)日：2015-01-01
申请号：US14298353
申请日：2014-06-06
申请人： Kibur Medical, Inc.
发明人： Robert I. Tepper , Jason Fuller , Oliver Jonas , John Santini
IPC分类号： A61B5/00 , A61B5/145 , A61B17/34 , A61M31/00 , A61M25/09 , A61B10/02
CPC分类号： A61M31/002 , A61B5/0084 , A61B5/145 , A61B5/4848 , A61B5/6861 , A61B10/0233 , A61B10/0266 , A61B10/0275 , A61B17/3468 , A61K9/0024 , A61K9/0097 , A61M37/0069 , A61M2202/06 , A61M2205/04 , A61M2207/00 , G01N1/31
摘要： Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. In an exemplary embodiment, the device has a cylindrical shape, having symmetrical wells on the outside of the device, each well containing one or more drugs, at one or more concentrations, sized to permit placement using a catheter, cannula, or stylet. Optionally, the device has a guidewire, and fiber optics, sensors and/or interactive features such as remote accessibility to provide for in situ retrieval of information and modification of device release properties. In a preferred embodiment, the fiber optics and/or sensors are individually accessible to discrete wells.
摘要翻译：描述了将一个或多个微量剂量的一种或多种活性剂单独或组合地以一种或多种剂量递送给患者的选定组织的装置。装置通常包括布置在支撑结构上或内部的多个微孔，并且以一种或多种剂量单独或组合地含有一种或多种活性剂和/或释放药代动力学。在一个示例性实施例中，该装置具有圆柱形形状，在装置的外侧上具有对称的孔，每个孔含有一种或多种药物，其一个或多个浓度，尺寸允许使用导管，插管或探针放置。可选地，该设备具有导丝，以及光纤，传感器和/或交互功能，例如远程可访问性，用于提供信息的原位检索和设备释放特性的修改。在一个优选实施例中，光纤和/或传感器可以单独访问离散井。

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