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1. 发明授权

US06933154B2 Optimal windows for obtaining optical data for characterization of tissue samples 失效
标题翻译：用于获取组织样本表征的光学数据的最佳窗口
公开(公告)号：US06933154B2
公开(公告)日：2005-08-23
申请号：US10295794
申请日：2002-11-15
申请人： Kevin T. Schomacker , Alex Zelenchuk , Ross Flewelling , Howard Kaufman
发明人： Kevin T. Schomacker , Alex Zelenchuk , Ross Flewelling , Howard Kaufman
IPC分类号： A61B5/00 , G01N21/31 , G01N21/64 , G01N31/00
CPC分类号： G01N21/6408 , A61B5/0059 , A61B5/7264 , A61B5/7267 , G01N21/31 , G01N21/6428 , Y10S435/808 , Y10T436/25
摘要： The invention provides methods for determining a characteristic of a tissue sample, such as a state of health, using spectral data and/or images obtained within an optimal period of time following the application of a chemical agent to the tissue sample. The invention provides methods of determining such optimal windows of time. Similarly, the invention provides methods of determining other criteria for triggering the acquisition of an optical signal for classifying the state of health of a region of a tissue sample.
摘要翻译：本发明提供了使用在向组织样本施加化学试剂之后的最佳时间段内获得的光谱数据和/或图像来确定组织样本的特性（例如健康状况）的方法。本发明提供了确定这种最佳时间窗口的方法。类似地，本发明提供了确定用于触发获取光信号以用于分类组织样本的区域的健康状态的其它标准的方法。

2. 发明申请

US20050064602A1 Methods of monitoring effects of chemical agents on a sample 审中-公开
标题翻译：监测化学试剂对样品的影响的方法
公开(公告)号：US20050064602A1
公开(公告)日：2005-03-24
申请号：US10911996
申请日：2004-08-05
申请人： Howard Kaufman , Alex Zelenchuk , Ross Flewelling , Philippe Schmid , Ze'ev Hed
发明人： Howard Kaufman , Alex Zelenchuk , Ross Flewelling , Philippe Schmid , Ze'ev Hed
IPC分类号： A61B1/00 , A61B5/00 , A61M11/00 , G01N21/00
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/0008 , A61B1/00142 , A61B5/0075 , A61B5/0084 , A61M11/00
摘要： The invention provides methods and systems for monitoring effects of chemical agents on optical signals produced by samples in response to the chemical agents. Preferred methods comprise application of multiple chemical agents that interact to alter an optical signal from the sample. Methods and systems of the invention also comprise monitoring an optical signal from an endogenous chromophore upon application of a chemical agent to a sample. Methods and systems of the invention also comprise the use of triggers, atomizers and image alignment to enhance the results of methods described herein.
摘要翻译：本发明提供了用于监测化学试剂对由样品响应于化学试剂产生的光学信号的影响的方法和系统。优选的方法包括应用多个化学试剂，其相互作用以改变来自样品的光信号。本发明的方法和系统还包括在向样品施加化学试剂时监测来自内生发色团的光学信号。本发明的方法和系统还包括使用触发器，雾化器和图像对准来增强本文所述方法的结果。

3. 发明授权

US06902935B2 Methods of monitoring effects of chemical agents on a sample 失效
公开(公告)号：US06902935B2
公开(公告)日：2005-06-07
申请号：US09738614
申请日：2000-12-15
申请人： Howard Kaufman , Alex Zelenchuk , Ross Flewelling , Philippe Schmid , Ze'ev Hed
发明人： Howard Kaufman , Alex Zelenchuk , Ross Flewelling , Philippe Schmid , Ze'ev Hed
IPC分类号： A61B1/00 , A61B5/00 , A61M11/00 , G01N21/64
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/0008 , A61B1/00142 , A61B5/0075 , A61B5/0084 , A61M11/00
摘要： The invention provides methods and systems for monitoring effects of chemical agents on optical signals produced by samples in response to the chemical agents. Preferred methods comprise application of multiple chemical agents that interact to alter an optical signal from the sample. Methods and systems of the invention also comprise monitoring an optical signal from an endogenous chromophore upon application of a chemical agent to a sample. Methods and systems of the invention also comprise the use of triggers, atomizers and image alignment to enhance the results of methods described herein.

4. 发明申请

US20060129038A1 Optical determination of in vivo properties 审中-公开
公开(公告)号：US20060129038A1
公开(公告)日：2006-06-15
申请号：US11109409
申请日：2005-04-19
申请人： Alex Zelenchuk , Howard Kaufman
发明人： Alex Zelenchuk , Howard Kaufman
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14552 , A61B5/489
摘要： A system and method for determining an in vivo property of a tissue or blood is described. The in vivo property may be a hematocrit value, a hemoglobin concentration, or a combination thereof. The system can automatically determine a location of a subcutaneous blood vessel. Based on the automatically determined location, the system illuminates the blood vessel with a light beam and detects light resulting from the illumination. The system determines the in vivo property based on the detected light. Alternatively, or in combination, the system displays an image corresponding to a spatial relationship between a subcutaneous blood vessel and a light beam. Based on the image, an operator can adjust the light beam with respect to the blood vessel to have a selected spatial relationship. The system determines an in vivo property based on the illumination of the blood vessel when the light beam has the selected spatial relationship.

