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1. 发明授权

US08843188B2 Adjustable nerve electrode 有权
标题翻译：可调神经电极
公开(公告)号：US08843188B2
公开(公告)日：2014-09-23
申请号：US12948848
申请日：2010-11-18
申请人： Kevin Kilgore , Douglas Michael Ackermann, Jr. , Niloy Bhadra , Narendra Bhadra , Joe Payer
发明人： Kevin Kilgore , Douglas Michael Ackermann, Jr. , Niloy Bhadra , Narendra Bhadra , Joe Payer
IPC分类号： A61B5/04 , A61N1/06 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/36185
摘要： Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve in an amount sufficient to produce an HFAC nerve conduction block in the nerve. The example adjustable electrode also includes a logic configured to selectively control which of the two or more contacts deliver HFAC to the nerve to control whether the nerve electrode is in a first (e.g., onset response mitigating) configuration or in a second (e.g., HFAC nerve conduction block maintenance) configuration. The electrode may be used in applications including, but not limited to, nerve block applications, and nerve stimulation applications. The electrode may be adjusted by changing attributes including, but not limited to, the number, length, orientation, distance between, surface area, and distance from a nerve of contacts to be used to deliver the HFAC.
摘要翻译：描述可调电极示例。一个示例性可调节电极包括两个或更多个触点，其被配置为以足以在神经中产生HFAC神经传导阻滞的量向神经选择性地递送高频交流电（HFAC）。示例性可调节电极还包括被配置为选择性地控制两个或多个触点中的哪一个将HFAC递送到神经以控制神经电极是否处于第一（例如起始应答缓解）配置或第二次（例如，HFAC）神经传导阻滞维持）配置。电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。可以通过改变属性来调节电极，包括但不限于数量，长度，取向，距离，表面积以及与用于递送HFAC的接触的神经的距离。

2. 发明申请

US20080294221A1 Action potential conduction prevention 有权
标题翻译：动作电位传导预防
公开(公告)号：US20080294221A1
公开(公告)日：2008-11-27
申请号：US12214256
申请日：2008-06-17
申请人： Kevin Kilgore , Niloy Bhadra
发明人： Kevin Kilgore , Niloy Bhadra
IPC分类号： A61N1/34 , A61N1/32
CPC分类号： A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having two phases and selectively depolarizing a nerve membrane using the electrical waveform. The nerve membrane is depolarized to a state where the nerve membrane cannot conduct an action potential. The depolarization is achieved by selectively repetitively providing the electrical waveform to a targeted nerve region associated with the nerve region to control m gates and h gates in the region and thus to control the availability of ions.
摘要翻译：提出了选择性地和可逆地防止目标神经区域中动作电位传导的示例性方法。该方法包括产生具有两相的电波形并且使用电波形选择性去极化神经膜。神经膜被去极化到神经膜不能发挥动作电位的状态。通过选择性地将电波形重复地提供给与神经区域相关联的目标神经区域来控制该区域中的m个门极和h个门，从而控制离子的可用性来实现去极化。

3. 发明授权

US09008800B2 Separated-interface nerve electrode 有权
标题翻译：分离界面神经电极
公开(公告)号：US09008800B2
公开(公告)日：2015-04-14
申请号：US12949074
申请日：2010-11-18
申请人： Douglas Michael Ackermann, Jr. , Kevin Kilgore , Niloy Bhadra , Narendra Bhadra
发明人： Douglas Michael Ackermann, Jr. , Kevin Kilgore , Niloy Bhadra , Narendra Bhadra
IPC分类号： A61N1/00 , A61N1/05 , A61N1/04 , A61N1/32 , A61N1/36
CPC分类号： A61N1/0551 , A61L31/048 , A61N1/0436 , A61N1/0556 , A61N1/325 , A61N1/36067 , A61N1/36103
摘要： Example ionic coupling electrodes are described. One example ionic conducting electrode includes a first portion that can be coupled to a single phase current source. The first portion carries current flow via electrons. The electrode includes a second portion to apply a current to a nerve tissue. The second portion carries current flow via ions. The second portion is positioned between the nerve tissue and the first portion to prevent the first portion from touching the nerve tissue. The current applied to the nerve tissue is produced in the second portion in response to a current that is present in the first portion. The current present in the first portion is provided from a single phase current source. The electrode may be used in applications including, but not limited to, nerve block applications and nerve stimulation applications.
摘要翻译：示例性的离子耦合电极被描述。一个示例性的离子导电电极包括可以耦合到单相电流源的第一部分。第一部分通过电子传送电流。电极包括将电流施加到神经组织的第二部分。第二部分通过离子传送电流。第二部分位于神经组织和第一部分之间，以防止第一部分接触神经组织。响应于存在于第一部分中的电流，在第二部分中产生施加到神经组织的电流。第一部分中存在的电流由单相电流源提供。电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。

