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1. 发明授权

US08249884B2 Methods and systems for implementing a loyalty program utilizing customizable rules 失效
标题翻译：使用可定制规则实施忠诚度计划的方法和系统
公开(公告)号：US08249884B2
公开(公告)日：2012-08-21
申请号：US13084736
申请日：2011-04-12
申请人： Kevin Turner , Omar Besim Hakim , Jeremy Kelley , John Ludlow
发明人： Kevin Turner , Omar Besim Hakim , Jeremy Kelley , John Ludlow
IPC分类号： G06Q40/00
CPC分类号： G06Q30/02 , G06Q30/0238
摘要： A method and system for making a donation to a third party includes storing, via a storage device, a user preference in a user account; receiving, via a receiver, information regarding a purchase transaction at a merchant; accessing, via a processor, the user preference from the user account; dynamically selecting, via the processor, a percentage discount to be allocated to the purchase transaction; donating, via the processor, a monetary value of the percentage discount to the third-party according to the user preference, where the user account is associated with a user, and includes rules for allocating the percentage discount to the third-party.
摘要翻译：用于向第三方进行捐赠的方法和系统包括经由存储设备在用户帐户中存储用户偏好; 通过接收者接收关于商家的购买交易的信息; 经由处理器从用户帐户访问用户偏好; 通过处理器动态地选择要分配给购买交易的百分比折扣; 通过处理器，根据用户偏好（其中用户帐户与用户相关联）向第三方提供百分比折扣的货币价值，并且包括用于向第三方分配百分比折扣的规则。

2. 发明申请

US20120047009A1 Methods And Systems For Implementing A Loyalty Program Utilizing Customizable Rules 失效
标题翻译：使用可定制规则实现忠诚度计划的方法和系统
公开(公告)号：US20120047009A1
公开(公告)日：2012-02-23
申请号：US13084736
申请日：2011-04-12
申请人： Kevin Turner , Omar Hakim , Jeremy Kelley , John Ludlow
发明人： Kevin Turner , Omar Hakim , Jeremy Kelley , John Ludlow
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0238
摘要： A method and system for making a donation to a third party includes storing, via a storage device, a user preference in a user account; receiving, via a receiver, information regarding a purchase transaction at a merchant; accessing, via a processor, the user preference from the user account; dynamically selecting, via the processor, a percentage discount to be allocated to the purchase transaction; donating, via the processor, a monetary value of the percentage discount to the third-party according to the user preference, where the user account is associated with a user, and includes rules for allocating the percentage discount to the third-party.
摘要翻译：用于向第三方进行捐赠的方法和系统包括经由存储设备在用户帐户中存储用户偏好; 通过接收者接收关于商家的购买交易的信息; 经由处理器从用户帐户访问用户偏好; 通过处理器动态地选择要分配给购买交易的百分比折扣; 通过处理器，根据用户偏好（其中用户帐户与用户相关联）向第三方提供百分比折扣的货币价值，并且包括用于向第三方分配百分比折扣的规则。

3. 发明申请

US20070099297A1 PRIMITIVE AND PROXIMAL HEPATIC STEM CELLS 有权
标题翻译：主要和临床干细胞
公开(公告)号：US20070099297A1
公开(公告)日：2007-05-03
申请号：US11609729
申请日：2006-12-12
申请人： Lola Reid , Nick Moss , Mark Furth , John Ludlow , Andrew Bruce
发明人： Lola Reid , Nick Moss , Mark Furth , John Ludlow , Andrew Bruce
IPC分类号： C12N5/08
CPC分类号： C12N5/0672 , C12N2500/25 , C12N2500/36 , C12N2500/90 , C12N2501/11 , C12N2502/13 , G01N33/5005 , G01N33/68 , G01N2333/705 , G01N2333/70525 , G01N2333/70596
摘要： Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
摘要翻译：肝祖细胞包含两个人类肝干细胞，原始和近端肝干细胞，以及两个定型祖细胞群，一个为胆汁细胞，一个为肝细胞。人原始肝干细胞是肝细胞群体的非常小的一部分，并且引起近端肝干细胞构成肝脏的大部分。人近端肝干细胞产生胆汁和肝细胞定向的祖细胞。原始和近端干细胞是人类肝脏的主要干细胞。人原始肝干细胞可以通过人肝脏的免疫选择或在选择人原始肝干细胞的条件下培养人肝细胞来分离。可以通过免疫选择或通过在包括发育因子的条件下培养人肝细胞来分离近端肝干细胞。也可以通过在包括发育因子的条件下培养包含原始肝干细胞的菌落来分离近端肝干细胞。所得组合物可用于治疗肝脏疾病和用于生产生物人造器官。