5. 发明申请

US20060129037A1 Optical determination of in vivo properties 失效
标题翻译：光学测定体内特性
公开(公告)号：US20060129037A1
公开(公告)日：2006-06-15
申请号：US11011714
申请日：2004-12-14
申请人： Howard Kaufman , Alex Zelenchuk
发明人： Howard Kaufman , Alex Zelenchuk
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/489 , A61B5/681 , A61B5/6824 , A61B5/742
摘要： A system and method for determining an in vivo property of a tissue or blood is described. The in vivo property may be a hematocrit value, a hemoglobin concentration, or a combination thereof. The system can automatically determine a location of a subcutaneous blood vessel. Based on the automatically determined location, the system illuminates the blood vessel with a light beam and detects light resulting from the illumination. The system determines the in vivo property based on the detected light. Alternatively, or in combination, the system displays an image corresponding to a spatial relationship between a subcutaneous blood vessel and a light beam. Based on the image, an operator can adjust the light beam with respect to the blood vessel to have a selected spatial relationship. The system determines an in vivo property based on the illumination of the blood vessel when the light beam has the selected spatial relationship.
摘要翻译：描述了用于确定组织或血液的体内特性的系统和方法。体内特性可以是血细胞比容值，血红蛋白浓度或其组合。系统可以自动确定皮下血管的位置。基于自动确定的位置，系统用光束照射血管并检测照明产生的光。该系统基于检测到的光来确定体内特性。或者或组合地，系统显示对应于皮下血管和光束之间的空间关系的图像。基于图像，操作者可以相对于血管调节光束以具有选定的空间关系。当光束具有选择的空间关系时，该系统基于血管的照明确定体内特性。

6. 发明申请

US20070004976A1 In vivo optical measurements of hematocrit 审中-公开
标题翻译：血细胞比容的体内光学测量
公开(公告)号：US20070004976A1
公开(公告)日：2007-01-04
申请号：US11293652
申请日：2005-12-02
申请人： Alex Zelenchuk , Howard Kaufman , Stephen Fantone
发明人： Alex Zelenchuk , Howard Kaufman , Stephen Fantone
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455
摘要： An apparatus for measuring hematocrit of a subject's blood includes an optical source that generates an optical beam that illuminates subcutaneous vessels under a subject's skin. An optical element is positioned to receive a near field portion of the optical beam that is reflected from the subcutaneous vessels under the subject's skin. A scanning mechanism positions the optical element relative to the subcutaneous vessels under the subject's skin over a plurality of relative distances. An optical detector generates a plurality of electrical signals in response to detecting the near field portion of the optical beam that is reflected from the subcutaneous vessels under the subject's skin at the plurality of relative distances between the optical element and the subcutaneous vessels. A processor determines a value of hematocrit in the subcutaneous vessels illuminated by the optical beam from the plurality of electrical signals generated by the optical detector.
摘要翻译：用于测量受试者血液的血细胞比容的装置包括产生在对象皮肤下照射皮下血管的光束的光源。光学元件被定位成接收从受试者皮肤下方的皮下血管反射的光束的近场部分。扫描机构将光学元件相对于受试者皮肤下方的皮下血管定位在多个相对距离上。光检测器响应于在光学元件和皮下血管之间的多个相对距离处检测在受试者皮肤下从皮下血管反射的光束的近场部分而产生多个电信号。处理器确定由光学检测器产生的多个电信号由光束照射的皮下血管中的血细胞比容的值。

7. 发明授权

US06385484B2 Spectroscopic system employing a plurality of data types 有权
标题翻译：采用多种数据类型的光谱系统
公开(公告)号：US06385484B2
公开(公告)日：2002-05-07
申请号：US09738613
申请日：2000-12-15
申请人： Robert J. Nordstrom , Peter J. Costa , Kwong Hui , Ross Flewelling , Howard Kaufman
发明人： Robert J. Nordstrom , Peter J. Costa , Kwong Hui , Ross Flewelling , Howard Kaufman
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0068
摘要： A system and method for classifying specimens using a plurality of spectral data types. Spectra are recorded as amplitudes at a series of discrete wavelengths. Pluralities of reference spectra are recorded for specimens having known conditions. A spectrum of a first type is observed for a test specimen. The specimen is characterized as to a first known condition. In the event that the specimen does not exhibit the first known condition, a spectrum of a second type is observed and analyzed to determine which of a plurality of conditions is to be ascribed to the test specimen. In some embodiments, the test specimen can comprise human cervical tissue, and the known conditions can include normal health, metaplasia, CIN I and CIN II/II.
摘要翻译：一种使用多种光谱数据类型分类样本的系统和方法。光谱被记录为一系列离散波长的幅度。对于具有已知条件的样品记录多个参考光谱。对于试样观察到第一类光谱。样品的特征在于第一已知条件。在样本不显示第一已知条件的情况下，观察并分析第二类型的光谱，以确定将多个条件中的哪一个归因于测试样本。在一些实施方案中，测试样品可以包含人宫颈组织，并且已知条件可以包括正常健康，化生，CIN I和CIN II / II。