4. 发明授权

US08060208B2 Action potential conduction prevention 有权
标题翻译：动作电位传导预防
公开(公告)号：US08060208B2
公开(公告)日：2011-11-15
申请号：US12214256
申请日：2008-06-17
申请人： Kevin Kilgore , Niloy Bhadra
发明人： Kevin Kilgore , Niloy Bhadra
IPC分类号： A61N1/34
CPC分类号： A61N1/36017 , A61N1/36021 , A61N1/36071
摘要： An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having two phases and selectively depolarizing a nerve membrane using the electrical waveform. The nerve membrane is depolarized to a state where the nerve membrane cannot conduct an action potential. The depolarization is achieved by selectively repetitively providing the electrical waveform to a targeted nerve region associated with the nerve region to control m gates and h gates in the region and thus to control the availability of ions.
摘要翻译：提出了选择性地和可逆地防止目标神经区域中动作电位传导的示例性方法。该方法包括产生具有两相的电波形并且使用电波形选择性去极化神经膜。神经膜被去极化到神经膜不能发挥动作电位的状态。通过选择性地将电波形重复地提供给与神经区域相关联的目标神经区域来控制该区域中的m个门极和h个门，从而控制离子的可用性来实现去极化。

5. 发明申请

US20110160798A1 SEPARATED-INTERFACE NERVE ELECTRODE 有权
标题翻译：分离界面神经电极
公开(公告)号：US20110160798A1
公开(公告)日：2011-06-30
申请号：US12949074
申请日：2010-11-18
申请人： Douglas Michael ACKERMANN, JR. , Kevin Kilgore , Niloy Bhadra , Narendra Bhadra
发明人： Douglas Michael ACKERMANN, JR. , Kevin Kilgore , Niloy Bhadra , Narendra Bhadra
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61L31/048 , A61N1/0436 , A61N1/0556 , A61N1/325 , A61N1/36067 , A61N1/36103
摘要： Example ionic coupling electrodes are described. One example ionic conducting electrode includes a first portion that can be coupled to a single phase current source. The first portion carries current flow via electrons. The electrode includes a second portion to apply a current to a nerve tissue. The second portion carries current flow via ions. The second portion is positioned between the nerve tissue and the first portion to prevent the first portion from touching the nerve tissue. The current applied to the nerve tissue is produced in the second portion in response to a current that is present in the first portion. The current present in the first portion is provided from a single phase current source. The electrode may be used in applications including, but not limited to, nerve block applications and nerve stimulation applications.
摘要翻译：示例性的离子耦合电极被描述。一个示例性的离子导电电极包括可以耦合到单相电流源的第一部分。第一部分通过电子传送电流。电极包括将电流施加到神经组织的第二部分。第二部分通过离子传送电流。第二部分位于神经组织和第一部分之间，以防止第一部分接触神经组织。响应于存在于第一部分中的电流，在第二部分中产生施加到神经组织的电流。第一部分中存在的电流由单相电流源提供。电极可用于包括但不限于神经阻滞应用和神经刺激应用的应用中。

6. 发明申请

US20130184787A1 NEURAL PROSTHESIS 有权
标题翻译：神经疾病
公开(公告)号：US20130184787A1
公开(公告)日：2013-07-18
申请号：US13550231
申请日：2012-07-16
申请人： Kevin Kilgore , Paul Hunter Packham , Timothy J. Crish , Brian Smith
发明人： Kevin Kilgore , Paul Hunter Packham , Timothy J. Crish , Brian Smith
IPC分类号： A61N1/36
CPC分类号： A61N1/36128 , A61N1/36003 , A61N1/37288 , A61N1/3787
摘要： A neural prosthesis includes a centralized device that can provide power, data, and clock signals to one or more individual neural prosthesis subsystems. Each subsystem may include a number of individually addressable, programmable modules that can be dynamically allocated or shared among neural prosthetic networks to achieve complex, coordinated functions or to operate in autonomous groups.
摘要翻译：神经假体包括可向一个或多个单独神经假体子系统提供功率，数据和时钟信号的集中式装置。每个子系统可以包括多个单独可寻址的可编程模块，其可以在神经假肢网络之间动态分配或共享，以实现复杂的协调功能或在自主组中操作。

7. 发明申请

US20070293915A1 NEURAL PROSTHESIS 有权
标题翻译：神经疾病
公开(公告)号：US20070293915A1
公开(公告)日：2007-12-20
申请号：US11842929
申请日：2007-08-21
申请人： Kevin Kilgore , Paul Peckham , Timothy Crish , Brian Smith
发明人： Kevin Kilgore , Paul Peckham , Timothy Crish , Brian Smith
IPC分类号： A61N1/08
CPC分类号： A61N1/36128 , A61N1/36003 , A61N1/37288 , A61N1/3787
摘要： A neural prosthesis includes a centralized device that can provide power, data, and clock signals to one or more individual neural prosthesis subsystems. Each subsystem may include a number of individually addressable, programmable modules that can be dynamically allocated or shared among neural prosthetic networks to achieve complex, coordinated functions or to operate in autonomous groups.
摘要翻译：神经假体包括可向一个或多个单独神经假体子系统提供功率，数据和时钟信号的集中式装置。每个子系统可以包括多个单独可寻址的可编程模块，其可以在神经假肢网络之间动态分配或共享，以实现复杂的协调功能或在自主组中操作。

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