4. 发明申请

US20070276507A1 Scaffolds for organ reconstruction and augmentation 有权
标题翻译：器官重建和扩充支架
公开(公告)号：US20070276507A1
公开(公告)日：2007-11-29
申请号：US11706081
申请日：2007-02-12
申请人： Timothy Bertram , Andrew Bruce , Deepak Jain , Manuel Jayo , John Ludlow , Darrell McCoy , Richard Payne , Namrata Sangha
发明人： Timothy Bertram , Andrew Bruce , Deepak Jain , Manuel Jayo , John Ludlow , Darrell McCoy , Richard Payne , Namrata Sangha
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译：生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。还提供了插入物，容器和端口用于将管状容器附接到新器官支架。将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。

5. 发明申请

US20070275363A1 Bioreactor for organ reconstruction and augmentation 审中-公开
标题翻译：用于器官重建和增生的生物反应器
公开(公告)号：US20070275363A1
公开(公告)日：2007-11-29
申请号：US11706173
申请日：2007-02-12
申请人： Timothy Bertram , Andrew Bruce , Deepak Jain , John Ludlow , Darrell McCoy , Namrata Sangha
发明人： Timothy Bertram , Andrew Bruce , Deepak Jain , John Ludlow , Darrell McCoy , Namrata Sangha
IPC分类号： A01N1/00 , C12M1/12
CPC分类号： C12M37/04 , A01N1/02 , A01N1/0231 , A01N1/0247 , C12M21/08 , C12M25/14 , C12M27/14
摘要： Bioreactors are used in neo-organ production to allow for an appropriate environment for the maintenance of healthy culturing conditions from pre-wetting to shipment of the neo-organ. The closed system “all-in-one bioreactor” is designed to allow for minimal exposure of the scaffold to the open air in order to maintain sterility. The design allows for the same container to be utilized for sterilization, pre-wetting, cell seeding, medium exchange, and shipment. The “all-in-one” bioreactor also remains completely closed after the urothelial cell seeding step to the implantation at the clinical site. This allows for sufficient time for release testing to occur so the neo-organ can be implanted into the patient.
摘要翻译：生物反应器用于新器官生产，以允许适当的环境来维持健康的培养条件，从预润湿到新器官的运输。封闭系统“一体化生物反应器”被设计成允许脚手架暴露于露天以保持无菌性。该设计允许将相同的容器用于灭菌，预润湿，细胞播种，培养基更换和运输。 “一体化”生物反应器在尿路上皮细胞接种步骤到临床部位植入后也保持完全闭合。这允许足够的时间进行释放测试，从而可以将新器官植入患者体内。

6. 发明申请

US20070249045A1 ADIPOSE DERIVED ADULT STEM CELLS IN HEPATIC REGENERATION 有权
标题翻译： ADIPOSE衍生成熟干细胞在HEPATIC再生
公开(公告)号：US20070249045A1
公开(公告)日：2007-10-25
申请号：US11738887
申请日：2007-04-23
申请人： Jeffery Gimble , John Ludlow
发明人： Jeffery Gimble , John Ludlow
IPC分类号： C12N5/08
CPC分类号： C12N5/0672 , C12N5/067 , C12N2500/30 , C12N2500/38 , C12N2500/42 , C12N2500/62 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/12 , C12N2501/23 , C12N2501/237 , C12N2506/1384 , C12N2533/54 , C12N2533/90
摘要： The present invention provides a method to derive hepatic stem cells from stem cells derived from non-liver tissue. In one embodiment of the invention, hepatic stem cells are derived from adipose stem cells. The invention also provides a method of enhancing hepatic cytokine production (e.g., HGF) from ASCs, which may be useful in the regeneration of liver tissue when transplanted in vivo. Tissue culture conditions, including media conditions, are provided.
摘要翻译：本发明提供从源自非肝组织的干细胞导出肝干细胞的方法。在本发明的一个实施方案中，肝干细胞衍生自脂肪干细胞。本发明还提供了一种增强来自ASCs的肝细胞因子产生（例如，HGF）的方法，其可以用于在体内移植时肝脏组织的再生。提供组织培养条件，包括培养条件。

7. 发明申请

US20070148141A1 METHOD OF USING HEPATIC PROGENITORS IN TREATING LIVER DYSFUNCTION 审中-公开
标题翻译：使用HEPICAL PROGENITORS治疗肝脏功能障碍的方法
公开(公告)号：US20070148141A1
公开(公告)日：2007-06-28
申请号：US11614703
申请日：2006-12-21
申请人： Mark Johnston , John Ludlow , Sonya Sherwood
发明人： Mark Johnston , John Ludlow , Sonya Sherwood
IPC分类号： A61K35/407
CPC分类号： A61K35/407 , A61K31/352 , A61K31/365 , A61K31/573 , A61K35/12 , A61K38/13 , C12N5/0672 , A61K2300/00
摘要： Methods of using hepatic progenitors in treating liver dysfunction are provided. More particularly, methods of using hepatic progenitor cells, including hepatic stem cells, in treating liver dysfunction in the absence of immune-suppressing amounts of an immunosuppressant.
摘要翻译：提供肝脏祖细胞治疗肝功能不全的方法。更具体地，在不存在免疫抑制量的免疫抑制剂的情况下，使用肝祖细胞（包括肝干细胞）来治疗肝功能障碍的方法。

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