8. 发明申请

US20050008618A1 Composition for delivering an agent to a target cell and uses thereof 审中-公开
标题翻译：用于将药剂递送至靶细胞的组合物及其用途
公开(公告)号：US20050008618A1
公开(公告)日：2005-01-13
申请号：US10789627
申请日：2004-02-26
申请人： Howard Kaufman , Michal Bereta
发明人： Howard Kaufman , Michal Bereta
IPC分类号： A01N63/00 , A01N65/00 , A61K39/00 , A61K47/48 , A61K48/00 , C07K16/30 , C12N20060101 , C12N1/18 , C12N1/21
CPC分类号： C07K16/3007 , A61K39/00 , A61K39/0011 , A61K47/6901 , A61K48/00 , A61K2039/505 , A61K2039/52 , A61K2039/522 , A61K2039/523 , A61K2039/6006 , C07K2317/622 , C12N2810/859 , Y02A50/476
摘要： The present invention provides a composition for delivering an agent to a target cell, comprising: (a) a microorganism that has, on its cell surface, at least one exogenous molecule that binds to an antigen on the surface of a target cell; and (b) an agent. The present invention further provides a vaccine comprising: (a) at least one microorganism that has, on its cell surface, at least one exogenous molecule that binds to an antigen on the surface of a target cell; (b) an agent; and (c) a pharmaceutically-acceptable carrier. Also provided are methods for treating and preventing neoplasia in a subject in need of treatment, by administering to the subject a composition or a vaccine of the present invention.
摘要翻译：本发明提供了一种用于将试剂递送至靶细胞的组合物，其包含：（a）在其细胞表面上具有至少一种结合靶细胞表面上的抗原的外源性分子的微生物; 和（b）代理人。本发明进一步提供一种疫苗，其包含：（a）至少一种在其细胞表面上具有至少一种与靶细胞表面上的抗原结合的外源性分子的微生物; （b）代理人; 和（c）药学上可接受的载体。还提供了通过向受试者施用本发明的组合物或疫苗来治疗和预防需要治疗的受试者的瘤形成的方法。

9. 发明授权

US08326014B2 Methods and systems for processing biological specimens utilizing multiple wavelengths 有权
标题翻译：用于处理利用多个波长的生物样品的方法和系统
公开(公告)号：US08326014B2
公开(公告)日：2012-12-04
申请号：US11864744
申请日：2007-09-28
申请人： Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
发明人： Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
IPC分类号： G06K9/00
CPC分类号： G06K9/00147 , G06K9/033 , G06K9/6253
摘要： Methods, systems and computer readable media for processing one or more biological specimens carried by specimen slides. Images of objects in a specimen are acquired and objects of interest in the acquired images are identified. Additional images of identified objects of interest may be acquired at multiple wavelengths. Cellular features of objects of interest are extracted from images and may be used for classifying the specimen, e.g., as normal or suspicious/abnormal, based a probabilistic model that utilizes the extracted features.
摘要翻译：方法，系统和计算机可读介质，用于处理标本载玻片携带的一个或多个生物样本。获取样本中的对象的图像，并且识别获取的图像中的感兴趣对象。可以在多个波长处获取所识别的感兴趣对象的附加图像。基于提取的特征的概率模型，从图像中提取感兴趣对象的细胞特征，并且可以将其用于分类样本，例如正常或可疑/异常。

10. 发明授权

US07260248B2 Image processing using measures of similarity 有权
标题翻译：图像处理采用相似度测度
公开(公告)号：US07260248B2
公开(公告)日：2007-08-21
申请号：US10099881
申请日：2002-03-15
申请人： Howard Kaufman , Philippe Schmid
发明人： Howard Kaufman , Philippe Schmid
IPC分类号： G06K9/00
CPC分类号： A61B5/0059 , G06K9/0014 , G06T7/11 , G06T7/155 , G06T7/174 , G06T2207/10056 , G06T2207/10064 , G06T2207/20016 , G06T2207/20152 , G06T2207/30016 , G06T2207/30024
摘要： The invention provides methods of relating a plurality of images based on measures of similarity. The methods of the invention are useful in the segmentation of a sequence of colposcopic images of tissue, for example. The methods may be applied in the determination of tissue characteristics in acetowhitening testing of cervical tissue, for example.
摘要翻译：本发明提供了基于相似性度量来相关联多个图像的方法。例如，本发明的方法在组织的阴道镜图像序列的分割中是有用的。例如，该方法可以应用于宫颈组织的乙酰紫杉醇检测中组织特征的测定。

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